Tag: M.W=300-350

McRae Page, Samantha published the artcilePromoting cell adhesion on slippery phosphorylcholine hydrogel surfaces, Category: chlorides-buliding-blocks, the publication is Journal of Materials Chemistry B: Materials for Biology and Medicine (2014), 2(6), 620-624, database is CAplus and MEDLINE.

The growing interest in regenerative medicine has created a need for superior polymer matrixes that suit multiple phys., mech., and biol. requirements. While the phospholipid bilayer of a cell membrane is considered optimal for interacting with biologics, polymeric materials composed of 2-methacryloyloxyethyl phosphorylcholine (MPC) offer a cell membrane-like synthetic alternative. In this work, thiol-containing phosphorylcholine polymers were synthesized by radical copolymerization of a lipoic acid-functionalized methacrylate with MPC. The canonical cell adhesion oligopeptide (GRGDS) was incorporated into the polymers by copolymerization of a GRGDS-containing methacrylamide prepared by solid phase peptide synthesis. The relative amounts of phosphorylcholine, lipoic acid and oligopeptide were controlled by the monomer feed ratios, and the polymers were characterized by NMR spectroscopy and aqueous gel permeation chromatog. (GPC). These multifunctional polymers formed hydrogels rapidly (<10 min) by Michael addition when poly(ethylene glycol)diacrylate (PEGDA) was added at pH 9 – an initiator-free gelation performed in a completely aqueous environment. Two cell lines, live mouse skeletal muscle myoblasts (C₂C₁₂) and human ovarian cancer (SKOV3) cells, were observed to specifically attach, spread and proliferate only on hydrogels containing the GRGDS peptide sequence, with a notable dependence on peptide concentration The remarkable hydrophilicity and biocompatibility attributed to polyMPC combined with the facile gelation conditions of these polymers affords a platform of new bio-cooperative materials suitable for cell studies.

Journal of Materials Chemistry B: Materials for Biology and Medicine published new progress about 42074-68-0. 42074-68-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 2-Chlorotrityl chloride, and the molecular formula is C19H14Cl2, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Farrell, Wesley S. published the artcilePrecision, Tunable Deuterated Polyethylene via Polyhomologation, Name: N-Benzyl-N,N-dibutylbutan-1-aminium chloride, the publication is Macromolecules (Washington, DC, United States) (2019), 52(15), 5741-5749, database is CAplus.

The ability to introduce isotopic labeling in a controlled fashion into polymers has long been an area of keen interest, as it allows for anal. by methods such as small-angle neutron scattering. In this work, polyhomologation (also known as “C1 polymerization”) of a deuterated ylide was performed, yielding linear polyethylene of high deuterium content. Copolymerization with the protonated analog allowed for the preparation of statistical copolymers, in which linear polyethylene with a uniform and tunable amount of deuterium is obtained. The amount of deuterium present, as well as its uniform distribution, is supported by vibrational spectroscopy, size-exclusion chromatog. with IR detection, and ²H NMR spectroscopy. This technique was extended to prepare a precision triblock copolymer in which the chain-ends are selectively deuterated. All polymers reported are of narrow dispersity, and will find use in myriad measurements sensitive to deuterium labeling, most notably small-angle neutron scattering.

Macromolecules (Washington, DC, United States) published new progress about 23616-79-7. 23616-79-7 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst, name is N-Benzyl-N,N-dibutylbutan-1-aminium chloride, and the molecular formula is C19H34ClN, Name: N-Benzyl-N,N-dibutylbutan-1-aminium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Tsunashima, Katsuhiko published the artcileThermal and transport properties of ionic liquids based on benzyl-substituted phosphonium cations, Related Products of chlorides-buliding-blocks, the publication is Journal of Physical Chemistry B (2009), 113(48), 15870-15874, database is CAplus and MEDLINE.

The physicochem. properties of two novel ionic liquids based on benzyltriethylphosphonium and benzyltributylphosphonium cations are described in this report. It was found that both benzyl-substituted phosphonium cations gave low-melting salts in combination with a bis(trifluoromethylsulfonyl)amide anion. The thermogravimetric anal. suggested that the benzyl-substituted phosphonium ionic liquids showed higher thermal stability than those of not only the alkyl-substituted phosphonium ILs but also the corresponding benzyl-substituted ammonium compounds The benzyl-substituted phosphonium ionic liquids also exhibited relatively high conductivities when compared to those of the corresponding ammonium compounds These results indicate an improving effect of introducing a benzyl group into the phosphonium cations on both the thermal stability and the conductivity

Journal of Physical Chemistry B published new progress about 23616-79-7. 23616-79-7 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst, name is N-Benzyl-N,N-dibutylbutan-1-aminium chloride, and the molecular formula is C12H10F2Si, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Barnes, Natalie G. published the artcileRapid access to Asp/Glu side-chain hydrazides as thioester precursors for peptide cyclization and glycosylation, HPLC of Formula: 42074-68-0, the publication is Chemical Communications (Cambridge, United Kingdom) (2021), 57(8), 1006-1009, database is CAplus and MEDLINE.

Head-to-side-chain macrocyclic peptides, and neoglycopeptides, were readily prepared by site-specific amidation of aspartic and glutamic acid side-chain hydrazides. Hydrazides, serving as latent thioesters, were introduced through regioselective opening of the corresponding N_α-Fmoc (Fmoc = 9-fluprenylmethoxycarbonyl) protected anhydride precursors.

Chemical Communications (Cambridge, United Kingdom) published new progress about 42074-68-0. 42074-68-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 2-Chlorotrityl chloride, and the molecular formula is C19H14Cl2, HPLC of Formula: 42074-68-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Appiah, Enoch published the artcileAcid-responsive HPMA copolymer-bradykinin conjugate enhances tumor-targeted delivery of nanomedicine, Computed Properties of 42074-68-0, the publication is Journal of Controlled Release (2021), 546-556, database is CAplus and MEDLINE.

Obstructed blood flow and erratic blood supply in the tumor region attenuate the distribution and accumulation of nanomedicines in the tumor. Therefore, improvement of these conditions is crucial for efficient drug delivery. In this study, we designed and synthesized a novel N-(2-hydroxypropyl)methacrylamide (HPMA)-based copolymer conjugate of BK, which possessed adequate systemic stability and tumor-selective action required to improve the accumulation of nanomedicines in the tumor. Levulinoyl-BK (Lev-BK) was conjugated to an HPMA-based polymer via an acid-cleavable hydrazone bond (P-BK). An acid-responsive release of Lev-BK from P-BK was observed, and P-BK alone after intradermal application showed below 10% of the BK activity, thus proving a reduction in the vascular permeability activity of BK when attached to the polymer carrier. P-BK pre-treatment improved blood flow in the tumor tissue by 1.4-1.7-fold, which was maintained for more than 4 h. In addition, P-BK pre-treatment increased the tumor accumulation of pegylated liposomal doxorubicin (PLD) by approx. 3-fold. Furthermore, P-BK pre-treatment led to superior antitumor activity of PLD and significantly improved the survival of tumor-bearing mice. The release of BK from P-BK in the acidic milieu of the tumor was a prerequisite for P-BK to exert its effect, as the vascular permeability enhancing activity of P-BK was negligible. Collectively, P-BK pre-treatment improved intratumoral blood flow and augmented tumor accumulation of nanomedicine, thereby resulting in a significant suppression of tumor growth. Therefore, these findings demonstrate that P-BK is a potential concomitant drug for improving the tumor delivery of nanomedicines.

Journal of Controlled Release published new progress about 42074-68-0. 42074-68-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 2-Chlorotrityl chloride, and the molecular formula is C19H14Cl2, Computed Properties of 42074-68-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Okada, Masahiro published the artcileChemical structure and biological activity of a quorum sensing pheromone from Bacillus subtilis subsp. natto, Product Details of C19H14Cl2, the publication is Bioorganic & Medicinal Chemistry Letters (2015), 25(19), 4293-4296, database is CAplus and MEDLINE.

Bacillus subtilis subsp. natto secretes a peptide pheromone, named ComX_natto pheromone, as an inducer for biofilm formation containing poly-γ-glutamic acid. Recently, the ComX_natto pheromone was identified to be a hexapeptide with an amino acid sequence of Lys-Trp-Pro-Pro-Ile-Glu, and the tryptophan residue was post-translationally modified with a farnesyl group. To determine the precise modification of the tryptophan residue, ComX_natto pheromone was synthesized using solid-phase peptide synthesis. Biol. activity of the ComX_natto pheromone was then investigated. It was demonstrated that poly-γ-glutamic acid production were accelerated by ComX_natto pheromone at more than 1 nM in natto.

Bioorganic & Medicinal Chemistry Letters published new progress about 42074-68-0. 42074-68-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 2-Chlorotrityl chloride, and the molecular formula is C19H14Cl2, Product Details of C19H14Cl2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Gathiaka, Symon published the artcileDesign, development and evaluation of novel dual PPARδ/PPARγ agonists, HPLC of Formula: 42074-68-0, the publication is Bioorganic & Medicinal Chemistry Letters (2013), 23(3), 873-879, database is CAplus and MEDLINE.

Type 2 diabetes is at epidemic proportions and thus development of pharmaceutical therapies for improving insulin sensitivity has become of paramount importance. The objectives of the current study were to develop novel dual PPARγ/δ agonists without the deleterious side effects associated with full PPARγ agonists and several compounds were made and evaluated.. Biol. evaluation of compounds was accomplished by transcriptional promoter activity assays, quant. PCR gene anal. for known PPARγ/δ targets as well as in vitro assays for lipid accumulation and mitochondrial biogenesis verses known PPAR agonists. It was found that compound I was the most potent and selective dual PPARγ/δ agonist which did not display the deleterious side effects associated with full PPARγ agonists.

Bioorganic & Medicinal Chemistry Letters published new progress about 42074-68-0. 42074-68-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 2-Chlorotrityl chloride, and the molecular formula is C19H14Cl2, HPLC of Formula: 42074-68-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Wissler, Joerg published the artcile5,5′-Dimethyl-4,4′-bis[2-(2-methyl-3-thienyl)cyclopentenyl]-2,2′-bithiophene, Product Details of C15H14Cl2S2, the publication is Acta Crystallographica, Section E: Structure Reports Online (2007), 63(6), o2813-o2814, database is CAplus.

The mol. of 5,5′-dimethyl-4,4′-bis[2-(2-methyl-3-thienyl)cyclopentenyl]-2,2′-bithiophene, C₃₀H₃₀S₄, is located on a center of inversion. The cyclopentene ring is almost planar. The thiophene rings are twisted out of the plane of the cyclopentene ring by 47.41(8) and 46.25(9)°. Crystallog. data are given.

Acta Crystallographica, Section E: Structure Reports Online published new progress about 219537-97-0. 219537-97-0 belongs to chlorides-buliding-blocks, auxiliary class Fused/Partially Saturated Cycles,Cyclopentenes, name is 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, and the molecular formula is C6H16OSi, Product Details of C15H14Cl2S2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Wissler, Joerg published the artcile1,2-Bis(5-chloro-2-methyl-3-thienyl)cyclopentene, SDS of cas: 219537-97-0, the publication is Acta Crystallographica, Section E: Structure Reports Online (2006), 62(12), o5649-o5650, database is CAplus.

The cyclopentene ring of 1,2-bis(5-chloro-2-methyl-3-thienyl)cyclopentene, C₁₅H₁₄Cl₂S₂, is almost planar. The 2 thiophene rings are twisted out of the mean plane of the cyclopentene ring by 39.97(5) and 50.84(5)°. Crystallog. data are given.

Acta Crystallographica, Section E: Structure Reports Online published new progress about 219537-97-0. 219537-97-0 belongs to chlorides-buliding-blocks, auxiliary class Fused/Partially Saturated Cycles,Cyclopentenes, name is 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, and the molecular formula is C19H17N2NaO4S, SDS of cas: 219537-97-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Jun, Bong-Hyun published the artcileSynthesis method of asymmetric gold particles, Formula: C19H14Cl2, the publication is Scientific Reports (2017), 7(1), 1-5, database is CAplus and MEDLINE.

Asym. particles can exhibit unique properties. However, reported synthesis methods for asym. particles hinder their application because these methods have a limited scale and lack the ability to afford particles of varied shapes. Herein, we report a novel synthetic method which has the potential to produce large quantities of asym. particles. Asym. rose-shaped gold particles were fabricated as a proof of concept experiment First, silica nanoparticles (NPs) were bound to a hydrophobic micro-sized polymer containing 2-chlorotritylchloride linkers (2-CTC resin). Then, half-planar gold particles with rose-shaped and polyhedral structures were prepared on the silica particles on the 2-CTC resin. Particle size was controlled by the concentration of the gold source. The asym. particles were easily cleaved from the resin without aggregation. We confirmed that gold was grown on the silica NPs. This facile method for synthesizing asym. particles has great potential for materials science.

Scientific Reports published new progress about 42074-68-0. 42074-68-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 2-Chlorotrityl chloride, and the molecular formula is C19H14Cl2, Formula: C19H14Cl2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics