Month: July 2021

Related Products of 96558-78-0, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 96558-78-0, name is 3-Bromo-5-chlorophenylamine, This compound has unique chemical properties. The synthetic route is as follows.

To a solution of 3-bromo-5-chloro-aniline (280 mg, 1.36 mmol) in l,4-dioxane (5 ml) and H20 (0.5 ml) was added 4,4,5,5-tetramethyl-2- [ 1 -methylprop- 1 -enyl]- 1 ,3 ,2-dioxaborolane (296 mg, 1.63 mmol), Pd(dppf)Cl2 (99 mg, 0.14 mmol) and Cs2C03 (1.33 g, 4.07 mmol) under N2. The mixture was heated at 130 C for 12 h under N2. The solution was filtered and concentrated in vacuo. The residue was purified by FCC (25 % EtOAc in petroleum ether) to give the title compound as a green oil (Y = 81 %). LC- MS (ESI): m/z: [M+H]+ = 182.1

The chemical industry reduces the impact on the environment during synthesis 3-Bromo-5-chlorophenylamine. I believe this compound will play a more active role in future production and life.

Reference:
Patent; NODTHERA LIMITED; HARRISON, David; WATT, Alan Paul; BOCK, Mark G.; (334 pag.)WO2019/121691; (2019); A1;,
Chloride – Wikipedia,
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Some common heterocyclic compound, 63857-00-1, name is N-((2-Chloro-3-((phenylimino)methyl)cyclohex-2-en-1-ylidene)methyl)aniline hydrochloride, molecular formula is C20H20Cl2N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: N-((2-Chloro-3-((phenylimino)methyl)cyclohex-2-en-1-ylidene)methyl)aniline hydrochloride

3.6 g 4-dimethylaminopyridine and 11. 8 g dye A (both available from Aldrich) were added under stirring to 60 ml Downanol PM in a 0. 5 1 three-necked flask equipped with a stirrer and a reflux condenser. Then 11.8 g 2-methylene-1, 3,3-trimethylindoline (Fischer base, available from Aldrich) was added under stirring for one minute to this suspension. The reaction mixture was heated to 80C for 2 hours. Then the reaction mixture was left to cool to room temperature and 200 ml of a 1 wt. -% hydrochloric acid were added. After the reaction mixture had cooled to room temperature, the insoluble portion was separated by filtration and washed with 0.5 1 of water. Then the product was dried for one day at 50C in a circulating air oven. Yield: 15.6 g (81.0 % based on dye A). The dried product was suspended in 150 ml methyl ethyl ketone and heated to 80C for one hour. Subsequently, the solution with a temperature of about 40C was filtered and the solid portion was washed with ethyl acetate. The product was air-dried. The yield after clean-up WAS 78 WT. -%; UV/VIS SPECTRUM IN METHANOL : 786 NM, EXTINCTION COEFFICIENT E = 381 1/G X CM.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 63857-00-1, its application will become more common.

Reference:
Patent; KODAK POLYCHROME GRAPHICS GMBH; WO2004/52995; (2004); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Electric Literature of 2533-69-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2533-69-9, name is Methyl 2,2,2-trichloroacetimidate belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

C. 2-Trichloromethyl-5-(2-trifluoromethoxy-phenyl)-lH-benzimidazole(3-tert-Butoxycarbonylamino-2′-trifluoromethoxy-biphenyl-4-yl)-carbamic acid tert-butyl ester (573 mg, 1.22 mmol, as prepared in the previous step) was placed in a 40 mL vial equipped with a magnetic stir bar. DCM (10 mL) and TFA (5 mL) were added, and the mixture stirred at rt for 12 h. The solvent was removed under reduced pressure, and the residue was dissolved in DCM and washed with 2M aq NaOH. The organic extract was dried over MgSO4 and concentrated in vacuo. The residue was dissolved in AcOH (5 mL) and placed in an 8 mL vial equipped with a magnetic stir bar. The mixture was cooled to 0 0C, treated with methyl-2,2,2-trichloroacetimidate (0.167 mL, 1.35 mmol) via syringe, and stirred at rt for 3 days. The solvent was removed under reduced pressure. The crude product was purified by column chromatography using a 12-g SiO2 pre-packed column eluting with EtOAc/hexanes, 0:1 to 2:5, v/v over 30 min, yielding 409 mg (85 %) of the desired compound. 1H-NMR (400 MHz, d4-MeOH) delta: 7.71 – 7.77 (m, 2H), 7.52 – 7.57 (m, IH), 7.39 – 7.51 (m, 4H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 2,2,2-trichloroacetimidate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; JANSSEN PHARMACEUTICA NV; PLAYER, Mark, R.; PARKS, Daniel, J.; PARSONS, William; MEEGALLA, Sanath, K; ILLIG, Carl, R.; BALLENTINE, Shelley, K.; WO2010/45166; (2010); A1;,
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Adding a certain compound to certain chemical reactions, such as: 1205-71-6, name is 4-Chloro-N-phenylaniline, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1205-71-6, Formula: C12H10ClN

Step A: Preparation of ((lr,4r)-4-(hydroxymethyl)cyc.ohexyl)methyl 4- chlorophenyl(phenyl)carbamate.4-Chloro-N-phenylaniline (15.0 g, 73.6 mmol), tribasic potassium phosphate, (fine powder, 4.69 g, 22.1 mmol), NN-carbonyldiimidazole (13.14 g, 81 mmol) and acetonitrile (75 mL) were charged to a 500-mL, jacketed, four-necked cylindrical reaction flask equipped with a mechanical stirrer and a condenser. The reaction mixture was heated at 65 C under nitrogen and monitored by HPLC. After about 2.5 h HPLC showed > 98% conversion to the intermediate N-(4-chlorophenyl)-N-phenyl-lH-imidazole-l-carboxamide. After about 5.5 h a solution of (lr,4r)-cyclohexane-l,4-diyldimethanol (37.2 g, 258 mmol) in acetonitrile (150 mL) at 65 C was added to the reaction mixture over 20 min. The resulting mixture was heated at 65 C overnight. HPLC showed about 98% conversion to the required product. The mixture was filtered, and the cake was rinsed with acetonitrile (2 x 25 mL). The filtrate was concentrated under reduced pressure (40 C, 32 torr) 124.125 g of distillate was collected. The residue was diluted with water (50 mL) and this mixture was concentrated under reduced pressure (40 C, 32 torr) and 35.184 g of distillate was collected. The residue was diluted with water (50 mL) and the resulting mixture was allowed to stir overnight to give a white paste. The mixture was filtered, and the cake was rinsed with 25% acetonitrile/water (2 x 75 mL). The solid was dried in a vacuum oven to leave a white solid (22.271 g); 94.8% purity by HPLC peak area. LCMS m/z = 374.3 [M+H]+; NMR (400 MHz, DMSO-i/6) delta ppm 0.77 – 0.93 (m, 4 H) 1.23 (dd, J = 6.22, 3.51 Hz, 1 H) 1.47 (dd, J = 6.32, 2.91 Hz, 1 H) 1.56 – 1.76 (m, 4 H) 3.20 (t, J= 5.78 Hz, 2 H) 3.92 (d, J = 6.13 Hz, 2 H) 4.33 (t, J = 5.31 Hz, 1 H) 7.28 – 7.35 (m, 5 H) 7.38 – 7.47 (m, 4 H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Chloro-N-phenylaniline, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ARENA PHARMACEUTICALS, INC.; BLACKBURN, Anthony C.; SHAKYA, Sagar Raj; DEMATTEI, John A.; CHUANG, Tsung-Hsun; WO2011/37613; (2011); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 6940-78-9, name is 1-Bromo-4-chlorobutane, A new synthetic method of this compound is introduced below., Recommanded Product: 1-Bromo-4-chlorobutane

To a solution of 7-Hydroxy-3,4-dihydrocarbostyril (100 g) and 1-Bromo-4-chlorobutane (245 g) in N,N-Dimethylformamide (500 ml) potassium carbonate (100 g) was added and stirred for 10-15 hours at ambient temperature. After completion of the reaction water (1500 ml) and Toluene (500 ml) was added and stirred. The organic layer was separated and evaporated to dryness to give residue. Cyclohexane (1000 ml) was added to the residue and stirred and filtered to give 7-(4-Chlorobutoxy)-3,4-dihydrocarbostyril (Yield 90% and HPLC purity 97%).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; PHARMATHEN S.A.; KOFTIS, Theocharis, V.; SONI, Rohit, Ravikant; ACHARYA, Hitarth, Harshendu; PATEL, Kandarpkumar, Hasmukhbhai; AHIRRAO, Manoh, Devidas; WO2013/20672; (2013); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

2106-04-9, name is 3-Chloro-2-fluoroaniline, belongs to chlorides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Computed Properties of C6H5ClFN

Using a modified procedure described by Gomez-Sanchez. (Reference: GomezSanchez, A. et al., Anales Dc Quimica, 8 1(2): 139 (1985).) A clear, faint yellow solution of ethyl nitroacetate (4.17 ml, 37.6 mmol) and triethylorthoacetate (6.93 mL, 37.6 mmol)in toluene (9.39 mL) was heated to 110 C. A Dean-Stark trap was used to azeotrope the ethanol. Approximately every 30 mm, the solvent was removed from the Dean-Stark and additional toluene (6 mL) was added to the reaction flask. Over the course of the reaction the color became a clear, dull yellow color. After 7.5 h, the reaction was stopped and it was cooled to rt. Excess solvent and starting materials were removed by distillation (5mm Hg at 100 C) leaving ethyl 3-ethoxy-2-nitrobut-2-enoate (5.46 g) as an orangeliquid. An orange solution of 3-chloro-2-fluoroaniline (5.86 g, 40.2 mmol) and ethyl 3- ethoxy-2-nitrobut-2-enoate (5.45 g, 26.8 mmol) in ethanol (13.41 mL) was stirred at a After 7 h, the reaction was stopped and concentrated to give an orange oil. The orange oil was diluted with EtOAc and washed with 1.0 N HC1 (2x), saturated NaHCO3, brine, driedover sodium sulfate, filtered and concentrated to give an orange oil. Purification by normal phase chromatography gave Intermediate 24A1 (2.90 g, 36%) as a viscous orange-yellow oil. ?HNMR indicated a 1:1 E:Z mixture. MS(ESI)m/z: 325.0 (M+H)t ?H NMR (500 MHz, CDC13) oe 11.54 (br. s., 1H), 10.77 (br. s., 1H), 7.50 – 7.45 (m, 1H), 7.44 – 7.38 (m, 1H), 7.24 – 7.12 (m, 4H), 4.39 (q, J 7.2 Hz, 2H), 4.34 (q, J 7.2 Hz,2H), 2.15 (d,J 1.4 Hz, 3H), 2.12 (d,J 1.4 Hz, 3H), 1.39 (t,J 7.2 Hz, 3H), 1.36 (t,J7.0 Hz, 3H).

The synthetic route of 2106-04-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; PABBISETTY, Kumar Balashanmuga; CORTE, James R.; DILGER, Andrew K.; EWING, William R.; ZHU, Yeheng; (178 pag.)WO2017/19819; (2017); A1;,
Chloride – Wikipedia,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 468075-00-5, name is 2-Bromo-1-chloro-4-(trifluoromethoxy)benzene belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. SDS of cas: 468075-00-5

mixture of 2-bromo-l-chloro-4-(trifluoromethoxy)benzene (5.00 g, 18.15 mmol), Pd(dppf)Cl2.CH2Cl2 (1.48 g, 1.82 mmol) and Et3N (5.51 g, 54.45 mmol) in EtOH (30 mL) was degassed, and refilled with CO. The reaction was stirred under CO (50 psi) for 16 hours at 80 C, at which point the desired product was observed by LCMS. The reaction mixture was diluted with EtOH (20 mL), and filtered through a Celite pad. The filtrate was concentrated. The residue was purified by flash chromatography on silica gel (EtOAc in PE = 0% ~ 5%) to afford compound 12-b (2.40 g, 8.93 mmol) as an oil. 1H NMR (400MHz, CDC13) deltaEta = 7.66 – 7.59 (m, 1H), 7.42 (d, 1H), 7.24 – 7.19 (m, 1H), 4.36 (q, 2H), 1.35 (t, 3H).

The synthetic route of 468075-00-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; PRAXIS PRECISION MEDICINES, INC.; REDDY, Kiran; MARTINEZ BOTELLA, Gabriel; GRIFFIN, Andrew, Mark; MARRON, Brian, Edward; (141 pag.)WO2018/98491; (2018); A1;,
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Chlorides – an overview | ScienceDirect Topics

Synthetic Route of 110407-59-5, A common heterocyclic compound, 110407-59-5, name is 2-Chloro-4-fluorobromobenzene, molecular formula is C6H3BrClF, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of l-bromo-2-chloro-4-fluorobenzene (2.5 g, 12.0 mmol) in toluene (10 mL) at -70 C was added n-BuLi (1.6 M in hexane) (7.5 mL, 12.0 mmol) dropwise over 5 min by syringe along the wall of the flask. After adding, the reaction was stirred at this temperature for 30 min. Then the resulting solution was added into a solution of (S)- tert-butyl l,6-dioxohexahydropyrrolo[l,2-a]pyrazine-2(lH) -carboxylate (2.8 g, 10.9 mmol) in toulene (10 mL). After stirred at -70 C for 5 min, the reaction mixture was quenched with saturated NH4CI and extracted with EtOAc (2 x 20 mL). The organic layer was washed with brine, dried over Na2S04, filtered and concentrated in vacuo. The residue was purified by silica gel chromatography to give the title compound (850.0 mg, yield : 20%); m/z (ES+): 385 [M + H] + .

The synthetic route of 110407-59-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; LEO PHARMA A/S; BLADH, Haakon; FELDING, Jakob; ZHOU, Ding; CAI, Zhen-wei; SØRENSEN, Morten Dahl; WO2015/24878; (2015); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 62593-17-3, name is 2,4-Dichloro-6-(trifluoromethyl)aniline belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. HPLC of Formula: C7H4Cl2F3N

Example 62 (General Procedure (D)) 3-Bromo-5-Tert-Butyl-N-(2,4-Dichloro-6-Trifluoromethyl-Phenyl)-6-Hydroxy-2-Methylbenzamide. The title compound was prepared from 3-tert-butyl-5-bromo-6-methylsalicylic acid and 2,4-dichloro-6-trifluoromethylanilin. 1H-NMR: (CDCl3, 400 MHz): delta ppm 1.40 (s, 9 H) 2.69 (s, 3 H) 7.15 (s, 1 H) 7.56 (s, 1 H) 7.68 (s, 1 H) 7.76 (s, 1 H) 9.50 (s, 1 H).); HPLC-MS (Method A): m/z=498, 500, 502 (M+1); Rt=5.9 min.

The synthetic route of 62593-17-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Hansen, Birgit Sehested; Hansen, Thomas Kruse; Tullin, Soren; Colding-Jorgensen, Morten; US2004/138301; (2004); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Electric Literature of 10061-02-6, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 10061-02-6 as follows.

11h were made from corresponding terminal alkyne and vinyl chloride S139 via route shown in Scheme 7. To a solution of S13 (600mg, 3.04 mmol ) in CH3CN was added K2CO3 (4.2g, 30.4 mmol) and continue stirred half of a hour, then added S9 (1g, 9.13 mmol) at room temperature, after the solution was heated at 40 C for 7h. The reaction was filter, and concentrated in vacuo. Purification via flash chromatography on silica gel(PE/EA = 20/1) provided S14( 490 mg,60% yield).Pd(PPh3)4 (97 mg, 0.084 mmol) andcopper iodide (32 mg, 0.169 mmol) were added to a seal-tube.Absorb the air andfill with nitrogen.S14 (460 mg, 1.69mmol) , prop-2-yn-1-ylbenzene ( 224 mg, 2.03 mmol ), tert-butylamine (185 mg,2.54 mmol) and 8 mL toluene was added.The mixture was heated to 70 C and stirred for 6 h. The reaction was thencooled and diluted with Et2O (10 mL) and saturated aqueous NH4Cl(5 mL). The organics were extracted with Et2O (2 *10 mL), dried overNa2SO4, filtered, and concentrated in vacuo. Purification via flash chromatography on silica gel (PE/EA = 10/1) provided 11h (317mg, 65% yield).

According to the analysis of related databases, 10061-02-6, the application of this compound in the production field has become more and more popular.

Reference:
Article; Xu, Hua-Dong; Wu, Hao; Jiang, Chun; Chen, Peng; Shen, Mei-Hua; Tetrahedron Letters; vol. 57; 26; (2016); p. 2915 – 2918;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics