Month: November 2022

Ai, Liankun published the artcileCopper-mediated construction of benzothieno[3,2-b]benzofurans by intramolecular dehydrogenative C-O coupling reaction, Category: chlorides-buliding-blocks, the publication is RSC Advances (2021), 11(57), 36305-36309, database is CAplus and MEDLINE.

An efficient method to synthesize benzothieno[3,2-b]benzofurans such as I [R = H, 3-Cl, 3-t-Bu; R¹ = H, 7,8-di-F, 8-Me, etc.] via intramol. dehydrogenative C-H/O-H coupling had been developed. Good to excellent yields (64-91%) could be obtained no matter if the substituted group was electron-donating or electron-withdrawing. Notably, three-to-six fused ring thienofuran compounds I could be constructed using this method. A reaction mechanism study showed that 1,1-diphenylethylene could be completely inhibited the reaction. Therefore, it was a radical pathway initiated by single electron transfer between the hydroxyl of the substrate and the copper catalyst.

RSC Advances published new progress about 1238196-66-1. 1238196-66-1 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Phenol,Boronic Acids,Boronic acid and ester, name is 4-Chloro-2-hydroxyphenylboronic acid, and the molecular formula is C6H6BClO3, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Mandour, A. H. published the artcileSynthesis, antimicrobial and antiaflatoxigenic activities of new coumarin derivatives, Computed Properties of 10543-42-7, the publication is Egyptian Journal of Pharmaceutical Sciences (1995), 36(1-6), 71-85, database is CAplus.

Coumarin-6-sulfonyl chloride reacted with m-or p- aminoacetophenone to give sulfonamide derivatives, which in turn were condensed with semicarbazide hydrochloride to give semicarbazone derivatives Also some sulfonamides reacted with thiosemicarbazide to give thiosemicarbazone derivatives Oxidative cyclization of semicarbazones or thiosemicarbazones using thionylchloride led to the formation of 4-substituted-1,2,3-thiadiazoles using selenium dioxide led to the formation of 4-substituted-1,2,3- selenadiazoles . Also, 4-[6-nitrocoumarin-3- sulfonamido-N-(m or p-phenylene)] -1,2,3-thiadiazoles and -1,2,3-selenadiazoles. The antimicrobial and antiaflatoxigenic activities of thiadiazoles and selenadiazoles were also investigated.

Egyptian Journal of Pharmaceutical Sciences published new progress about 10543-42-7. 10543-42-7 belongs to chlorides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Chloride,Sulfonyl chlorides,Ester, name is Coumarin-6-sulfonyl chloride, and the molecular formula is C9H5ClO4S, Computed Properties of 10543-42-7.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Gupta, Atul published the artcileInduction of targeted osteogenesis with 3-aryl-2H-benzopyrans and 3-aryl-3H-benzopyrans: Novel osteogenic agents, Related Products of chlorides-buliding-blocks, the publication is Journal of Steroid Biochemistry and Molecular Biology (2016), 63-75, database is CAplus and MEDLINE.

Development of target oriented chemotherapeutics for treatment of chronic diseases have been considered as an important approach in drug development. Following this approach, in our efforts for exploration of new osteogenic leads, substituted 3-aryl-2H-benzopyran and 3-aryl-3H-benzopyran derivatives (19, 20a-e, 21, 22a-e, 26, 27, 28a-e, 29, 31a-b, 32 and 33) have been characterized as estrogen receptor-β selective osteogenic (bone forming) agents. The synthesized compounds were evaluated for osteogenic activity using mouse calvarial osteoblast cells. Four compounds viz 20b, 22a, 27 and 32 showed significant osteogenic activity at EC₅₀ values 1.35, 34.5, 407 and 29.5 pM resp. Out of these, 20b and 32 were analyzed for their bone mineralization efficacy and osteogenic gene expression by qPCR. The results showed that 20b and 32 significantly increased mineral nodule formation and the transcript levels of BMP-2, RUNX-2 and osteocalcin at 100 pM concentrations resp. Further mechanistic studies of 20b and 32 using transiently knocked down expression of ER-α and β in mouse osteoblast (MOBs) showed that 20b and 32 exerts osteogenic efficacy via activation of estrogen receptor-β preferentially. Addnl., compounds showed significant anticancer activity in a panel of cancer cell lines within the range of (IC₅₀) 6.54-27.79 μM. The most active mol., 22b inhibited proliferation of cells by inducing apoptosis and arresting cell cycle at sub-G₀ phase with concomitant decrease in cells at S phase.

Journal of Steroid Biochemistry and Molecular Biology published new progress about 4584-49-0. 4584-49-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Salt,Amine,Aliphatic hydrocarbon chain, name is 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, and the molecular formula is C5H13Cl2N, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Singh, Sarita published the artcileSynthesis of 3,5-dihydroxy-7,8-dimethoxy-2-(4-methoxyphenyl)benzopyran-4-one derivatives as anticancer agents, Synthetic Route of 4584-49-0, the publication is Bioorganic & Medicinal Chemistry Letters (2016), 26(21), 5322-5327, database is CAplus and MEDLINE.

Different alkyl amide and alkyl amine derivatives of 7,8-dimethoxy-3-hydroxy-2-(4-methoxyphenyl)benzopyran-4-one were synthesized and evaluated for their anticancer activity against five different cancer cell lines using SRB assay. The most promising mol., 5-(1-(dimethylamino)propan-2-yloxy)-3-hydroxy-7,8-dimethoxy-2-(4-methoxyphenyl)-4H-chromen-4-one, was further analyzed for its effect on cell cycle and apoptosis of estrogen receptor pos. cancer cells (MCF-7 cells) which showed that 5-(1-(dimethylamino)propan-2-yloxy)-3-hydroxy-7,8-dimethoxy-2-(4-methoxyphenyl)-4H-chromen-4-one triggered apoptosis in MCF-7 cells and arrested cells population at sub-G₀ (apoptotic) and G₂M phase. In tubulin polymerization assay, 5-(1-(dimethylamino)propan-2-yloxy)-3-hydroxy-7,8-dimethoxy-2-(4-methoxyphenyl)-4H-chromen-4-one interfered with kinetics of tubulin polymerization

Bioorganic & Medicinal Chemistry Letters published new progress about 4584-49-0. 4584-49-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Salt,Amine,Aliphatic hydrocarbon chain, name is 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, and the molecular formula is C6H5N3S, Synthetic Route of 4584-49-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Kalaba, Predrag published the artcileHeterocyclic Analogues of Modafinil as Novel, Atypical Dopamine Transporter Inhibitors, Quality Control of 75341-23-0, the publication is Journal of Medicinal Chemistry (2017), 60(22), 9330-9348, database is CAplus and MEDLINE.

Modafinil is a wake promoting compound with high potential for cognitive enhancement. It is targeting the dopamine transporter (DAT) with moderate selectivity, thereby leading to reuptake inhibition and increased dopamine levels in the synaptic cleft. A series of modafinil analogs have been reported so far, but more target-specific analogs remain to be discovered. It was the aim of this study to synthesize and characterize such analogs and, indeed, a series of compounds were showing higher activities on the DAT and a higher selectivity toward DAT vs. serotonin and norepinephrine transporters than modafinil. This was achieved by substituting the amide moiety by five- and six-membered aromatic heterocycles. In vitro studies indicated binding to the cocaine pocket on DAT, although mol. dynamics revealed binding different from that of cocaine. Moreover, no release of dopamine was observed, ruling out amphetamine-like effects. The absence of neurotoxicity of a representative analog may encourage further preclin. studies of the above-mentioned compounds

Journal of Medicinal Chemistry published new progress about 75341-23-0. 75341-23-0 belongs to chlorides-buliding-blocks, auxiliary class Thiadiazole,Chloride, name is 2-(Chloromethyl)-5-methyl-1,3,4-thiadiazole, and the molecular formula is C4H5ClN2S, Quality Control of 75341-23-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Thajudeen, H. published the artcilePhase Transfer Catalysis: Polymerization Kinetics and Mechanism of Methyl Acrylate, Quality Control of 23616-79-7, the publication is International Journal of Polymeric Materials (2008), 57(9), 904-917, database is CAplus.

Kinetics and mechanism of Me acrylate (MA) radical polymerization using KHSO₅ as water-soluble initiator in the presence of benzyltributylammonium chloride (BTBAC) as a phase-transfer catalyst were studied. Polymerization was carried out under inert and unstirred conditions at 60±1° in EtOAc/water biphasic medium. The rate of polymerization increased with increasing concentrations of MA, BTBAC and KHSO₅. The reaction order with respect monomer, initiator and catalyst was 1.0, 0.5 and 0.5, resp. The rate was independent of ionic strength and pH of the medium. Based on the kinetic evidence, a suitable mechanism is proposed.

International Journal of Polymeric Materials published new progress about 23616-79-7. 23616-79-7 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst, name is N-Benzyl-N,N-dibutylbutan-1-aminium chloride, and the molecular formula is C19H34ClN, Quality Control of 23616-79-7.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Tselios, Theodore published the artcileRational design and synthesis of altered peptide ligands based on human myelin oligodendrocyte glycoprotein 35-55 epitope: inhibition of chronic experimental autoimmune encephalomyelitis in mice, SDS of cas: 42074-68-0, the publication is Molecules (2014), 19(11), 17968-17984, 17 pp., database is CAplus and MEDLINE.

Exptl. autoimmune encephalomyelitis (EAE) is a demyelinating disease of the central nervous system and is an animal model of multiple sclerosis (MS). Although the etiol. of MS remains unclear, there is evidence T-cell recognition of immunodominant epitopes of myelin proteins, such as the 35-55 epitope of myelin oligodendrocyte glycoprotein (MOG), plays a pathogenic role in the induction of chronic EAE. Cyclization of peptides is of great interest since the limited stability of linear peptides restricts their potential use as therapeutic agents. Herein, we have designed and synthesized a number of linear and cyclic peptides by mutating crucial T cell receptor (TCR) contact residues of the human MOG35-55 epitope. In particular, we have designed and synthesized cyclic altered peptide ligands (APLs) by mutating Arg41 with Ala or Arg41 and Arg46 with Ala. The peptides were synthesized in solid phase on 2-chlorotrityl chloride resin (CLTR-Cl) using the Fmoc/t -Bu methodol. The purity of final products was verified by RP-HPLC and their identification was achieved by ESI-MS. It was found that the substitutions of Arg at positions 41 and 46 with Ala results in peptide analogs that reduce the severity of MOG-induced EAE clin. symptoms in C57BL/6 mice when co-administered with mouse MOG35-55 peptide at the time of immunization.

Molecules published new progress about 42074-68-0. 42074-68-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 2-Chlorotrityl chloride, and the molecular formula is C8H7NO4, SDS of cas: 42074-68-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Kumar, Sunil published the artcileSolvent-free synthesis of bacillamide analogues as novel cytotoxic and anti-inflammatory agents, SDS of cas: 3696-23-9, the publication is European Journal of Medicinal Chemistry (2016), 718-726, database is CAplus and MEDLINE.

Synthesis of fourteen analogs of bacillamide, a bioactive tryptamide alkaloid of marine origin, has been accomplished through a highly efficient convergent route. The present solvent-free protocol involves the formation of the thiazole ring in the initial step followed by amide coupling between substituted Et 2-alkyl/aryl/heteroaryl/amino/aminoarylthiazole-4-carboxylates and tryptamine in the presence of 2-hydroxy-4,6-dimethylpyrimidine, a solid phase catalyst to yield N-[2-(1H-indol-3-yl)ethyl]-2-alkyl/aryl/heteroaryl/amino/aminoarylthiazole-4-carboxamides I (R = Me, Ph, 2-furyl, etc.) and II (R¹ = H, 4-BrC₆H₄, 4-O₂NC₆H₄, etc.) as bacillamide analogs having structural variation at position-2 of thiazole ring. Bacillamide and its analogs were evaluated for their cytotoxic activity against three cancer cell lines (HCT-116, MDA-MD-231 and JURKAT cell lines) using colorimetric cell proliferation assay. Compounds II (R¹ = H, Ph) exhibited potent anti-cell proliferation activity with IC₅₀ values in the range of ∼3.0 μM and ∼0.1-0.6 μM, resp., against these cell lines. Preliminary mechanism of action studies indicates that these compounds initiate caspase dependent apoptosis. Also, compounds I (R = 4-MeC₆H₄, 2-thienyl) and II (R¹ = H, 4-FC₆H₄) exhibited excellent anti-inflammatory activity comparable to well-known NSAID indomethacin and better than bacillamide when evaluated using carrageenan induced rat hind paw edema method.

European Journal of Medicinal Chemistry published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, SDS of cas: 3696-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Bera, Milan published the artcileRhodium-Catalyzed meta-C-H Functionalization of Arenes, HPLC of Formula: 243139-71-1, the publication is Angewandte Chemie, International Edition (2017), 56(19), 5272-5276, database is CAplus and MEDLINE.

Rhodium-catalyzed ortho-C-H functionalization is known in the literature. Described herein is the Xphos-supported rhodium catalysis of meta-C-H olefination of benzylsulfonic acid and Ph acetic acid frameworks with the assistance of a para-methoxy-substituted cyano phenol as the directing group. Complete mono-selectivity is observed for both scaffolds. A wide range of olefins and functional groups attached to arene are tolerated in this protocol.

Angewandte Chemie, International Edition published new progress about 243139-71-1. 243139-71-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 2,4,5-Trifluorobenzyl chloride, and the molecular formula is C7H4ClF3, HPLC of Formula: 243139-71-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Singh, Sarita published the artcileSynthesis and evaluation of substituted 8,8-dimethyl-8H-pyrano[2,3-f]chromen-2-one derivatives as vasorelaxing agents, SDS of cas: 4584-49-0, the publication is Bioorganic & Medicinal Chemistry Letters (2020), 30(1), 126759, database is CAplus and MEDLINE.

A series of substituted 8,8-dimethyl-8H-pyrano[2,3-f]chromen-2-ones I [R = Me, (CH₂)₂NMe₂, CH₂C(O)N(Me)(n-Bu), etc.] was synthesized from scopoletin as vasorelaxing agents. The synthesized compounds were evaluated for vasorelaxation in endothelium intact rat main mesenteric artery (MMA). Scopoletin, and compounds I [R = Me, CH₂C(O)N(Me)(n-Bu), (CH₂)₄C(O)N(Me)(n-Bu), CH₂C(O)NH(n-pentyl), (CH₂)₃C(O)N(Me)(n-pentyl), (CH₂)₄C(O)NH(n-pentyl)] showed significant vasorelaxation in precontracted MMA within the range of EC₅₀ value 1.58-5.02μM. These derivatives presented 29.40-70.89 fold increased sensitivity for exptl. tissue compared to scopoletin, the parent mol. Among others, compound I [R = Me] was found to be the most active compound which had EC₅₀ 1.58μM with 70.89 fold increased sensitivity. The mechanistic evaluation of compound I [R = Me] showed that it exerted vasorelaxation through Ca²⁺-activated K⁺ (BKca) channel and the effect was endothelium-independent.

Bioorganic & Medicinal Chemistry Letters published new progress about 4584-49-0. 4584-49-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Salt,Amine,Aliphatic hydrocarbon chain, name is 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, and the molecular formula is C15H23BO2, SDS of cas: 4584-49-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics