6940-78-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 6940-78-9 name is 1-Bromo-4-chlorobutane, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
1-bromo-4-chlorobutane (3.4 g, 20 mmol), anhydrous potassium carbonate powder (4.14 g, 30 mmol) and 7-hydroxy-3,4-dihydro-2(1H)quinolinone 10 mmol)Was added to 10 ml of acetone, refluxed for 24 hours,, the reaction solution was evaporated to dryness, and the mixture was partitioned with 20 ml portions of dichloromethane and water. The organic layer was extracted with 20 ml of water * 2 and 20 ml of saturated brine successively, dried over anhydrous magnesium sulfate , Evaporate to dryness to give a pale yellow powder. The obtained powder is washed with slurry with 20 ml * 3 of n-hexane, filtered, and dried to obtain 1.98 g of 7-(4-chlorobutoxy)-3,4-dihydro-2(1H)quinolinone. Yield is 78%.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Bromo-4-chlorobutane, and friends who are interested can also refer to it.
Reference:
Patent; JIANGSU HENGYI PHARMACEUTICAL COMPANY LIMITED; SHANGHAI INSTITUTE OF PHARMACEUTICAL INDUSTRY; Li, JIANQI; PENG, SHAOPING; CAI, WANGPING; GAO, KAI; (39 pag.)JP5714152; (2015); B2;,
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