Tag: M.W=300-350

Sinatra, Laura published the artcileHydroxamic Acids Immobilized on Resins (HAIRs): Synthesis of Dual-Targeting HDAC Inhibitors and HDAC Degraders (PROTACs), Application In Synthesis of 42074-68-0, the publication is Angewandte Chemie, International Edition (2020), 59(50), 22494-22499, database is CAplus and MEDLINE.

Inhibition of more than one cancer-related pathway by multi-target agents is an emerging approach in modern anticancer drug discovery. Here, based on the well-established synergy between histone deacetylase inhibitors (HDACi) and alkylating agents, we present the discovery of a series of alkylating HDACi using a pharmacophore-linking strategy. For the parallel synthesis of the target compounds, we developed an efficient solid-phase-supported protocol using hydroxamic acids immobilized on resins (HAIRs) as stable and versatile building blocks for the preparation of functionalized HDACi. The most promising compound, 3n (I), was significantly more active in apoptosis induction, activation of caspase 3/7, and formation of DNA damage (γ-H2AX) than the sum of the activities of either active principle alone. Furthermore, to demonstrate the utility of our preloaded resins, the HAIR approach was successfully extended to the synthesis of a proof-of-concept proteolysis-targeting chimera (PROTAC), which efficiently degrades histone deacetylases.

Angewandte Chemie, International Edition published new progress about 42074-68-0. 42074-68-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 2-Chlorotrityl chloride, and the molecular formula is C7H3Cl2F3O2S, Application In Synthesis of 42074-68-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Duman, Osman published the artcileAdsorptive removal of cationic surfactants from aqueous solutions onto high-area activated carbon cloth monitored by in situ UV spectroscopy, Recommanded Product: N-Benzyl-N,N-dibutylbutan-1-aminium chloride, the publication is Journal of Hazardous Materials (2010), 174(1-3), 359-367, database is CAplus and MEDLINE.

Activated C cloth (ACC) was used as adsorbent for the removal of cationic surfactants such as benzyltrimethylammonium chloride (BTMACl), benzyltriethylammonium chloride (BTEACl), benzyltributylammonium chloride (BTBACl), benzyldimethyldecylammonium chloride (BDMDACl), benzyldimethyltetradecylammonium chloride (BDMTDACl), benzyldimethylhexadecylammonium chloride (BDMHDACl), N-dodecylpyridinium chloride (N-DPCl) and N-cetylpyridinium chloride (CPCl) from aqueous solutions The adsorption efficiency of the ACC was evaluated for cationic surfactants. Adsorption process was followed by in situ UV spectroscopic technique. The kinetic data, so obtained, were treated according to the pseudo 1st-order, the pseudo 2nd-order, the Elovich and the intraparticle diffusion models in order to understand the adsorption mechanism of cationic surfactants onto the ACC. The best fit was found with the pseudo 2nd-order model. The exptl. isotherm data were obtained at 30° and analyzed by the Freundlich and the Langmuir models. The parameters of isotherm equations were determined The Freundlich model was found to represent the exptl. data better than the Langmuir model. The observed adsorption behaviors are discussed in terms of the pH of the solution, the nature of cationic surfactants (e.g. functional groups, size, and hydrophobicity) and the nature of the ACC (e.g. surface charge, pore size). A fair linear correlation was found between some adsorption parameters and apparent molar volumes at infinite dilution for benzyltrialkylammonium chlorides.

Journal of Hazardous Materials published new progress about 23616-79-7. 23616-79-7 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst, name is N-Benzyl-N,N-dibutylbutan-1-aminium chloride, and the molecular formula is C19H34ClN, Recommanded Product: N-Benzyl-N,N-dibutylbutan-1-aminium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Duman, Osman published the artcileApparent molar volumes and isentropic compressibilities of benzyltrialkylammonium chlorides in water at (293.15, 303.15, 313.15, 323.15, and 333.15)K, Synthetic Route of 23616-79-7, the publication is Journal of Chemical Thermodynamics (2009), 41(8), 911-915, database is CAplus.

Densities and ultrasound speeds of benzyltrialkylammonium chlorides (BTAACls) were measured accurately in aqueous solutions at 5 temperatures (293.15, 303.15, 313.15, 323.15, and 333.15) K. The data were utilized in determining apparent molar volumes, V_Φ, and apparent molar isentropic compressibilities, K_SΦ. Infinite dilution values of these apparent molar quantities, V_Φ and K_SΦ , were determined by extrapolation procedures. Contribution of CH₂ groups, along the alkyl groups of BTAACls, to VΦ and K_SΦ values were derived from plots of these quantities as a function of number of addnl. CH₂ groups in going from benzyltrimethylammonium chloride to benzyltributylammonium chloride. The temperature dependencies of V_Φ and K_SΦ values were examined on the basis of isobaric expansivity. Apparent molar isobaric expansivities at infinite dilution, E⁰_Φ, were obtained from the slopes of V_Φ vs. temperature data. Concentration dependencies of V_Φ and K_SΦ were examined A fair correlation was observed between V_Φ and K⁰_SΦ values of the 3 BTAACls.

Journal of Chemical Thermodynamics published new progress about 23616-79-7. 23616-79-7 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst, name is N-Benzyl-N,N-dibutylbutan-1-aminium chloride, and the molecular formula is C19H34ClN, Synthetic Route of 23616-79-7.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Oseland, Elizabeth E. published the artcileSurface patterning of polyacrylamide gel using scanning electrochemical cell microscopy (SECCM), COA of Formula: C19H34ClN, the publication is Chemical Communications (Cambridge, United Kingdom) (2016), 52(64), 9929-9932, database is CAplus and MEDLINE.

Scanning electrochem. cell microscopy is introduced as a new tool for the synthesis and deposition of polymers on SAM-functionalized Au surfaces. The deposition of poly(N-hydroxyethyl acrylamide) is enhanced through the electrochem. generation of activating Cu(I)Cl/Me₆TREN catalyst. Initiation of the polymerization reaction is most likely due to in situ generation of reactive O species following O reduction

Chemical Communications (Cambridge, United Kingdom) published new progress about 23616-79-7. 23616-79-7 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst, name is N-Benzyl-N,N-dibutylbutan-1-aminium chloride, and the molecular formula is C19H34ClN, COA of Formula: C19H34ClN.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Moya, Sergio E. published the artcileExplanation for the Apparent Absence of Collapse of Polyelectrolyte Brushes in the Presence of Bulky Ions, Computed Properties of 23616-79-7, the publication is Journal of Physical Chemistry B (2007), 111(25), 7034-7040, database is CAplus and MEDLINE.

The conformational behavior of poly[2-(methacryloyloxy)ethyltrimethylammonium chloride] (PMETAC) brushes with different chain d. in the presence of large benzyltributylammonium chloride (BTBAC) ions was studied by a Quartz Crystal Microbalance with Dissipation (QCM-D) and Scanning Force Microscopy. Dense brushes do not collapse in the presence of BTBAC solutions of increasing ionic strength, contrary to what is observed in the presence of NaCl. Brush collapse can be observed for low-ionic-strength solutions of BTBAC when the brush d. was reduced. These phenomena can be explained by considering the Hofmeister series and ion size and free space in the brush.

Journal of Physical Chemistry B published new progress about 23616-79-7. 23616-79-7 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst, name is N-Benzyl-N,N-dibutylbutan-1-aminium chloride, and the molecular formula is C19H34ClN, Computed Properties of 23616-79-7.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Strizhak, Alexander V. published the artcileDiarylethene moiety as an enthalpy-entropy switch: photoisomerizable stapled peptides for modulating p53/MDM2 interaction, Computed Properties of 219537-97-0, the publication is Organic & Biomolecular Chemistry (2020), 18(28), 5359-5369, database is CAplus and MEDLINE.

Analogs of the known inhibitor (peptide pDI) of the p53/MDM2 protein-protein interaction are reported, which are stapled by linkers bearing a photoisomerizable diarylethene moiety. The corresponding photoisomers possess significantly different affinities to the p53-interacting domain of the human MDM2. Apparent dissociation constants are in the picomolar-to-low nanomolar range for those isomers with diarylethene in the “open” configuration, but up to eight times larger for the corresponding “closed” isomers. Spectroscopic, structural, and computational studies showed that the stapling linkers of the peptides contribute to their binding. Calorimetry revealed that the binding of the “closed” isomers is mostly enthalpy-driven, whereas the “open” photoforms bind to the protein stronger due to their increased binding entropy. The results suggest that conformational dynamics of the protein-peptide complexes may explain the differences in the thermodn. profiles of the binding.

Organic & Biomolecular Chemistry published new progress about 219537-97-0. 219537-97-0 belongs to chlorides-buliding-blocks, auxiliary class Fused/Partially Saturated Cycles,Cyclopentenes, name is 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, and the molecular formula is C4Br2N2O4S, Computed Properties of 219537-97-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Catel, Yohann published the artcileHigh refractive index monofunctional monomers as promising diluents for dental composites, Product Details of C19H34ClN, the publication is Dental Materials (2021), 37(2), 351-358, database is CAplus and MEDLINE.

To evaluate high refractive index methacrylates as diluents for the formulation of radiopaque esthetic bulk-fill composites.2-(4-Cumylphenoxy)ethyl methacrylate 1, 2-(2-phenylphenoxy)ethyl methacrylate 2 and 2-[2-(2-phenylphenoxy)ethoxy]ethyl methacrylate 3 were synthesized and characterized by ¹H NMR spectroscopy. The reactivity of each monomer was studied using photo-DSC. Bulk-fill composites based on monomers 1-3 were formulated. Translucency (before and after light cure) was measured using a spectrophotometer. The depth of cure and the water sorption of these materials were determined according to ISO 4049. The flexural strength and modulus of elasticity were measured using a three-point bending setup, according to ISO 4049. The shrinkage force was assessed based on a method described by Watts et al. using a universal testing machine.Monomers 1-3 were easily synthesized in two steps. They exhibit a low viscosity and a high refractive index (1.553-1.573). Monofunctional methacrylates 1-3 were found to be more reactive than triethylene glycol dimethacrylate (TEGDMA). Bulk-fill composites based on these monomers were successfully prepared They exhibit a high depth of cure and excellent esthetic properties (low transparency). These composites provide higher flexural modulus as well as lower water sorption than a corresponding material based on TEGDMA. Methacrylates 1 and 3 are particularly interesting as they led to composites showing lower shrinkage force.Methacrylates 1-3 are promising diluents for the formulation of highly esthetic radiopaque bulk-fill composites.

Dental Materials published new progress about 23616-79-7. 23616-79-7 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst, name is N-Benzyl-N,N-dibutylbutan-1-aminium chloride, and the molecular formula is C19H34ClN, Product Details of C19H34ClN.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Harvey, Emma C. published the artcileIncorporating cobalt carbonyl moieties onto ethynylthiophene-based dithienylcyclopentene switches. 1. Photochemistry, Formula: C15H14Cl2S2, the publication is Organometallics (2014), 33(2), 447-456, database is CAplus.

Dithienylcyclopentenes I [X = H, F; Y = bond: 1o, M = void; 3o, M = Co₂(CO)₆; 5o, M = Co₂(CO)₄(dppm); Y = 1,4-C₆H₄: 2, M = void; 4, M = Co₂(CO)₆; 6, M = Co₂(CO)₄(dppm)] undergo photochem. conrotatory cyclization, giving the corresponding complexes II [1-C_s – 6-C_s] thus exhibiting photochromic switching properties. The synthesis and characterization of a series of dithienyl perhydro- and perfluorocyclopentene photochromic mol. switches 1o–6o appended with cobalt carbonyl binding 3-ethynylthiophene and phenyl-3-ethynylthiophene substituents are reported. Their photochromic properties, fatigue resistance, and thermal stability were examined to establish the effect of substituents on their performance as mol. photoswitches. The photochem. properties of the dithienylethene core were retained to the greatest extent by the inclusion of Ph units and a hexafluorocyclopentene ring. The alkyne units of the switches were used to coordinate cobalt carbonyl moieties: i.e., Co₂(CO)₆ and Co₂(CO)₄(dppm). The cobalt carbonyl moieties were found to reduce the efficiency of cyclization and cycloreversion of the dithienylethene unit. D. functional theory was used to identify the excited states responsible for cyclization.

Organometallics published new progress about 219537-97-0. 219537-97-0 belongs to chlorides-buliding-blocks, auxiliary class Fused/Partially Saturated Cycles,Cyclopentenes, name is 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, and the molecular formula is C15H14Cl2S2, Formula: C15H14Cl2S2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

van Herpt, Jochem T. published the artcileLight-Controlled Formation of Vesicles and Supramolecular Organogels by a Cholesterol-Bearing Amphiphilic Molecular Switch, Recommanded Product: 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, the publication is Chemistry – A European Journal (2014), 20(6), 1737-1742, database is CAplus and MEDLINE.

A new responsive material composed of an amphiphilic light-switchable dithienyl ethene unit functionalized with a hydrophobic cholesterol unit and a hydrophilic poly(ethylene glycol)-modified pyridinium group has been designed. This unique single-mol. system shows responsive light-switchable self-assembly in both water and organic solvents. Light-triggered reversible vesicle formation in aqueous solutions is reported. The mol. shows a different behavior in apolar aromatic solvents, in which light-controlled formation of organogel fibers is observed The light-triggered aggregation behavior of this mol. demonstrates that control of a supramol. structure with light can be achieved in both aqueous and organic media and that this ability can be present in a single mol. This opens the way toward the effective development of new strategies in soft nanotechnol. for applications in controlled chem. release systems.

Chemistry – A European Journal published new progress about 219537-97-0. 219537-97-0 belongs to chlorides-buliding-blocks, auxiliary class Fused/Partially Saturated Cycles,Cyclopentenes, name is 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, and the molecular formula is C25H47NO8, Recommanded Product: 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Wesenhagen, Philana published the artcilePhotochromism and Electrochemistry of a Dithienylcyclopentene Electroactive Polymer, SDS of cas: 219537-97-0, the publication is Langmuir (2008), 24(12), 6334-6342, database is CAplus and MEDLINE.

A bifunctional substituted dithienylcyclopentene photochromic switch bearing electropolymerisable methoxystyryl units, which enable immobilization of the photochromic unit on conducting substrates, is reported. The spectroscopic, electrochem., and photochem. properties of a monomer in solution are compared with those of the polymer formed through oxidative electropolymerization The electroactive polymer films prepared on Au, Pt, glassy C, and In Ti oxide (ITO) electrodes were characterized by cyclic voltammetry, XPS, and at. force microscopy (AFM). The thickness of the films formed is limited to several monolayer equivalent The photochromic properties and stability of the polymer films were studied by UV/visible spectroscopy, electrochem., and XPS. Although the films are electrochem. and photochem. stable, their mech. stability with respect to adhesion to the electrode is sensitive to both the solvent and the electrode material employed, with more apolar solvents, glassy C, and ITO electrodes providing good adhesion of the polymer film. The polymer film is formed consistently as a thin film and can be switched both optically and electrochem. between the open and closed state of the photochromic dithienylethene moiety.

Langmuir published new progress about 219537-97-0. 219537-97-0 belongs to chlorides-buliding-blocks, auxiliary class Fused/Partially Saturated Cycles,Cyclopentenes, name is 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, and the molecular formula is C13H10O3, SDS of cas: 219537-97-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics