Tag: M.W=300-350

Fukuda, Takashi published the artcileNectriatide, a potentiator of amphotericin B activity from Nectriaceae sp. BF-0114, HPLC of Formula: 42074-68-0, the publication is Journal of Natural Products (2019), 82(10), 2673-2681, database is CAplus and MEDLINE.

A new compound, designated nectriatide (1), was isolated as a potentiator of amphotericin B (AmB) activity against Candida albicans from the culture broth of Nectriaceae sp. BF-0114. This structure was elucidated based on spectroscopic analyses (1D and 2D NMR data), chem. methods, and total synthesis. Compound 1 was a unique cyclotetrapeptide consisting of L-N-methyltyrosine, anthranilic acid, L-alanine, and L-valine. Compound 1 and several synthetic derivatives, including linear peptides, potentiated AmB activity against C. albicans by up to 16-fold (the MIC value of AmB decreased from 0.5μg/mL to 0.031μg/mL in combination with test compound).

Journal of Natural Products published new progress about 42074-68-0. 42074-68-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 2-Chlorotrityl chloride, and the molecular formula is C19H14Cl2, HPLC of Formula: 42074-68-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Novell, Arnau published the artcileOctaproline, a conformationally flexible chiral selector in liquid chromatographic enantioseparation, Synthetic Route of 42074-68-0, the publication is Journal of Chromatography A (2014), 109-118, database is CAplus and MEDLINE.

A proline octapeptide-derived chiral selector (CS) end-capped using a pivaloyl group was covalently linked to a silica gel chromatog. matrix by the C-terminal group. The chromatog. behavior of the resulting chiral stationary phase (CSP) using different conditions was compared to those containing 3,5-dimethylphenylcarbamate residues on the proline units. An enantioseparation ability highly dependent on the mobile phase used is observed for these CSPs. When mixtures of alkane/alc. or alkane/ether were used as mobile phase a similar enantioselectivity was obtained. Nevertheless, in the presence of chlorinated solvents, and without a hydrogen bonding donor in the mobile phase, enantioselectivity is extremely reduced. The reversibility of this phenomenon, attributed to a conformational change in the CS, was examined

Journal of Chromatography A published new progress about 42074-68-0. 42074-68-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 2-Chlorotrityl chloride, and the molecular formula is C19H14Cl2, Synthetic Route of 42074-68-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Shrivash, Manoj K. published the artcileIn-silico designing, chemical synthesis, characterization and in-vitro assessment of antibacterial properties of some analogues of curcumin, SDS of cas: 23616-79-7, the publication is Microbial Pathogenesis (2018), 89-97, database is CAplus and MEDLINE.

In the present work two key regulator proteins, monomeric MipZ of Caulobacter vibrioides (similar to Pseudomonas aeruginosa) and Pyruvate kinase of Staphylococcus aureus were docked with curcumin, the wonder mol. from the spice turmeric and structures of its twelve analogs were designed, synthesized and tested in-vitro for antibacterial activity. Based on the test results a comparative account of the probable mechanism has been given Two major alternative targets are possible for antibacterial activity of drug mols. These may be bacterial cell wall lipids or the proteins responsible for smooth functioning of bacterial cells. In the former case, due to significant difference in the structural components of the cell walls of Gram pos. and Gram neg. bacteria, it is improbable that same ligand will affect both equally. Majority of com. drugs are anti-Gram neg. bacteria while in the present work we have found most effective drugs against Gram pos. bacteria. Based on the test results a comparative account of the probable mechanism has been given. Evidently along with the cell wall damaging mechanism other parallel mechanisms are also operative.

Microbial Pathogenesis published new progress about 23616-79-7. 23616-79-7 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst, name is N-Benzyl-N,N-dibutylbutan-1-aminium chloride, and the molecular formula is C5H6BNO2, SDS of cas: 23616-79-7.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Tezel, Ulas published the artcileThree-tier methodology for quantification and characterization of naphthenic acids in aqueous solutions, Computed Properties of 23616-79-7, the publication is Preprints of Symposia – American Chemical Society, Division of Fuel Chemistry (2010), 55(2), 435-438, database is CAplus.

A novel, three-tier methodol. developed for the quantification, elucidation of naphthenic acid (NA) distribution and identification of the mol. structure of NAs present in com. NA aqueous mixtures is described. The methodol. was tested on an aqueous solution of TCl NA salts as a model NA mixture Pair-ion extraction with BTBA and consecutive quantification of BTBA or extracted ions with HPLC-UV/Vis and ESI/MS, resp. is used to quantify NAs in the solution at concentrations as low as 0.5 mg/L. The min. detection limit of the PIX method was 2 to 40 times lower than the conventional NA measurement methods. Also the method requires low sample volume and no sample pretreatment. The extract which is used for NA quantification was analyzed by ESI/MS in neg. ionization mode to elucidate NA distribution in the sample. Results showed that the TCl NA mixture is mainly composed of mono and dicyclic carboxylic acids with a carbon number ranging between 10 and 25. The methodol. discussed will help to characterize NAs in crude oil, desalter brine petroleum refining process wastewater, oil-affected natural water resources, as well as to identify those NA compounds which may be potentially toxic in engineered and natural biol. systems.

Preprints of Symposia – American Chemical Society, Division of Fuel Chemistry published new progress about 23616-79-7. 23616-79-7 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst, name is N-Benzyl-N,N-dibutylbutan-1-aminium chloride, and the molecular formula is C16H24BNO2, Computed Properties of 23616-79-7.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Spare, Lawson K. published the artcileA continuous flow protocol to generate, regenerate, load, and recycle chlorotrityl functionalised resins, Product Details of C19H14Cl2, the publication is Reaction Chemistry & Engineering (2019), 4(7), 1309-1317, database is CAplus.

From a screen of chlorinating agent concentration, flow rates, and reagent addition methodologies, a continuous flow protocol to activate, reactivate, and recycle both 2-chlorotrityl chloride functionalised polystyrene and trityl-hydroxy ChemMatrix functionalised resins was established. This protocol significantly reduced resin loading periods. Under batch conditions, previously reported trityl resin chlorination protocols are effected over 1-24 h whereas the continuous flow chlorination procedure was completed within 10 min. Further amino acid residue tethering to the resin was effected within 5 min as opposed to the 2-h loading period typically applied under batch conditions. Moreover, an injection-based continuous-flow methodol. proved effective in maintaining the chiral integrity of Fmoc-His(Trt)-OH, Fmoc-Cys(Trt)-OH, and Fmoc-Ser(t-Bu)-OH, which are susceptible to direct base-induced epimerisation. Further, through incorporating the optimized AcCl resin chlorination protocol into a continuous flow solid-phase peptide construction procedure, a facile and resin recyclable approach to conduct SPPS was established.

Reaction Chemistry & Engineering published new progress about 42074-68-0. 42074-68-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 2-Chlorotrityl chloride, and the molecular formula is C7H9BO3S, Product Details of C19H14Cl2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Davis, Holly J. published the artcileIon Pair-Directed Regiocontrol in Transition-Metal Catalysis: A Meta-Selective C-H Borylation of Aromatic Quaternary Ammonium Salts, Related Products of chlorides-buliding-blocks, the publication is Journal of the American Chemical Society (2016), 138(39), 12759-12762, database is CAplus and MEDLINE.

The use of noncovalent interactions to direct transition-metal catalysis is a potentially powerful yet relatively underexplored strategy, with most investigations thus far focusing on using hydrogen bonds as the controlling element. We have developed an ion pair-directed approach to controlling regioselectivity in the iridium-catalyzed borylation of two classes of aromatic quaternary ammonium salts, leading to versatile meta-borylated products. By examining a range of substituted substrates, this provides complex, functionalized aromatic scaffolds amenable to rapid diversification and more broadly demonstrates the viability of ion-pairing for control of regiochem. in transition-metal catalysis.

Journal of the American Chemical Society published new progress about 23616-79-7. 23616-79-7 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst, name is N-Benzyl-N,N-dibutylbutan-1-aminium chloride, and the molecular formula is C19H34ClN, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Buckton, Laura K. published the artcileImproving the Cell Permeability of Polar Cyclic Peptides by Replacing Residues with Alkylated Amino Acids, Asparagines, and D-Amino Acids, Product Details of C19H14Cl2, the publication is Organic Letters (2018), 20(3), 506-509, database is CAplus and MEDLINE.

The design, synthesis, and cell permeability of 19 hydrophilic macrocyclic peptides is presented. By systematically analyzing the impact of three different approaches (alkylated amino acids, asparagines, and D-amino acids) on the permeability of polar peptides, a well-defined strategy for optimizing cell permeability is provided. These three new methods can be used individually or in combination to effectively convert polar peptides into cell permeable mols., and the results can be applied to the rapidly expanding peptide therapeutic industry.

Organic Letters published new progress about 42074-68-0. 42074-68-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 2-Chlorotrityl chloride, and the molecular formula is C19H14Cl2, Product Details of C19H14Cl2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Rahimi, Marwa N. published the artcileProtein-protein inhibitor designed de novo to target the MEEVD region on the C-terminus of Hsp90 and block co-chaperone activity, Quality Control of 42074-68-0, the publication is Chemical Communications (Cambridge, United Kingdom) (2019), 55(6), 846-849, database is CAplus and MEDLINE.

Protein-protein interactions control all cellular functions. Presented is the 1st de novo designed protein-protein interaction inhibitor that targets the C-terminus of heat shock protein 90 (Hsp90) and blocks co-chaperones from binding. Compound LB76, which was created from an Hsp90 co-chaperone, selectively pulls down Hsp90 from cell lysates, binds to Hsp90’s C-terminal domain, and blocks the interactions between Hsp90 and TPR-containing co-chaperones. Through these interactions, LB76 inhibits the protein-folding function of Hsp90. Blocking these protein-protein interactions between Hsp90 and C-terminal co-chaperones regulate the cell’s entire protein-folding machinery.

Chemical Communications (Cambridge, United Kingdom) published new progress about 42074-68-0. 42074-68-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 2-Chlorotrityl chloride, and the molecular formula is C19H14Cl2, Quality Control of 42074-68-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Orehovec, Iva published the artcileBis-pyrene photo-switch open- and closed-form differently bind to ds-DNA, ds-RNA and serum albumin and reveal light-induced bioactivity, Application In Synthesis of 219537-97-0, the publication is International Journal of Molecular Sciences (2021), 22(9), 4916, database is CAplus and MEDLINE.

Newly designed and synthesized diarylethene (DAE) derivatives with aliphatic amine sidearms I and one with two pyrenes II, revealed excellent photo-switching property of central DAE core in MeOH and water. The only exception was bis-pyrene analog, its DAE core very readily photochem. closed, but reversible opening completely hampered by aromatic stacking interaction of pyrene(s) with cyclic DAE. In this process, pyrene fluorescence showed to be a reliable monitoring method, an open form characterized by strong emission at 480 nm (typical for pyrene-aggregate), while closed form emitted weakly at 400 nm (typical for pyrene-DAE quenching). Only open DAE-bis-pyrene form interacted measurably with ds-DNA/RNA by flexible insertion in polynucleotide grooves, while self-stacked closed form did not bind to DNA/RNA. For the same steric reasons, flexible open DAE-bis-pyrene form was bound to at least three different binding sites at bovine serum albumin (BSA), while rigid, self-stacked closed form interacted dominantly with only one BSA site. Preliminary screening of antiproliferative activity against human lung carcinoma cell line A549 revealed that all DAE-derivatives were non-toxic. However, bis-pyrene analog efficiently entered cells and located in the cytoplasm, whereby irradiation by light (315-400 nm) resulted in a strong, photo-induced cytotoxic effect, typical for pyrene-related singlet oxygen species production

International Journal of Molecular Sciences published new progress about 219537-97-0. 219537-97-0 belongs to chlorides-buliding-blocks, auxiliary class Fused/Partially Saturated Cycles,Cyclopentenes, name is 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, and the molecular formula is C15H14Cl2S2, Application In Synthesis of 219537-97-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Gal, Noga published the artcileMembrane interactions of ionic liquids: Possible determinants for biological activity and toxicity, Recommanded Product: N-Benzyl-N,N-dibutylbutan-1-aminium chloride, the publication is Biochimica et Biophysica Acta, Biomembranes (2012), 1818(12), 2967-2974, database is CAplus and MEDLINE.

Ionic liquids (ILs) are a class of diverse organic salts with relatively low m.ps. (below 100 °C) which have attracted considerable interest as a promising “green” substitute for organic solvents. The broad solvation properties of ILs and their high solubility in water, however, present health risks, in particular since it was shown that many ILs exhibit cytotoxic properties. In this context, interactions of ILs with the cellular membrane are believed to constitute a primary culprit for toxicity. We present a comprehensive biophys. and microscopy study of membrane interactions of a series of ILs having different side-chain compositions and lengths, and cationic head-group structures and orientations. The exptl. data reveal that the ILs studied exhibit distinct mechanisms of membrane binding, insertion, and disruption which could be correlated with their biol. activities. The results indicate, in particular, that both the side chain composition and particularly the head-groups of ILs constitute determinants for membrane activity and consequent cell toxicity. This work suggests that tuning membrane interactions of ILs should be an important factor for designing future compounds with benign environmental impact.

Biochimica et Biophysica Acta, Biomembranes published new progress about 23616-79-7. 23616-79-7 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst, name is N-Benzyl-N,N-dibutylbutan-1-aminium chloride, and the molecular formula is C19H34ClN, Recommanded Product: N-Benzyl-N,N-dibutylbutan-1-aminium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics