Month: July 2021

Related Products of 1005-56-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1005-56-7, name is O-Phenyl carbonochloridothioate belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

(Scheme 5) 438.5 mg (1.0 mmol) of a rhodamine compound (for example, a synthetic product of 1,6-dihydroxy naphthalene and 4-diethylamino keto acid),690.4 mg (4.0 mmol) phenyl thiochloroformate and (350 muL)N,N-diisopropylethylamine(DIPEA) dissolved in 15 mL of dichloromethane,Then stir at room temperature for 15h,After vortexing to obtain a crude product,Finally using dichloromethane:Column chromatographic separation of the methanol system (30:1, v/v)506 mg of pure product was obtained with a yield of 88%.

The synthetic route of O-Phenyl carbonochloridothioate has been constantly updated, and we look forward to future research findings.

Reference:
Patent; University of Jinan; Zhang Meng; Wu Liu; Zhao Ziyang; Yuan Ruifang; Fang Zhaotong; Wang Ruikang; Liu Caiyun; Zhu Baocun; (11 pag.)CN107903237; (2018); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

These common heterocyclic compound, 4090-55-5, name is 2-Chloro-5,5-dimethyl-1,3,2-dioxaphosphorinane 2-oxide, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. HPLC of Formula: C5H10ClO3P

Comparative Synthesis Example 1 (Synthesis of Comparative Phosphorus Compound 1); A mixture was obtained in the same manner as in Synthesis example 1 except that 114.4 g of toluene were used in place of 114.4 g of chlorobenzene, 89.3 g (0.95 mole) of phenol were used in place of 161.5 g (0.95 mole) of 2-phenylphenol (ortho-phenylphenol) and chlorobenzene was not used to add to the reaction mixture.(After-treatment) The obtained mixture was neutralized at 85 C by adding hydrochloric acid solution which corresponds to an excess amount of triethylamine and the mixture was allowed to stand to separate an oil phase. Next, the obtained oil phase was washed with approximately 85 C water and then any liquid was removed by a centrifugal filter. The obtained solid was dried by a vacuum desiccator at 100 C, to give 210.0 g of a white solid. The purity of the obtained solid was found to be 99.2 area % by GPC. Also, if all of the solids were assumed to be an object compound, the crude yield was 86.8 %.

The synthetic route of 2-Chloro-5,5-dimethyl-1,3,2-dioxaphosphorinane 2-oxide has been constantly updated, and we look forward to future research findings.

Reference:
Patent; DAIHACHI CHEMICAL INDUSTRY CO., LTD.; EP1925622; (2008); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 771583-81-4, name is 4-Chloro-2-(trifluoromethyl)benzylamine, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 771583-81-4

5-((4- (ethylsulfonyl) benzyl) carbamoyl) -2-isopropoxybenzoic acid (300.0 mg, 0.7 mmol), HATU (422.0 mg, 1.1 mmol) and DIPEA (477.2 mg , 3.7 mmol) was dissolved in tetrahydrofuran (10 mL), and after stirring at room temperature for 0.5 hours, 4-chloro-2- (trifluoromethyl) benzylamine (232.6 mg, 1.1 mmol) was added, and the reaction was performed at room temperature for 4 hours. Then, add an appropriate amount of water and extract 3 times with ethyl acetate. The organic phases were combined and washed with a saturated sodium chloride solution, dried over anhydrous sodium sulfate, filtered, and the filtrate was concentrated. The concentrate was purified by preparative high performance liquid chromatography to obtain the title compound (300.0 mg, yield: 65%).

According to the analysis of related databases, 771583-81-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Sichuan Kelun Botai Bio-pharmaceutical Co., Ltd.; Liu Chunchi; Liu Jinming; Ren Yun; Cai Jiaqiang; Wang Lichun; Wang Jingyi; (42 pag.)CN110724075; (2020); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthetic Route of 29671-92-9, A common heterocyclic compound, 29671-92-9, name is Carbamimidic chloride hydrochloride, molecular formula is CH4Cl2N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step 3; The previous aminobenzonitrile (40.0 mg; 0.15 mmol) and chloroformamidine hydrochloride (18.0 mg; 0.16 mmol) were heated at 140 C in diglyme for 3 hours. The reaction mixture was diluted with water, stirred for 2 hours, filtered, washed with water and dried. Purification by silica gel chromatography (5- 10% methanol in dichloromethane) to yield 14 milligrams of 5-(4- chlorophenoxymethyl) quinazoline-2,4-diamine.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; DECODE CHEMISTRY, INC.; SINGH, Jasbir; GURNEY, Mark E.; WO2005/123724; (2005); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 2533-69-9, name is Methyl 2,2,2-trichloroacetimidate, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2533-69-9, HPLC of Formula: C3H4Cl3NO

A mixture of 1.98 g of 4-trifluoromethylbenzene-1, 2-diamine and 15 ml of acetic acid was added to a mixture of1.98 g of methyl-2,2,2-trichloroacetimidate and 15 ml of acetic acid under ice cooling, followed by stirring for 3 hours at room temperature. The reaction mixture was concentrated under reduced pressure, ethyl acetate was added to the residues, and the resultant was washed with an aqueous saturated sodium hydrogen carbonate solution and saturated saline. The organic layer was dried over magnesium sulfate and then concentrated under reduced pressure, thereby obtaining 3.39 g of 2-trichioromethyl-5-trifluoromethylbenzimidazole. 1H-NMR (DMSO-D5) oe: 8.18-8.00 (m, 1H), 7.94-7.80 (m, 1H), 7.72-7.65 (m, 1H)

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 2,2,2-trichloroacetimidate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; SUMITOMO CHEMICAL COMPANY, LIMITED; Mukumoto, Fujio; Tamaki, Hiroaki; Kusaka, Shintaro; Iwakoshi, Mitsuhiko; US2015/289512; (2015); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 870-24-6, name is 2-Chloroethanamine hydrochloride, A new synthetic method of this compound is introduced below., Product Details of 870-24-6

4-Methoxythiophenol (50 g, 0.357 mol), 2-chloroethylamine monohydrochloride (39.8 g, 0.343 mol.), K2CO3(78.8 g, 0.57 mol) and diisopropyl ethylamine (32 mL, 0.178 mol) were mixed in 200 mL of THF. The mixture was degassed for 5 min. under reduced pressure and refluxed under argon overnight. The solvent was removed and water (300 mL) was added to the flask. The mixture was extracted with dichloromethane (3*200 mL). The organics were collected, dichloromethane was removed and 50 mL conc. HCl was added, followed by 200 mL of water. The solution was extracted with 1:1 EtOAc/hexane (3*200 mL). The aqueous layer was adjusted to pH 10 with 2 M NaOH, and was extracted with dichloromethane (3*200 mL). The combined organic solution was dried over anhydrous sodium sulfate. Removal of solvent provided 61 g of the target compound as a colorless liquid, with a yield of 97%. 1H-NMR (300 MHz, CDCl3): 7.35 (d, J=8.7 Hz, 2H), 6.81 (d, J=8.7 Hz, 2H), 3.77 (s, 3H), 2.88-2.80 (m, 4H), 1.44 (s, 2H).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Deng, Shixian; Belvedere, Sandro; Yan, Jiaming; Landry, Donald; US2009/227788; (2009); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Some common heterocyclic compound, 694-80-4, name is 1-Bromo-2-chlorobenzene, molecular formula is C6H4BrCl, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 694-80-4

General procedure: In a Schlenk flask under N2 atmosphere, 2a (5 mg, 0.011 mmol), PdCl2 (2 mg, 0.011 mmol), Cs2CO3 (358 mg, 1,1 mmol) and DMF(1.5 mL) were added. The reaction mixture was heated at 90 C for 30 min. Then, an aryl halide (1.0 mmol) and an olefin (1.2 mmol)were added and the mixture was further stirred at 125 C under air atmosphere conditions. The reaction progress was monitored by Thin Layer Chromatography (EtOAc/hexane, 1:9). After completion of the reaction, the mixture was cooled to room temperature, and water (8 mL) was added and was extracted with EtOAc (3 10 mL).The organic solvent was dried over Na2SO4 and was evaporated under vacuum to give the crude product which was further purified by column chromatography using EtOAc/hexane, 1:9.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 694-80-4, its application will become more common.

Reference:
Article; Takallou, Ahmad; Habibi, Azizollah; Halimehjani, Azim Ziyaei; Balalaie, Saeed; Journal of Organometallic Chemistry; vol. 888; (2019); p. 24 – 28;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

These common heterocyclic compound, 622-24-2, name is (2-Chloroethyl)benzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 622-24-2

To the reaction flask by adding material five, substance six, dimethyl formamide, potassium carbonate, reaction, Cooled to 25 C, The reaction solution was added to ice water, The mass of the ice water was 10 times of that of the reaction solution, filter, Washed, Drying, Substance seven was obtained

The synthetic route of (2-Chloroethyl)benzene has been constantly updated, and we look forward to future research findings.

Reference:
Patent; China Three Gorges University; Tan, Xiao; Liu, Sen; Yang, Liting; (21 pag.)CN106214681; (2016); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Reference of 57946-56-2, A common heterocyclic compound, 57946-56-2, name is 4-Chloro-2-fluoroaniline, molecular formula is C6H5ClFN, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

[0146] Sodium nitrite (2.35 g, 34.13mmol) solution (40 mL) was added dropwise to 4- Chloro-2-fluoro aniline (4. [5G,] 31mmol) in 170 mL HBr [AT-10C] bath temperature, then the mixture was stirred for 30 min at-10C bath temperature. In parallel, copper sulfate (10.22g, 24. [29MMOL)] and sodium bromide (3.79 g, 36. [8MMOL)] were mixed and the reaction mixture was heated at [60C] for 30 min. Then sodium sulfite (2.66g, 21. [2MMOL)] was added into this copper sulfate reaction mixture and heated for [95C] for 30 min. The reaction mixture was cooled to room temperature and solid formed was washed with water to afford white solid cuprous bromide. The diazonium salt was portion wise added into the freshly prepared cuprous bromide in 40 mL HBr [AT-10C] bath temperature and the reaction mixture was then warmed to room temperature. The reaction mixture was heated at [55C] for 20 min, cooled and then extracted with ethyl acetate three times. The combined organic layer was washed with water and saturated brine solution, dried over sodium sulfate and concentrated. The crude material was purified by column chromatography (5: 95 ethyl acetate: pet ether) to afford solid product.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; CHEMOCENTRYX, INC.; WO2003/105853; (2003); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 14490-19-8, name is 1,4-Dichloropyrido[3,4-d]pyridazine, This compound has unique chemical properties. The synthetic route is as follows., COA of Formula: C7H3Cl2N3

To a round bottomed flask were added tert-butyl piperidin-4-ylmethylcarbamate (0.29mL, 55mmol)1 ,4-dichloropyrido[3,4-d]pyridazine (1 3.48mL, 5Ommol) , N,N-diisopropylethylamine (26mL,1 5Ommol) , NMP (50mL) and heated to 100C for 1 hour. The reaction was diluted with EtOAc andwashed with water (5×1 OOmL). The organic layer was dried over sodium sulphate, filtered andconcentrated in vacuo. The resulting residue was purified by silica flash chromatography using 30%EtOAc in heptane using a slow isocratic elution and concentrated in vacuo to afford the majorregioisomer tert-butyl N-[1 -(1 -chloropyrido[3,4-d]pyridazin-4-yl)-4-piperidyl]-N-methyl-carbamate(1 .lg, 2.9mmol, 5.8%, 98% purity). Further mixed fractions of lower purity were also obtained.1H NMR (400MHz, ODd3) s/ppm: 9.46 (s, 1 H), 9.03 (d, J5.6Hz, 1 H), 7.94 (d, J5.6Hz, 1 H), 4.33(m(br), 1H), 4.22-4.12 (m(br), 2H), 3.29 (t, J12.5Hz, 2H), 2.83 (s, 3H), 2.11-1.97 (m, 2H), 1.90-1.81(m, 2H), 1.50 (s, 9H).MS Method 2: RT: 1 .73mm. m/z 378.9[M÷H]

According to the analysis of related databases, 14490-19-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; REDX PHARMA LIMITED; ARMER, Richard; BINGHAM, Matilda; BHAMRA, Inder; MCCARROLL, Andrew; WO2014/191737; (2014); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics