Month: December 2022

Yuan, Dan published the artcileThe enzyme-instructed assembly of the core of yeast prion Sup35 to form supramolecular hydrogels, Name: 2-Chlorotrityl chloride, the publication is Journal of Materials Chemistry B: Materials for Biology and Medicine (2016), 4(7), 1318-1323, database is CAplus and MEDLINE.

Based on the self-assembly capability of the core segment (GNNQQNY) of yeast prion Sup35, we design and synthesize a series of structurally related precursors for the enzymic formation of hydrogels. We found that, with the catalysis of alk. phosphatase, the precursor becomes a hydrogelator that self-assembles in water to form nanofibers with an average width less than ten nanometers. Interestingly, the introduction of an amyloid segment into a cytotoxic precursor (N’ffyp: D-1P) is able to abrogate the cytotoxicity of the precursor, making the resulting peptide cell compatible. This work contributes a new insight into the use of enzymes to form cell compatible hydrogels of peptide cross-β spine.

Journal of Materials Chemistry B: Materials for Biology and Medicine published new progress about 42074-68-0. 42074-68-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 2-Chlorotrityl chloride, and the molecular formula is C17H18N2O6, Name: 2-Chlorotrityl chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Fu, Ying published the artcileA visible-light photoinduced charge-transfer complex promoted the ring opening of N-alkyl-4-piperidinols, Safety of 4-Chloro-3-(trifluoromethyl)benzenesulfonyl Chloride, the publication is Green Chemistry (2020), 22(7), 2264-2269, database is CAplus.

A visible-light photoinduced ring opening of N-alkyl-4-piperidinols under mild conditions was achieved. The reaction sequence involved a visible-light-induced charge-transfer complex, which promoted the S-Cl bond cleavage of sulfonyl chlorides. The generated sulfonyl radical further reacts with N-alkyl-4-piperidinol cation radicals to achieve C-N and C-C bond cleavages to yield homoallylamine products.

Green Chemistry published new progress about 32333-53-2. 32333-53-2 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Sulfonyl chlorides,Benzene, name is 4-Chloro-3-(trifluoromethyl)benzenesulfonyl Chloride, and the molecular formula is C7H3Cl2F3O2S, Safety of 4-Chloro-3-(trifluoromethyl)benzenesulfonyl Chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Jonnalagadda, S. B. published the artcileKinetics and mechanism of the oxidation of methylene violet by bromate at acidic pH and the dual role of bromide ion, Application of 3-Amino-7-(diethylamino)-5-phenylphenazin-5-ium chloride, the publication is Journal of Physical Chemistry A (2009), 113(19), 5540-5549, database is CAplus and MEDLINE.

A phenazinium-type dye during oxidation by bromate ion under acidic conditions exhibited a complex nonlinear behavior. The intricate kinetics of reaction of 3-amino-7-(dimethylamino)-5-phenylphenazium chloride (MV⁺) with acidic bromate was investigated using the stopped flow technique. Under excess acid and bromate concentration conditions, MV⁺ exhibited a very slow reaction initially but a very rapid reaction after an induction time. The reaction had first-order dependence on both H⁺ and BrO₃^– ions. The overall stoichiometric reaction is 2MV⁺ + 2BrO₃^– + H2O → 2MP + 2HONEt₂ + N₂O + 2H⁺ + 2Br^–, where MP is dioxophenylphenazine. The active roles of various bromo and oxybromo species in the mechanism are discussed. The rapid kinetics of the direct reaction of bromine with MV⁺ is also reported. A 19-step mechanism, consistent with the exptl. data and validated by simulations using Simkine-2, is proposed.

Journal of Physical Chemistry A published new progress about 4569-86-2. 4569-86-2 belongs to chlorides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Benzene, name is 3-Amino-7-(diethylamino)-5-phenylphenazin-5-ium chloride, and the molecular formula is C22H23ClN4, Application of 3-Amino-7-(diethylamino)-5-phenylphenazin-5-ium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Jonnalagadda, S. B. published the artcileUncatalyzed and ruthenium(III)-catalyzed reaction of acidic chlorite with methylene violet, Computed Properties of 4569-86-2, the publication is International Journal of Chemical Kinetics (2003), 35(7), 294-303, database is CAplus.

The kinetics and mechanism of the uncatalyzed and Ru(III)-catalyzed oxidation of methylene violet [3-amino-7-(diethylamino)-5-phenylphenazinium chloride] (MV) by acidic chlorite is reported. With excess concentrations of other reactants, both uncatalyzed and catalyzed reactions had pseudo-first-order kinetics with respect to MV. The uncatalyzed reaction had first-order dependence on chlorite and H⁺ concentrations, but the catalyzed reaction had first-order dependence on both chlorite and catalyst, and a fractional order with respect to [H⁺]. The rate coefficient of the uncatalyzed reaction is (5.72 ± 0.19) M^-2 s^-1, while the catalytic constant for the catalyzed reaction is (22.4 ± 0.3) × 10³ M^-1 s^-1. Stoichiometry is dependent on the initial concentration of chlorite present. Consistent with the exptl. results, pertinent mechanisms are proposed. The proposed 15-step mechanism is simulated using literature; exptl. and estimated rate coefficients and the simulated plots agreed well with the exptl. curves.

International Journal of Chemical Kinetics published new progress about 4569-86-2. 4569-86-2 belongs to chlorides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Benzene, name is 3-Amino-7-(diethylamino)-5-phenylphenazin-5-ium chloride, and the molecular formula is C22H23ClN4, Computed Properties of 4569-86-2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Mar’yanchik, I. V. published the artcileQuantitative determination of decamethoxine in sodium sulfapyridazine eyedrops, Quality Control of 38146-42-8, the publication is Pharmaceutical Chemistry Journal (Translation of Khimiko-Farmatsevticheskii Zhurnal) (2000), 34(8), 445-447, database is CAplus.

Decamethoxine (I), or 1,10-decamethylene-bis[N-dimethyl(carbomethoxymethyl)ammonium]dichloride, was suggested for use as a conservant additive in previously developed sodium sulfapyridazine (II) eyedrops. Strict requirements posed on the quality of ophthalmol. preparation necessitate thorough quant. monitoring of all eyedrop components, including the conservant. The proposed method was used for the quant. anal. of conservant I in eyedrops II packed in dropping bottles made of poly(ethylene). The measurements were performed in the course of aging under natural storage conditions. The content of I in the preparation gradually increases on storage, in proportion to the water lost via the bottle walls. This behavior was retained over the entire observation time of 5.5 yr.

Pharmaceutical Chemistry Journal (Translation of Khimiko-Farmatsevticheskii Zhurnal) published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C38H74Cl2N2O4, Quality Control of 38146-42-8.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Drake, Robert published the artcileHigh surface area polystyrene resin-supported Pt alkene hydrosilylation catalysts: ultimate performance and sting in the tail’, Computed Properties of 14799-93-0, the publication is Reactive & Functional Polymers (2004), 65-75, database is CAplus.

Two vinylbenzyl chloride (VBC)-based resins were prepared by suspension polymerization with a VBC feed in each of 5 vol%. A high level of divinylbenzene (DVB) was employed with toluene as a porogen to produce high surface areas (>600 m² g^-1) in the resins. Each resin was aminated using N,N,N’-trimethylethylenediamine and Pt loaded onto each. The so formed resin catalysts were evaluated in the hydrosilylation of oct-1-ene using methyldichlorosilane at room temperature, and in the absence of solvent. Extensive recycling and Pt leaching studies were carried out and the most active, selective and stable catalyst identified. Heterogeneous species with an overall performance superior to that a soluble K₂PtCl₆ were produced. The results also confirm that hydrosilylation is catalyzed by immobilized Pt complexes and that any concurrent alkene isomerization is due to leached soluble Pt species. Anal. of spent resin catalyst from multiple recycling experiments has shown the presence of chem. bonded oligosiloxane arising from hydrosilylation of pendent unreacted vinyl groups in the resin followed by hydrolysis and condensation when exposed to atm. moisture. This fouling of the resin is however not a problem while the resin catalysts are being recycled.

Reactive & Functional Polymers published new progress about 14799-93-0. 14799-93-0 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(methyl)(octyl)silane, and the molecular formula is C9H20Cl2Si, Computed Properties of 14799-93-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Drake, Robert published the artcileHigh surface area polystyrene resin-supported Pt catalysts in room temperature solventless octene hydrosilylation using methyldichlorosilane, Formula: C9H20Cl2Si, the publication is Journal of the Chemical Society, Perkin Transactions 1 (2002), 1523-1534, database is CAplus.

Eight macroporous styrene-divinylbenzene-vinylbenzyl chloride resins have been synthesized by suspension polymerization The first four employed toluene as the porogen and the second four Bu acetate, at a level of 1 : 1 volume/volume relative to the comonomers. In all cases a high level of divinylbenzene leads to resins with high surface area, ∼500 m² g^-1, as determined from a BET treatment of N₂ sorption data. The functional group content of each group of four resins was varied from 5-25%. All resins were aminated to generate benzyltrimethylethylenediamine ligands on the polymer matrix, and then each was loaded with Pt(II) using KPtCl₄. The anal. data confirmed the formation of ligand PtCl₂ mol. complexes. Each of the resin immobilized Pt complexes has been assessed for catalytic activity in the room temperature, solventless, hydrosilylation of oct-1-ene using methyldichlorosilane, and a comparison made with soluble Speier’s catalyst under identical conditions. Though less active than the soluble catalyst the activity of all the polymer catalysts is good, and of practical value, the activity being higher than we have previously reported in the case of supports with lower surface area. Furthermore while Speier’s catalyst induces significant levels of oct-1-ene isomerization, isomerization in the case of the polymer catalysts is much lower, and indeed can be all but eliminated by appropriate washing. Extensive catalyst leaching and recycling studies have been carried out, with the best catalysts showing retention of useful activity after 10 cycles. Careful control experiments have provided strong circumstantial evidence that the isomerization that does arise with the polymer catalysts can be attributed to a component of leached soluble Pt species. Overall the most active and stable polymer catalyst has the highest surface area (∼550 m² g^-1) of those studied, along with the lowest ligand and Pt contents (each ∼0.25 mmol g^-1). The surface area dependence confirms our earlier view that maximum accessibility to potential metal complex catalytic sites is vital in these systems, and the metal complex loading dependence suggests that generating discrete isolated ligand PtCl₂ species provides optimal use of the loaded Pt.

Journal of the Chemical Society, Perkin Transactions 1 published new progress about 14799-93-0. 14799-93-0 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(methyl)(octyl)silane, and the molecular formula is C9H20Cl2Si, Formula: C9H20Cl2Si.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Mohamed, Heba A. published the artcileSilver(I) N-Heterocyclic Carbene Complexes Derived from Clotrimazole: Antiproliferative Activity and Interaction with an Artificial Membrane-Based Biosensor, Formula: C19H14Cl2, the publication is Organometallics (2020), 39(8), 1318-1331, database is CAplus.

With the aim of combining the potential anticancer properties of both clotrimazole, an imidazole based antifungal agent, and Ag(I) N-heterocyclic carbenes, 13 novel Ag(I) N-heterocyclic carbene complexes derived from clotrimazole were synthesized. The complexes were fully characterized, and the partition coefficient of each provides a measure of hydrophobicity. The antiproliferative properties of the complexes against cancerous and noncancerous cell lines found optimum cytotoxicity when the complex displays an intermediate lipophilicity, which describes a complex that possesses both water-soluble groups and lipophilic aromatic groups. The Ag complexes were screened on a synthetic biomembrane-like device using a chip-based phospholipid-coated Pt/Hg electrode embedded in a flow cell system. The results are recorded as rapid cyclic voltammograms (RCVs), which give insight into the interactions of the complexes with a cell membrane. The principle of intermediate lipophilicity also applies to the monolayer interaction to which the Ag atom significantly implements an irreversibility.

Organometallics published new progress about 42074-68-0. 42074-68-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 2-Chlorotrityl chloride, and the molecular formula is C19H14Cl2, Formula: C19H14Cl2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Sanin, P. I. published the artcileEffect of lubricating oil additives on wear under friction, Related Products of chlorides-buliding-blocks, the publication is Wear (1960), 200-18, database is CAplus.

Additives in an oil with a viscosity of 20.8 centistokes at 50° were tested in a modified 4-ball machine for reduction of wear and load-carrying capacity. Chlorinated compounds, such as methyl dichlorostearate, tetrachloronaphthalene, and chlorinated wax fractions increase the critical load and lower frictional wear by chem. reaction at high temperature Optimum results were obtained with >7% of chlorinated fractions containing >40% Cl. Tests on organic S-P compounds indicated that the activity of organic phosphites depends on the structure of the hydrocarbon radical; e.g., the critical load for an oil containing tripropyl trithiophosphite is 110 kg., almost twice that of the base oil or of the oil containing tri-noctadecyl trithiophosphite. Only lower trialkyl trithiophosphites with C₃-C₅ alkyls, are potential additives for increasing the lubricating properties of oils; trialkylthiophosphates are less active. Butyl esters of phosphorous, phosphoric, thiophosphorous, and thiophosphoric acids are active additives. Increasing the S content of phosphites, and particularly of phosphates, resulted in a reduction of the critical load but reduced wear above the critical load by formation of a sulfide film on the frictional surfaces under heavy load and at high temperature P in the mol. increased the critical load and S improved frictional behavior. Cl reduced wear even more than S. Phosphonic compounds were more active than compounds containing alkoxy groups, e.g., trichloromethyl phosphonates (I) and dichloroethyl chloroethylphosphonate increased the critical load from 68 to 140-50 kg. and reduced wear at loads higher than the critical load. Tetrachloroalkanes increased the critical load and reduced wear above the critical load but compounds containing the CCl₃ group and P, such as I, are markedly more active owing to action of the trichloromethyl group and of P from additive decomposition Increasing the number of CCl₃ groups in the mol. of organic P compounds enabled an oil containing such an additive to carry enormous loads without seizure, e.g., tri(trichloroethyl)phosphite and tri(trichloro-tert-butyl)phosphite reduced wear to lower than 0.8 mm. at 300 kg. loads. 21 references.

Wear published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Myannik, A. O. published the artcileThe effect of composition of some esters of phosphoric and phosphonic acids on their activity as mixtures, in decreasing friction wear, SDS of cas: 866-23-9, the publication is Teoriya Smazochnogo Deistviya i Novye Materialy (1965), 63-7, database is CAplus.

H₃PO₄ esters were synthesized from dialkylphosphoric acid chlorides and of alcs. Almost all the esters are liquids soluble in hydrocarbons and lubricating oils. The experiment was carried by adding 6 millimoles of ester to 100 g. oil (1.4-2.2%). Wear-load curves were constructed. H₃PO₄ esters considerably increase the critical load (80 kg.) for pure lubricating oil to 150 kg., after addition of diethyl isoamyl phosphate, and to 227 kg. after addition of diethyl trichloropentyl phosphate. Increasing wear resistance is seen after addition of compounds containing (RO₂)P(:S) S < (RO)₂P(:S)O < (RO)₂P(:O)S < (RO)₂P(:O)O groups. The addition of methyl- and trichloromethyl phosphonic acids increases the load to 300 kg.

Teoriya Smazochnogo Deistviya i Novye Materialy published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, SDS of cas: 866-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics