Month: December 2022

Myannik, A. O. published the artcileSynthesis and properties of some esters of phosphoric, thiophosphoric, and phosphonic acids, Application In Synthesis of 866-23-9, the publication is Neftekhimiya (1964), 4(6), 899-905, database is CAplus.

The influence of the trichloromethyl group in different esters of phosphoric, thiophosphoric, and alkylphosphorous esters on their antiabrasive properties were studied. The following compounds prepared by known methods [b.p. (mm.), d₂₀, n²⁰_D), and MR_D given]: iso-AmOP(O)(OEt)₂, 85-8°(3), 1.0164, 1.4150, 55.21; CCl₃CH₂OP(O)(OEt)₂, 119-20°(4), 1.3473, 1.4490, 56.85; CCl₃CH₂OP(O)(OBu)₂, 126-7°(2), 1.2097, 1.4480, 75.48; CCl₃(CH₂)₄OP(O)(OEt)₂, 155-6°(2), 1.2685, 1.4850, 70.48; CCl₃(CH₂)₄OP(O)(OBu)₂, 196-7°(2), 1.1637, 1.4550, 89.39; AmSP(O)(OEt)₂, 145-6°(6), 1.0434, 1.4575, 62.73; Me(CH₂)₈SP(O)(OEt)₂, 177-8°(2), 0.9985, 1.4600, 81.19; CCl₃(CH₂)₄SP(O)(OEt)₂, 165-7°(2), 1.2892, 1.4940, 77.40; CCl₃(CH₂)₄SP(O)(OPr)₂, 186-7°(2), 1.2226, 1.4890, 87.45; CCl₃(CH₂)₄SP(O)(OBu-iso)₂, 183-4°(2), 1.1875, 1.4850, 96.42; CCl₃(CH₂)₈SP(O)(OEt)₂, 217- 18°(2), 1.1900, 1.4885, 96.80; EtOP(S)(OEt)₂, 88-9°(8), 1.0746, 1.4480, 49.33; BuOP(S)(OEt)₂, 120-1°(5), 1.0412, 1.4505, 58.40; CCl₃CH₂OP(S)(OEt)₂, 130-1°(3), 1.3414, 1.4840, 64.32; CCl₃(CH₂)₄OP(S)(OEt)₂, 153-4°(4), 1.2647, 1.4873, 78.14; MeP(O)(OEt)₂, 74-5°(10), 1.0685, 1.4140, 35.53; MeP(O)(OAm)₂, 98-9°(2), 0.9618, 1.4307, 63.33; CCl₃P(O)(OEt)₂, 88-9°(2), 1.3738, 1.4645, 51.30; CCl₃P(O)(OAm)₂, 123-4°(1), 1.1745, 1.4601, 79.01; MeP(O)OCH₂CCl₃)₂, –(m. 63-3.5°), –, –, –; MeP(O)[O(CH₂)₄CCl₃₂, 177-8°(1), 1.3838, 1.4941, 92.91; CCl₃P(O)(OCH₂CCl₃)₂ –(m. 94-94.5°),–, –, –.

Neftekhimiya published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, Application In Synthesis of 866-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Yao, Shengxin published the artcileSynthesis and spectroscopic properties of BODIPY-dithienylethene conjugates, Recommanded Product: 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, the publication is Journal of Porphyrins and Phthalocyanines (2021), 25(10/12), 930-936, database is CAplus.

Two red fluorescent triads containing photochromic dithienylethene moiety linked to two 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene (BODIPY) via acetylene bond, 1a or single bond, 1b were synthesized and characterized. Although no evident absorption and NMR spectra changes were observed upon irradiation with visible light, the absorption and fluorescence spectra of 1a and 1b are remarkably solvent dependent, in contrast to those of the reference BODIPY-thienyl compounds 2a and 2b, which are essentially solvent independent. Fluorescence intensities of 1a and 1b decreased as the solvent polarity increased, and the fluorescence decay showed two exponentials in polar solvents other than n-hexane. DFT calculations have been carried out to elucidate the spectral behavior of investigated compounds

Journal of Porphyrins and Phthalocyanines published new progress about 219537-97-0. 219537-97-0 belongs to chlorides-buliding-blocks, auxiliary class Fused/Partially Saturated Cycles,Cyclopentenes, name is 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, and the molecular formula is C14H14, Recommanded Product: 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Liu, Caiyan published the artcileNon-directed copper-catalyzed regioselective C-H sulfonylation of phenothiazines, Synthetic Route of 10543-42-7, the publication is Organic & Biomolecular Chemistry (2019), 17(20), 5009-5013, database is CAplus and MEDLINE.

A simple and general method for the synthesis of phenothiazinyl sulfones I [R = n-Bu, Ph, Bn, etc.; R¹ = cyclopropyl, 4-MeC₆H₄, 2-naphthyl, etc.; R² = H, SMe, Cl; R³ = H, Cl] was developed via copper-catalyzed regioselective C-H sulfonylation of phenothiazines with sulfonyl chlorides. The broad scope of aryl/alkyl sulfonyl chlorides was applicable to produce C3 sulfonylation products of phenothiazines in moderate to good yields. The further transformation of the sulfonylation products was successful, which afforded valuable polyheterocycles.

Organic & Biomolecular Chemistry published new progress about 10543-42-7. 10543-42-7 belongs to chlorides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Chloride,Sulfonyl chlorides,Ester, name is Coumarin-6-sulfonyl chloride, and the molecular formula is C9H5ClO4S, Synthetic Route of 10543-42-7.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Cheng, Hua published the artcileDiscovery of 1,2,4-triazole-1,3-disulfonamides as dual inhibitors of mitochondrial complex II and complex III, Related Products of chlorides-buliding-blocks, the publication is New Journal of Chemistry (2015), 39(9), 7281-7292, database is CAplus.

Respiratory chain succinate-ubiquinone oxidoreductase (SQR or complex II) and ubihydroquinone-cytochrome (cyt) c oxidoreductase (cyt bc₁ or complex III) have been demonstrated as the promising targets of numerous antibiotics and fungicides. As a continuation of our research work on the development of new fungicides, a series of 1,2,4-triazole-1,3-disulfonamide derivatives with dual functions targeting both SQR and cyt bc₁ were designed and synthesized by coupling diverse di-Ph ether moieties with triazolesulfonamide units. These newly synthesized compounds were characterized by elemental analyses, ¹H NMR and ESI-MS spectrometry. The in vitro assay indicated that most of the synthesized compounds displayed good inhibition against porcine succinate-cytochrome reductase (SCR) with IC₅₀ values ranging from 3.2 to 81.8 μM, revealing much higher activity than that of the com. control amisulbrom whose IC₅₀ value is 93.0 μM. Further evaluation against the resp. SQR and cyt bc₁ indicated that most compounds exhibited SQR-inhibiting activity as well as cyt bc₁-inhibiting activity, but the inhibition potency against SQR is much higher than that against cyt bc₁, showing that the SCR inhibition might be contributed greatly by the SQR inhibition. The further antibacterial evaluation against Xanthomonas oryzae pv. oryzae revealed that four compounds showed excellent potency at the concentration of 20 μg mL^-1. In particular, compounds (I) and (II) exhibited much better antibacterial activity than the com. control bismerthiazol in terms of their EC₅₀. Impressively, II has an EC₉₀ of 33.62 μg mL^-1, more than 10-fold higher than that of bismerthiazol.

New Journal of Chemistry published new progress about 350-30-1. 350-30-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Nitro Compound,Benzene, name is 3-Chloro-4-fluoronitrobenzene, and the molecular formula is C6H3ClFNO2, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Feng, Yanli published the artcileNew photochromic bisthienylethene derivatives containing carbazole, SDS of cas: 219537-97-0, the publication is Journal of Physical Organic Chemistry (2007), 20(11), 968-974, database is CAplus.

Some new photochromic bisthienylethene (BTE) derivatives containing carbazole were synthesized by Suzuki coupling method. All compounds were characterized by ¹H NMR spectra, ¹³C NMR, mass spectra, etc. Their optical, photochromic, and electrochem. properties were described. Moreover, their two-photon absorption (TPA) properties were investigated both in open and closed forms, finding observable distinction in the TPA of the ring-open and ring-closed forms. These compounds could be used as two-photon switches and for the potential applications in three-dimensional optical storage.

Journal of Physical Organic Chemistry published new progress about 219537-97-0. 219537-97-0 belongs to chlorides-buliding-blocks, auxiliary class Fused/Partially Saturated Cycles,Cyclopentenes, name is 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, and the molecular formula is C15H14Cl2S2, SDS of cas: 219537-97-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Wang, Jing published the artcileMichael acceptor in gambogic acid-Its role and application for potent antitumor agents, Recommanded Product: trimethyloxosulphonium chloride, the publication is Bioorganic & Medicinal Chemistry Letters (2015), 25(14), 2844-2848, database is CAplus and MEDLINE.

Gambogic acid (GA), a natural product with unique structure, was reported to have broad antiproliferation activities against cancer cell lines. As a reactive Michael acceptor, the 10-position of GA is susceptible to nucleophiles, thus limiting its clin. application as an anticancer agent. Moreover, the 6-OH forms an intramol. hydrogen bond with 8-C=O, which can make the 9, 10 double bond more reactive to nucleophiles. In this essay, two strategies (A and B) were applied to solve the above-mentioned problems. Strategy A was to increase the steric hindrance of C-10 to reduce the activity of GA towards nucleophiles. Strategy B was to replace the hydroxyl of C-6 with other substituents based on the assumption that the intra-mol. hydrogen bond could increase the electrophilicity of C-10. Results showed the electrophilicity of C-10 disappeared as well as the antiproliferation activity against cancer cell lines by introducing a Me group at C-10. Strategy B showed that the electrophilicity of C-10 was reduced dramatically while maintained the activity by replacement of the hydroxyl of C-6 with neutral or basic groups.

Bioorganic & Medicinal Chemistry Letters published new progress about 5034-06-0. 5034-06-0 belongs to chlorides-buliding-blocks, auxiliary class Salt,Aliphatic hydrocarbon chain, name is trimethyloxosulphonium chloride, and the molecular formula is C17H18N3NaO3S, Recommanded Product: trimethyloxosulphonium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Liu, Pengfei published the artcileMultipathways for the Synthesis of Fused Bicyclic 2-Aminothiazolyl Compounds Tuned by Ring Size, Product Details of C7H7ClN2S, the publication is Synlett (2014), 25(19), 2797-2801, database is CAplus.

A new methodol. for the synthesis of fused bicyclic 2-aminothiazolyl compounds was developed, using cyclocondensation of aromatic thioureas with α,β-epoxy cycloketones in alc. under microwave irradiation without any catalyst. The product distribution is related to the ring size of α,β-epoxy cycloketones. Mechanistic studies suggest that the reactions share analogous bicyclic dihydroxy intermediates but undergo different further reactions to give diverse products.

Synlett published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, Product Details of C7H7ClN2S.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Cui, Shuzhen published the artcileSynthesis and characterisation of photochromic dithienylcyclopentene liquid crystal with thermal irreversibility, Recommanded Product: 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, the publication is Liquid Crystals (2016), 43(6), 803-810, database is CAplus.

A series of photochromic liquid crystal dithienylcyclopentene derivatives I (n = 4, 5, 6, 7) was synthesized from the initial material 2-chloro-5-methylthiophene. They were characterized by ¹H NMR, high resolution mass spectrometer, differential scanning calorimetry (DSC) and polarized optical microscopy (POM) with a hot stage. All of them exhibited excellent photochem. reversible isomerization between the open-ring form and the closed-ring form in both organic solvents and LC media, resulting in the color change between colorless and purple under different light irradiations. The typical textures from POM showed that their isomers both had nematic phase and smectic phase with different colors. These compounds with bent shape were more sensitive to light than those of diarylethenes reported.

Liquid Crystals published new progress about 219537-97-0. 219537-97-0 belongs to chlorides-buliding-blocks, auxiliary class Fused/Partially Saturated Cycles,Cyclopentenes, name is 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, and the molecular formula is C15H14Cl2S2, Recommanded Product: 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Wang, Shuai published the artcileDiscovery of [1,2,4]triazolo[1,5-a]pyrimidine derivatives as new bromodomain-containing protein 4 (BRD4) inhibitors, COA of Formula: C8H6ClF3, the publication is Chinese Chemical Letters (2020), 31(2), 418-422, database is CAplus.

Targeting bromodomain-containing protein 4 (BRD4) has been proved to be an effective strategy for cancer therapy. To date, numerous BRD4 inhibitors and degraders have been identified, some of which have advanced into clin. trials. In this work, a focused library of new [1,2,4]triazolo[1,5-a]pyrimidine derivatives were discovered to be able to inhibit BRD4. WS-722 inactivated BRD4 (BD1/BD2), BRD2 (BD1/BD2) and BRD3 (BD1/BD2) broadly with the IC₅₀ values less than 5μmol/L. Besides, WS-722 inhibited growth of THP-1 cells with an IC₅₀ value of 3.86μmol/L. Like (+)-JQ1, WS-722 inhibited BRD4 in a reversible manner and enhanced protein stability. Docking studies showed that WS-722 occupied the central acetyl-lysine (Kac) binding cavity and formed a hydrogen bond with Asn140. In THP-1 cells, WS-722 showed target engagement to BRD4. Cellular effects of WS-722 on THP-1 cells were also examined, showing that WS-722 could block c-MYC expression, induce G0/G1 phase arrest and p21 up-regulation, and promote differentiation of THP-1 cells. BRD4 inhibition by WS-722 resulted in cell apoptosis and up-regulated expression of cleaved caspased-3/7 and PARP in THP-1 cell lines. The [1,2,4]triazolo[1,5-a]pyrimidine is a new template for the development of new BRD4 inhibitors.

Chinese Chemical Letters published new progress about 939-99-1. 939-99-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 1-(Chloromethyl)-4-(trifluoromethyl)benzene, and the molecular formula is C8H15ClN2, COA of Formula: C8H6ClF3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Boryak, O. A. published the artcileBinding of two cationic compounds with graphene oxide: comparative analysis and observation of synergetic effect, Synthetic Route of 38146-42-8, the publication is Functional Materials (2021), 28(3), 450-462, database is CAplus.

The present paper reports on the results of the joint interaction of two organic cationic compounds of different structure and nature, namely bisquaternary ammonium decamethoxinum (Dec) with flexible dication and methylene blue (MB) with heterocyclic planar cation, with graphene oxide (GO) in aqueous dispersion. The qual. differences in the 3D structures of GO modified in binary (GO + Dec), (GO + MB) and ternary (GO + Dec + MB) systems were observed and described on the basis of the UV-vis spectral anal. of the systems. On mixing the components of the binary (GO + Dec) system, a rather rapid gelation of GO dispersion was observed The appearance of binary (GO + MB) system showed dependence on GO to MB ratio: at low GO content, MB-induced coagulation of GO to tiny bluish flakes took place followed by their sedimentation with time while at high GO content, the GO complexes with MB preserved solubility in water. The result of the joint addition of both Dec and MB to GO dispersion differed qual. from the above results of action of individual components. On creation of the (GO + Dec + MB) ternary system rapid flocculation of all components of the system was observed resulting in the formation of dark residue surfacing over the purified decolorized liquid UV-vis spectra of the liquid phase showed suppression of the lines of all components or their complexes practically to the baseline. The compression of (GO + Dec + MB) composite to flocs is explained by the matching of the size of MB cation to that of Dec dication linker, which provides tight filling of the gaps between GO sheets. The observed flocculation effect in the (GO + Dec + MB) system may be of practical interest in the development of nanocomposite and sorption materials. Information on the features of GO interactions with organic cations differing in structure may be useful for advances in drug delivery problem.

Functional Materials published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C38H74Cl2N2O4, Synthetic Route of 38146-42-8.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics