Tag: M.W=300-350

Remy, Sandrine published the artcileFunctionalization of zinc oxide nanorods with diarylethene-based photochromic compounds, Quality Control of 219537-97-0, the publication is Dyes and Pigments (2011), 89(3), 266-270, database is CAplus.

Two diarylethene mols. functionalized with a carboxylic acid function were grafted onto the surface of zinc oxide nanorods. Photochromic studies based on electronic absorption spectroscopy in solution showed that the switching units operate in a bidirectional mode, allowing both ring closure and ring-opening processes to take place successively in photochem. sequences combining irradiations of the open species at 300 nm and the closed ones at 500 nm. Depending on the mol. structure, some losses were observed presumably due to photodegradation Compound 2 containing a terminal Ph unit provides a longer conjugation pathway, thus offering red-shifted electronic absorption and better photochem. stability.

Dyes and Pigments published new progress about 219537-97-0. 219537-97-0 belongs to chlorides-buliding-blocks, auxiliary class Fused/Partially Saturated Cycles,Cyclopentenes, name is 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, and the molecular formula is C15H14Cl2S2, Quality Control of 219537-97-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Kato, Naoya published the artcileSynthesis and evaluation of a novel adapter lipid derivative for preparation of cyclic peptide-modified PEGylated liposomes: Application of cyclic RGD peptide, Formula: C19H14Cl2, the publication is European Journal of Pharmaceutical Sciences (2022), 106239, database is CAplus and MEDLINE.

Peptide ligand modified nanoparticles can simply prepared by post-insertion method to mix pre-formed nanoparticles with peptide-lipid conjugates in an aqueous solution at an optimal temperature Therefore, water dispersibility of peptide-lipid conjugates is a very important factor for implementing the post-insertion method. We proposed that highly water dispersible peptide-lipid conjugates can be easily synthesized by sep. designing novel adapter lipids with different water dispersibility and reacting them with ligands in a highly efficient manner. Adapter lipids have three critical roles; as spacers of ligand-conjugated lipids for efficient ligand presentation, as structures that form discrete mol. weight distributions, and as providing water dispersibility. In this study, we developed a novel adapter-lipid derivative that enables a variety of cyclic peptide modifications using the click reaction. The integrin αvβ3-targeted cyclic RGDfK (cRGD) peptide was selected as the cyclic peptide ligand. We designed a novel alkyne-tagged lipid with a discrete peptide spacer and bound the cRGD peptide using a click reaction to synthesize a cRGD-conjugated lipid with good water dispersibility for the preparation of cRGD-modified PEGylated liposomes using the post-insertion method. We also revealed that cRGD-modified PEGylated liposomes are efficiently associated with integrin αvβ3-expressing murine colon carcinoma (Colon-26) cells in a modification amount- and peptide sequence-dependent manner, showing high cytotoxicity upon loading with doxorubicin. This novel adapter lipid derivative can be used to synthesize various cyclic peptides by click reactions and will provide useful insights for the future development of cyclic peptide-modified PEGylated liposomes.

European Journal of Pharmaceutical Sciences published new progress about 42074-68-0. 42074-68-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 2-Chlorotrityl chloride, and the molecular formula is C19H14Cl2, Formula: C19H14Cl2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Herder, Martin published the artcileImproving the Fatigue Resistance of Diarylethene Switches, Application In Synthesis of 219537-97-0, the publication is Journal of the American Chemical Society (2015), 137(7), 2738-2747, database is CAplus and MEDLINE.

When applying photochromic switches as functional units in light-responsive materials or devices, an often disregarded yet crucial property is their resistance to fatigue during photoisomerization. In the large family of diarylethene photoswitches, formation of an annulated isomer as a byproduct of the photochromic reaction turns out to prevent the desired high reversibility for many different derivatives To overcome this general problem, we have synthesized and thoroughly investigated the fatigue behavior of a series of diarylethenes, varying the nature of the hetaryl moieties, the bridging units, and the substituents. By anal. of photokinetic data, a quantification of the tendency for byproduct formation in terms of quantum yields could be achieved, and a strong dependency on the electronic properties of the substituents was observed In particular, substitution with 3,5-bis(trifluoromethyl)phenyl or 3,5-bis(pentafluorosulfanyl)phenyl groups strongly suppresses the byproduct formation and opens up a general strategy to construct highly fatigue-resistant diarylethene photochromic systems with a large structural flexibility.

Journal of the American Chemical Society published new progress about 219537-97-0. 219537-97-0 belongs to chlorides-buliding-blocks, auxiliary class Fused/Partially Saturated Cycles,Cyclopentenes, name is 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, and the molecular formula is C15H14Cl2S2, Application In Synthesis of 219537-97-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Wodtke, Robert published the artcileSynthesis and kinetic characterization of water-soluble fluorogenic acyl donors for transglutaminase 2, Application of 2-Chlorotrityl chloride, the publication is ChemBioChem (2016), 17(13), 1263-1281, database is CAplus and MEDLINE.

Small Glu-containing peptides bearing coumarin derivatives as fluorescent leaving groups attached to the γ-carboxylic acid group of the Glu residue were synthesized and investigated with regard to their potential to act as substrates for transglutaminase 2 (TGase 2). Their synthesis was accomplished by an efficient solid-phase approach. The excellent water solubility of the compounds enabled their extensive kinetic characterization in the context of TGase 2-catalyzed hydrolysis and aminolysis. The influence of the coumarin skeleton’s substitution pattern on the kinetic properties was studied. Derivatives containing 7-hydroxy-4-methylcoumarin (HMC) revealed properties superior to those of their 7-hydroxycoumarin counterparts; analogous amides were not accepted as substrates. Z-Glu(HMC)-Gly-OH, which exhibited the best substrate properties out of the investigated derivatives, was selected for representative kinetic characterization of acyl acceptor substrates and irreversible inhibitors.

ChemBioChem published new progress about 42074-68-0. 42074-68-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 2-Chlorotrityl chloride, and the molecular formula is C7H13BrSi, Application of 2-Chlorotrityl chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Dong, Bin published the artcileCation Modules as Building Blocks Forming Supramolecular Assemblies with Planar Receptor-Anion Complexes, Application In Synthesis of 23616-79-7, the publication is Journal of the American Chemical Society (2013), 135(4), 1284-1287, database is CAplus and MEDLINE.

Ion-based materials were fabricated through ion pairing of planar receptor-anion complexes and cation modules as neg. and pos. charged building blocks, resp. Anion receptors that could not form soft materials by themselves provided mesophases upon anion binding and subsequent ion pairing with aliphatic cation modules. The mesogenic behaviors were affected by structural modification of both the cation module and the anion receptor. Synchrotron x-ray diffraction measurements suggested the formation of columnar mesophases with contributions from charge-by-charge and charge-segregated arrangements. Flash-photolysis time-resolved microwave conductivity measurements further revealed a higher charge-carrier mobility in the assembly with a large contribution from the charge-segregated arrangement than in the charge-by-charge-based assembly.

Journal of the American Chemical Society published new progress about 23616-79-7. 23616-79-7 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst, name is N-Benzyl-N,N-dibutylbutan-1-aminium chloride, and the molecular formula is C19H34ClN, Application In Synthesis of 23616-79-7.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Bahrami, Kiumars published the artcile[BTBA]Cl-FeCl₃ as an Efficient Lewis Acid Ionic Liquid for the Synthesis of Perimidine Derivatives, HPLC of Formula: 23616-79-7, the publication is Synthesis and Reactivity in Inorganic, Metal-Organic, and Nano-Metal Chemistry (2016), 46(6), 852-856, database is CAplus.

An effective synthesis of various biol. important 2,3-dihydroperimidines from reaction of aldehydes and naphthalene-1,8-diamine was developed using [BTBA]Cl-FeCl₃ as an efficient Lewis acid ionic liquid This method was a very simple and high yielding reaction for the preparation of the titled compounds Different functional groups were tolerated under this reaction conditions including ether, phenol, amine, and alkene.

Synthesis and Reactivity in Inorganic, Metal-Organic, and Nano-Metal Chemistry published new progress about 23616-79-7. 23616-79-7 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst, name is N-Benzyl-N,N-dibutylbutan-1-aminium chloride, and the molecular formula is C19H34ClN, HPLC of Formula: 23616-79-7.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Estrader, Marta published the artcileA Magneto-optical Molecular Device: Interplay of Spin Crossover, Luminescence, Photomagnetism, and Photochromism, Safety of 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, the publication is Angewandte Chemie, International Edition (2017), 56(49), 15622-15627, database is CAplus and MEDLINE.

A bis(pyrazolylpyridyl) ligand, L, containing a central photochromic dithienylethene spacer predictably forms a ferrous [Fe₂L₃]⁴⁺ helicate exhibiting spin crossover (SCO). In solution, the compound [Fe₂L₃](ClO₄)₄ (1) preserves the magnetic properties and is fluorescent. The structure of 1 is photo-switchable following the reversible ring closure/opening of the central dithienylethene via irradiation with UV/visible light. This photoisomerization switches on and off some emission bands of 1 and provides a means of externally manipulating the magnetic properties of the assembly.

Angewandte Chemie, International Edition published new progress about 219537-97-0. 219537-97-0 belongs to chlorides-buliding-blocks, auxiliary class Fused/Partially Saturated Cycles,Cyclopentenes, name is 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, and the molecular formula is C15H14Cl2S2, Safety of 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Albuini-Oliveira, Nathalia M. published the artcileThe influence of ammonium and phosphonium salts on natural rubber vulcanization with experimental and commercial accelerators, Recommanded Product: N-Benzyl-N,N-dibutylbutan-1-aminium chloride, the publication is Polymer Bulletin (Heidelberg, Germany), database is CAplus.

The influence of eight different quaternary ammonium and phosphonium salts on the vulcanization of natural rubber was investigated. The central atom (P or N) of the cation was of minor importance, but the nature of the organic chains greatly affected the rheometrical parameters of the process and the mech. properties of the vulcanizates. Studies of rubber compositions containing binary mixtures of a quaternary salt and the com. accelerators ZDEC, TBBS, TMTD and MBTS showed a synergistic effect, mainly with TBBS and MBTS. With such binary systems, it is possible to reduce the amount of accelerator and improve the vulcanization parameters and the quality of the vulcanized rubber. The anionic complex bis(N-phenylsulfonyldithiocarbimato)zincate(II) (Z), one amine-free exptl. accelerator, was prepared and isolated as tetrabutylammonium (B₂Z) and benzyltriphenylphosphonium (H₂Z) salts. The H₂Z complex salt is a new substance and behaved as an ultra-accelerator, being faster than ZDEC and TMTD. B₂Z was a medium rate accelerator, being faster than TBBS and similar to MBTS. In addition, the tensile and tear strength of the specimens vulcanized with the zinc-dithiocarbimate salts were superior when compared to compositions containing the com. accelerators. The differences in the behavior of B₂Z and H₂Z showed that the zinc-dithiocarbimates are versatile accelerators for natural rubber as the process and the quality of the vulcanizate can be modulated by the choice of the cation.

Polymer Bulletin (Heidelberg, Germany) published new progress about 23616-79-7. 23616-79-7 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst, name is N-Benzyl-N,N-dibutylbutan-1-aminium chloride, and the molecular formula is C19H34ClN, Recommanded Product: N-Benzyl-N,N-dibutylbutan-1-aminium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Bodendiek, Silke B. published the artcileTriarylmethanes, a new class of Cx50 inhibitors, Category: chlorides-buliding-blocks, the publication is Frontiers in Pharmacology of Ion Channels and Channelopathies (2012), 3(June), 106, database is CAplus and MEDLINE.

The paucity of specific pharmacol. agents has been a major impediment for delineating the roles of gap junction (GJ) channels formed by connexin proteins in physiol. and pathophysiol. Here, we used the selective optimization of side activities (SOSA) approach, which has led to the design of high affinity inhibitors of other ion channels, to identify a specific inhibitor for channels formed by Cx50, a connexin subtype that is primarily expressed in the lens. We initially screened a library of common ion channel modulating pharmacophores for their inhibitory effects on Cx50 GJ channels and identified four new classes of compounds The triarlymethane (TRAM) clotrimazole was the most potent Cx50 inhibitor and we therefore used it as a template to explore the structure activity relationship (SAR) of the TRAMs for Cx50 inhibition. We describe the design of T122 (N-[(2-methoxyphenyl)diphenylmethyl]-1,3-thiazol-2-amine) and T136 (N-[(2-iodophenyl)diphenylmethyl]-1,3-thiazol-2-amine), which inhibit Cx50 with IC₅₀s of 1.2 and 2.4 μM. Both compounds exhibit at least 10-fold selectivity over other connexins as well as major neuronal and cardiac voltage-gated K⁺ and Na⁺ channels. The SAR studies also indicated that the TRAM pharmacophore required for connexin inhibition is significantly different from the pharmacophore required for blocking the calcium-activated KCa3.1 channel. Both T122 and T136 selectively inhibited Cx50 GJ channels in lens epithelial cells, suggesting that they could be used to further explore the role of Cx50 in the lens. In addition, our results indicate that a similar approach may be used to find specific inhibitors of other connexin subtypes.

Frontiers in Pharmacology of Ion Channels and Channelopathies published new progress about 42074-68-0. 42074-68-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 2-Chlorotrityl chloride, and the molecular formula is C19H14Cl2, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Fallah Fini, Mojtaba published the artcileExperimental and QSPR Studies on the Effect of Ionic Surfactants on n-Decane-Water Interfacial Tension, COA of Formula: C19H34ClN, the publication is Journal of Surfactants and Detergents (2012), 15(4), 477-484, database is CAplus.

A quant. structure property relationship approach was performed to find the relation between the surfactant structure and its effect on water-oil interfacial tension. As a result, a new database has been developed measuring the interfacial tension between n-decane as the model oil and different aqueous solutions of some ionic compounds In spite of other reports we selected surfactants by a scientific method that covers all structural information. Twenty four different compounds were selected by the principal component anal. method and their interfacial tensions were measured at their critical micelle concentrations The geometrical optimization of surfactants was performed at the B3LYP/6-311G** level and quantum chem. and structural descriptors were calculated using relevant computer software programs. The best fitted descriptors were selected using the variable selection of the genetic algorithm (GA-MLR). The predictive test was performed for an external prediction set of 6 compounds, chosen out of 24 compounds The resulted GA-MLR model can reasonably predict the interfacial tension using only three selected descriptors. The deviation between predicted and measured values was found to be <7%.

Journal of Surfactants and Detergents published new progress about 23616-79-7. 23616-79-7 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst, name is N-Benzyl-N,N-dibutylbutan-1-aminium chloride, and the molecular formula is C19H34ClN, COA of Formula: C19H34ClN.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics