Kaplanek, Robert published the artcileFast and effective reduction of nitroarenes by sodium dithionite under PTC conditions: application in solid-phase synthesis, Synthetic Route of 35112-05-1, the main research area is nitroarene reduction aryl amine preparation solid phase synthesis; solid phase nitroarene reduction phase transfer catalyst.
Herein, conditions for the fast and effective reduction of aromatic nitro groups bound to hydrophobic polystyrene-based Wang and Rink resins utilizing sodium dithionite in dichloromethane-water under PTC conditions are reported. Tetrabutylammonium hydrogen sulfate (TBAHS) was found to be an effective phase-transfer catalyst for this reaction. This method allows for the reduction of nitro groups to amino groups under mild conditions with complete conversion and is tolerant of other functional groups. This method is a superior alternative to tin(II) chloride-based reduction, which is known for its shortcomings.
Tetrahedron Letters published new progress about Aromatic amines Role: SPN (Synthetic Preparation), PREP (Preparation). 35112-05-1 belongs to class chlorides-buliding-blocks, name is 4-Chloro-2-fluoro-5-nitrobenzoic acid, and the molecular formula is C7H3ClFNO4, Synthetic Route of 35112-05-1.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics