Tag: M.W=250-300

Brady, P. Rex published the artcileEvaluation of some reactive disperse dyes for sublimation transfer printing of wool, SDS of cas: 18791-02-1, the publication is Journal of the Society of Dyers and Colourists (1981), 97(4), 159-65, database is CAplus.

The transfer printing of wool by the sublimation method was examined using 12 azo and 2 anthraquinone low-mol.-weight dyes containing 6 different types of reactive groups. To achieve build-up of the dyes to heavy depths, the wool was pretreated with a polymer, e.g. Primal K3 (I) [37331-35-4], or a surfactant and steamed after dye transfer. Only the yellow dyes exhibited good fastness properties on pure wool. On wool-polyester blend fabrics that had been treated with I, fastness values were generally intermediate between those for pure polyester fabrics and I-treated wool.

Journal of the Society of Dyers and Colourists published new progress about 18791-02-1. 18791-02-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 2,3-Dibromopropionylchloride, and the molecular formula is C3H3Br2ClO, SDS of cas: 18791-02-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Vilceanu, R. published the artcileStructure-activity correlations for the toxicity of organic phosphorus compounds of the Schrader type, Quality Control of 866-23-9, the publication is Analele Universitatii din Timisoara, Stiinte Fizice-Chimice (1977), 15(1), 61-77, database is CAplus.

The toxicity in mice of 71 phosphororg. compounds of the Schrader type, R¹R²PO₂R³, was correlated with parameters for intermol. forces [number of atoms with lone electron pairs (HA), molar refractions (R), Hammett constants of the R³ groups (H), number of aromatic cycles (AR), electron attracting character in charge transfer (CT)] and minimal steric difference (MSD), with respect to acetylcholine. The best linear correlational equation obtained (71 compounds, 6 parameters) was: A = 0.555 + 0.476(HA)-0.017(R) + 0.343(H)-0.402(AR) + 0.611(CT)-0.063(MSD), where A = -lgLD₅₀. This correlation was obtained for a very wide range of chem. structures with the R¹, R² and R³ groups.

Analele Universitatii din Timisoara, Stiinte Fizice-Chimice published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C3H6O2, Quality Control of 866-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Miller, Susanne L. published the artcileC-H Borylation Catalysts that Distinguish Between Similarly Sized Substituents Like Fluorine and Hydrogen, Related Products of chlorides-buliding-blocks, the publication is Organic Letters (2019), 21(16), 6388-6392, database is CAplus and MEDLINE.

By modifying ligand steric and electronic profiles it is possible to C-H borylate ortho or meta to substituents in aromatic and heteroaromatic compounds, where steric differences between accessible C-H sites are small. Dramatic effects on selectivities between reactions using B₂pin₂ or 4,4,5,5-tetramethyl-1,3,2-dioxaborolane (HBpin) are described for the 1st time. Judicious ligand and borane combinations give highly regioselective C-H borylations on substrates where typical borylation protocols afford poor selectivities.

Organic Letters published new progress about 765917-27-9. 765917-27-9 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Boronic acid and ester,Benzene,Boronate Esters, name is 2-(4-Chloro-2-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, and the molecular formula is C12H15BClFO2, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Jahan, Humera published the artcileAnthranilic Acid Derivatives: Novel Inhibitors of Protein Glycation and the Associated Oxidative Stress in the Hepatocytes, Computed Properties of 60091-87-4, the publication is Medicinal Chemistry (Sharjah, United Arab Emirates) (2018), 14(5), 516-523, database is CAplus and MEDLINE.

Anthranilic acid derivatives are important pharmacophores in drug discovery. Several of them are currently being used, such as mefenamic acid and meclofenamates, possess analgesic, anti-inflammatory and antipyretic activities. Some anthranilic acid-based scaffolds have also been reported for the management of metabolic disorders. The aim of the current study was to investigate the antiglycation potential of 2-anilino benzoic acid derivatives against (N-phenylanthranilic acid) fructose- human serum albumin (HSA) glycation. The study also analyzed the effects of newly identified antiglycation inhibitors on AGEs-mediated intracellular reactive oxygen species production, and associated impaired proliferation of the hepatocytes. The present study focuses on the antiglycation activity of 2- anilinobenzoic acid derivatives 1-18 in in-vitro human serum albumin (HSA)- fructose model. These derivatives were also identified as non-toxic to 3T3 mouse fibroblast cell-line using metabolic assay. The effect of the most promising derivative 1, 2- (2, 4- dinitroanilino)benzoic acid, was studied in a dose dependent manner, co-incubated with fructose-derived AGEs (0- 200 μg/mL), on rat hepatocytes proliferation and associated intracellular generation of ROS via MTT assay and DCFH-DA technique, resp. We found that derivative 1 ameliorates the elevated intracellular oxidative stress and associated diminished proliferation of the hepatocytes in response to AGEs. In conclusion, we identify novel 2- anilino benzoic acid derivatives as antiglycation agents through in-vitro and cellular-based models.

Medicinal Chemistry (Sharjah, United Arab Emirates) published new progress about 60091-87-4. 60091-87-4 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Nitro Compound,Carboxylic acid,Amine,Benzene, name is 2-((4-Chloro-2-nitrophenyl)amino)benzoic acid, and the molecular formula is C13H9ClN2O4, Computed Properties of 60091-87-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Wang, Peng published the artcileChemoselective Borono-Catellani Arylation for Unsymmetrical Biaryls Synthesis, COA of Formula: C13H18BClO2, the publication is Organic Letters (2019), 21(9), 3323-3327, database is CAplus and MEDLINE.

In the presence of Pd(OAc)₂ and a norbornenedicarboxylate, arylpinacolboronates such as 2-methylphenyl pinacolboronate underwent chemoselective aerobic borono-Catellani reactions with aryl bromides such as Me 2-bromobenzoate and alkenes (including α,β-unsaturated esters) such as tert-Bu acrylate to yield unsym. biaryl alkenes such as biphenylpropenoate I. In the absence of alkene, a bromophenylcarbamate underwent coupling and cyclization with 2-naphthylpinacolboronate to yield a mixture of benzocarbazoles in 45% combined yield; a bromophenol underwent coupling without cyclization.

Organic Letters published new progress about 1030832-75-7. 1030832-75-7 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Boronate Esters,Boronic acid and ester, name is 2-(4-Chloro-2-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, and the molecular formula is C18H35NO, COA of Formula: C13H18BClO2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Liu, Xiaoguang published the artcileCopper-Catalyzed γ-Sulfonylation of α,β-Unsaturated Carbonyl Compounds by Means of Silyl Dienol Ethers, Computed Properties of 21286-54-4, the publication is Organic Letters (2015), 17(14), 3572-3575, database is CAplus and MEDLINE.

γ-Sulfonyl-α,β-unsaturated ketones such as I [R = Ph, 4-MeC₆H₄, 4-O₂NC₆H₄, 2,4,6-R¹₃C₆H₂, F₅C₆, 8-quinolinyl, Me, i-Pr, ClCH₂CH₂, cyclopropyl, (1S)-10-camphorsulfonyl; R¹ = Me, i-Pr; R² = H] were prepared regioselectively by reaction of dienyl silyl ethers such as II (TBDMS = tert-butyldimethylsilyl) with sulfonyl chlorides RSO₂Cl [R = Ph, 4-MeC₆H₄, 4-O₂NC₆H₄, 2,4,6-R¹₃C₆H₂, F₅C₆, 8-quinolinyl, Me, i-Pr, ClCH₂CH₂, cyclopropyl, (1S)-10-camphorsulfonyl; R¹ = Me, i-Pr] in the presence of CuCl in MeCN. Selected sulfonylated unsaturated ketones underwent regioselective alkylation and Michael addition reactions and cyclocondensations to yield products such as I (R = Ph; R² = Me, MeO₂CCH₂CH₂).

Organic Letters published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C10H15ClO3S, Computed Properties of 21286-54-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Lin, Shuangjie published the artcileVisible-light-driven spirocyclization of epoxides via dual titanocene and photoredox catalysis, HPLC of Formula: 21286-54-4, the publication is Chemical Science (2020), 11(3), 839-844, database is CAplus and MEDLINE.

The synergistic utilization of titanocene/photoredox dual catalysis driven by visible light for the radical opening/spirocyclization of easily accessible epoxyalkynes. This environmentally benign process used organic donor-acceptor fluorophore 2,4,5,6-tetra(9H-carbazol-9-yl)isophthalonitrile as a photocatalyst and Hantzsch ester as an electron donor instead of stoichiometric metallic reductants. The photocatalytic conditions showed exceptionally high reactivity for the synthesis of privileged and synthetically challenging spirocycles, e.g., I, featuring a spiro all-carbon quaternary stereocenter. Cyclic voltammetry studies suggest that Cp₂TiIIICl is the catalytically active species.

Chemical Science published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C10H15ClO3S, HPLC of Formula: 21286-54-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Froneman, M. published the artcileDialkylamino group transfer from titanium(IV) to a phosphoryl center. Structure-reactivity studies, Recommanded Product: Diethyltrichloromethylphosphonate, the publication is Phosphorus, Sulfur and Silicon and the Related Elements (1990), 47(3-4), 273-81, database is CAplus.

Reaction between phosphoryl substrates (EtO)₂P(O)R (R = H, Me, OEt) and Ti(NR₂)_nCl_4-n (R¹ = Me, Et, n = 2, 3, 4) and Mn(NEt₂)₂ leads to the exchange of one or both EtO groups for the NR₂ substituent. The reactivity of the system depends on electronic as well as steric effects of both substrates, and approx. correlates with Lewis acid-base interactions between the substrates.

Phosphorus, Sulfur and Silicon and the Related Elements published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, Recommanded Product: Diethyltrichloromethylphosphonate.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Wang, Rongkang published the artcileElectrochemical Thiolation and Borylation of Arylazo Sulfones with Thiols and B₂pin₂, Recommanded Product: 2-(4-Chloro-2-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, the publication is Advanced Synthesis & Catalysis (2021), 363(7), 1904-1911, database is CAplus.

An efficient electrochem. synthesis approach of various unsym. thioethers and arylboronates has been developed. Bench stable arylazo sulfones were used as radical precursors for carbon-heteroatom bond formation under electrochem. conditions. Moreover, the scalability of this approach was evaluated by performing the electrochem. thiolation and borylation of arylazo sulfones with thiols and B₂pin₂ on a gram scale. This protocol not only avoided the use of stoichiometric oxidants, metal catalysts, activating agents and even added bases, but also exhibited favorable functional group tolerance.

Advanced Synthesis & Catalysis published new progress about 1030832-75-7. 1030832-75-7 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Boronate Esters,Boronic acid and ester, name is 2-(4-Chloro-2-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, and the molecular formula is C5H8N2O2, Recommanded Product: 2-(4-Chloro-2-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Johnson, Sherida L. published the artcileStructure-activity relationship studies of a novel series of anthrax lethal factor inhibitors, Safety of 4-Chloro-3-(trifluoromethyl)benzenesulfonyl Chloride, the publication is Bioorganic & Medicinal Chemistry (2009), 17(9), 3352-3368, database is CAplus and MEDLINE.

We report on the identification of a novel small mol. inhibitor of anthrax lethal factor using a high-throughput screening approach. Guided by mol. docking studies, we carried out structure-activity relationship (SAR) studies and evaluated activity and selectivity of most promising compounds in in vitro enzyme inhibition assays and cellular assays. Selected compounds were further analyzed for their in vitro ADME properties, which allowed us to select two compounds for further preliminary in vivo efficacy studies. The data provided represents the basis for further pharmacol. and medicinal chem. optimizations that could result in novel anti-anthrax therapies.

Bioorganic & Medicinal Chemistry published new progress about 32333-53-2. 32333-53-2 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Sulfonyl chlorides,Benzene, name is 4-Chloro-3-(trifluoromethyl)benzenesulfonyl Chloride, and the molecular formula is C7H3Cl2F3O2S, Safety of 4-Chloro-3-(trifluoromethyl)benzenesulfonyl Chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics