Tag: M.W=500-600

Formula: C8H12I2Pt. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: Diiodo(1,5-cyclooctadiene)platinum(II), is researched, Molecular C8H12I2Pt, CAS is 12266-72-7, about Utilizing Redox-Mediated Bergman Cyclization toward the Development of Dual-Action Metalloenediyne Therapeutics. Author is Lindahl, Sarah E.; Park, Hyunsoo; Pink, Maren; Zaleski, Jeffrey M..

Reaction of 2 equiv of 1,2-bis((diphenylphosphino)ethynyl)benzene (dppeb, 1) with Pt(cod)Cl2 followed by treatment with N2H4 yields the reduced Pt(0) metalloenediyne, I (Pt(dppeb)2, 2). This complex is stable to both air oxidation and metal-mediated Bergman cyclization under ambient conditions due to the nearly idealized tetrahedral geometry. Reaction of 2 with 1 equiv of I2 in the presence of excess 1,4-cyclohexadiene (1,4-CHD) radical trap rapidly and near-quant. generates the cis-Bergman-cyclized, diiodo product II (3, 31P: δ = 41 ppm, JPt-P = 3346 Hz) with concomitant loss of 1 equiv of uncyclized phosphine chelate (31P: δ = -33 ppm). In contrast, addition of 2 equiv of I2 in the absence of addnl. radical trap instantaneously forms a metastable Pt(dppeb)22+ intermediate species, 4, that was characterized by δ = 51 ppm in the 31P NMR (JPt-P = 3171 Hz) and νCC = 2169 cm-1 in the Raman profile, indicating that it is an uncyclized, bis-ligated complex. Over 24 h, 4 undergoes ligand exchange to form a neutral, square planar complex that spontaneously Bergman cyclizes at ambient temperature to give the crystalline product Pt(dppnap-I2)I2 (dppnap-I2 = (1,4-diiodonaphthalene-2,3-diyl)bis(diphenylphosphine)), 5, in 52% isolated yield. Computational anal. of the oxidation reaction proposes two plausible flattened tetrahedral structures for intermediate 4: one where the phosphine core has migrated to a trans-spanning chelate geometry, and a second, higher energy structure (3.3 kcal/mol) with two cis-chelating phosphine ligands (41° dihedral angle) via a restricted alkyne-terminal starting point. While the energies are disparate, the common theme in both structures is the elongated Pt-P bond lengths (>2.4 Å), indicating that nucleophilic ligand substitution by I- is on the reaction trajectory to the cyclized product 5. The efficiency of the redox-mediated Bergman cyclization reaction of this stable Pt(0) metalloenediyne prodrug and resulting cisplatin-like byproduct represents an intriguing new strategy for potential dual-threat metalloenediyne therapeutics.

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HPLC of Formula: 12266-72-7. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: Diiodo(1,5-cyclooctadiene)platinum(II), is researched, Molecular C8H12I2Pt, CAS is 12266-72-7, about Spectroscopic studies on organometallic compounds. XLIX. Hydrogen-nuclear magnetic resonance spectra of cyclooctatetraene and 1,5-cyclooctadiene platinum complexes. Author is Fritz, Heinz P.; Sellmann, Dieter.

cf. CA 67: 48643x. The 1H-N.M.R. spectra of C8H8PtX2 and C8H12PtX2 (X = Cl, Br, I, and CH3) are reported and discussed in connection with far ir spectra given earlier. The magnitudes of σ- and π-bonding in the Pt-olefin bonds are estimated

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The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: Diiodo(1,5-cyclooctadiene)platinum(II)(SMILESS: I[Pt]I.C1=CCC/C=CCC/1,cas:12266-72-7) is researched.Recommanded Product: 38006-08-5. The article 《3,6-Bis(2′-pyridyl)pyridazine iridium-palladium and iridium-platinum heterodinuclear complexes》 in relation to this compound, is published in Congr. Naz. Chim. Inorg., [Atti], 16th. Let’s take a look at the latest research on this compound (cas:12266-72-7).

[Ir(NO)L(PPh3)2]2+ (I) (L = 3,6-bis(2′-pyridyl)pyridazine) reacted with (PhCN)2PdCl2 to give Ir(NO)L(PPh3)2[PdCl2]2+ which lost PPh3 in CH3CN and added Cl- to give [Ir(NO)L(PPh3)PdCl3]+ (II). I also reacted with halide ions to give [Ir(NO)L(PPh3)X]+ (III) (X = Cl, Br, I) which then reacted with (PhCN)2PdCl2 to give II. I reacted with (COD)PtI2 (COD = cyclooctadiene) to give [Ir(NO)L(PPh3)PtI3]+ but I or III (X = Cl) reacted with (COD)PtCl2 to give [IrL(PPh3)2Cl2]+. The complexes were characterized by IR and 31P NMR spectra and elec. conductivity data.

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Quality Control of Diiodo(1,5-cyclooctadiene)platinum(II). The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: Diiodo(1,5-cyclooctadiene)platinum(II), is researched, Molecular C8H12I2Pt, CAS is 12266-72-7, about Reaction of the Carbodiphosphorane Ph3P:C:PPh3 with Platinum(II) and -(0) Compounds: Platinum Induced Activation of C-H Bonds. Author is Petz, Wolfgang; Kutschera, Christian; Neumueller, Bernhard.

The complex [(cod)PtI2] (cod = 1,5-cyclooctadiene) reacts with 3 equivalent of the hexaphenylcarbodiphosphorane Ph3P:C:PPh3 (1) in THF solution to give the novel Pt(II) complex [(η3-C8H11)Pt(C6H4PPh2CPPh3)] (2) along with the salt [HC(PPh3)2]I. In addition to the coordination of the ylidic carbon atom at the Pt atom, 2 contains two further Pt-C σ bonds originating from H to Pt exchange in the ortho position of one Ph group of the carbodiphosphorane ligand and in the former cod ligand. The resulting C8H11 moiety is coordinated to the Pt atom in an η3 manner via a double bond and a σ bond and contains a further uncoordinated double bond. From a 1:1 reaction mixture in toluene/CH2Cl2 the majority of the crystals consist of the salt [HC(PPh3)2]I·2CH2Cl2 (3) with small amounts of platinum compounds as byproducts. The Pt(0) complex [(PPh3)2Pt(CH2:CH2)] does not react with 1 but decomposes at elevated temperatures to give the known dinuclear complex [Pt2(PPh3)2(μ-PPh2)2] (4). The complexes 2 and 4 and the salt 3 could be characterized by x-ray analyses and the usual spectroscopic methods.

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Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: Diiodo(1,5-cyclooctadiene)platinum(II), is researched, Molecular C8H12I2Pt, CAS is 12266-72-7, about Mass spectrometric and X-ray studies on complexes of the type (COD)PtX2 (X = Cl, Br, I, CH3, CH2CMe3, CH2SiMe3).Synthetic Route of C8H12I2Pt.

Investigations by mass spectrometry at complexes of the type (COD)PtX2 (X = Cl (1), Br (2), I (3), Me (4), CH2CMe3 (5) and CH2SiMe3 (6), (COD) = 1,5-cyclooctadiene) show the mole peak of all compounds with the characteristic isotopic pattern of platinum and platinum with chlorine, bromine or silicon resp. The group of peaks of the complexes 1-5 at 300 m/e show a high stability of the (COD)Pt fragment. A new route of synthesis of (COD)PtBr2 (2) is described. The compounds (COD)Pt(CH2CMe3)2 (5) and (COD)Pt(CH2SiMe3)2 (6) were characterized by x-ray structure.

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The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: Diiodo(1,5-cyclooctadiene)platinum(II)(SMILESS: I[Pt]I.C1=CCC/C=CCC/1,cas:12266-72-7) is researched.Safety of 5-Iodo-2-furaldehyde. The article 《Rhodium(I), palladium(II) and platinum(II) coordination chemistry of the short-bite chiral ligands (Sc)-N,N-bis(diphenylphosphanyl)-sec-butylamine, (Ra,Ra)-N,N-bis(binaphthylphosphonito)phenylamine and (Ra,Sc)-N-(diphenylphosphanyl)-N-(binaphthylphosphonito)-sec-butylamine》 in relation to this compound, is published in European Journal of Inorganic Chemistry. Let’s take a look at the latest research on this compound (cas:12266-72-7).

The new short-bite chiral ligands (Sc)-N,N-bis(diphenylphosphanyl)-sec-butylamine [(Sc)-1], (Ra,Ra)-N,N-bis(binaphthylphosphonito)phenylamine [(Ra,Ra)-2] and (Ra,Sc)-N-(diphenylphosphanyl)-N-(binaphthylphosphonito)-sec-butylamine [(Ra,Sc)-3] were treated with Rh(I), Pd(II) and Pt(II) substrates. The (Sc)-1 ligand reacts with [Pd(C6H5CN)2Cl2], [Pt(COD)Cl2] and [Rh(COD)(THF)2]PF6 (generated in situ) to afford [Pd(Sc-1)Cl2] (4), [Pt(Sc-1)Cl2] (5) and [Rh(COD)(Sc-1)]PF6 (6), resp., in high yields. By bubbling CO to a CH2Cl2 solution of 6, the dicarbonyl species [Rh(CO)2(Sc-1)]PF6 (7) was formed, which is stable only in solution under CO. Compounds 4 and 5 were characterized addnl. by x-ray diffraction studies. The ligand (Ra,Ra)-2 reacts with [Pd(C6H5CN)2Cl2] and [Pt(COD)I2] to give [Pd(Ra,Ra-2)Cl2] (8) and [Pt(Ra,Ra-2)I2] (9), resp.; the reaction with [Rh(CO)2Cl]2 or [Rh(COD)(THF)2]PF6 affords a mixture of mono- and binuclear compounds, in which the ligand is oxidized to the corresponding phosphonate or is partially hydrolyzed. [Pd(Ra,Sc-3)Cl2] (10) and [Pt(Ra,Sc-3)I2] (11) were obtained in the analogous reactions using the asym. (Ra,Sc)-3 ligand. This ligand reacted with [Rh(CO)2Cl]2 in a 2:1 molar ratio in hexane to give a mixture of products in almost equal amounts The 31P{1H} NMR spectrum recorded in CDCl3 allowed identification of the chelate [Rh(Ra,Sc-3)(CO)Cl] (12); the nature of the accompanying dinuclear species 13 is not clear, though a structure is proposed. The catalytic systems formed by [Rh(acac)(CO)2] and the ligands (Ra,Ra)-2 and (Ra,Sc)-3, at ligand/metal ratios of 1:1 and 1:2, were unstable under the exptl. conditions used (CO/H2 pressure of 50 atm and temperature of 40°) for the hydroformylation of styrene; instead, metallic Rh was afforded together with unidentified decomposition products.

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The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: Diiodo(1,5-cyclooctadiene)platinum(II)( cas:12266-72-7 ) is researched.SDS of cas: 12266-72-7.Bennett, Martin A.; Jin, Hong; Willis, Anthony C. published the article 《Preparation and x-ray structure of a platinum(II) hydroxycarbonyl, Pt(CO2H){C6H3(CH2PPh2)2-2,6}, containing a trans-spanning, tridentate P,C,P-ligand》 about this compound( cas:12266-72-7 ) in Journal of Organometallic Chemistry. Keywords: bisphosphinomethylbenzene cyclometalation platinum; crystal structure platinum cyclometalated diphosphine hydroxycarbonyl; mol structure platinum diphosphine hydroxycarbonyl. Let’s learn more about this compound (cas:12266-72-7).

The ligand 1,3-{bis(diphenylphosphino)methyl}benzene, 1,3-C6H4(CH2PPh2)2 (3a) undergoes cyclometalation on heating in 2-methoxyethanol either with PtCl(CH3)(COD) or, in the presence of 2-methylaminoethanol, with PtCl2(COD) to give PtCl{C6H3(CH2PPh2)2-2,6} [I; R = Ph, X = Cl (6)]. In this complex, the tridentate anionic ligand C6H3(CH2PPh2)2-2,6 (2a) is attached to platinum via a σ-bonded carbon atom and mutually trans-phosphorus atoms. Successive treatment of 6 with AgBF4 and KOH gives the hydroxo-complex I (R = Ph, X = OH), which reacts with CO to give the corresponding hydroxycarbonyl I [X = CO2H (12)]. The structure of 12·1.5C6H6 was determined by x-ray diffraction methods and shown to consist of a dimer in which two planar trans-Pt(CO2H)(2a) units are joined by hydrogen-bonded carboxylate groups. The hydrogen-bonded O…O distance [2.750(4)Å] is significantly larger than that in trans-Pt(CO2H)(C6H5)(PEt3)2 [2.695(8)Å], which may be related to the greater tendency of 2a to form a monomer in dichloromethane.

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Johnson, David K.; Rukachaisirikul, Thitima; Sun, Yan; Taylor, Nicholas J.; Canty, Allan J.; Carty, Arthur J. published the article 《Coupling of acetylenes held proximate to a metal: alkyne-alkyne interactions in cis-phosphinoacetylene complexes, including structural characterization of the unsymmetrical diphosphine 1-phenyl-2,3-bis(diphenylphoshino)naphthalene and three platinum(II) complexes of Ph2PCCPh》. Keywords: acetylene platinum coordination coupling reaction; diphosphinonaphthalene formation crystal structure; naphthalene diphosphinophenyl formation structure; platinum phosphinoacetylene derivative complex structure reaction; crystal structure diphosphinonaphthalene platinum phosphinoacetylene complex.They researched the compound: Diiodo(1,5-cyclooctadiene)platinum(II)( cas:12266-72-7 ).Synthetic Route of C8H12I2Pt. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:12266-72-7) here.

Cis-PtX(Z)(Ph2PCCPh)2 [X = Z = Cl, I, CF3, C6F5, Me; X(Z) = o-C6H4O2, Me(Cl)] were synthesized, and for all of the complexes except for di-Me complex, intramol. coupling of the phosphinoacetylene ligands occurs on heating to form cis-PtX(Z){o-C16H10(PPh2)2]. A mixture of the 2 possible structural isomers is formed for cis-PtMe(Cl){o-C16H10(PPh2)2}. Cis-PtMe2{o-C16H10(PPh2)2} was obtained by reaction of the dichloro analog with MeLi. Unsym. 1-phenyl-2,3-bis(diphenylphosphino)naphthalene [o-C16H10(PPh2)2], produced as a coordinated ligand via these intramol. coupling reactions, was isolated in moderate yield from the dichloro complex and its structure determined by x-ray diffraction. Crystals of o-C16H10(PPh2)2 are triclinic, space group P1, Z = 2, R = 0.058, Rw = 0.070. Structure determinations of cis-PtCl2(Ph2PCCPh)2.2MeCN, cis-PtMe(Cl)(Ph2PCCPh)2.0.5CH2Cl2, and cis-PtMe2(Ph2PCCPh)2 were carried out to evaluate interligand interactions in the complexes. Crystal data: cis-PtCl2(Ph2PCCPh)2.2MeCN, monoclinic, space group P21/c, Z = 4, R = 0.031, Rw = 0.035; cis-PtMe(Cl)(Ph2PCCPh)2.0.5CH2Cl2, orthorhombic, space group Pbca, Z = 8, R = 0.039, Rw = 0.044; cis-PtMe2(Ph2PCCPh)2, orthorhombic, space group Pbca, Z = 8, R = 0.037, Rw = 0.042. Factors affecting the occurrence of intramol. coupling are assessed, together with a comparison of this reaction with related reactions of organic diacetylenes. Cis-PtMe(Cl)(Ph2PCCPh)2 reacts with Ph2PH to form a mixture of the 2 structural isomers of cis-PtMe(Cl){Ph2PCH:C(Ph)PPh2}.

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Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 12266-72-7, is researched, SMILESS is I[Pt]I.C1=CCC/C=CCC/1, Molecular C8H12I2PtJournal, Article, Research Support, Non-U.S. Gov’t, Journal of Medicinal Chemistry called (2,2′:6′,2”-Terpyridine)platinum(II) Complexes Are Irreversible Inhibitors of Trypanosoma cruzi Trypanothione Reductase But Not of Human Glutathione Reductase, Author is Bonse, Susanne; Richards, Jonathan M.; Ross, Steven A.; Lowe, Gordon; Krauth-Siegel, R. Luise, the main research direction is terpyridine platinum complex Trypanosoma trypanothione reductase inhibitor.Related Products of 12266-72-7.

(2,2′:6′,2”-Terpyridine)platinum(II) complexes possess pronounced cytostatic activities against trypanosomes and leishmania. As shown here, the complexes are irreversible inhibitors of trypanothione reductase (TR) from Trypanosoma cruzi, the causative agent of Chagas’ disease. The most effective derivatives are the (4′-chloro-2,2′:6′,2”-terpyridine)platinum(II) ammine and the (4-picoline)(4′-p-bromophenyl-2,2′:6′,2”-terpyridine)platinum(II) complexes which in the presence of NADPH inhibit TR with second-order rate constants of about 1.3×104 M-1 s-1. The modified enzyme species possess increased oxidase activities. The inhibition is not reversed upon dialysis or treatment with low-mol.-mass thiols. Kinetic and spectroscopic data suggest that Cys52 in the active site has been specifically altered. Inhibition of this key enzyme of parasite thiol metabolism probably contributes to the antitrypanosomal activity of the compounds In contrast to the parasite enzyme, most (terpyridine)platinum complexes interact only reversibly with human glutathione reductase and an initial inhibition is completely abolished during the course of the assay.

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Recommanded Product: Diiodo(1,5-cyclooctadiene)platinum(II). Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: Diiodo(1,5-cyclooctadiene)platinum(II), is researched, Molecular C8H12I2Pt, CAS is 12266-72-7, about Synthesis, Structures, and Emissive Properties of Platinum(II) Complexes with a Cyclometalating Aryldiamine Ligand. Author is Jude, Hershel; Bauer, Jeanette A. Krause; Connick, William B..

A new series of square planar Pt(II) complexes with the mer-coordinating tridentate ligand, pip2NCN- (pip2NCNH = 1,3-bis(piperdylmethyl)benzene), has been prepared: Pt(pip2NCN)Cl (2), Pt(pip2NCN)Br (3), Pt(pip2NCN)I (4), and [Pt(pip2NCN)(CH3N:C(CH3)2)][CF3SO3] (5). The complexes have been fully characterized by 1H NMR spectroscopy, elemental anal., and UV-vis spectroscopy. The x-ray crystal structures of pip2NCNBr (1), 2, and 5 are reported. Compound 1: triclinic, P1̅, a = 10.081(1) Å, b = 10.153(2) Å, c = 10.390(1) Å, α = 66.05(1)°, β = 79.07(1)°, γ = 64.51(1)°, V = 877.1(2) Å3, Z = 2. Complex 2: triclinic, P1̅, a = 9.897(2) Å, b = 10.191(2) Å, c = 19.174(4) Å, α = 75.09(3)°, β = 76.14(3)°, γ = 71.00(3)°, V = 1741.2(6) Å3, Z = 4. Complex 5: triclinic, P1̅, a = 10.709(2) Å, b = 11.2321(10) Å, c = 12.447(2) Å, α = 110.509(8)°, β = 112.417(10)°, γ = 91.066(9)°, V = 1276.1(3) Å3, Z = 2. In 77 K 3:1 EtOH/MeOH glassy solution, these colorless complexes exhibit weak red-orange to red emissions originating from a lowest spin-forbidden ligand field excited state.

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