Month: December 2022

Yakubenko, Artyom A. published the artcileSelf-association of diphenylpnictoginic acids in solution and solid state: covalent vs. hydrogen bonding, Quality Control of 7080-50-4, the publication is Physical Chemistry Chemical Physics (2022), 24(13), 7882-7892, database is CAplus and MEDLINE.

Triphenylpnictogens were oxidized to access diphenylpnictioginic acids Ph₂XOOH (X = P, As, Sb, Bi). Oxidation with chloramine-T does not lead to the cleavage of a C-pnictogen bond. The preliminary reductive cleavage with sodium in liquid ammonia followed by the oxidation with hydrogen peroxide was successfully used for the synthesis of diphenylphosphinic and diphenylarsinic acids. In solid state (by XRD), all diphenylpnictoginic acids form polymeric chains. Diphenylbismuthinic and diphenylantimonic acids form polymeric covalent adducts, while diphenylphosphinic and diphenylarsinic chains are associated through hydrogen bonding. Unlike diphenylphosphinic acid, diphenilarsinic acid forms two polymorphs of hydrogen-bonded infinite chains. In solution in a polar aprotic solvent diphenylarsinic acid, similarly to dimethylarsinic, forms hydrogen-bonded cyclic dimers together with a small amount of cyclic trimers.

Physical Chemistry Chemical Physics published new progress about 7080-50-4. 7080-50-4 belongs to chlorides-buliding-blocks, auxiliary class Halogenation Reagent,Inhibitor, name is Sodium chloro(tosyl)amide trihydrate, and the molecular formula is C9H20Cl2Si, Quality Control of 7080-50-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Seth, Kapileswar published the artcileCooperative Catalysis by Palladium-Nickel Binary Nanocluster for Suzuki-Miyaura Reaction of Ortho-Heterocycle-Tethered Sterically Hindered Aryl Bromides, SDS of cas: 480438-56-0, the publication is Organic Letters (2014), 16(9), 2334-2337, database is CAplus and MEDLINE.

The palladium-nickel binary nanocluster is reported as a new catalyst system for Suzuki-Miyaura cross-coupling of ortho-heterocycle-tethered sterically hindered aryl bromides. The inferior results obtained with the reported Pd/Ni salts/complexes or individual Pd/Ni nanoparticles as catalyst reveal the cooperative catalytic effect of the Pd and Ni nanoparticles in the Pd-Ni nanocluster. The broad substrate scope with respect to variation of the 2-arylbenzoxazole moiety and boronic acids, which offers a means for diversity generation and catalyst recyclability, marks a distinct advantage. E.g., in presence of palladium-nickel binary nanoclusters in DMF, Suzuki-Miyaura cross-coupling of PhB(OH)₂ with sterically hindered aryl bromide (I) gave 80% II.

Organic Letters published new progress about 480438-56-0. 480438-56-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Ether,Boronic Acids,Boronic acid and ester, name is 3-Chloro-4-isopropoxyphenylboronic acid, and the molecular formula is C4H3Cl2N3, SDS of cas: 480438-56-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Nelson, Peter J. published the artcileEffect of ascorbic acid deficiency on the in vivo synthesis of carnitine, Synthetic Route of 6249-56-5, the publication is Biochimica et Biophysica Acta, General Subjects (1981), 672(1), 123-7, database is CAplus and MEDLINE.

Guinea pig liver and kidney carnitine [541-15-1] levels were not affected by ascorbic acid [50-81-7] deficiency, but scorbutic animals had 50% less carnitine in heart and skeletal muscle than control animals. Labeled carnitine precursors, 6-N-trimethyl-L-lysine [23284-33-5] and 4-N-trimethylaminobutyrate [407-64-7], both of which require ascorbate for their enzymic hydroxylation, were injected into the vena cava of control, pair-fed and scorbutic animals. The uptake of trimethyllysine by the liver was <2% in 1 h, while the kidney took up ∼20% of the ¹⁴C. Control and pair-fed animals converted trimethyllysine to kidney trimethylaminobutyrate 8-10 times as well as did scorbutic animals. Trimethylaminobutyrate hydroxylase [56803-11-3], present in the liver but almost absent from the kidney, converted nearly all of substrate taken up by the liver to carnitine in both the scorbutic and control animals.

Biochimica et Biophysica Acta, General Subjects published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C7H16ClNO2, Synthetic Route of 6249-56-5.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Dylag, Mariusz published the artcileAntifungal activity of organotin compounds with functionalized carboxylates evaluated by the microdilution bioassay in vitro, Recommanded Product: 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, the publication is Medical Mycology (2010), 48(2), 373-383, database is CAplus and MEDLINE.

We investigated the susceptibility of 96 well-characterized strains of yeast-like and filamentous fungi towards new organotin compounds: (1) [Sn(C₄H₉)₃(OOCC₆H₄SO₃H-2)], (2) Sn(C₄H₉)₃OOC(CH₂)₃P(C₆H₅)₃Br, and (3) [Sn(C₆H₅)₃OOC(CH₂)₃N(CH₃)₃]Cl. In the case of yeast-like fungi, the in vitro susceptibility tests were carried out according to the Clin. Laboratory Standards Institute (CLSI, formerly NCCLS) reference method M27-A2, while for filamentous fungi the investigations were conducted according to the M38-A and M38-P methods. The organotin complexes 1, 2 and 3 are active antifungal agents. Minimal inhibitory concentrations (MIC) were in the range of 0.25-4.68 μg/mL for all tested fungal strains. Considerably larger differences were found for minimal fungicidal concentrations (MFC). In the case of yeast-like fungi, the fungicidal effect was generally observed at organotin compounds concentrations of 2.34-9.37 μg/mL. The MFC values for filamentous fungi were considerably higher and were in the range of 18.74-50 μg/mL. In conclusion, organotin compounds 1, 2 and 3 showed high fungistatic and fungicidal activities against different species of pathogenic and nonpathogenic fungi. However, they were also highly cytotoxic towards two mammalian cell lines.

Medical Mycology published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C7H16ClNO2, Recommanded Product: 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

D’Agostino, Paul A. published the artcileCapillary column isobutane chemical ionization mass spectrometry of mustard and related compounds, Application of 1,2-Bis(2-chloroethyl)disulfane, the publication is Biomedical & Environmental Mass Spectrometry (1988), 15(10), 553-64, database is CAplus and MEDLINE.

Capillary column isobutane chem. ionization was an excellent method for the mass spectral characterization of mustard, other S vesicants, and related compounds Interpretation of [M + H]⁺ and fragmentation ion information afforded by this technique enabled the identification of many previously unreported mustard impurities. The developed methodol. was applied to the anal. of an Iran/Iraq soil sample suspected to have been contaminated with mustard. Mustard and 17 other mustard related impurities were identified and characterized in this sample under electron impact and isobutane chem. ionization conditions.

Biomedical & Environmental Mass Spectrometry published new progress about 1002-41-1. 1002-41-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 1,2-Bis(2-chloroethyl)disulfane, and the molecular formula is C4H8Cl2S2, Application of 1,2-Bis(2-chloroethyl)disulfane.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

D’Agostino, P. A. published the artcileGas chromatographic retention indexes of chemical warfare agents and simulants, HPLC of Formula: 1002-41-1, the publication is Journal of Chromatography (1985), 331(1), 47-54, database is CAplus.

Temperature-programmed retention indexes, relative to a homologous n-alkane series, were determined for 22 chem. warfare agents and simulants using fused-silica capillary columns coated with DB-1, DB-5, DB-1701, and DBWAX films. Reproducibility of retention indexes, based on Van den Dool’s equation, was excellent over the course of the study. The applicability of this method for compound verification was demonstrated by the anal. of a soil sample containing chem. warfare agents. In addition, an on-column injector of the design was evaluated for use with wide bore fused-silica capillary columns.

Journal of Chromatography published new progress about 1002-41-1. 1002-41-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 1,2-Bis(2-chloroethyl)disulfane, and the molecular formula is C4H8Cl2S2, HPLC of Formula: 1002-41-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

D’Agostino, P. A. published the artcileGas chromatographic retention indexes of sulfur vesicants and related compounds, Safety of 1,2-Bis(2-chloroethyl)disulfane, the publication is Journal of Chromatography (1988), 436(3), 399-411, database is CAplus and MEDLINE.

Temperature-programmed retention indexes, relative to a normal alkane homologous series, were determined for 37 sulfur vesicant or vesicant-related compounds using DB-1, DB-5, and DB-1701 fused-silica capillary columns. Many of the compounds, including long chain dichloro, vinylchloro, vinyl alc. and macrocyclic compounds have either not been previously identified or have not been associated with sulfur vesicant anal. Reproducibility of the retention indexes, based on Van den Dool’s equation, was excellent over the course of the study. In addition, changes in retention index (ΔRI), which may enable the prediction of uncharacterized homolog chromatog. behavior, were calculated for several homologous series.

Journal of Chromatography published new progress about 1002-41-1. 1002-41-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 1,2-Bis(2-chloroethyl)disulfane, and the molecular formula is C4H8Cl2S2, Safety of 1,2-Bis(2-chloroethyl)disulfane.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Gasparini, Giulio published the artcileExploiting neighboring-group interactions for the self-selection of a catalytic unit, Related Products of chlorides-buliding-blocks, the publication is Angewandte Chemie, International Edition (2008), 47(13), 2475-2479, database is CAplus and MEDLINE.

A tethering strategy is used to self-select groups that assist in the cleavage of a neighboring carboxylic ester moiety. A correlation is observed between the amplification at thermodn. equilibrium and the catalytic efficiency.

Angewandte Chemie, International Edition published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C7H16ClNO2, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Toledo-Sherman, Leticia M. published the artcileDevelopment of a Series of Aryl Pyrimidine Kynurenine Monooxygenase Inhibitors as Potential Therapeutic Agents for the Treatment of Huntington’s Disease, Name: 3-Chloro-4-isopropoxyphenylboronic acid, the publication is Journal of Medicinal Chemistry (2015), 58(3), 1159-1183, database is CAplus and MEDLINE.

We report on the development of a series of pyrimidine carboxylic acids that are potent and selective inhibitors of kynurenine monooxygenase and competitive for kynurenine. We describe the SAR for this novel series and report on their inhibition of KMO activity in biochem. and cellular assays and their selectivity against other kynurenine pathway enzymes. We describe the optimization process that led to the identification of a program lead compound with a suitable ADME/PK profile for therapeutic development. We demonstrate that systemic inhibition of KMO in vivo with this lead compound provides pharmacodynamic evidence for modulation of kynurenine pathway metabolites both in the periphery and in the central nervous system.

Journal of Medicinal Chemistry published new progress about 480438-56-0. 480438-56-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Ether,Boronic Acids,Boronic acid and ester, name is 3-Chloro-4-isopropoxyphenylboronic acid, and the molecular formula is C8H19NO, Name: 3-Chloro-4-isopropoxyphenylboronic acid.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Fuson, Reynold C. published the artcileLevinstein mustard gas. I. 2-Haloalkylsulfenyl halides, SDS of cas: 1002-41-1, the publication is Journal of Organic Chemistry (1946), 469-74, database is CAplus and MEDLINE.

In the reaction mechanism postulated by Conant, et al. ( C.A. 14, 1677), ClCH₂CH₂SCl (I) is suggested as an intermediate in the formation of (ClCH₂CH₂)₂S (II) although I has never been obtained in a pure state. When 169 g. Cl is passed into 453 g. (ClCH₂CH₂)₂S₂ (III) in dry CCl₄ at such a rate that the temperature does not exceed 10° the solvent distilled off, and the residue fractionated, 57-79% I, b₁₅ 47-7.5° n_D²⁰ 1.5290, is obtained. I, orange liquid, is moderately stable when kept in a brown bottle in the refrigerator. The residue (173 g.) from the distillation, on further fractionation, gives III and a new compound, C₄H₇Cl₃S₂, yellow liquid, n_D^21.8 1.5768. When I is treated with KI, III is formed with liberation of iodine. When I is treated with H₂O, III, b₂ 83-8°, n_D²⁰ 1.5670, m. 1° is formed, in addition to an unidentified product, probably the thiosulfonic ester. When equal mols. I and S are heated for 3 h. at 60-5° and distilled, S₂Cl₂, III and (ClCH₂CH₂)₂S₃ (IV) are obtained. Oxidation of 4.8 g. I with 30 cc. HNO₃ (d. 1.42) on a steam bath, evaporation to dryness, dissolution of the residue in an excess of NH₄OH, and evaporation again give 79% ClCH₂CH₂SO₂ONH₄, m. 191-3°. When CH₂:CH₂ is passed into 10 g. I in 90 cc. CCl₄, the solution is decolorized with formation of 70% II, b₁ 54-5°, n_D²⁰ 1.5281. I and cydohexene (V) give 69% 2-chlorocyclohexyl 2-chloroethyl sulfide (VI), b_0.2 84-6° (p-tolylsulfonylsulfilimine, prepared by treating VI with Chloramine-T, m. 145.5-6° (preheated bath)). When 185 g. I is dropped into 1500 cc. AcOEt over a period of 2 h. saturated with CHCH at 0° with continuous introduction of CHCH, 56% 2-chloroethyl 2-chlorovinyl sulfide, b_0.15 30°, b_0.75 46°, m. -24° n_D²⁰ 1.5480 (p-tolylsulfonylsulfilimine m. 105-5.5° sulfone, platelets from petr. ether, m. 37.5-8°), is obtained. When 35 g. I and Me₂CO are allowed to react, HCl is evolved and the solution becomes colorless, giving acetonyl 2-chloroethyl sulfide, b_0.75 76-85° (semicarbazone m. 145-6°). When I and piperazine are allowed to react according to Rheinboldt and Mott (C.A. 33, 4959.4), 1,4-bis(2-chloroethylmercapto)piperazine, needles from EtOH, m. 117-18° is obtained. When III is treated with Br in 150 cc. CCl₄, ClCH₂CH₂SBr is obtained after distilling off the solvent in vacuo at room temperature It decomposes on distillation at 3 mm. When V is added to the bromination reaction mixture, 75% 2-bromocyclohexyl 2-chloroethyl sulfide is formed, decomposing slightly on distillation at 0.35 mm. (p-tolylsulfonylsulfilimine, crystals from EtOH, m. 145-6°).

Journal of Organic Chemistry published new progress about 1002-41-1. 1002-41-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 1,2-Bis(2-chloroethyl)disulfane, and the molecular formula is C4H8Cl2S2, SDS of cas: 1002-41-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics