Month: November 2022

Rajabi, Mahboobeh published the artcileClick synthesis of 1,4-disubstituted-1,2,3-triazoles catalyzed by melamine-supported CuO nanoparticles as an efficient recyclable catalyst in water, Category: chlorides-buliding-blocks, the publication is Research on Chemical Intermediates (2020), 46(8), 3879-3889, database is CAplus.

Melamine-supported CuO nanoparticles (M-CuO nanocatalyst) are prepared as a new and efficient recyclable nanocatalyst for the regioselective synthesis of 1,2,3-triazoles I (R = Me, Ph, 4-methylphenyl, etc.; R¹ = H, OMe) in water. This new nanocatalyst was prepared by co-precipitation method and characterized by FT-IR spectral study, TGA, DSC, XRF, ICP-OES, XRD, SEM, EDS and BET anal. A wide range of 1,4-disubstituted-1,2,3-triazoles I was synthesized from reaction of benzyl halides or alkyl halides RCH₂Cl with Ph acetylene and sodium azide in high yields. M-CuO nanocatalyst could be reused more than 6 times without considerable loss of its initial activity.

Research on Chemical Intermediates published new progress about 620-20-2. 620-20-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 3-Chlorobenzylchloride, and the molecular formula is C7H6Cl2, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Beni, Zohreh Hashemi published the artcilePreparation, characterization and catalytic study of a nano-inorganic composite of CuO/NiO for the regioselective synthesis of 1,4-disubstituted-1,2,3-triazoles in water, Computed Properties of 620-20-2, the publication is Inorganic and Nano-Metal Chemistry, database is CAplus.

In this research, a nano-inorganic composite of CuO/NiO is prepared by co-precipitation method as an efficient recyclable nanocatalyst for the regioselective synthesis of 1,4-disubstituted-1,2,3-triazoles in water. The catalyst was characterized by several techniques such as the field emission SEM (FESEM), energy dispersive spectroscopy (EDS), x-ray diffraction (XRD), transmission electron microscopy (TEM), thermogravimetric anal. (TGA), x-ray fluorescence, inductively coupled plasma at. emission spectroscopy (ICP-OES), and brunauer-emmett-teller (BET) surface area anal. The regioselective synthesis of 1,4-disubstituted-1,2,3-triazoles was carried out from reaction of various benzyl halides or alkyl halides with Ph acetylene and sodium azide in water under reflux condition in high yields. The CuO/NiO nanocatalyst can be simply recovered and reused 6 runs without a significant slight in activity.

Inorganic and Nano-Metal Chemistry published new progress about 620-20-2. 620-20-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 3-Chlorobenzylchloride, and the molecular formula is C7H6Cl2, Computed Properties of 620-20-2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Siddiqui, Nadeem published the artcileDesign, synthesis, anticonvulsant evaluation and docking study of 2-[(6-substituted benzo[d]thiazol-2-ylcarbamoyl)methyl]-1-(4-substituted phenyl)isothioureas, Synthetic Route of 3696-23-9, the publication is Bioorganic Chemistry (2017), 230-243, database is CAplus and MEDLINE.

In this paper, we report the synthesis of 2-[(6-substituted benzo[d]thiazol-2-ylcarbamoyl)methyl]-1-(4-substituted phenyl)isothiourea derivatives (4a-y) carrying active pharmacophores essential for anticonvulsant activity. The anticonvulsant activity was evaluated in vivo by maximal electroshock (MES) test and s.c. pentylenetetrazole (scPTZ) test in mice. Most of the compounds showed promising anticonvulsant activity. The most active compounds 4b and 4q were found active in both MES and scPTZ models, without signs of neurotoxicity. Compound 4b showed the moderate change in SGOT and alk. phosphatase level as compared to control. Compounds 4b and 4w were also found to elevate GABA levels in the olfactory lobe, mid brain, medulla oblongata and cerebellum regions of rat brain. In mol. docking study, the title compounds exhibited good binding properties with epilepsy mol. targets such as GABA-A. Structure-activity relationships are also elaborated along with the anal. of lipophilicity. The results suggested that compound 4b is likely to have varied mechanisms of action including voltage-gated ion channel inhibition and modulating GABAergic action.

Bioorganic Chemistry published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C18H17NO8, Synthetic Route of 3696-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Kharbanda, Chetna published the artcileNovel Piperine Derivatives with Antidiabetic Effect as PPAR-γ Agonists, HPLC of Formula: 3696-23-9, the publication is Chemical Biology & Drug Design (2016), 88(3), 354-362, database is CAplus and MEDLINE.

Piperine is an alkaloid responsible for the pungency of black pepper. In this study, piperine isolated from Piper nigrum L. was hydrolyzed under basic condition to obtain piperic acid and was used as precursor to carry out the synthesis of twenty piperine derivatives containing benzothiazole moiety. All the benzothiazole derivatives were evaluated for their antidiabetic potential by OGT test followed by assessment of active derivatives on STZ-induced diabetic model. It was observed that nine of twenty novel piperine analogs (5b, 6a-h), showed significantly higher antidiabetic activity in comparison with rosiglitazone (standard). Furthermore, these active derivatives were evaluated for their action as PPAR-γ agonists demonstrating their mechanism of action. The effects on body weight, lipid peroxidation, and hepatotoxicity after administration with active derivatives were also studied to further establish these derivatives as lead mols. for treatment of diabetes with lesser side-effects.

Chemical Biology & Drug Design published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, HPLC of Formula: 3696-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Alsharif, Zakeyah A. published the artcileModular synthesis of thiazoline and thiazole derivatives by using a cascade protocol, Recommanded Product: 1-(4-Chlorophenyl)thiourea, the publication is RSC Advances (2017), 7(52), 32647-32651, database is CAplus and MEDLINE.

The first synthetic protocol by which both thiazolines I (R = Me, allylamino, pyridin-2-yl, (E)-2-[(4-chlorophenyl)methylidene]hydrazin-1-yl, etc.) and thiazoles II [R¹ = 4-chlorophenyl, 4-trifluoromethylphenyl, benzylamino, (4-carboxyphenyl)aminyl] can be prepared has been reported. Novel mols. I and II are efficiently synthesized by using readily available and inexpensive substrates. The reaction conditions are mild and pure products were obtained without work-up and column purification

RSC Advances published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, Recommanded Product: 1-(4-Chlorophenyl)thiourea.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Tonzola, Christopher J. published the artcileNew silicon-containing polyquinolines: Synthesis, characterization, and electroluminescence, Synthetic Route of 14799-93-0, the publication is Macromolecular Chemistry and Physics (2005), 206(13), 1271-1279, database is CAplus.

This study reports the synthesis, characterization, and electroluminescent device application of three new silicon-containing polyquinolines: poly(2,2′-(bis(p-phenyl)-diphenylsilane)-6,6′-bis(4-Ph quinoline)), poly(2,2′-(bis(p-phenyl)octylmethylsilane)-6,6′-bis(4-Ph quinoline)), and poly(2,2′-(bis(p-phenyl)diphenylsilane)-6,6′-bis(4-hexylquinoline)). The polymers with alkyl side chains were soluble in organic solvents. The new polymers showed robust thermal properties with glass transitions of 161°-339°. Cyclic voltammetry of the polymers revealed quasireversible reductions with onsets of -1.55 to -1.71 V (vs SCE) and corresponding electron affinities of 2.69-2.85 eV. Organic light-emitting devices using new polyquinolines as emissive materials showed blue (CIE coordinates = 0.21, 0.20) or blue-green (0.23, 0.36) electroluminescence with a moderate brightness (≈140 cd·m^-2) and efficiency (0.04%). The results demonstrate that silicon-containing polyquinolines are promising n-type wide band-gap semiconductors for organic electronics.

Macromolecular Chemistry and Physics published new progress about 14799-93-0. 14799-93-0 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(methyl)(octyl)silane, and the molecular formula is C14H26O2, Synthetic Route of 14799-93-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Siddiqui, Farid A. published the artcilePDE6D Inhibitors with a New Design Principle Selectively Block K-Ras Activity, Formula: C9H5ClO4S, the publication is ACS Omega (2020), 5(1), 832-842, database is CAplus and MEDLINE.

The trafficking chaperone PDE6D (also referred to as PDEδ) has been nominated as a surrogate target for K-Ras4B (hereafter K-Ras). Arl2-assisted unloading of K-Ras from PDE6D in the perinuclear area is significant for correct K-Ras localization and therefore activity. However, the unloading mechanism also leads to the undesired ejection of PDE6D inhibitors. To counteract ejection, others have recently optimized inhibitors for picomolar affinities; however, cell penetration generally seems to remain an issue. To increase resilience against ejection, we engineered a “chem. spring” into prenyl-binding pocket inhibitors of PDE6D. Furthermore, cell penetration was improved by attaching a cell-penetration group, allowing us to arrive at micromolar in cellulo potencies in the first generation. Our model compounds, Deltaflexin-1 and -2, selectively disrupt K-Ras, but not H-Ras membrane organization. This selectivity profile is reflected in the antiproliferative activity on colorectal and breast cancer cells, as well as the ability to block stemness traits of lung and breast cancer cells. While our current model compounds still have a low in vitro potency, we expect that our modular and simple inhibitor redesign could significantly advance the development of pharmacol. more potent compounds against PDE6D and related targets, such as UNC119 in the future.

ACS Omega published new progress about 10543-42-7. 10543-42-7 belongs to chlorides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Chloride,Sulfonyl chlorides,Ester, name is Coumarin-6-sulfonyl chloride, and the molecular formula is C6H13NO2, Formula: C9H5ClO4S.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Tuktarov, A. R. published the artcileSynthesis and photochromic properties of hybrid molecules based on fullerene C₆₀ and 3,3′-(cyclopent-1-ene-1,2-diyl)bis(5-chloro-2-methylthiophene), Safety of 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, the publication is Russian Journal of Organic Chemistry (2017), 53(6), 891-897, database is CAplus.

A series of C₆₀ adducts with azides derived from 3,3′-(cyclopent-1-ene-1,2-diyl)bis(5-chloro-2-methylthiophene) have been synthesized for the first time, and their photochromic properties have been studied. The effects of the structure of the spacer connecting the fullerene and dihetarylethene moieties and electronic structure of the fullerene skeleton on the efficiency of photoinduced transformations of the new hybrid mols. have been estimated

Russian Journal of Organic Chemistry published new progress about 219537-97-0. 219537-97-0 belongs to chlorides-buliding-blocks, auxiliary class Fused/Partially Saturated Cycles,Cyclopentenes, name is 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, and the molecular formula is C5H10O, Safety of 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Odlyha, M. published the artcileDSC study of chemically modified porous silica powders, Category: chlorides-buliding-blocks, the publication is Thermochimica Acta (1988), 457-61, database is CAplus.

DSC was used to characterize silica samples following their reaction with n-octylmethyldichlorosilane by using the fluidized bed technique. The observed thermal effects varied with the progressive increase in octylsilyl groups bonded to the silica surface in a regular manner.

Thermochimica Acta published new progress about 14799-93-0. 14799-93-0 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(methyl)(octyl)silane, and the molecular formula is C9H20Cl2Si, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Yamamoto, Takeshi published the artcileHighly enantioselective synthesis of axially chiral biarylphosphonates: asymmetric Suzuki-Miyaura coupling using high-molecular-weight, helically chiral polyquinoxaline-based phosphines, Name: 4-Chloro-2-methylphenylboronic acid, the publication is Angewandte Chemie, International Edition (2011), 50(38), 8844-8847, S8844/1-S8844/74, database is CAplus and MEDLINE.

Axially-chiral 1-arylnaphthalene-2-phosphonates [(S)-3, aryl = 2-MeC₆H₄, 1-naphthyl, 4-MeO-2-MeC₆H₃, 2,3-Me₂C₆H₃, 2,5-Me₂C₆H₃, 4-Cl-2-MeC₆H₃] were prepared by Suzuki-Miyaura coupling of arylboronic acids with dialkyl 1-bromonaphthalene-2-phosphonates (alkyl = Me, Et), catalyzed by palladium complexes with helically-chiral polyquinoxaline phosphines. The 20-mer helically-chiral polyquinoxaline block 10-1-10 copolymers (L^1a-L^1d), containing the 5-arylphosphino group and bearing chiral (R)-2-butoxy auxiliaries were prepared by polymerization of 10 equiv of 4,5-di-(R)-sec-butoxymethyl-3,6-dimethyl-1,2-benzenediisocyanide [(R)-1], reaction with 1 equiv of 2,3-diisocyano-4-methyl-2′-diarylphosphinyl-1,1′-biphenyl [aryl = Ph, 3,5-Me₂C₆H₃, 4-MeC₆H₄, 3,5-(CF₃)₂C₆H₃], and again with 10 equiv of (R)-1, initiated by chiral palladium imidazolidinylphenylquinoxaline complex with subsequent HSiCl₃ reduction Analogous 950/50 polyphosphine copolymers (L^2a-L^2d) were prepared by copolymerization of (R)-1 with 2,3-diisocyano-4-methyl-2′-diarylthiophosphinyl-1,1′-biphenyl, catalyzed by achiral nickel complex [Ni(o-Tol)Cl(PMe₃)₂] and reduction The Suzuki-Miyaura coupling reactions were performed in the presence of 1 mol% of [PdCl(π-allyl)]₂ and 2 mol% of the helical ligands L¹ and L², yielding the phosphonates (S)-3 with 56-93% yields and 78-98% ee.

Angewandte Chemie, International Edition published new progress about 209919-30-2. 209919-30-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Boronic Acids,Boronic acid and ester, name is 4-Chloro-2-methylphenylboronic acid, and the molecular formula is C13H9ClN2O4, Name: 4-Chloro-2-methylphenylboronic acid.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics