Month: December 2022

Tarakhovskii, M. L. published the artcileAnticholinesterase activity and toxicity of some phosphonate esters containing a trichloromethyl group, Formula: C5H10Cl3O3P, the publication is Fiziologicheski Aktivnye Veshchestva (1976), 33-6, database is CAplus.

Of 11 phosphonic acid esters tested [ROP:O(OR1)R2], the 2 compds, where R = Et, R1 = (CH2)4CCl3, R2 = Me and where R = R1 = Et, R2 = CCl3 had the greatest anticholinesterase activity, inhibiting the enzyme 50% at 8.3 × 10-7 and 7.6 × 10-6 mol/L, resp. The compound where R = R1 = Et, R2 = Me had no anticholinesterase activity and the remaining compounds inhibited the enzyme at concentrations ranging from 5.75 × 10-5 to 6.5 × 10-1 mol/L. The i.p. LD50 values in mice ranged from 720 to 2240 mg/kg, the most active anticholinesterase having the greatest toxicity and the inactive compound having the least. These compounds were less toxic than some presently used in medical practice.

Fiziologicheski Aktivnye Veshchestva published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C10H11NO4, Formula: C5H10Cl3O3P.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Mohammadhosseini, Negar published the artcileSynthesis and biological evaluation of novel benzyl piperazine derivatives of 5-(5-nitroaryl)-1,3,4-thiadiazoles as anti-Helicobacter pylori agents, Name: 2,4,5-Trifluorobenzyl chloride, the publication is Daru, Journal of Pharmaceutical Sciences (2013), 66/1-66/8, 8 pp., database is CAplus and MEDLINE.

A series of 1-(substituted benzyl)-4-(5-(5-nitroheteroaryl-2-yl)-1,3,4-thiadiazol-2-yl) piperazine derivatives I [X = O, S; R= 3-MeO, 2-O₂N, 2,5-(Cl)₂, 2,4,5-(F)₃, etc.] were synthesized. The synthesized compounds I were evaluated against three metronidazole-resistant isolates of Helicobacter pylori using disk diffusion bioassay test. The results of SAR study indicated that the potency and anti-H. pylori activity profile of synthesized derivatives was mainly attributed to the substituted nitroaryl moiety at the C-5 position of 1,3,4-thiadiazole ring. Compound I [X = O; R = 3-MeO] was found to be the most potent.

Daru, Journal of Pharmaceutical Sciences published new progress about 243139-71-1. 243139-71-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 2,4,5-Trifluorobenzyl chloride, and the molecular formula is C7H4ClF3, Name: 2,4,5-Trifluorobenzyl chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Parmar, Tejasvi H. published the artcileSynthesis of novel drug-like small molecules library based on 1H-benzo[d]imidazole, Quality Control of 915763-60-9, the publication is Australian Journal of Chemistry (2022), 75(4), 276-284, database is CAplus.

A series of novel ‘drug-like’ small mols. based on 1H-benzo[d]imidazole derivatives bearing furan-2-yl, 4-piperidine and 5-aryl/aminoaryl substitutions were designed and synthesized. The key intermediate tert-butyl-4-(5-bromo-2-(furan-2-yl)-1H-benzo[d]imidazol-1-yl)piperidine-1-carboxylate was synthesized via sequential reaction starting from 4-bromo-1-fluoro-2-nitrobenzene. The 5-aryl-substituted mol. library was generated via Suzuki-Miyaura coupling of the key intermediate with various boronic acids while Buchwald coupling with various anilines generated the second mol. library of tert-butyl-4-(2-(furan-2-yl)-5-(arylamino)-1H -benzo[d]imidazol-1-yl)piperidine-1-carboxylates. The structures of all the newly synthesized compounds were confirmed by spectral anal. The optimized procedure gives easy access to two new mol. libraries of 1H-benzo[d]imidazoles with operational simplicity and good yield.

Australian Journal of Chemistry published new progress about 915763-60-9. 915763-60-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Nitrile,Boronic acid and ester,Benzene,Boronic Acids,Boronic acid and ester, name is (3-Chloro-5-cyanophenyl)boronic acid, and the molecular formula is C7H5BClNO2, Quality Control of 915763-60-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Veeresham, A. published the artcileGas chromatography/mass spectrometry analysis of reaction products of sulfur mustards with phenol, Application of 1,2-Bis(2-chloroethyl)disulfane, the publication is European Journal of Mass Spectrometry (2020), 26(3), 213-224, database is CAplus and MEDLINE.

Screening of chems. related to chem. weapons convention including their all possible degrdation and reaction products in environmental samples is important in the organization for prohibition of chem. weapons verification process. Sulfur mustards, commonly known as blistering agents, are included in schedule 1 chems. of chem. weapons convention. Because of the presence of chlorine atoms in sulfur mustards, they are highly reactive and prone to react with other organic mols. such as phenols to produce corresponding reaction products. In this study, the reaction products of the sulfur mustards with phenol (compounds 1-7) were studied by gas chromatog./mass spectrometry under electron ionization and chem. ionization conditions. The EI spectra of 1-7 displayed mol. ion and characteristic fragments that provided structure information. The methane or isobutane CI spectra showed M^+., [M + H]⁺, and [M – H]⁺ ions including reagent specific adduct ions. The CI spectra also showed other adduct ions formed by association of analyte mols. with its most abundant fragment ion. The gas chromatog./retention index values were also calculated, which support unambiguous identification of targeted mols. in suspected environmental samples. The method was demonstrated for detection of the targeted mols. spiked in soil samples.

European Journal of Mass Spectrometry published new progress about 1002-41-1. 1002-41-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 1,2-Bis(2-chloroethyl)disulfane, and the molecular formula is C7H7IN2O, Application of 1,2-Bis(2-chloroethyl)disulfane.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Macsari, Istvan published the artcilePhenyl isoxazole voltage-gated sodium channel blockers: Structure and activity relationship, Computed Properties of 3919-74-2, the publication is Bioorganic & Medicinal Chemistry Letters (2011), 21(13), 3871-3876, database is CAplus and MEDLINE.

Blocking of certain sodium channels is considered to be an attractive mechanism to treat chronic pain conditions. Ph isoxazole carbamate (I) was identified as a potent and selective Na_V1.7 blocker. Structural analogs of I, both carbamates, ureas and amides, were proven to be useful in establishing the structure-activity relation and improving ADME related properties. Amide II showed a good overall in vitro profile, that translated well to rat in vivo PK.

Bioorganic & Medicinal Chemistry Letters published new progress about 3919-74-2. 3919-74-2 belongs to chlorides-buliding-blocks, auxiliary class Isoxazole,Fluoride,Chloride,Carboxylic acid,Benzene, name is 3-(2-Chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylic acid, and the molecular formula is C11H7ClFNO3, Computed Properties of 3919-74-2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Ibarra-Lara, L. published the artcileClofibrate improves myocardial ischemia-induced damage through regulation of renin-angiotensin system and favours a pro-vasodilator profile in left ventricle, Formula: C12H15ClO3, the publication is Journal of Pharmacological Sciences (Amsterdam, Netherlands) (2020), 144(4), 218-228, database is CAplus and MEDLINE.

Myocardial ischemia initiates a chain of pathol. conditions leading to cardiomyocyte death. Therefore, pharmacol. treatment to stop ischemia-induced damage is necessary. Fibrates, have been reported to decrease inflammatory markers and to modulate the renin-angiotensin system (RAS). Our aim was to explore if clofibrate treatment, administered one week after myocardial event, decreases MI-induced cardiac damage. Wistar rats were assigned to: 1. Sham or 2. Coronary artery ligation (MI). Seven days after, rats were subdivided to receive vehicle (V) or clofibrate [100 mg/kg (C)] daily for 7 days. Blood samples and left ventricle were analyzed. RAS components [angiotensin II, angiotensin converting enzyme (ACE), and AT1-receptor] decreased in MI-C compared to MI-V, while [Ang-(1-7), bradykinin, ACE-2, and AT2-receptor] raised in response to clofibrate treatment. Oxidative stress markers increased in MI-V rats, a profile reverted in MI-C rats. Nitric oxide (NO) pathway (Akt, eNOS, and NO) exhibits a lower participation in MI-V, but clofibrate raised NO-pathway components and its production MI-induced fibrosis and structural damage was also improved by clofibrate-treatment. In conclusion, clofibrate administration to 7 days MI-rats exerts an antioxidant, pro-vasodilator expression profile, and anti-fibrotic effect suggesting that PPARα activation can be considered a therapeutic target to improve cardiac condition posterior to ischemia.

Journal of Pharmacological Sciences (Amsterdam, Netherlands) published new progress about 637-07-0. 637-07-0 belongs to chlorides-buliding-blocks, auxiliary class Inhibitor,Cell Cycle,PPAR, name is Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate, and the molecular formula is C12H15ClO3, Formula: C12H15ClO3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Creber, K. A. M. published the artcileAn investigation into the use of ionizing radiation for the destruction of sulphur mustard, Safety of 1,2-Bis(2-chloroethyl)disulfane, the publication is Journal of Radioanalytical and Nuclear Chemistry (2009), 282(2), 597-600, database is CAplus.

Chem. warfare agents have been stockpiled for almost a decade and their destruction has become an environmental issue that will continue to require attention for many years. There are hundreds of thousands of tons yet to be destroyed, and the current chem. or incineration techniques are not without problems. While many researchers are seeking better chem. techniques, we decided to try ionizing radiation to destroy sulfur mustard with the goal of producing non-toxic products. We irradiated a variety of sulfur mustard samples by both a mixed field source (β, γ and neutrons) and a pure gamma source. The mixed field irradiation of wet sulfur mustard for long irradiation times was the most successful at destroying the chem. agent.

Journal of Radioanalytical and Nuclear Chemistry published new progress about 1002-41-1. 1002-41-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 1,2-Bis(2-chloroethyl)disulfane, and the molecular formula is C4H8Cl2S2, Safety of 1,2-Bis(2-chloroethyl)disulfane.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Estrader, Marta published the artcileA Magneto-optical Molecular Device: Interplay of Spin Crossover, Luminescence, Photomagnetism, and Photochromism, Safety of 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, the publication is Angewandte Chemie, International Edition (2017), 56(49), 15622-15627, database is CAplus and MEDLINE.

A bis(pyrazolylpyridyl) ligand, L, containing a central photochromic dithienylethene spacer predictably forms a ferrous [Fe₂L₃]⁴⁺ helicate exhibiting spin crossover (SCO). In solution, the compound [Fe₂L₃](ClO₄)₄ (1) preserves the magnetic properties and is fluorescent. The structure of 1 is photo-switchable following the reversible ring closure/opening of the central dithienylethene via irradiation with UV/visible light. This photoisomerization switches on and off some emission bands of 1 and provides a means of externally manipulating the magnetic properties of the assembly.

Angewandte Chemie, International Edition published new progress about 219537-97-0. 219537-97-0 belongs to chlorides-buliding-blocks, auxiliary class Fused/Partially Saturated Cycles,Cyclopentenes, name is 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, and the molecular formula is C15H14Cl2S2, Safety of 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Abdeen, Sanofar published the artcileTargeting the HSP60/10 chaperonin systems of Trypanosoma brucei as a strategy for treating African sleeping sickness, SDS of cas: 10543-42-7, the publication is Bioorganic & Medicinal Chemistry Letters (2016), 26(21), 5247-5253, database is CAplus and MEDLINE.

Trypanosoma brucei are protozoan parasites that cause African sleeping sickness in humans (also known as Human African Trypanosomiasis-HAT). Without treatment, T. brucei infections are fatal. There is an urgent need for new therapeutic strategies as current drugs are toxic, have complex treatment regimens, and are becoming less effective owing to rising antibiotic resistance in parasites. The authors hypothesize that targeting the HSP60/10 chaperonin systems in T. brucei is a viable anti-trypanosomal strategy as parasites rely on these stress response elements for their development and survival. The authors recently discovered several hundred inhibitors of the prototypical HSP60/10 chaperonin system from Escherichia coli, termed GroEL/ES. One of the most potent GroEL/ES inhibitors the authors discovered was compound (I). While examining the PubChem database, the authors found that a related analog, 4-methyl-N-(4-(5-((4-methylphenyl)sulfonamido)benzo[d]oxazol-2-yl)phenyl)benzenesulfonamide (2e-p), exhibited cytotoxicity to Leishmania major promastigotes, which are trypanosomatids highly related to Trypanosoma brucei. Through initial counter-screening, the authors found that compounds (I) and 2e-p were also cytotoxic to Trypanosoma brucei parasites (EC₅₀ = 7.9 and 3.1 μM, resp.). These encouraging initial results prompted the authors to develop a library of inhibitor analogs and examine their anti-parasitic potential in vitro. Of the 49 new chaperonin inhibitors developed, 39% exhibit greater cytotoxicity to T. brucei parasites than parent compound (I). While many analogs exhibit moderate cytotoxicity to human liver and kidney cells, the authors identified mol. substructures to pursue for further medicinal chem. optimization to increase the therapeutic windows of this novel class of chaperonin-targeting anti-parasitic candidates. An intriguing finding from this study is that suramin, the first-line drug for treating early stage T. brucei infections, is also a potent inhibitor of GroEL/ES and HSP60/10 chaperonin systems.

Bioorganic & Medicinal Chemistry Letters published new progress about 10543-42-7. 10543-42-7 belongs to chlorides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Chloride,Sulfonyl chlorides,Ester, name is Coumarin-6-sulfonyl chloride, and the molecular formula is C9H5ClO4S, SDS of cas: 10543-42-7.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Bahrami, Kiumars published the artcile[BTBA]Cl-FeCl₃ as an Efficient Lewis Acid Ionic Liquid for the Synthesis of Perimidine Derivatives, HPLC of Formula: 23616-79-7, the publication is Synthesis and Reactivity in Inorganic, Metal-Organic, and Nano-Metal Chemistry (2016), 46(6), 852-856, database is CAplus.

An effective synthesis of various biol. important 2,3-dihydroperimidines from reaction of aldehydes and naphthalene-1,8-diamine was developed using [BTBA]Cl-FeCl₃ as an efficient Lewis acid ionic liquid This method was a very simple and high yielding reaction for the preparation of the titled compounds Different functional groups were tolerated under this reaction conditions including ether, phenol, amine, and alkene.

Synthesis and Reactivity in Inorganic, Metal-Organic, and Nano-Metal Chemistry published new progress about 23616-79-7. 23616-79-7 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst, name is N-Benzyl-N,N-dibutylbutan-1-aminium chloride, and the molecular formula is C19H34ClN, HPLC of Formula: 23616-79-7.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics