Tag: M.W=300-350

Agelis, George published the artcileFacile and efficient syntheses of a series of N-benzyl and N-biphenylmethyl substituted imidazole derivatives based on (E)-urocanic acid, as angiotensin II AT1 receptor blockers, Computed Properties of 42074-68-0, the publication is Molecules (2013), 7510-7532, database is CAplus and MEDLINE.

In the present work, a facile and efficient route for the synthesis of a series of N-substituted imidazole derivatives is described. Docking studies have revealed that N-substituted imidazole derivatives based on (E)-urocanic acid may be potential antihypertensive leads. Therefore, new AT1 receptor blockers bearing either the benzyl or the biphenylmethyl moiety at the N-1 or N-3 position, either the (E)-acrylate or the propanoate fragment and their related acids at the C-4 position as well as a halogen atom at the C-5 position of the imidazole ring [I; R = CH:CHCO₂H, CH:CHCO₂Me, CH₂CH₂ CO₂H, CH₂CH₂CO₂Me] and [II; X = H, R = CH:CHCO₂R¹ or CH₂CH₂CO₂R¹, R¹ = H, Me, Q; X = Cl, Br, or iodo, R = CH₂CH₂R¹, R¹ = H or Q] were synthesized. The newly synthesized analogs were evaluated for binding to human AT1 receptor. The biol. results showed that this class of mols. possesses moderate or no activity, thus not always confirming high docking scores. Nonetheless, important conclusions can be derived for their mol. basis of their mode of action and help medicinal chemists to design and synthesize more potent ones. An aliphatic group as in losartan seems to be important for enhancing binding affinity and activity.

Molecules published new progress about 42074-68-0. 42074-68-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 2-Chlorotrityl chloride, and the molecular formula is C19H14Cl2, Computed Properties of 42074-68-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Chotana, Ghayoor A. published the artcileIridium-catalyzed borylation of thiophenes: versatile, synthetic elaboration founded on selective C-H functionalization, Category: chlorides-buliding-blocks, the publication is Tetrahedron (2008), 64(26), 6103-6114, database is CAplus and MEDLINE.

Iridium-catalyzed borylation has been applied to various substituted thiophenes to synthesize poly-functionalized thiophenes in good to excellent yields. Apart from common functionalities compatible with iridium-catalyzed borylations, addnl. functional group tolerance to acyl (COMe) and trimethylsilyl (TMS) groups was also observed High regioselectivities were observed in borylation of 3- and 2,5-di-substituted thiophenes. Electrophilic aromatic C-H/C-Si bromination on thiophene boronate esters is shown to take place without breaking the C-B bond, and one-pot C-H borylation/Suzuki-Miyaura cross-coupling has been accomplished on 2- and 3-borylated thiophenes.

Tetrahedron published new progress about 942070-02-2. 942070-02-2 belongs to chlorides-buliding-blocks, auxiliary class Thiophene,Chloride,Bromide,Boronic acid and ester,Boronate Esters,Boronic Acids,Boronic acid and ester,, name is 2-(4-Bromo-5-chlorothiophen-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, and the molecular formula is C10H13BBrClO2S, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Govindhan, Raman published the artcileTyrosine derivative of aminoacid produced bio inspired nanotubes and nanovesicles-synthesis and characterization, COA of Formula: C19H14Cl2, the publication is Advanced Science, Engineering and Medicine (2020), 12(6), 853-857, database is CAplus.

3,5-Bis(trifluoromethyl)benzylamine derivative of tyrosine single aminoacids have produced self-assembled peptide nanotubes and nanovesicles (BTTPNTs) depending on the concentration of the monomer study through optical and microscopic anal. DFT simulations were carried out for a system of BTTPNTs and nanovesicles which also exptl. characterized by high resolution transmission electron microscopy (HR-TEM) and UV-visible (UV-Vis) absorbance. These results are used to examine the morphologies, size of the nanostructure and study its recognition of aminoacid motif is discussed. However, the length of the nanotubes gets larger with the increases of concentration UV-Vis spectra clearly showed slight decrease in the intensity in absorption after the formation of nanotubes and nanovesicles. Theor. calculations indicate that H-bonding is the key factor in making ring while other interactions including Van der Walls force, π-π stacking plays role to making self-assembled nanotubes and vesicles.

Advanced Science, Engineering and Medicine published new progress about 42074-68-0. 42074-68-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 2-Chlorotrityl chloride, and the molecular formula is C19H14Cl2, COA of Formula: C19H14Cl2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Govindhan, Raman published the artcileNano Cu interaction with single amino acid tyrosine derived self-assemblies; study through XRD, AFM, confocal Raman microscopy, SERS and DFT methods, Quality Control of 42074-68-0, the publication is Journal of Physics and Chemistry of Solids (2017), 123-134, database is CAplus.

3,5-Bis(trifluoromethyl)benzylamine derivatives of single amino acid tyrosine produced self-assembled nanotubes (BTTNTs) as simple Phe-Phe. It has been observed that tyrosine derivative gives exclusively micro and nano tubes irresp. of the concentration of the precursor monomer. However, the introduced xenobiotic trifluoromethyl group (TFM) present in key backbone positions of the self assembly gives the specific therapeutic function has been highlighted. Herein this work study of such self assembled nanotubes were studied through exptl. and theor. methods. The interaction of nanocopper cluster with the nanotubes (Cu@BTTNTs) were extensively studied by various methods like XRD, AFM, confocal Raman microscopy, SERS and theor. methods like Mullikens at. charge anal. SERS reveals that the interactions of Cu cluster with NH₂, OH, NH and Ph ring π-electrons system of BTTNTs. DFT studies gave the total dipole moment values of Cu@BTTNTs and explained the nature of interaction.

Journal of Physics and Chemistry of Solids published new progress about 42074-68-0. 42074-68-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 2-Chlorotrityl chloride, and the molecular formula is C19H14Cl2, Quality Control of 42074-68-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zou, Qi published the artcileNew photochromic chemosensors for Hg²⁺ and F^–, SDS of cas: 219537-97-0, the publication is Tetrahedron (2011), 67(5), 915-921, database is CAplus.

Two new chemosensors (1a and 1b) based on photochromic dithienylcyclopentene were designed and synthesized, and their spectral behaviors toward various metal ions and anions were studied. Compounds show excellent optical properties and distinguish Hg²⁺ and F^– in CH₃CN. Job’s plot reveals that the presence of Hg²⁺ induces the formation of a 1:1 complex between 1a or 1b and Hg²⁺. From the spectral responses and ¹H NMR anal., the deprotonation of the thioamide protons is proposed to explain the sensing mechanism for 1a and 1b toward F^–. 1A and 1b exhibit ring-opening and ring-closing photoisomerization with UV-visible light irradiation Also, their photochromic properties can be modulated by Hg²⁺ and F^– ions. Also, 1a and 1b in photostationary states become promising sensors for Hg²⁺ and F^– with high selectivity.

Tetrahedron published new progress about 219537-97-0. 219537-97-0 belongs to chlorides-buliding-blocks, auxiliary class Fused/Partially Saturated Cycles,Cyclopentenes, name is 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, and the molecular formula is C14H17BClNO2, SDS of cas: 219537-97-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Ma, Shaomin published the artcileHydrophobic deep eutectic solvent-based ultrasonic-assisted liquid-liquid micro-extraction combined with HPLC-FLD for diphenylamine determination in fruit, Product Details of C19H34ClN, the publication is Food Additives & Contaminants, Part A (2021), 38(2), 339-349, database is CAplus and MEDLINE.

In this paper, novel high extraction efficiency hydrophobic eutectic solvents (DESs), n-octanoic acid as a hydrogen bond donor (HBD) and menthol as a hydrogen bond acceptor (HBA), were selected from five hydrophobic DESs to extract trace diphenylamine (DPA) in fruits apple, pear and orange under ultrasonic-assisted liquid-liquid micro-extraction (UA-LLME) technol. before high-performance liquid chromatog. (HPLC) anal. Working parameters such as the DESs type, molar ratio, extractant volume, and ultrasonic time of the LLME hydrophobic DESs technol. were optimized. Average recoveries between 96% and 108% were obtained on actual samples. This method gave lower detection limit (LOD) than other existing methods due to combining the high-efficiency extraction of hydrophobic DES and high sensitivity of fluorescence detector. This method was sensitive and eco-friendly, and can be used for the determination of trace components in fruits.

Food Additives & Contaminants, Part A published new progress about 23616-79-7. 23616-79-7 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst, name is N-Benzyl-N,N-dibutylbutan-1-aminium chloride, and the molecular formula is C19H34ClN, Product Details of C19H34ClN.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Johnston, Brandon M. published the artcileThe effect of comb architecture on complex coacervation, SDS of cas: 42074-68-0, the publication is Organic & Biomolecular Chemistry (2017), 15(36), 7630-7642, database is CAplus and MEDLINE.

Complex coacervation is a widely utilized technique for effecting phase separation, though predictive understanding of mol.-level details remains underdeveloped. Here, we couple coarse-grained Monte Carlo simulations with exptl. efforts using a polypeptide-based model system to investigate how a comb-like architecture affects complex coacervation and coacervate stability. Specifically, the phase separation behavior of linear polycation-linear polyanion pairs was compared to that of comb polycation-linear polyanion and comb polycation-comb polyanion pairs. The comb architecture was found to mitigate cooperative interactions between oppositely charged polymers, as no discernible phase separation was observed for comb-comb pairs and complex coacervation of linear-linear pairs yielded stable coacervates at higher salt concentration than linear-comb pairs. This behavior was attributed to differences in counterion release by linear vs. comb polymers during polyelectrolyte complexation. Addnl., the comb polycation formed coacervates with both stereoregular poly(L-glutamate) and racemic poly(D,L-glutamate), whereas the linear polycation formed coacervates only with the racemic polyanion. In contrast, solid precipitates were obtained from mixtures of stereoregular poly(L-lysine) and poly(L-glutamate). Moreover, the formation of coacervates from cationic comb polymers incorporating up to ∼90% pendant zwitterionic groups demonstrated the potential for inclusion of comonomers to modulate the hydrophilicity and/or other properties of a coacervate-forming polymer. These results provide the first detailed investigation into the role of polymer architecture on complex coacervation using a chem. and architecturally well-defined model system, and highlight the need for addnl. research on this topic.

Organic & Biomolecular Chemistry published new progress about 42074-68-0. 42074-68-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 2-Chlorotrityl chloride, and the molecular formula is C19H14Cl2, SDS of cas: 42074-68-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Hwang, Gi Won published the artcileSensitive ratiometric detection of Al(III) ions in a 100% aqueous buffered solution using a fluorescent probe based on a peptide receptor, Formula: C19H14Cl2, the publication is New Journal of Chemistry (2018), 42(2), 1437-1445, database is CAplus.

Ratiometric detection of Al(III) ions in aqueous buffered solutions is still a significant challenge. Herein, a fluorescent probe [1-pyrenyl]-CH₂CO-L-Ser-L-Asp-OH (I) based on a dipeptide receptor bearing a pyrene fluorophore was synthesized by solid phase synthesis for the ratiometric detection of Al(III) ions in aqueous solutions The peptidyl bioprobe detected Al(III) ions sensitively in a 100% aqueous buffered solution through ratiometric response. Upon the addition of Al(III) ions, the excimer emission at 476 nm increased significantly, and the monomer emission at 395 nm decreased considerably. Approx. 3.5 equiv of Al(III) was required for the complete ratiometric response of I. Also, I showed linear responses to nanomolar concentrations (0-500 nM) of Al(III) by change in the intensity ratio of the excimer and monomer emissions. The detection limit of I for Al(III) was 138.1 nM (R² = 0.980) in 100% aqueous solutions The probe showed highly selective response to Al(III) in the presence of 16 metal ions. The fluorescent peptidyl probe was suitable for the ratiometric detection of Al(III) ions in ground water, tap water, and urine.

New Journal of Chemistry published new progress about 42074-68-0. 42074-68-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 2-Chlorotrityl chloride, and the molecular formula is C19H14Cl2, Formula: C19H14Cl2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Liu, Danni published the artcileCellular membrane-anchored fluorescent probe with aggregation-induced emission characteristics for selective detection of Cu²⁺ ions, Formula: C19H14Cl2, the publication is Faraday Discussions (2017), 377-393, database is CAplus and MEDLINE.

The exploration of advanced fluorescent probes that can detect divalent copper (Cu²⁺) in aqueous environments and even in live organisms is particularly valuable for understanding the occurrence and development of Cu²⁺-related diseases. In this work, we report the design and synthesis of an aggregation-induced emission luminogen (AIEgen)-based probe (TPE-Py-EEGTIGYG) by integrating an AIEgen, TPE-Py, with a peptide, EEGTIGYG, which can selectively detect Cu²⁺ in both aqueous solution and live cells. Peptide EEGTIGYG has dual functionality in the probe design, namely improving water solubility and providing specific cell membrane-binding ability. TPE-Py-EEGTIGYG can self-assemble into nanoaggregates at high concentration in aqueous solution (e.g., 25 μM), which possess large fluorescence output due to the restriction of intramol. rotation of the Ph rings on TPE-Py. The fluorescence of the TPE-Py-EEGTIGYG nanoaggregates can be significantly quenched by Cu²⁺ but not by other metal ions, achieving the selective detection of Cu²⁺ in aqueous media. Furthermore, TPE-Py-EEGTIGYG can exist as a mol. species and is very weakly fluorescent in dilute aqueous solution (e.g., 5 μM), but can however largely switch on its fluorescence upon specifically anchoring onto the cell membrane. The emissive probes on the cell membrane can be used for the detection of Cu²⁺ ions that move in and out of cells with a fluorescence “turn-off” mode.

Faraday Discussions published new progress about 42074-68-0. 42074-68-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 2-Chlorotrityl chloride, and the molecular formula is C19H14Cl2, Formula: C19H14Cl2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Hu, Fang published the artcileThe photocyclization-dependent ratiometric fluorescent switch: Synthesis, characterization and properties of some terpyridyl-based dithienylethenes, Computed Properties of 219537-97-0, the publication is Dyes and Pigments (2017), 161-167, database is CAplus.

Some terpyridyl-based dithienylethenes were synthesized and their structures were confirmed by NMR spectroscopy, mass spectroscopy and elemental anal. The photochromic properties and fluorescence behaviors of these compounds have been measured upon irradiation with UV or visible light in solution UV/vis absorption spectra and fluorescence spectra indicated that the dithienylethenes displayed obvious photochromism and fluorescent switch properties. Specially, when compared with other terpyridyl-based dithienylethenes, the triphenylamine and terpyridyl-based dithienylethene showed the photocyclization-dependent ratiometric fluorescent switch behaviors. D. functional theory indicated that the photocyclization-dependent ratiometric fluorescent changes were due to the donor-acceptor system of the switch.

Dyes and Pigments published new progress about 219537-97-0. 219537-97-0 belongs to chlorides-buliding-blocks, auxiliary class Fused/Partially Saturated Cycles,Cyclopentenes, name is 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, and the molecular formula is C15H14Cl2S2, Computed Properties of 219537-97-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics