Tag: M.W=300-350

Reisinger, Bernd published the artcileExploiting Protein Symmetry To Design Light-Controllable Enzyme Inhibitors, Name: 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, the publication is Angewandte Chemie, International Edition (2014), 53(2), 595-598, database is CAplus and MEDLINE.

The activity of the metabolic branch-point enzyme PriA from Mycobacterium tuberculosis (mtPriA) can be controlled reversibly by light. Two-pronged inhibitors based on the dithienylethene scaffold were designed utilizing mtPriA’s natural rotational symmetry. Switching from the flexible, ring-open to the rigid, ring-closed isomer reduces inhibition activity by one order of magnitude.

Angewandte Chemie, International Edition published new progress about 219537-97-0. 219537-97-0 belongs to chlorides-buliding-blocks, auxiliary class Fused/Partially Saturated Cycles,Cyclopentenes, name is 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, and the molecular formula is C15H14Cl2S2, Name: 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Kim, Jonghoon published the artcileFabrication of biodegradable nanofibers of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) via electrospinning, COA of Formula: C19H34ClN, the publication is Journal of Nanoscience and Nanotechnology (2009), 9(2), 914-918, database is CAplus and MEDLINE.

For the first time, poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) nanofibrous membrane has been fabricated via electrospinning method. To improve the electrospinnability and reduce the diameter of fibers, the solvent and salt additives were used that affected on the parameters including such as the viscosity and the conductivity of the electrospinning solution for poly(3-hydroxybutyrate-co-3-hydroxyhexanoate). Since the addnl. salts should be removed, it could be inferred that the co-solvent system was predominant to prepare the nanofibrous poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) membrane. This biodegradable nanofibrous poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) membrane has a great potential to be used in the various application fields such as tissue engineering, implants, packaging materials, agriculture, and so on.

Journal of Nanoscience and Nanotechnology published new progress about 23616-79-7. 23616-79-7 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst, name is N-Benzyl-N,N-dibutylbutan-1-aminium chloride, and the molecular formula is C19H34ClN, COA of Formula: C19H34ClN.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Bianchini, Giulio published the artcileEfficient isonitrile hydration through encapsulation within a hexameric self-assembled capsule and selective inhibition by a photo-controllable competitive guest, Application In Synthesis of 219537-97-0, the publication is Chemical Communications (Cambridge, United Kingdom) (2013), 49(46), 5322-5324, database is CAplus and MEDLINE.

Catalytic hydration of neutral isonitriles to yield the corresponding N-formylamides was achieved by reversible encapsulation in a self-assembled hexameric resorcin[4]arene capsule. Encapsulation of a photochromic dithienylethene bis-cation provides different levels of competitive inhibition depending on the geometry assumed by the cationic inhibitor.

Chemical Communications (Cambridge, United Kingdom) published new progress about 219537-97-0. 219537-97-0 belongs to chlorides-buliding-blocks, auxiliary class Fused/Partially Saturated Cycles,Cyclopentenes, name is 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, and the molecular formula is C15H14Cl2S2, Application In Synthesis of 219537-97-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Hovlid, Marisa L. published the artcileEncapsidated Atom-Transfer Radical Polymerization in Qβ Virus-like Nanoparticles, Safety of 2-Chlorotrityl chloride, the publication is ACS Nano (2014), 8(8), 8003-8014, database is CAplus and MEDLINE.

Virus-like particles (VLPs) are unique macromol. structures that hold great promise in biomedical and biomaterial applications. The interior of the 30 nm-diameter Qβ VLP was functionalized by a three-step process: (1) hydrolytic removal of endogenously packaged RNA, (2) covalent attachment of initiator mols. to unnatural amino acid residues located on the interior capsid surface, and (3) atom-transfer radical polymerization of tertiary amine-bearing methacrylate monomers. The resulting polymer-containing particles were moderately expanded in size; however, biotin-derivatized polymer strands were only very weakly accessible to avidin, suggesting that most of the polymer was confined within the protein shell. The polymer-containing particles were also found to exhibit phys. and chem. properties characteristic of pos. charged nanostructures, including the ability to easily enter mammalian cells and deliver functional small interfering RNA.

ACS Nano published new progress about 42074-68-0. 42074-68-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 2-Chlorotrityl chloride, and the molecular formula is C19H14Cl2, Safety of 2-Chlorotrityl chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Areephong, Jetsuda published the artcileOn/Off Photoswitching of the Electropolymerizability of Terthiophenes, Synthetic Route of 219537-97-0, the publication is Journal of the American Chemical Society (2008), 130(39), 12850-12851, database is CAplus and MEDLINE.

The polymerization of terthiophene to obtain an alkene bridged α,α-coupled sexithiophene polymer, was controlled by light; i.e., the electropolymerizability of the bis-terthiophene monomer is switched off and on upon illumination with UV and visible light, resp. The system comprises both bis-terthiophene and photochromic dithienylethene units. The presence of a light-switchable unit allows on-off switching of the electropolymerization of the monomer with light. The incorporation of dithienylethene in the backbone increases dramatically the homogeneity of the polymer formed (i.e., only sexithiophene units are formed). The films are robust and fully retain electrochromism as was demonstrated through cyclic voltammetry while spatial control (patterning) is readily achieved by applying simple optical masking techniques.

Journal of the American Chemical Society published new progress about 219537-97-0. 219537-97-0 belongs to chlorides-buliding-blocks, auxiliary class Fused/Partially Saturated Cycles,Cyclopentenes, name is 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, and the molecular formula is C15H14Cl2S2, Synthetic Route of 219537-97-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Suzuki, Keiko published the artcileA novel macroreticular-type fluorous polystyrene resin and its application to the synthesis of a 3-amino-β-carboline derivative with N-methyl-N-nitrosourea conjugation via fluorous solid-phase reaction: a comparative study of fluorous solid-, solid-, and liquid-phase reactions, SDS of cas: 42074-68-0, the publication is Tetrahedron (2015), 71(30), 4999-5012, database is CAplus.

A novel fluorous polystyrene (FPS) MR-resin was applied to a fluorous solid-phase (FSP) reaction. The MR-FPS resin actually was developed previously and possessed excellent chem. resistance to acids and alkalis, and a fluorous-tagged compound was homogeneously and loosely immobilized on the resin. The synthesis of an antitumor drug, an N-methyl-N-nirosourea conjugated 3-amino-β-carboline derivative, was accomplished with a high yield by using this new fluorous reaction system. Using only filtration, the fluorous 3-amino-β-carboline derivatives immobilized on the MR-FPS resin were easily recovered from the reaction mixtures As an extention of this approach, a diversity synthesis of 3-amino-9-benzyl-β-carboline derivatives was applied to the FSP method giving high yields. Finally, the FSP synthesis was compared with the corresponding conventional solid- and liquid-phase methods of synthesis. The FSP reaction was superior in terms of the reactivity of the substrate and the ease of product separation

Tetrahedron published new progress about 42074-68-0. 42074-68-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 2-Chlorotrityl chloride, and the molecular formula is C9H9ClN2, SDS of cas: 42074-68-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Yadav, Sanjay Kumar published the artcileCounterion-specific clouding in aqueous anionic surfactant: a case of Hofmeister-like series, Formula: C19H34ClN, the publication is Colloid and Polymer Science (2017), 295(5), 869-876, database is CAplus.

Two ionic surfactants (sodium dodecylsulfate (SDS) and sodium dodecylbenzenesuphonate (SDBS)) are chosen, and effect of addition of quaternary bromide or chloride (tetra-n-butylammonium bromide, tetra-n-butylphosphonium bromide, tetraphenylphosphonium bromide, tetra-npentylammonium bromide and benzyl tributylammonium chloride) has been studied on the cloud point (CP) behavior in aqueous solution CP behavior was observed due to dehydration of headgroup region in presence of quaternary counterion. Order of counterion to decrease CP is as follows: TPeA⁺ > BTA⁺ > TBP⁺ > TPhP⁺ > TBA⁺ for SDS and TPeA⁺ > TPhP⁺ > BTA⁺ > TBP⁺ > TBA⁺ for SDBS. CP data have been used to select surfactant + salt system. Effect of additives (carbohydrate, amino acid or vitamin), on the CP, has been seen on above such selected systems. Additive may either decrease or increase the CP, depending upon the structure of counterion and/or the additive. Counterion (cations) can be arranged in an order like Hofmeister series.

Colloid and Polymer Science published new progress about 23616-79-7. 23616-79-7 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst, name is N-Benzyl-N,N-dibutylbutan-1-aminium chloride, and the molecular formula is C6H11BF3KO, Formula: C19H34ClN.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Abdildinova, Aizhan published the artcileHeterocycles as a peptidomimetic scaffold: solid-phase synthesis strategies, Name: 2-Chlorotrityl chloride, the publication is Pharmaceuticals (2021), 14(5), 449, database is CAplus and MEDLINE.

A review. Peptidomimetics are a privileged class of pharmacophores that exhibit improved physicochem. and biol. properties. Solid-phase synthesis is a powerful tool for gaining rapid access to libraries of mols. from small mols. to biopolymers and also is widely used for the synthesis of peptidomimetics. Small mols. including heterocycles serve as a core for hundreds of drugs, including peptidomimetic mols. This review covers solid-phase synthesis strategies for peptidomimetics mols. based on heterocycles.

Pharmaceuticals published new progress about 42074-68-0. 42074-68-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 2-Chlorotrityl chloride, and the molecular formula is C19H14Cl2, Name: 2-Chlorotrityl chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Kathan, Michael published the artcileControl of Imine Exchange Kinetics with Photoswitches to Modulate Self-Healing in Polysiloxane Networks by Light Illumination, Recommanded Product: 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, the publication is Angewandte Chemie, International Edition (2016), 55(44), 13882-13886, database is CAplus and MEDLINE.

Various aldehyde-containing photoswitches have been developed whose reactivity toward amines can be controlled externally. A thermally stable bifunctional diarylethene, which in its ring-closed form exhibits imine formation accelerated by one order of magnitude, was used as a photoswitchable crosslinker and mixed with a com. available amino-functionalized polysiloxane to yield a rubbery material with viscoelastic and self-healing properties that can be reversibly tuned by irradiation

Angewandte Chemie, International Edition published new progress about 219537-97-0. 219537-97-0 belongs to chlorides-buliding-blocks, auxiliary class Fused/Partially Saturated Cycles,Cyclopentenes, name is 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, and the molecular formula is C15H14Cl2S2, Recommanded Product: 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Faas, Henryk M. published the artcileAccelerated 19F·MRI detection of matrix metalloproteinase-2/-9 through responsive deactivation of paramagnetic relaxation enhancement, Application In Synthesis of 42074-68-0, the publication is Contrast Media & Molecular Imaging (2019), 4826520/1-4826520/13, database is CAplus and MEDLINE.

Paramagnetic gadolinium ions (GdIII), complexed within DOTA-based chelates, have become useful tools to increase the magnetic resonance imaging (MRI) contrast in tissues of interest. Recently, “on/off” probes serving as 19F·MRI biosensors for target enzymes have emerged that utilize the increase in transverse (T*2 or T2) relaxation times upon cleavage of the paramagnetic GdIII center. Mol. 19F·MRI has the advantage of high specificity due to the lack of background signal but suffers from low signal intensity that leads to low spatial resolution and long recording times. In this work, an “on/off” probe concept is introduced that utilizes responsive deactivation of paramagnetic relaxation enhancement (PRE) to generate 19F longitudinal (T1) relaxation contrast for accelerated mol. MRI. The probe concept is applied to matrix metalloproteinases (MMPs), a class of enzymes linked with many inflammatory diseases and cancer that modify bioactive extracellular substrates. The presence of these biomarkers in extracellular space makes MMPs an accessible target for responsive PRE deactivation probes. Responsive PRE deactivation in a 19F biosensor probe, selective for MMP-2 and MMP-9, is shown to enable mol. MRI contrast at significantly reduced exptl. times compared to previous methods. PRE deactivation was caused by MMP through cleavage of a protease substrate that served as a linker between the fluorine-containing moiety and a paramagnetic GdIII-bound DOTA complex. Ultrashort echo time (UTE) MRI and, alternatively, short echo times in standard gradient echo (GE) MRI were employed to cope with the fast 19F transverse relaxation of the PRE active probe in its “on-state.” Upon responsive PRE deactivation, the 19F·MRI signal from the “off-state” probe diminished, thereby indicating the presence of the target enzyme through the associated neg. MRI contrast. Null point 1H·MRI, obtainable within a short time course, was employed to identify false-pos. 19F·MRI responses caused by dilution of the contrast agent.

Contrast Media & Molecular Imaging published new progress about 42074-68-0. 42074-68-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 2-Chlorotrityl chloride, and the molecular formula is C19H14Cl2, Application In Synthesis of 42074-68-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics