Tag: M.W=300-350

Li, Bin published the artcileGold(I)-Coordination Triggered Multistep and Multiple Photochromic Reactions in Multi-Dithienylethene (DTE) Systems, Computed Properties of 219537-97-0, the publication is Inorganic Chemistry (2012), 51(3), 1933-1942, database is CAplus and MEDLINE.

The preparation, characterization, and photochromic properties of a mononuclear Au(I) complex (100) with two identical DTE-acetylides and a dinuclear Au(I) complex (2000) with both DTE-acetylide and DTE-diphosphine are described. Both Au(I) complexes exhibit multistep and multiple photocyclization/cycloreversion reactions. Particularly, four-state and four-color photochromic switch is successfully achieved for the dinuclear Au(I) complex upon irradiation with appropriate wavelengths of light. In contrast, fully ring-closed form is unattained through multiple photocyclization for the two corresponding model organic compounds coupling with the same DTE units as Au(I) complexes but without Au(I)-participation. It is demonstrated that coordination of Au(I) ion to DTE-acetylides exerts indeed a crucial role in achieving stepwise and selective photocyclization and cycloreversion reactions for both Au(I) complexes, in which the coordinated Au(I) atom acts as an effective “barrier” to prohibit intramol. energy transfer between multi-DTE moieties.

Inorganic Chemistry published new progress about 219537-97-0. 219537-97-0 belongs to chlorides-buliding-blocks, auxiliary class Fused/Partially Saturated Cycles,Cyclopentenes, name is 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, and the molecular formula is C15H14Cl2S2, Computed Properties of 219537-97-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Androvic, Ladislav published the artcileCyclotriphosphazene-Based Star Copolymers as Structurally Tunable Nanocarriers with Programmable Biodegradability, COA of Formula: C19H14Cl2, the publication is Macromolecules (Washington, DC, United States) (2021), 54(7), 3139-3157, database is CAplus.

Myriad nanocarriers have been developed to improve the therapeutic index of low-mol.-weight drugs for cancer treatment, but many have suboptimal size and/or are too stable for optimal penetration into tumors and their subsequent excretion from the body. To address this challenge, we developed a series of novel nanocarriers based on star polymers consisting of hydrophilic poly[N-(2-hydroxypropyl)methacrylamide] (PHPMA) or poly(ethylene glycol) (PEG) polymer arms attached to hexavalent cyclotriphosphazene (CTP)-derived cores through either stable or stimuli-responsive linkers. The star polymers were assembled using either “grafting from” or “grafting onto” approaches and characterized by quant. arm substitution at the core. The resulting star polymers were precisely defined water-soluble nanomaterials with a suitable hydrodynamic size (~10-25 nm) for tumor uptake; those with stimuli-responsive linkers exhibited programmable pH- or cathepsin-mediated degradability. Finally, low-mol.-weight drugs-an anthracycline-based cancerostatic and an imidazoquinoline-based immunostimulant-were linked to exemplary CTP-based star polymers to demonstrate their suitability for drug delivery.

Macromolecules (Washington, DC, United States) published new progress about 42074-68-0. 42074-68-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 2-Chlorotrityl chloride, and the molecular formula is C19H14Cl2, COA of Formula: C19H14Cl2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Yu, Chuanming published the artcilePhotochromic dithienylethene based on porphyrin for a nondestructive information processing, HPLC of Formula: 219537-97-0, the publication is Journal of Porphyrins and Phthalocyanines (2018), 22(6), 475-480, database is CAplus.

A 1-[2-methyl-5-((4-tetraphenylporphyrinphenyl)-3-thienyl)-2-[2-methyl-3-thienyl]]cyclopentene combined by 3,3′-(1-cyclopentene-1,2-diyl)bis(5-chloro-2-methyl)thiophene and tetraphenylporphyrin can transform between the open isomer and the closed isomer upon the irradiation of UV or visible light. Thus they can be utilized to write binary data. Furthermore, the open form can emit luminescence but the closed cannot while irradiated by another light that cannot cause optical chem. reactions. Therefore, data can be read out without damage.

Journal of Porphyrins and Phthalocyanines published new progress about 219537-97-0. 219537-97-0 belongs to chlorides-buliding-blocks, auxiliary class Fused/Partially Saturated Cycles,Cyclopentenes, name is 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, and the molecular formula is C6H5NO, HPLC of Formula: 219537-97-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Chen, Kuang-Yen published the artcileTetrapodal Molecular Switches and Motors: Synthesis and Photochemistry, Application In Synthesis of 219537-97-0, the publication is Journal of Organic Chemistry (2014), 79(15), 7032-7040, database is CAplus and MEDLINE.

The design, synthesis, and dynamic behavior of a series of novel tetrapodal mol. switches and motors containing common functional groups for attachment to various inorganic and organic surfaces are presented. Using a Diels-Alder reaction, an anthracene unit with four functionalized alkyl substituents (“legs”) was coupled to maleimide-functionalized mol. switches or motors under ambient conditions. Terminal functional groups at the “legs” include thioacetates and azides, making these switches and motors ideal candidates for attachment to metallic or alkyne-functionalized surfaces. UV/vis absorption spectroscopy shows that the mol. switches and motors retain their ability to undergo reversible photoinduced and/or thermally induced structural changes after attachment to the tetrapodal anthracene.

Journal of Organic Chemistry published new progress about 219537-97-0. 219537-97-0 belongs to chlorides-buliding-blocks, auxiliary class Fused/Partially Saturated Cycles,Cyclopentenes, name is 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, and the molecular formula is C15H14Cl2S2, Application In Synthesis of 219537-97-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Wei, Xiaoxiao published the artcileFabrication of di-selective adsorption platform based on deep eutectic solvent stabilized magnetic polydopamine: Achieving di-selectivity conversion through adding CaCl₂, HPLC of Formula: 23616-79-7, the publication is Chemical Engineering Journal (Amsterdam, Netherlands) (2021), 421(Part_2), 127815, database is CAplus.

Seeking effective synthesis strategy of adsorbents with di-selective adsorption ability to remove dyes in wastewater is of great significance for solving the increasing environmental problems. Hence, three deep eutectic solvents (DESs) were synthesized and polymerized on the surface of magnetic (Fe3O4) polydopamine (MPDA), in which DES acted as both stabilizer and surface modifier for PDA coating. The fabricated nanoparticles (named as MPDA-PDES) were used as adsorbents for selective adsorption of binary dyes solution Langmuir and Dubinin-Radushkevich isotherm models were suitable to describe adsorption process of malachite green (MG) and sunset yellow FCF (SY) on MPDA-PDES1, resp., indicated that the adsorption of MG was monolayer uptake, and that of SY was phys. adsorption. The effect of solution pH and ionic strength suggested that electrostatic interaction was mainly adsorption driving force. Interestingly, the addition of CaCl₂ in adsorption system realized dynamic transformation from selective adsorption of MG by MPDA-PDES1 to selective adsorption of SY. And selectivity factor reduced from 37.57 to 0.30. MPDA-PDES1 adsorbent possessed excellent anti-interference ability, regeneration and reusability, can be continuously reused six times and adsorption capacity remained basically unchanged. The adsorption of MG-SY from synthetic wastewater manifested that MPDA-PDES1 had unlimited potential for selective removal of target dyes in actual wastewater. Mechanism exploration revealed that MPDA stabilized by DES containing long-chain alkyl groups exhibited better selective adsorption capacity for cationic dyes in binary dyes solutions This was due to the synergistic effect of electrostatic interaction, hydrophobic interaction, hydrogen bonding and π-π stacking between MPDA-PDES1 and dyes. Therefore, proposed DES-based PDA modification strategy improved the stability and reusability of PDA materials, and achieved outstanding selective adsorption ability because of tailorability of DES structure, which provided new ideas for design and synthesis of high-efficiency adsorbents.

Chemical Engineering Journal (Amsterdam, Netherlands) published new progress about 23616-79-7. 23616-79-7 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst, name is N-Benzyl-N,N-dibutylbutan-1-aminium chloride, and the molecular formula is C18H28N2O7, HPLC of Formula: 23616-79-7.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Wei, Xiaoxiao published the artcileAdsorption of pharmaceuticals and personal care products by deep eutectic solvents-regulated magnetic metal-organic framework adsorbents, Synthetic Route of 23616-79-7, the publication is Chemical Engineering Journal (Amsterdam, Netherlands) (2020), 124808, database is CAplus.

The ecol. and human health threats brought by emerging pollutants are increasingly serious. Development of efficient removal methods is urgent. Herein, seven deep eutectic solvents (DESs) composed by quaternary ammonium salts and lactic acid or glycolic acid were synthesized and used to regulate magnetic (Fe₃O₄) metal organic framework (MUiO-66-NH₂) composites. The obtained nanoparticles (named as DES-MUiO-66-NH₂) were used as adsorbents to adsorb pharmaceuticals and personal care products (PPCPs). Langmuir isotherm model and pseudo-second-order kinetics model were suitable to analyze the adsorption process of DES-MUiO-66-NH₂ to PPCPs, indicated that the adsorption of PPCPs was chemisorption on homogeneous surface of DES-MUiO-66-NH₂ adsorbents. Under the optimal conditions, the adsorption capacity of DES-MUiO-66-NH₂ toward ofloxacin and mefenamic acid reached up to 97.60 and 79.22 mg/g, resp. Mechanism exploration indicated that DES-MUiO-66-NH₂ selectively adsorbed PPCPs through electrostatic interaction, chelation, π-π stacking, hydrophobic interaction and hydrogen bonding. D. functional theory proved the chelation through theor. calculation Selective experiments manifested that the structures of DESs directly determined the specificity of DES-MUiO-66-NH₂ for different PPCPs, and the investigation of structure-activity relationship provided new ideas for designing efficient tailor-made adsorbents for PPCPs. The proposed PPCPs removal approach focused on the guiding role of DESs in selective adsorption. And this green DESs regulation idea provided more options for the synthesis of high-efficiency and functional adsorbents for emerging pollutants.

Chemical Engineering Journal (Amsterdam, Netherlands) published new progress about 23616-79-7. 23616-79-7 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst, name is N-Benzyl-N,N-dibutylbutan-1-aminium chloride, and the molecular formula is C15H14O3, Synthetic Route of 23616-79-7.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Ran, Fen published the artcileNano vanadium nitride incorporated onto interconnected porous carbon via the method of surface-initiated electrochemical mediated ATRP and heat-treatment approach for supercapacitors, Formula: C19H34ClN, the publication is Electrochimica Acta (2017), 405-413, database is CAplus.

A neg. electrode material of nano V nitride/interconnected porous C (Nano-VN/IPC) is fabricated via a novel method combining surface-initiated electrochem. mediated ATRP and heat-treatment process. The structural and composition characterization display that a low crystallinity of VN nanoparticles was obtained, which distributes uniformly in the interconnected pores of the C scaffold materials. The high-distribution of nano-VN particles in the interconnected pores significantly enhances the usage efficiency of the electrochem.-active materials to ensure the high electrochem. performance of the electrode materials. The interconnected pore structure is convenient for diffusion and transfer of electrolyte ions during charging-discharging process. The Nano-VN/IPC electrodes exhibit a high specific capacitance of 284.0 F/g at 0.5 A/g in 2 M KOH aqueous electrolyte with a low resistance and good rate capability. An asym. supercapacitor is assembled with Ni(OH)₂ and Nano-VN/IPC electrodes as the pos. and neg. electrodes. The device presents a high specific capacitance of 122 F/g at the c.d. of 0.5 A/g, and when the c.d. increases to 5 A/g the capacitance still remains 70 F/g. Remarkably, the device delivers an ultrahigh power d. of 35.6 Wh/kg at a power d. of 362.5 W/kg.

Electrochimica Acta published new progress about 23616-79-7. 23616-79-7 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst, name is N-Benzyl-N,N-dibutylbutan-1-aminium chloride, and the molecular formula is C19H34ClN, Formula: C19H34ClN.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Kulkarni, Sameer S. published the artcileDiselenide-selenoester ligation for chemical protein synthesis, COA of Formula: C19H14Cl2, the publication is Nature Protocols (2019), 14(7), 2229-2257, database is CAplus and MEDLINE.

Chemoselective peptide ligation methods have provided synthetic access to numerous proteins, including those bearing native post-translational modifications and unnatural labels. This protocol outlines the chem. synthesis of proteins using a recently discovered reaction (diselenide-selenoester ligation (DSL)) in a rapid, additive-free manner. After ligation, the products can be chemoselectively deselenized to produce native peptide and protein products. We describe methods for the synthesis of suitably functionalized peptide diselenide and peptide selenoester fragments via Fmoc-solid-phase peptide synthesis (SPPS) protocols, fusion of these fragments by DSL, and the chemoselective deselenization of the ligation products to generate native synthetic proteins. We demonstrate the method’s utility through the total chem. synthesis of the post-translationally modified collagenous domain of the hormone adiponectin via DSL-deselenization at selenocystine (the oxidized form of selenocysteine) and the rapid preparation of two tick-derived thrombin-inhibiting proteins by DSL-deselenization at β-selenoaspartate and γ-selenoglutamate. This method should find widespread use for the rapid synthesis of proteins, including cases in which other peptide ligation methods cannot be used (or cannot be used efficiently), e.g., at sterically hindered or deactivated acyl donors. The method’s speed and efficiency may render it useful in the generation of synthetic protein libraries. Each protein discussed can be synthesized within 15 working days from resin loading and can be readily produced by practitioners with master’s-level experience in organic chem. Each synthesis using these protocols was performed independently by two labs (one academic and one industrial), which attained comparable yields of the protein products.

Nature Protocols published new progress about 42074-68-0. 42074-68-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 2-Chlorotrityl chloride, and the molecular formula is C19H14Cl2, COA of Formula: C19H14Cl2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Senaweera, Sameera published the artcileS_NAr catalysis enhanced by an aromatic donor-acceptor interaction; facile access to chlorinated polyfluoroarenes, Name: N-Benzyl-N,N-dibutylbutan-1-aminium chloride, the publication is Chemical Communications (Cambridge, United Kingdom) (2017), 53(54), 7545-7548, database is CAplus and MEDLINE.

Selective catalytic S_NAr reaction of polyfluoroaryl C-F bonds with chloride is shown. Stoichiometric TMSCl makes the reaction exergonic and allows catalysis, which involves ground state elevation of chloride, aromatic donor-acceptor interactions, and stabilization of the Meisenheimer complex. Traditional cross-coupling of the products is now possible and demonstrates the utility. Thus, e.g., treatment of pentafluoropyridine with TMSCl and benzyltributylammonium chloride afforded 4-chloro-2,3,5,6-tetrafluoropyridine (95%).

Chemical Communications (Cambridge, United Kingdom) published new progress about 23616-79-7. 23616-79-7 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst, name is N-Benzyl-N,N-dibutylbutan-1-aminium chloride, and the molecular formula is C2H2N4O2, Name: N-Benzyl-N,N-dibutylbutan-1-aminium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Chen, Xinyu published the artcileAcetylcholinesterase Inhibitors with Photoswitchable Inhibition of β-Amyloid Aggregation, Computed Properties of 219537-97-0, the publication is ACS Chemical Neuroscience (2014), 5(5), 377-389, database is CAplus and MEDLINE.

Photochromic cholinesterase inhibitors were obtained from cis-1,2-α-dithienylethene-based compounds by incorporating one or two aminopolymethylene tacrine groups. All target compounds are potent acetyl- (AChE) and butyrylcholinesterase (BChE) inhibitors in the nanomolar concentration range. Compound I bearing an octylene linker exhibited interactions with both the catalytic active site (CAS) and the peripheral anionic site (PAS) of AChE. Yet upon irradiation with light, the mechanism of interaction varied from one photochromic form to another, which was investigated by kinetic studies and proved “photoswitchable”. The AChE-induced β-amyloid (Aβ) aggregation assay gave further exptl. support to this finding: Aβ_1-40 aggregation catalyzed by the PAS of AChE might be inhibited by compound I in a concentration-dependent manner and seems to occur only with one photochromic form. Computational docking studies provided potential binding modes of the compound Docking studies and mol. dynamics (MD) simulations for the ring-open and -closed form indicate a difference in binding. Although both forms can interact with the PAS, more stable interactions are observed for the ring-open form based upon stabilization of a water mol. network within the enzyme, whereas the ring-closed form lacks the required conformational flexibility for an analogous binding mode. The photoswitchable inhibitor identified might serve as valuable mol. tool to investigate the different biol. properties of AChE as well as its role in pathogenesis of AD in in vitro assays.

ACS Chemical Neuroscience published new progress about 219537-97-0. 219537-97-0 belongs to chlorides-buliding-blocks, auxiliary class Fused/Partially Saturated Cycles,Cyclopentenes, name is 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, and the molecular formula is C15H14Cl2S2, Computed Properties of 219537-97-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics