Tag: M.W=300-350

Hasanebrahimi, Gholamreza published the artcileExploring beneficial structural features of ionic surfactants for wettability alteration of carbonate rocks using QSPR modeling technique, Related Products of chlorides-buliding-blocks, the publication is Journal of Molecular Liquids (2017), 196-208, database is CAplus.

Surfactant induced wettability alteration of reservoir rocks is an efficient process that enhances oil recovery of carbonate reservoirs. Finding a suitable surfactant for such a process is an interesting challenge in petroleum industry. To this purpose, generating a database of surfactant properties would be a good idea but property measurement of hundreds of surfactants and then screening them is a highly time consuming and expensive method. Therefore, the application of a math. model for prediction of surfactant properties may well be so helpful for our purpose. Quant. structure-property relationship (QSPR) is a math. model that relates a specific property of materials to their structural characteristics. For the sake of QSPR modeling a dataset of 24 structurally different surfactants was created through the measurement of contact angles (as the most important surfactant characteristic in the wettability alteration process). Contact angle measurement was carried out through imaging a drop of n-decane as the model oil resting on a carbonate rock which has spent 2 days immersed in surfactant solution For this dataset a linear QSPR model of oil contact angle on carbonate rocks was derived using genetic algorithm based on multi-linear regression (GA-MLR) and verified by internal and external validation metrics. From a descriptive point of view, descriptors of the proposed model have a mechanistic interpretation and give an insight to the desired structural features enhancing wettability alteration ability of surfactants.

Journal of Molecular Liquids published new progress about 23616-79-7. 23616-79-7 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst, name is N-Benzyl-N,N-dibutylbutan-1-aminium chloride, and the molecular formula is C19H34ClN, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Chen, Xingchen published the artcilePotent, multi-target serine protease inhibition achieved by a simplified β-sheet motif, Application In Synthesis of 42074-68-0, the publication is PLoS One (2019), 14(1), e0210842, database is CAplus and MEDLINE.

Engagement of an extended β-sheet is a common substrate/inhibitor interaction at the active site of serine proteases and is an important feature of Laskowski mechanism inhibitors that present a substrate-like loop to a target protease. This loop is cleaved but subsequently relegated forming a stable inhibitor/protease complex. Laskowski inhibitors are ubiquitous in nature and are used extensively in serine protease inhibitor design. However, most studies concentrate on introducing new sidechain interactions rather than the direct contributions of the substrate-like β-sheet to enzyme inhibition. Here we report the crystal structure of an simplified β-sheet inhibitory motif within the Sunflower Trypsin Inhibitor (SFTI) in complex with trypsin. We show that the intramol. hydrogen bond network of this SFTI variant (SFTI-TCTR) engages the inhibitor sidechains that would normally interact with a target protease, giving mainchain interactions a more prominent role in complex formation. Despite having reduced sidechain interactions, this SFTI variant is remarkably potent and inhibits a diverse range of serine proteases. Crystal structural anal. and mol. modeling of SFTI-TCTR complexes again indicates an interface dominated by β-sheet interactions, highlighting the importance of this motif and the adaptability of SFTI as a scaffold for inhibitor design.

PLoS One published new progress about 42074-68-0. 42074-68-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 2-Chlorotrityl chloride, and the molecular formula is C19H14Cl2, Application In Synthesis of 42074-68-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Pijper, Thomas C. published the artcileMild Ti-mediated transformation of t-butyl thio-ethers into thio-acetates, Category: chlorides-buliding-blocks, the publication is Organic & Biomolecular Chemistry (2015), 13(1), 265-268, database is CAplus and MEDLINE.

The authors report a straightforward method for the rapid conversion of thio-ethers to thio-acetates using TiCl₄, in good to excellent yields. The reaction conditions tolerate a variety of functional groups, including halide, nitro, ether, thiophene and acetylene functionalities. A catalytic variant of this reaction is also described.

Organic & Biomolecular Chemistry published new progress about 219537-97-0. 219537-97-0 belongs to chlorides-buliding-blocks, auxiliary class Fused/Partially Saturated Cycles,Cyclopentenes, name is 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, and the molecular formula is C15H14Cl2S2, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Grassi, Luigi published the artcileAn explorative study towards the chemical synthesis of the immunoglobulin G1 Fc CH3 domain, Formula: C19H14Cl2, the publication is Journal of Peptide Science (2018), 24(12), n/a, database is CAplus and MEDLINE.

Monoclonal antibodies, fusion proteins including Ig fragment c (Ig Fc) CH2-CH3 domains, and engineered antibodies are prominent representatives of an important class of drugs and drug candidates, which are referred to as biotherapeutics or biopharmaceuticals. These recombinant proteins are highly heterogeneous due to their glycosylation pattern. In addition, enzyme-independent reactions, like deamidation, dehydration, and oxidation of sensitive side chains, may contribute to their heterogeneity in a minor amount To investigate the biol. impact of a spontaneous chem. modification, especially if found to be recurrent in a biotherapeutic, it would be necessary to reproduce it in a homogeneous manner. Here, we undertook an explorative study toward the chem. synthesis of the IgG1 Fc CH3 domain, which has been shown to undergo spontaneous changes like succinimide formation and methionine oxidation We used Fmoc-solid-phase peptide synthesis (SPPS) and native chem. ligation (NCL) to test the accessibility of large fragments of the IgG1 Fc CH3 domain. In general, the incorporation of pseudoproline dipeptides improved the quality of the crude peptide precursors; however, sequences larger than 44 residues could not be achieved by standard stepwise elongation with Fmoc-SPPS. In contrast, the application of NCL with Cys residues, which were either native or introduced ad hoc, allowed the assembly of the C-terminal IgG1 Fc CH3 sequence 371 to 450. The syntheses reported here show advantages and limitations of the chem. approaches chosen for the preparation of the synthetic IgG1 Fc CH3 domain and will guide future plans toward the synthesis of both the native and selectively modified full-length domain.

Journal of Peptide Science published new progress about 42074-68-0. 42074-68-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 2-Chlorotrityl chloride, and the molecular formula is C19H14Cl2, Formula: C19H14Cl2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Balaraman, Harish Babu published the artcileHigh selective purification of IgY from quail egg: Process design and quantification of deep eutectic solvent based ultrasound assisted liquid phase microextraction coupled with preparative chromatography, HPLC of Formula: 23616-79-7, the publication is International Journal of Biological Macromolecules (2020), 253-262, database is CAplus and MEDLINE.

The present research investigates on task-specific deep eutectic solvents (TDES) based aqueous two-phase extraction and purification of Igs by chromatog. from quail egg. The synthesis of TDES was accomplished with quaternary ammonium salt as hydrogen bond acceptor (HBA) and glycerol as hydrogen bond donor (HBD). Aqueous two-phase (ATPS) formation of TDESs with various salts was established and phase partitioning ability was evaluated using standard bovine Ig. Ultrasound-assisted liquid-liquid microextraction (UA-LLME) was performed with ATPS of better partitioning ability for quail egg yolk. Optimization of influential variables with response surface methodol. was accomplished and maximum yield was achieved for 85% (volume/volume) of NADES for feed of 18μg/mL of egg yolk isolate with ultrasound temperature of 35°C and 12 min contact time resp. The quantification of recovery was accomplished by gel filtration process with the determination of retention time, volume and resolution of separation using marker protein. Ultrapure Ig-Y (IgY) is achieved with anion exchange chromatog. and yield was calculated The results revealed that the selective concentration of Ig-Y from quail egg yolk could be performed using environment-friendly TDES based UA-LLME coupled with chromatog.

International Journal of Biological Macromolecules published new progress about 23616-79-7. 23616-79-7 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst, name is N-Benzyl-N,N-dibutylbutan-1-aminium chloride, and the molecular formula is C19H34ClN, HPLC of Formula: 23616-79-7.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Balaraman, Harish Babu published the artcileKinetics and microwave-assisted extractive transesterification studies of high octane methyl esters (HOME) from karanja and chicken lard oil using protic deep eutectic solvent, Quality Control of 23616-79-7, the publication is Fuel (2020), 117299, database is CAplus.

The bio-conversion of fatty oils recovered from chicken waste and Karanja by both enzymic and microwave-assisted transesterification (MATE) into fatty acid Me esters (FAME) were performed in the present investigation. Evaluation of physicochem. properties and yield of biodiesel produced reveals the production of esters from chicken waste oil to be effective than the counterparts obtained from karanja oil. Intensification of transesterification process with chicken waste oil was carried out by employing protic deep eutectic solvents (pDES) for production of high octane Me esters (HOME). The thermophys. evaluation of synthesized pDES show low values of d., viscosity and refractive index which decrease with the further increase in temperature The use pDES reduces the mass transfer limitation in biodiesel formation at the lowest acyl acceptor ratio of 1:4. Response surface methodol. based optimization for microwave-assisted biodiesel production indicate the usage of the lowest power of 1.4 kW with a min. volume of pDES (8%) at the optimal time of 25 min yields 96.4% pure biodiesel. The composition of obtained biodiesel was evaluated with GC-MS. The resulting biodiesel obtained is suitable additive to mineral based fuels.

Fuel published new progress about 23616-79-7. 23616-79-7 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst, name is N-Benzyl-N,N-dibutylbutan-1-aminium chloride, and the molecular formula is C19H34ClN, Quality Control of 23616-79-7.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Sadhukhan, Dipali published the artcileWeak Interactions Modulating the Dimensionality in Supramolecular Architectures in Three New Nickel(II)-Hydrazone Complexes, Magnetostructural Correlation, and Catalytic Potential for Epoxidation of Alkenes under Phase Transfer Conditions, Category: chlorides-buliding-blocks, the publication is Inorganic Chemistry (2011), 50(17), 8326-8339, database is CAplus and MEDLINE.

Three different ONO donor acetyl hydrazone Schiff bases have been synthesized from the condensation of acetic hydrazide with three different carbonyl compounds: salicylaldehyde (HL¹), 2-hydroxyacetophenone (HL²), and 2,3-dihydroxybenzaldehyde (HL³). These tridentate ligands are reacted with Ni(OOCCF₃)₂·xH₂O to yield three new Ni(II) complexes having distorted octahedral geometry at each Ni center: [Ni(L¹)(OOCCF₃)(CH₃OH)]₂ (1), [Ni(L²)(OOCCF₃)(H₂O)]₂ (2), and [Ni(L³)(L³H)](OOCCF₃)(H₂O)_1.65(CH₃OH)_0.35 (3). The ligands and the complexes have been characterized by elemental anal. and IR and UV-visible spectroscopy, and the structures of the complexes have been established by single crystal XRD study. 1 And 2 are centrosym. dinuclear complexes and are structural isomers whereas 3 is a bis chelated cationic monomer coordinated by one neutral and one monoanionic ligand. O-H···O hydrogen bonds in 3 give a dimer. Slight steric and electronic modifications in the ligand backbone provoke differences in the supramol. architectures of the complexes, leading to a variety of one, two, and three-dimensional hydrogen bonded networks in complexes 1–3, resp. Variable temperature magnetic susceptibility measurements reveal that moderate antiferromagnetic interactions operate between phenoxo bridged Ni(II) dimers in 1 and 2 whereas very weak antiferromagnetic exchange occurs through hydrogen bonding and π-π stacking interactions in 3. All complexes are efficient catalysts for the epoxidation of alkenes by NaOCl under phase transfer condition. The efficiency of alkene epoxidation is dramatically enhanced by lowering the pH, and the reactions are supposed to involve high valent Ni^III-OCl or Ni^III-O·intermediates. 3 Is the best epoxidation catalyst among the three complexes with 99% conversion and very high turnover number (TON, 396).

Inorganic Chemistry published new progress about 23616-79-7. 23616-79-7 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst, name is N-Benzyl-N,N-dibutylbutan-1-aminium chloride, and the molecular formula is C19H34ClN, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Fox, Richard J. published the artcileGeneral User Guide for Partitioning of Tetraalkylammonium and Tetraalkylphosphonium Salts: Impacts of Cation, Anion, and Solvent, Category: chlorides-buliding-blocks, the publication is Organic Process Research & Development (2020), 24(2), 235-241, database is CAplus.

Using a gravimetric approach, the partitioning of 57 tetraalkylammonium and 10 tetraalkylphosphonium salts in 12 different organic solvent/water mixtures was determined The data show that the partitioning is dramatically affected by the identity of the cation, anion, and solvent, and this comprehensive compilation can serve as a general user guide to aid as a starting point for reagent selection, especially in cases where efficient removal of the tetraalkylammonium or phosphonium salt is required.

Organic Process Research & Development published new progress about 23616-79-7. 23616-79-7 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst, name is N-Benzyl-N,N-dibutylbutan-1-aminium chloride, and the molecular formula is C19H34ClN, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Nielsen, Alexander L. published the artcileMechanism-based inhibitors of SIRT2: structure-activity relationship, X-ray structures, target engagement, regulation of α-tubulin acetylation and inhibition of breast cancer cell migration, Quality Control of 42074-68-0, the publication is RSC Chemical Biology (2021), 2(2), 612-626, database is CAplus and MEDLINE.

Sirtuin 2 (SIRT2) is a protein deacylase enzyme that removes acetyl groups and longer chain acyl groups from post-translationally modified lysine residues. It affects diverse biol. functions in the cell and has been considered a drug target in relation to both neurodegenerative diseases and cancer. Therefore, access to well-characterized and robust tool compounds is essential for the continued investigation of the complex functions of this enzyme. Here, we report a collection of chem. probes that are potent, selective, stable in serum, water-soluble, and inhibit SIRT2-mediated deacetylation and demyristoylation in cells. Compared to the current landscape of SIRT2 inhibitors, this is a unique ensemble of features built into a single compound We expect the developed chemotypes to find broad application in the interrogation of SIRT2 functions in both healthy and diseased cells, and to provide a foundation for the development of future therapeutics.

RSC Chemical Biology published new progress about 42074-68-0. 42074-68-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 2-Chlorotrityl chloride, and the molecular formula is C19H14Cl2, Quality Control of 42074-68-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

O’Hagan, Michael P. published the artcileVisible-light photoswitching of ligand binding mode suggests G-quadruplex DNA as a target for photopharmacology, Formula: C15H14Cl2S2, the publication is Chemical Communications (Cambridge, United Kingdom) (2020), 56(38), 5186-5189, database is CAplus and MEDLINE.

We report the selective targeting of telomeric G4 DNA with a dithienylethene ligand and demonstrate the robust visible-light mediated switching of the G4 ligand binding mode and G-tetrad structure in physiol.-relevant conditions. The toxicity of the ligand to cervical cancer cells is modulated by the photoisomeric state of the ligand, indicating for the first time the potential of G4 to serve as a target for photopharmacol. strategies.

Chemical Communications (Cambridge, United Kingdom) published new progress about 219537-97-0. 219537-97-0 belongs to chlorides-buliding-blocks, auxiliary class Fused/Partially Saturated Cycles,Cyclopentenes, name is 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, and the molecular formula is C15H14Cl2S2, Formula: C15H14Cl2S2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics