Month: November 2022

El-Abbady, A. M. published the artcileγ-Ray initiated reactions. II. The addition of silicon hydrides to alkenes, HPLC of Formula: 14799-93-0, the publication is Journal of the American Chemical Society (1958), 1737-9, database is CAplus.

The appropriate alkene 1 equivalent) and silicon hydride (3 equivalents) (in the case of the fluoroalkenes the ratio was 1: 4) in a Pyrex tube purged 15 min. with N, sealed, and irradiated with the γ-radiation from 3.0 kilocurie Co₆₀ at a rate of 810,000 r.e.p./hr., the unreacted hydride and alkene evaporated, and the residue fractionated gave the corresponding adduct. In this manner were prepared adducts from SiHCl₃ (I) (alkene used, g. weight, adduct, irradiation time, % yield, b.p./mm., and n²⁵_D, of adduct given): 1-octene, 15, C₈H₁₇SiCl₃, 40, 99, 112°/15, 1.4453; Me₂C:CH₂ 20.5, iso-BuSiCl₃, 70, 95, 141°/760, 1.4346; (MeCH:)₂ (II), 12.7, EtCHMeSiCl₃65, 95, 57-8°/34, 1.4403; MeCH:CHMe₂ (III), 14, C₅H₁₁SiCl₃ (IV), 63, 94, 44-5°/8, 1.4489; cyclohexene, 30, C₆H₁₁SiCl₃, 57, 98, 81°/10, 1.4773; styrene, 30, 6 g. viscous glassy material, 20, -, -, -. Similarly were prepared adducts from MeSiHCl₂ (V) (same data given): 1-octene, 11.2, C₈H₁₇SiMeCl₂, 62, 55, 117-18°/21, 1.4422 (and 1.5 g. viscous residue); cyclohexene, 12.3, C₆H₁₁SiMeCl₂, 62, 45, 83°/15, 1.4711; CH₂:CHCH₂OAc (VI), 20, AcO(CH₂)₃SiMeCl₂, 85, 47, 121°/30, 1.4437 (and 14 g. viscous residue). Similarly were prepared new adducts from I (same data given): cyclopentene (VII), 13.6, C₅H₉SiCl₃, 39, 96, 70-1°/19, 1.4688; 1-methylcyclohexene, 6.7, MeC₆H₁₀S-MeCl₂ (VIII), 61, 92, 82-3°/8, 1.4805; CH₂:CHCH₂Cl (IX), 15.3, Cl(CH₂)₃SiCl₃, 62, 40, 58-60°/8, 1.4646 [and 34% H(CH₂CHClCH₂)₂SiO₂)₂SiCl₃, 80-110°/1.4, 1.4871, and 3.5 g. residue]; VI, 20, AcO(CH₂)₃SiCl₃, 61, 22, 101-2°/34 1.4380 [and 71% H (AcOCH₂:CHCH₂)₂SiCl₃, b₂₄ 120°, 1.4474, and 8 g. residue]; CH₂:CHCH₂CN, 16, NC(CH₂)₃SiCl₃ (X), 61, 8, 93-4°/8, 1.4654 (and 13 g. residue); cis-CHCl:CHCl, 19.4, CH₂ClCHClSiCl₃, 68, 27, 63-4°/13, 1.4762 [and 12% CH₂Cl(CHCl)₃SiCl₃, b₁₃ 103-5°, 1.4996]; PhMeC:CH₂, 17.7 g., 0.9 g. viscous oil, 39, -, 115-20°/0.4, -; C₂F₅CH:CH₂, 10.2 g., C₂F₅(CH₂)₂SiCl₃, 66, 40, 120°/760, 1.3705 (and 1.4 g. residue); C₂F₅CMe:CH₂ (XI), 19, C₂F₅CHMeCH₂SiCl₃, 65, 9, 64-5°/28, 1.3812; C₃F₇CH:CH₂ (XII), 16, C₃F₇(CH₂)₂SiCl₃, 61, 52, 62-4°/49, 1.3626 (and 0.9 g. residue); C₃F₇CMe:CH₂ (XIII), 28, C₃F₇CMeCH₂SiCl₃, 65, 11, 53-4°/24, 1.3722. X treated with MeMgI gave 62.5% NC(CH₂)₃SiMe₃, b₂₅ 91-2°, n²⁵_D 1.4254, which was hydrolyzed to Me₃Si(CH₂)₃CONH₂, flakes, m. 65-7° (petr. ether). Similarly were prepared new adducts from V (same data given): II, 12.7, EtMeCHSiMeCl₂, 65, 57, 45°/20, 1.4343; III, 14, C₅H₁₁SiMeCl₂, 63, 30, 49-50°/11, 1.4433; VII, 13.6, C₅H₉SiMeCl₂ (XIV), 62, 20, 75°/23, 1.4627 (and 0.9 g. residue); IX, 15.3, Cl(CH₂)₃SiMeCl₂, 65, 4, 68-70°/15, 1.4585 [and 11% H(CH₂ClCHCH₂)₂SiMeCl₂, b₂ 105-10°, n²⁵_D 1.4820, and 3.9 g. residue]; XI, 20, C₂F₅CHMeCH₂SiMeCl₂, 87, 1.7, 65°/52, 1.3884; XII, 13.5, C₃F₇(CH₂)₂SiMeCl₂ (XV), 111, 23, 54-5°/33, 1.3707; XIII, 15, C₃F₇ CHMeCH₂SiMeCl₂, 85, 6.4, 65°/26, 1.3748. The appropriate chlorosilane derivative in Et₂O added dropwise with stirring and cooling to a slight excess of MeMgI in Et₂O, refluxed about 17 hrs., and distilled to remove the Et₂O, the residue heated 5 hrs. on the steam bath, the Et₂O distillate again added to the residual mixture, the mixture hydrolyzed with H₂O, the precipitate dissolved with 10% H₂SO₄, the aqueous layer extracted with Et₂O, and the combined Et₂O layer and extract washed, dried, and distilled gave the corresponding tetra-alkylsilane (compound, b.p./mm., n²⁵_D, % yield, and starting material given): C₅H₁₁SiMe₃, 50°/37, 1.4191, 61, IV; MeC₆H₁₀SiMe₃, 85°/40, 1.4519, 54, VIII; C₂F₅(CH₂)₂SiMe₃, 100-1°/760, 1.3000, 56, C₂F₅(CH₂)₂SiCl₃; C₃F₇(CH₂)₂SIMe₃, 36°/30, 1.3390, 50, C₃F₇(CH₂)₂SiCl₃. The appropriate alkylchlorosilane (about 3-4 g.) in cold Et₂O treated dropwise with stirring with 100 cc. iced H₂O and shaken 5 min., the aqueous layer extracted with Et₂O, the combined Et₂O layer and extract washed with NH₃ and H₂O, dried, and distilled, and the residue dried at 100° in vacuo gave the corresponding tetraalkylsiloxane; in this manner were prepared: [C₅H₁₁SiMeO]_x, n²⁵_D 1.4478; (C₅H₉SiMeO)_x, n²⁵_D 1.4747; [C₃F₇(CH₂)₂SiMeO]_x, b₁ 110-40°, n²⁵_D 1.3592, 71.5% yield; [C₃F₇(CH₂)SiO_1.5]_x, n²⁵_D 1.3530, 98% yield.

Journal of the American Chemical Society published new progress about 14799-93-0. 14799-93-0 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(methyl)(octyl)silane, and the molecular formula is C9H20Cl2Si, HPLC of Formula: 14799-93-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Charlesworth, E. H. published the artcileAction of zinc on α,β-dibromopropionyl halides, Formula: C3H3Br2ClO, the publication is Canadian Journal of Research, Section B: Chemical Sciences (1950), 1-4, database is CAplus.

BrCH₂CHBrCOBr (I) reacts vigorously with Zn in absolute Et₂O to give CH₂:CHCO₂Et (II) (55%), EtBr (6-8%), and HBr (42%). Steps for the reaction have been suggested. I was prepared by treating BrCH₂CHBrCO₂H with P and Br. The Hell-Volhard-Zelinskii reaction on BrCH₂CH₂CO₂H (anilide, m. 119-20°; Pr β-bromopropionate, b. 76-8°, n_D²⁰ 1.467), gave only BrCH₂CH₂COBr (III). Zn with BrCH₂CHBrCOCl gave II also. Zn and III yielded 60% BrCH₂CH₂CO₂Et.

Canadian Journal of Research, Section B: Chemical Sciences published new progress about 18791-02-1. 18791-02-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 2,3-Dibromopropionylchloride, and the molecular formula is C3H3Br2ClO, Formula: C3H3Br2ClO.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Bennett, D. Jonathan published the artcileNovel water soluble 2,6-dimethoxyphenyl ester derivatives with intravenous anaesthetic activity, Computed Properties of 18791-02-1, the publication is Bioorganic & Medicinal Chemistry Letters (2003), 13(12), 1971-1975, database is CAplus and MEDLINE.

A number of water soluble bis-amino-2,6-dimethoxyphenyl ester derivatives were found to exhibit improved anesthetic activity in mice relative to propofol. Of the analogs disclosed, 44 was further profiled in rodents and a superior agent to propofol for the induction and maintenance of anesthesia.

Bioorganic & Medicinal Chemistry Letters published new progress about 18791-02-1. 18791-02-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 2,3-Dibromopropionylchloride, and the molecular formula is C3H3Br2ClO, Computed Properties of 18791-02-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Li, Mingxue published the artcileSimulation degradation of bromophenolic compounds in chlorine-based advanced oxidation processes: Mechanism, microscopic and apparent kinetics, and toxicity assessment, Category: chlorides-buliding-blocks, the publication is Chemosphere (2022), 291(Part_3), 133034, database is CAplus and MEDLINE.

Chlorine-based advanced oxidation processes (AOPs) have been extensively studied to remove contaminants through generating HO• and reactive chlorine species, including ClO• and Cl•. In this work, 2,4,6-tribromoanisole (246TBA) and 2,4,6-tribromophenol (246TBP) were selected as model to investigate the reaction mechanisms and micro-kinetics of brominated contaminants with HO•, ClO• and Cl• in chlorine-based AOPs. Also, the apparent degradation kinetics of two compounds were simulated at pH 3.0-9.5 under UV/H₂O₂, UV/chlorine and UV/NH₂Cl. Calculated results showed that neutral 246TBA and 246TBP exhibited similar reactivity to HO• and ClO•, which was different from anionic 2,4,6-tribromophenolate (246TBPT): radical adduct formation (RAF) and H atom abstraction (HAA) were predominant mechanisms for the HO• and ClO• initiated reactions of 246TBA and 246TBP, while RAF and single electron transfer (SET) for 246TBPT; the reaction rate constants of 246TBA and 246TBP with HO• and ClO• were lower than 107 M^-1 s^-1, and such rate constants dramatically increased to 1010 M^-1 s^-1 once 246TBP was deprotonated to 246TBPT. The apparent degradation kinetics of 246TBA at pH 3.0-9.5 was simulated in the order of UV/NH₂Cl > UV/chlorine > UV/H₂O₂, and UV/chlorine and UV/NH₂Cl were more effective for the removal of 246TBP and 246TBPT than UV/H₂O₂. UV and/or Cl• dominated 246 TBA degradation under three AOPs. The main radicals mediating 246TBP and 246TBPT degradation are resp. HO• under UV/H₂O₂, ClO• under UV/chlorine, and HO• and Cl• under UV/NH₂Cl. The transformation products of 246TBA, 246TBP and 246TBPT, especially methoxylated and hydroxylated polybrominated di-Ph ethers (MeO-PBDEs and HO-PBDEs), were still toxic pollutants.

Chemosphere published new progress about 7080-50-4. 7080-50-4 belongs to chlorides-buliding-blocks, auxiliary class Halogenation Reagent,Inhibitor, name is Sodium chloro(tosyl)amide trihydrate, and the molecular formula is C7H13ClNNaO5S, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Song, Qingbao published the artcileCatalytic asymmetric Henry reaction using copper(II) chiral tridentate Schiff-base complexes and their polymer-supported complexes, Recommanded Product: 5-Bromo-3-chloro-2-hydroxybenzaldehyde, the publication is Comptes Rendus Chimie (2015), 18(2), 215-222, database is CAplus.

A series of chiral tridentate Schiff-base ligands and their polymer-supported ligands were conveniently prepared and introduced as copper(II) chiral complexes for the asym. Henry reaction. The structures of these ligands have been characterized by IR, ¹H NMR, ¹³C NMR and MS. The exptl. results showed that the corresponding β-nitro alcs. were obtained in moderate to high yields (up to 98%) with up to 98% ee under mild conditions. The complex catalyst forming from copper(II) polymer-supported ligands could be recycled by a simple filtration and reused 6 times at least with similar good catalytic effect (about 94% yield and 90% ee).

Comptes Rendus Chimie published new progress about 19652-33-6. 19652-33-6 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Bromide,Benzene,Phenol,Aldehyde, name is 5-Bromo-3-chloro-2-hydroxybenzaldehyde, and the molecular formula is C14H31NO2, Recommanded Product: 5-Bromo-3-chloro-2-hydroxybenzaldehyde.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Liao, Lihao published the artcileCatalytic Access to Functionalized Allylic gem-Difluorides via Fluorinative Meyer-Schuster-Like Rearrangement, Recommanded Product: Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate, the publication is Angewandte Chemie, International Edition (2020), 59(27), 11010-11019, database is CAplus and MEDLINE.

An unprecedented approach for efficient synthesis of functionalized allylic gem-difluorides via catalytic fluorinative Meyer-Schuster-like rearrangement is disclosed. This transformation proceeded with readily accessible propargylic fluorides, and low-cost B-F reagents and electrophilic reagents by sulfide catalysis [e.g., I → II (88%) in presence of PhSPh as Lewis basic catalyst, tetrafluoroboric acid di-Et ether complex and NIS]. A series of iodinated, brominated, and trifluoromethylthiolated allylic gem-difluorides that were difficult to access by other methods were facilely produced with a wide range of functional groups. Importantly, the obtained iodinated products could be incorporated into different drugs and natural products, and could be expediently converted into many other valuable gem-difluoroalkyl mols. as well. Mechanistic studies revealed that this reaction went through a regioselective fluorination of alkynes followed by a formal 1,3-fluorine migration under the assistance of the B-F reagents to give the desired products.

Angewandte Chemie, International Edition published new progress about 637-07-0. 637-07-0 belongs to chlorides-buliding-blocks, auxiliary class Inhibitor,Cell Cycle,PPAR, name is Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate, and the molecular formula is C12H15ClO3, Recommanded Product: Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Di Matteo, Mauro published the artcileSynthesis and biological characterization of 3-(imidazol-1-ylmethyl)piperidine sulfonamides as aromatase inhibitors, Name: 2-Chloro-4-cyanobenzene-1-sulfonyl chloride, the publication is Bioorganic & Medicinal Chemistry Letters (2016), 26(13), 3192-3194, database is CAplus and MEDLINE.

The most frequently used treatment for hormone receptor pos. breast cancer in post-menopausal women are aromatase inhibitors. In order to develop new aromatase inhibitors, we designed and synthesized new imidazolylmethylpiperidine sulfonamides using the structure of the previously identified aromatase inhibitor SYN 20028567 as starting lead. By this approach, three new aromatase inhibitors with IC₅₀ values that are similar to that of letrozole and SYN 20028567 were identified.

Bioorganic & Medicinal Chemistry Letters published new progress about 254749-11-6. 254749-11-6 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Nitrile,Benzene, name is 2-Chloro-4-cyanobenzene-1-sulfonyl chloride, and the molecular formula is C7H3Cl2NO2S, Name: 2-Chloro-4-cyanobenzene-1-sulfonyl chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Lerner Yardeni, Jenny published the artcileSequence dependent proton conduction in self-assembled peptide nanostructures, Computed Properties of 42074-68-0, the publication is Nanoscale (2016), 8(4), 2358-2366, database is CAplus and MEDLINE.

The advancement of diverse electrochem. technologies depends on the development of novel proton conducting polymers. Inspired by the efficacy of proton transport through proteins, we show in this work that self-assembling peptide nanostructures may be a promising alternative for such organic proton conducting materials. We demonstrate that aromatic amino acids, which participate in charge transport in nature, unprecedentedly promote proton conduction under both high and low relative humidity conditions for D,L α-cyclic peptide nanotubes. For dehydrated networks long-range order of the assemblies, induced by the aromatic side chains, is shown to be a dominating factor for promoting conductivity However, for hydrated networks this order of effect is less significant and conductivity can be improved by the introduction of proton donating carboxylic acid peptide side chains in addition to the aromatic side chains despite the lower order of the assemblies. Based on these observations, a novel cyclic peptide that incorporates non-natural naphthyl side chains was designed. Self-assembled nanotubes of this peptide show greatly improved dehydrated conductivity, while maintaining high conductivity under hydrated conditions. We envision that the demonstrated modularity and versatility of these bio inspired nanostructures will make them extremely attractive building blocks for the fabrication of devices for energy conversion and storage applications, as well as other applications that involve proton transport, whether dry or wet conductivity is desired.

Nanoscale published new progress about 42074-68-0. 42074-68-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 2-Chlorotrityl chloride, and the molecular formula is C19H14Cl2, Computed Properties of 42074-68-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Dhanabal, T. published the artcileSynthesis, spectral, thermal and optical characterization of benzyltributylammonium trichlorobarium(II) monohydrate crystal, Formula: C19H34ClN, the publication is Optik (Munich, Germany) (2014), 125(1), 159-163, database is CAplus.

A new nonlinear optical semiorg. crystal, benzyltributylammonium trichlorobarium(II) monohydrate was grown by slow evaporation solution growth method at ambient temperature The powder X-ray diffraction pattern of the crystal confirms its crystallinity. The absorption spectrum of the material shows a peak at 265 nm and no absorption observed in the entire visible region indicates that the compound can be used as a nonlinear optical material. The optical transmittance spectrum of the grown crystal shows a lower cut-off wavelength at 235 nm with transparency of 88%. Thermal stability of the crystal was studied by thermogravimetry-differential thermogravimetry and differential thermal analyses (TG-DTG and DTA). The differential scanning calorimetry (DSC) anal. shows thermal anomalies in the heating and cooling cycles that indicates the occurrence of a first order phase transition. The various characteristics absorption chem. bands and BaCl₃^– vibration were assigned through fourier transform IR (FTIR) spectral anal. The second harmonic generation efficiency (SHG) of the grown crystal was analyzed by Kurtz-Perry powder technique using Nd:YAG laser. The dielec. constant and dielec. loss of the compound decrease with increase in frequency.

Optik (Munich, Germany) published new progress about 23616-79-7. 23616-79-7 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst, name is N-Benzyl-N,N-dibutylbutan-1-aminium chloride, and the molecular formula is C19H34ClN, Formula: C19H34ClN.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Kordestani, Nazanin published the artcileCopper(II) complexes with tridentate halogen-substituted Schiff base ligands: synthesis, crystal structures and investigating the effect of halogenation, leaving groups and ligand flexibility on antiproliferative activities, Safety of 5-Bromo-3-chloro-2-hydroxybenzaldehyde, the publication is Dalton Transactions (2021), 50(11), 3990-4007, database is CAplus and MEDLINE.

To study the effect of different halogen substituents and leaving groups and the flexibility of ligands on the anticancer activity of copper complexes, sixteen copper(II) complexes with eight different tridentate Schiff-base ligands containing pyridine and 3,5-halogen-substituted phenol moieties were synthesized and characterized by spectroscopic methods. Four of these complexes were also characterized by x-ray crystallog. The cytotoxicity of the complexes was determined in three different tumor cell lines (i.e. the A2780 ovarian, HCT116 colorectal and MCF7 breast cancer cell line) and in a normal primary fibroblast cell line. Complexes induce a higher loss of cell viability in the ovarian carcinoma cell line (A2780) with respect to the other two tumor cell lines, and therefore the biol. mechanisms underlying this loss of viability were further studied. Complexes with ligand L₁ (containing a 2-pycolylamine-type motif) were more cytotoxic than complexes with L₂ (containing a 2-(2-pyridyl)ethylamine-type motif). The loss of cell viability in A2780 tumor cells was observed in the order Cu(Cl₂-L₁)NO₃ > Cu(Cl₂-L₁)Cl > Cu(Br₂-L₁)Cl > Cu(BrCl-L₁)Cl. All complexes were able to induce reactive oxygen species (ROS) that could be related to the loss of cell viability. Complexes Cu(BrCl-L₁)Cl and Cu(Cl₂-L₁)NO₃ were able to promote A2780 cell apoptosis and autophagy and for complex Cu(BrCl-L₁)Cl the increase in apoptosis was due to the intrinsic pathway. Cu(Cl₂-L₁)Cl and Cu(Br₂-L₁)Cl complexes lead to cellular detachment allowing to correlate with the results of loss of cell viability. Despite the ability of the Cu(BrCl-L₁)Cl complex to induce programmed cell death in A2780 cells, its therapeutic window turned out to be low making the Cu(Cl₂-L₁)NO₃ complex the most promising candidate for addnl. biol. applications.

Dalton Transactions published new progress about 19652-33-6. 19652-33-6 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Bromide,Benzene,Phenol,Aldehyde, name is 5-Bromo-3-chloro-2-hydroxybenzaldehyde, and the molecular formula is C7H4BrClO2, Safety of 5-Bromo-3-chloro-2-hydroxybenzaldehyde.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics