Application of 93-50-5, These common heterocyclic compound, 93-50-5, name is 4-Chloro-2-methoxyaniline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Stepl[00173j To a stirred solution of Intermediate 1(0.25 g, 1.22 mmol) in DMA (3 mL) was added 4-chloro-2-methoxyaniline (0.25 g, 1.58 mmol) followed by NaHMDS (1M in THF, 3.66 mL, 3.66 mmol). The reaction was stirred for 20 minutes and then water was gradually added resulting in the product crashing out as a precipitate. The product was collected by filtration, washed with additional water and then dried under vacuum providing Intermediate 12 (361 mg, 91% yield). LC retention time 3.44 mm [A].
The synthetic route of 93-50-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; MOSLIN, Ryan M.; LIN, Shuqun; WEINSTEIN, David S.; WROBLESKI, Stephen T.; ZHANG, Yanlei; TOKARSKI, John S.; WO2014/74660; (2014); A1;,
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