Month: December 2022

Honda, Mitsunori published the artcileSynthesis of 1-hydrocarbon substituted cyclopropyl silyl ketones, Safety of trimethyloxosulphonium chloride, the publication is Tetrahedron Letters (2018), 59(42), 3777-3781, database is CAplus.

The synthesis of cyclopropyl silyl ketones possessing a hydrocarbon group at 1-position of three-membered ring was investigated. The reaction of sulfoxonium ylide with α,β-unsaturated acylsilanes derived from α,β-unsaturated aldehydes did not afford the desired acylsilane derivatives Instead, the corresponding silyl enol ethers were yielded exclusively. On the other hand, the Corey-Chaykovsky cyclopropanation of α-substituted α,β-unsaturated aldehydes proceeded well to give 1-substituted cyclopropyl aldehydes. The silyl substitution of formyl proton in the obtained aldehydes via umpolung of carbonyl group afforded the target acylsilanes.

Tetrahedron Letters published new progress about 5034-06-0. 5034-06-0 belongs to chlorides-buliding-blocks, auxiliary class Salt,Aliphatic hydrocarbon chain, name is trimethyloxosulphonium chloride, and the molecular formula is C3H9ClOS, Safety of trimethyloxosulphonium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Le Menn, Jean Christophe published the artcileElectrochemically generated phosphonate carbanions: formation and reactivity towards aldehydes, Application of Diethyltrichloromethylphosphonate, the publication is Canadian Journal of Chemistry (1989), 67(8), 1332-43, database is CAplus.

Reactivity towards p-methoxybenzaldehyde (ArCHO) of electrochem. generated phosphonate carbanions was investigated. Electrolysis were carried out at a Hg cathode in DMF and two routes to the desired carbanion were compared: (i) deprotonation of phosphonates of general formula (EtO)₂P(O)CHYW (Y = W = Cl; Y = H, W = Cl; Y = Cl, W = CO₂Et; Y = H, W = CO₂Et; Y = CH₃, W = CO₂Et; Y = Cl, W = CH₃), by the bases resulting from the electroreduction of azobenzene; addition of the carbanion formed onto the carbonyl group takes place and leads to the adduct (EtO)₂P(O)CYW(Ar)O^–. (Ii) Two-electron reduction of halophosphonates (EtO)₂P(O)CXYZ (X = Cl, Y and W as above; X = Br, W = CO₂Et, Y = Cl, Br, or CH₃); when no H atoms is present on the carbon bearing the phosphonate group (Y and W ≠ H), the same evolution leading to the above adduct is observed; on the contrary, when Y = H, the electrogenerated carbanion deprotonates the substrate and the resulting carbanion (EtO)₂P(O)CXW^– reacts with the aldehyde, giving the adduct (EtO)₂P(O)CXW(Ar)O^–. Evolution of the intermediate adduct depends on the substituents Y (or X) and W: when W = CO₂Et, whatever the nature of Y (or X), di-Et phosphate is eliminated with formation of the ethylenic ArCH = CWY (or X) (Wittig-Horner reaction); the same evolution is observed when Y = W = Cl. When W = Cl and Y = H or CH₃, the final product is the phosphonate epoxide resulting from chloride elimination (Darzens reaction). Chemo- and stereoselectivity depends only on the nature of Y and W but are independent of the mode of generation of the carbanion. Yields are limited by side-protonation reactions, which are related to the basicity of the phosphonate carbanions. Anal. of the results permits selection of the optimal electrolysis conditions for purposes of synthesis.

Canadian Journal of Chemistry published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, Application of Diethyltrichloromethylphosphonate.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Le Menn, J. Christophe published the artcileElectrochemical synthesis of diethyl 1,1-dichloroalkylphosphonates, Related Products of chlorides-buliding-blocks, the publication is Journal of Chemical Research, Synopses (1989), 26-7, database is CAplus.

The electrochem. reduction of diethyl(trichloromethyl)phosphonate in aprotic medium containing alkyl halides forms diethyl-1,1-dichloroalkylphosphonates in good yields. Thus, in a 2-compartment cell a mixture of trichloromethylphosphonate and alkylating agent in DMF containing Bu₄NBF₄ was electrolyzed using a Hg pool cathode. The product was isolated and distilled under reduced pressure.

Journal of Chemical Research, Synopses published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Le Menn, J. C. published the artcileThe methoxy-iminium cation issued from DMF in organic electrosynthesis: an electrophile and a supporting-electrolyte cation, Related Products of chlorides-buliding-blocks, the publication is Electrochimica Acta (1991), 36(5-6), 819-23, database is CAplus.

Electrophilic reactivity of the methoxy-iminium cation (I), resulting from the reaction between dimethyl sulfate and DMF, has been investigated towards electrogenerated carbanions produced by electroreduction of activated polyhalo compounds Controlled potential reduction of di-Et trichloromethylphosphonate (II) in the presence of three equivalent of I in DMF leads to the expected adduct (EtO)₂P(O)CCl₂-CH(NMe₂)OMe (60% yield). Galvanostatic reduction of II in the presence of two equivalent of I leads to mixtures of the enamine (EtO)₂P(O)CCl=CH(NM₂) and the ynamine (EtO)₂P(O)CCNMe₂; when acetic acid is added, a mixture of the enamine and the enol-ether (EtO)₂P(O)CCl=CH(OMe) is obtained. Lastly, the enamine can be synthesized with a 80% yield by electroreducing II in the presence of four equivalent of I in the same way, enamines (MeO₂C)₂C=CH(NMe₂) (40% yield) and (EtO₂C)CCl=CH(NMe₂) (50% yield) are obtained from the electroreduction of di-Me dibromomalonate or Et trichloroacetate, resp.

Electrochimica Acta published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Sarmah, N. K. published the artcileSynthesis and antimicrobial evaluation of a novel series of some s-triazine moiety, Related Products of chlorides-buliding-blocks, the publication is Journal of Applicable Chemistry (Lumami, India) (2014), 3(5), 1936-1944, 9 pp., database is CAplus.

Some new 2-[N-(3,4,5-trimethoxybenzylidino)(benzoylhydrazinoyl)-amino-4-yl]-4-(4-cyclohexylamino)-6-(arylthioureido)-1,3,5-triazines I (R = 2-OMe, 2-Me, 2-Cl, etc.) were synthesized and evaluated for their in vitro antimicrobial activity against gram pos. and gram neg. strains using micro dilution procedure. Synthesized compounds proved to be effective with MIC (mg ml^-1), among them I (R = 4-OMe, 2-O₂N, 2,4-di-O₂N, R = 2-Cl-4-O₂N) showed excellent activity against a panel of microorganisms.

Journal of Applicable Chemistry (Lumami, India) published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Kalita, Pranjal published the artcileKIT-5 Supported Copper (II) Oxide Mesoporous Materials: An Efficient Catalyst for Regioselective Synthesis of 1,4- Disubstituted-1H-1,2,3-Triazoles in Water, HPLC of Formula: 620-20-2, the publication is Polycyclic Aromatic Compounds, database is CAplus.

We have synthesized copper-incorporated KIT-5 mesoporous materials which were characterized thoroughly by powder x-ray diffraction, N₂-sorption, UV-Vis, HR-SEM & EDS and HR-TEM techniques. The low angle PXRD with theta values of 0.609, 0.660, 0.704 and 0.746 confirmed the mesoporosity of the synthesized materials. In addition, the materials showed type-IV isotherms which are spherical in morphol. and fringes with pores of materials supporting the formation of mesoporous materials. The catalytic activity of synthesized materials was also investigated. We have used our materials as catalyst for the synthesis of 1,2,3-triazole derivatives via three component reaction of alkyl/aryl halide, terminal alkynes and sodium azide in water as a solvent. The desired triazole products were obtained in very good yields. This study indicates the importance of Cu element, solid support with uniformity of metal nanoparticles over the materials. The recyclability study with PXRD data of the catalyst confirmed the existence of the mesoporosity of the catalyst after the reaction and the yield decreased marginally from 98 to 91% over three cycles. This reaction has broad substrate scope and is compatible for aliphatic, aromatic, allyl substrates giving high yield of triazole products.

Polycyclic Aromatic Compounds published new progress about 620-20-2. 620-20-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 3-Chlorobenzylchloride, and the molecular formula is C7H6Cl2, HPLC of Formula: 620-20-2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Bagherzadeh, Nastaran published the artcileGreen and efficient synthesis of thioureas, ureas, primary O-thiocarbamates, and carbamates in deep eutectic solvent/catalyst systems using thiourea and urea, Recommanded Product: 1-(4-Chlorophenyl)thiourea, the publication is New Journal of Chemistry (2021), 45(26), 11852-11858, database is CAplus.

An efficient and general catalysis process was developed for the direct preparation of various primary O-thiocarbamates/carbamates as well as monosubstituted thioureas/ureas by using thiourea/urea as biocompatible thiocarbonyl (carbonyl) sources. This procedure used choline chloride/tin(II) chloride [ChCl][SnCl₂]₂ with a dual role as a green catalyst and reaction medium to afford the desired products in moderate to excellent yields. Moreover, the DES can be easily recovered and reused for seven cycles with no significant loss in its activity. Besides, the method shows very good performance for synthesizing the desired products on a large scale.

New Journal of Chemistry published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, Recommanded Product: 1-(4-Chlorophenyl)thiourea.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Cardenas, Mariel M. published the artcileCatalytic atroposelective dynamic kinetic resolutions and kinetic resolutions towards 3-arylquinolines via S_NAr, Computed Properties of 145349-62-8, the publication is Chemical Communications (Cambridge, United Kingdom) (2021), 57(78), 10087-10090, database is CAplus and MEDLINE.

Herein authors report the catalytic atroposelective syntheses of pharmaceutically relevant 3-arylquinolines via the nucleophilic aromatic substitution (SNAr) of thiophenols into 3-aryl-2-fluoroquinolines mediated by catalytic amounts of Cinchona alkaloid-derived ureas. These reactions displayed a spectrum of dynamic kinetic resolution (DKR) and kinetic resolution (KR) characters depending upon the stereochem. stability of the starting material. Low barrier substrates proceeded via DKR while higher barrier substrates proceeded via KR. On the other hand, substrates with intermediate stabilities displayed hallmarks of both DKR and KR. Finally, authors also show that they can functionalize the atropisomerically enriched quinolines into pharmaceutically privileged scaffolds with minimal observed racemization.

Chemical Communications (Cambridge, United Kingdom) published new progress about 145349-62-8. 145349-62-8 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Boronic Acids, name is 2-Chloro-4-methylphenylboronic acid, and the molecular formula is C7H8BClO2, Computed Properties of 145349-62-8.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Kodolov, V. I. published the artcileMechanism of the reaction of diethyl alkylphosphonates with hydroxyl-containing polyethers, Safety of Diethyltrichloromethylphosphonate, the publication is Vysokomolekulyarnye Soedineniya, Seriya A (1968), 10(11), 2541-9, database is CAplus.

Di-Et alkylor arylphosphonates are treated with OH-containing oligoethers to obtain products which are useful as additives possessing fire resistance in foamed plastics, glass reinforced plastics, and other materials. Di-Et phosphonate and methyl-, allyl-, trichloromethyl-, and phenylphosphonates are used, and the oligoethers are HO[CH2CH2O2CRCO]mOCH2CH2OH, where R = -CH2-CH2-, -CH:CH-, or -o-C6H4-, where m is 1-2. The compounds are heated at 160-80° under N. The quantity of condensate increases after 4-6 hrs. with the acid number increasing and the OH-group content decreasing. Chromatograms, kinetic data, and ir spectra are given for the products and discussed, and a mechanism for the reaction, based on the destruction of the oligoether by alcoholysis, followed by a proton-radical exchange between the oligoether and the Et Cellosolve formed is proposed.

Vysokomolekulyarnye Soedineniya, Seriya A published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, Safety of Diethyltrichloromethylphosphonate.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Nandi, Sudipta published the artcileUrea transporter and its specific and nonspecific inhibitors: State of the art and pharmacological perspective, Application of 1-(4-Chlorophenyl)thiourea, the publication is European Journal of Pharmacology (2021), 174508, database is CAplus and MEDLINE.

Hypertension is a major concern for a wide array of patients. The traditional drugs are commonly referred as ′water pills′ and these mols. have been successful in alleviating hypertension. However, this comes at the high expense of precious electrolytes in our body. To dissipate this major adverse effect, the urea transporter inhibitors play especially important roles in maintaining the fluid balance by maintaining the concentration of urea in the inner medullary collecting duct. The purpose of this communication is to provide insights into the structural feature of these target proteins and inhibition of both urea transporter types A (UT-A) and B (UT-B) selectively and non-selectively with a special focus on the UT-A inhibitors as they are the primary target for diuresis. It was observed that a wide class of drugs such as thiourea analogs, 2,7-disubstituted fluorenones can inhibit both the protein non-selectively whereas 8-hydroxyquinoline, aminothiazolone, 1,3,5-triazine, triazolothienopyrimidine, thienoquinoline, arylthiazole, γ-sultambenzosulfonamide and 1,2,4-triazoloquinoxaline classes of compounds inhibit UT-A. The goal of this study is to highlight the important aspects that may be useful to understanding the perspectives of urea transporter inhibitors in rational drug discovery.

European Journal of Pharmacology published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, Application of 1-(4-Chlorophenyl)thiourea.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics