Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 3460-24-0, name is 1,4-Dibromo-2-chlorobenzene, A new synthetic method of this compound is introduced below., category: chlorides-buliding-blocks
1.00 g (3.02 mmol) of 1- [4- (4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl) phenyl] isoquinoline,370 mg (1.37 mmol) of 1,4-dibromo-2-chlorobenzene,83.9 mg (0.0726 mmol) of tetrakis (triphenylphosphine) palladium,And 5.45 mL (5.45 mmol) of 1 M potassium carbonate aqueous solution were dissolved in 40 mL of dioxane,And the mixture was heated and stirred at 100 C. After cooling to room temperature, 400 mL of pure water was added and separation and extraction was performed with chloroform. After distilling off the solvent under reduced pressure, the obtained crude product was purified by silica gel column chromatography (developing solvent: chloroform)2′-Chloro-4,4 “-di (1-isoquinolyl) -1,1 ‘: 4’, 1″Of a light yellow solid (Yield 490 mg, yield 68.9%).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; TOSOH CORPORATION; FUJITA, KANA; ARAI, NOBUMICHI; NOMURA, KEISUKE; IIDA, TAKASHI; TANAKA, TSUYOSHI; (76 pag.)JP6264877; (2018); B2;,
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