Tag: M.W=250-300

Pan, Cheng published the artcilePalladium-Catalyzed Site-Selective Benzocylization of Aromatic Acids with o-Fluoro-Substituted Diaryliodonium Salts toward 3,4-Benzocoumarins, COA of Formula: C6H3ClFI, the main research area is benzocoumarin preparation palladium catalyzed site selective benzocyclization; benzocyclization aromatic acid fluoro substituted diaryliodonium salt.

By using 2-fluoro-substituted diaryliodonium salts, a novel benzocylization has been accomplished for the synthesis of 3,4-benzocoumarin derivatives via a cascade of ortho-arylation and defluorination in the presence of palladium catalysts. The reaction exhibits a broad compatibility of readily available aromatic acids with an excellent level of site-selectivity. Mechanistic investigations revealed a unique reactivity of carboxylic acid directed arylation by followed nucleophilic substitution of aromatic fluoride in the present system.

Organic Letters published new progress about Aromatic carboxylic acids Role: RCT (Reactant), RACT (Reactant or Reagent). 6797-79-1 belongs to class chlorides-buliding-blocks, name is 4-Chloro-2-fluoroiodobenzene, and the molecular formula is C6H3ClFI, COA of Formula: C6H3ClFI.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Kuzmina, Olesya M. published the artcileLigand-Accelerated Iron- and Cobalt-Catalyzed Cross-Coupling Reactions between N-Heteroaryl Halides and Aryl Magnesium Reagents, COA of Formula: C6H3ClFI, the main research area is biaryl preparation; heteroaryl halide cross coupling arylmagnesium iron cobalt isoquinoline catalyst.

Addition of quinoline or isoquinoline as a ligand dramatically increased the rate and yield of Fe- and Co-catalyzed cross-coupling reactions of heteroaryl chlorides and bromides with arylmagnesium reagents. This new catalytic process extends the scope of such cross-coupling reactions to include complex functional groups and allows the formation of bis(heteroarene)s.

Angewandte Chemie, International Edition published new progress about Aryl halides Role: RCT (Reactant), RACT (Reactant or Reagent) (heteroaryl). 6797-79-1 belongs to class chlorides-buliding-blocks, name is 4-Chloro-2-fluoroiodobenzene, and the molecular formula is C6H3ClFI, COA of Formula: C6H3ClFI.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Dubost, Emmanuelle published the artcileGeneral method for the synthesis of substituted phenanthridin-6(5H)-ones using a KOH-mediated anionic ring closure as the key step, Recommanded Product: 4-Chloro-2-fluoroiodobenzene, the main research area is fluoro arylboronic acid preparation halo arylnitrile Suzuki coupling palladium; fluorobiphenyl carbonitrile preparation anionic ring closure potassium hydroxide microwave; phenanthridinone preparation; microwave irradiation anionic ring closure mediator; potassium hydroxide anionic ring closure mediator; palladium Suzuki cross coupling catalyst.

Substituted phenanthridin-6(5H)-ones were obtained in a two-step procedure involving a Suzuki cross-coupling reaction followed by a KOH-mediated anionic ring closure. The influence of the nature and the position of the substituents on the cyclization step were studied. This methodol. offers a general and practical route to diversely substituted phenanthridin-6(5H)-ones, e.g., I (R = H, F).

Tetrahedron published new progress about Aromatic nitriles Role: RCT (Reactant), RACT (Reactant or Reagent) (halo). 6797-79-1 belongs to class chlorides-buliding-blocks, name is 4-Chloro-2-fluoroiodobenzene, and the molecular formula is C6H3ClFI, Recommanded Product: 4-Chloro-2-fluoroiodobenzene.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Thorat, Raviraj Ananda published the artcileSynthesis of Chiral-Substituted 2-Aryl-ferrocenes by the Catellani Reaction, Product Details of C6H3ClFI, the main research area is palladium catalyzed three component coupling iodoarene acrylate iodoferrocencarboxamide; chiral aryl ferroceneamide preparation.

A Pd-catalyzed and norbornene-mediated methodol. was developed for the synthesis of chiral 2-aryl-ferroceneamides from chiral 2-iodo-N,N-diisopropylferrocencarboxamide, iodoarenes, and alkenes using a JohnPhos ligand and K carbonate as a base in DMF at 105°. The developed three-component coupling protocol allows the compatibility of electron-withdrawing fluoro, chloro, ester, and nitro and electron-donating Me, methoxy, dimethoxy, benzyl ether-substituted iodo-benzenes, other iodoarenes, such as iodo-naphthalene, heteroarenes, such as iodothiophene, and terminating substrates, such as Me, Et, tert-Bu acrylates, and substituted styrenes with 2-iodo-N,N-diisopropylferrocencarboxamide. Also, the developed three-component Catellani method proceeded with the retention of the configuration of the planar chiral ferrocene, which depends on the role of the participating C-I bond in ferrocene. Consequently, the developed protocol enabled the formation of densely substituted chiral 2-aryl ferroceneamides, exhibiting good to excellent enantioselectivity. The conversion of an ester of the synthesized chiral 2-aryl ferroceneamides also was carried out to further accommodate the easily expendable acid and alc. functionalities.

Journal of Organic Chemistry published new progress about Alkynylation catalysts (Pd complexes). 6797-79-1 belongs to class chlorides-buliding-blocks, name is 4-Chloro-2-fluoroiodobenzene, and the molecular formula is C6H3ClFI, Product Details of C6H3ClFI.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Huang, Hai-Yun published the artcilePd-Catalyzed Direct Arylations of Heteroarenes with Polyfluoroalkoxy-Substituted Bromobenzenes, COA of Formula: C7H3BrClF3O, the main research area is fluoroalkoxy bromobenzene heteroarene palladium catalyst arylation; arylated heteroarene preparation.

The reactivity of di-, tri- and tetra-fluoroalkoxy-substituted bromobenzenes in the direct arylation of 5-membered ring heteroarenes using palladium catalysis was explored. High yields in arylated heteroarenes, e.g., I, were obtained using only 1 mol-% of Pd(OAc)2 catalyst with KOAc as an inexpensive base. Similar yields were obtained with o/m/p trifluoromethoxy-, o/p difluoromethoxy-, and tetrafluoroethoxy-substituents on the aryl bromide. A bromo-substituted difluorobenzo[d][1,3]dioxole was successfully coupled. The major side-products of the reaction are HBr/KOAc. Therefore, this synthetic scheme is very attractive for the access to such polyfluoroalkoxy-containing arylated heteroaromatics in terms of cost, simplicity, and low environmental impact, compared to reactions involving arylation of heteroarenes with bromophenols followed by polyfluoroalkylation.

European Journal of Organic Chemistry published new progress about Aryl halides Role: RCT (Reactant), RACT (Reactant or Reagent) (fluoroalkoxy). 468075-00-5 belongs to class chlorides-buliding-blocks, name is 2-Bromo-1-chloro-4-(trifluoromethoxy)benzene, and the molecular formula is C7H3BrClF3O, COA of Formula: C7H3BrClF3O.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Ilhan, Suleyman published the artcileEssential Oils from Vitex agnus castus L. Leaves Induces Caspase-Dependent Apoptosis of Human Multidrug-Resistant Lung Carcinoma Cells through Intrinsic and Extrinsic Pathways, HPLC of Formula: 18585-06-3, the main research area is Vitex agnus essential oil caspase lung carcinoma apoptosis human.

Essential oil (EO) fractions of plants are complex mixtures of volatile compounds with broad-spectrum biol. properties. In the current study, the EO content of Vitex agnus castus L. (VAC) leaves growing in the Aegean region of Turkey was extracted and identified. Then, VAC EOs were investigated for their potential antioxidant, cytotoxic and apoptotic effects in human H69AR multi-drug resistant cancer cells. EOs were isolated by hydrodistillation and chem. composition was determined by GC-MS. Cell viability was assessed via MTT and trypan blue assays. Antioxidant activity was evaluated by measuring the total antioxidant activity and free radical scavenging activity. Apoptosis was evaluated via DNA fragmentation and caspase 3/7 activity assays. Changes in the levels of apoptotic genes were determined by RT-qPCR. The results indicated strong antioxidant activity and cytotoxic effect on H69AR cancer cells but not on HEK-293 human normal cells indicating the tumor-specific effect. VAC EOs induced caspase 3/7 activation and apoptosis through triggering both extrinsic- and intrinsic-pathways by modulating Bcl-2, Bcl-XL, Bax, Bad, FADD, Caspase-8, Caspase-9, TRAIL R1/DR4 and TRAIL R2/DR5. This study revealed that VAC EOs may be a promising candidate in the development of novel therapeutic agents for multi-drug resistant lung cancer treatment.

Nutrition and Cancer published new progress about Animal gene, Bcl-2 Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 18585-06-3 belongs to class chlorides-buliding-blocks, name is Ethyl (4-chloro-3-(trifluoromethyl)phenyl)carbamate, and the molecular formula is C10H9ClF3NO2, HPLC of Formula: 18585-06-3.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Mikami, Shinichi published the artcileSilica gel-assisted preparation of (bromo)(chloro)(iodo)benzo[b]thiophenes bearing halogen atoms at the 2-, 4-, and 7-positions, Name: 4-Chloro-2-fluoroiodobenzene, the main research area is benzothiophene dihalo trihalo preparation stereoselective silica gel; sulfide adamantyl alkynylaryl halo preparation intramol cyclization silica.

Six types of (bromo)(chloro)(iodo)benzo[b]thiophenes bearing halogen atoms at the 2-, 4-, and 7-positions were prepared from the corresponding 2-(1-adamantylthio)-1,4-dihalo-3-(haloethynyl)benzene derivatives, by treatment with silica gel under thermal conditions. 4,7-Dihalobenzo[b]thiophenes, bearing two different halogen atoms (chlorine, bromine, or iodine), were also prepared from 2-(1-adamantylthio)-3-(ethynyl)-1,4-dihalobenzenes.

Heterocycles published new progress about Aldehydes, halo Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 6797-79-1 belongs to class chlorides-buliding-blocks, name is 4-Chloro-2-fluoroiodobenzene, and the molecular formula is C6H3ClFI, Name: 4-Chloro-2-fluoroiodobenzene.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Ito, Motoki published the artcileSynthesis of Boron-Substituted Diaryliodonium Salts and Selective Transformation into Functionalized Aryl Boronates, Safety of 2-(2-Chloro-6-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, the main research area is boron substituted iodonium salt preparation cross coupling functionalized aromatic; aryl boronate regioselective aromatic nucleophilic substitution hypervalent iodine.

Diaryliodonium salts were synthesized from aryl boronate derivatives according to two alternative general methods with hypervalent iodine(III) reagents and fluoroalc. solvents: transformation of an aryl C-H bond and boron-iodine(III) exchange. The salts could be functionalized by both catalyst-free and metal-catalyzed reactions without loss of the boron functionality.

Angewandte Chemie, International Edition published new progress about Cross-coupling reaction, regioselective. 1061367-22-3 belongs to class chlorides-buliding-blocks, name is 2-(2-Chloro-6-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, and the molecular formula is C13H18BClO3, Safety of 2-(2-Chloro-6-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Wang, Sheng-Li published the artcileSynthesis of biphenylenes and their higher homologues by cyclization of aryne derivatives, Category: chlorides-buliding-blocks, the main research area is halobiaryl cyclization; biphenylene preparation; arynes; biphenyls; cyclizations; lithium; synthetic methods.

This investigation demonstrates that a series of biphenylenes, e.g., I, can be easily prepared from their corresponding halobiphenyls by the cyclization of in situ generated 2′,3′-didehydro-2-lithiobiphenyls at low temperature Two remarkable advantages of this synthetic method include the lack of any need for transition-metal catalysts or reagents in the cyclization, and the ability to obtain C1-functionalized products by treating the reaction intermediate 1-lithiobiphenylene with an electrophilic reagent. π-Extended derivatives, such as benzobiphenylenes, dibenzobiphenylene, linear/angular [3]phenylenes, and biphenyleno[2,3-b]biphenylenes, were synthesized similarly using suitable biaryls or teraryls.

Angewandte Chemie, International Edition published new progress about Aromatic hydrocarbons, arynes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 6797-79-1 belongs to class chlorides-buliding-blocks, name is 4-Chloro-2-fluoroiodobenzene, and the molecular formula is C6H3ClFI, Category: chlorides-buliding-blocks.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Lakshmi, Parvathi K. published the artcileAn efficient Mn-catalyzed reductive carbonylation of aryl iodides to aryl aldehydes and their benzimidazole and benzoxazoles, Recommanded Product: 4-Chloro-2-fluoroiodobenzene, the main research area is aryl aldehyde benzimidazole benzoxazole preparation; carbon monoxide aryl iodide reductive carbonylation manganese catalyst.

The present study envisaged the development of an efficient protocol of Mn-catalyzed reductive carbonylation of aryl iodides to aryl aldehydes and their corresponding imidazole and oxazole derivatives, by using CO as a carbonyl source, in the presence of hydrosilanes and base [Na2CO3 and NaHCO3 (1:1)] under mild reaction conditions gave a series of aldehydes in good yields. This approach could be extended for further functionalization of aryl aldehydes and to their corresponding benzimidazole and benzoxazole derivatives with high efficiency.

Synthetic Communications published new progress about Aryl iodides Role: RCT (Reactant), RACT (Reactant or Reagent). 6797-79-1 belongs to class chlorides-buliding-blocks, name is 4-Chloro-2-fluoroiodobenzene, and the molecular formula is C6H3ClFI, Recommanded Product: 4-Chloro-2-fluoroiodobenzene.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics