Tag: M.W=250-300

Tobe, Yoshito published the artcile[2 + 2] Cycloreversion of [4.3.2]Propella-1,3,11-trienes: An Approach to Cyclo[n]carbons from Propellane-Annelated Dehydro[n]annulenes, Application In Synthesis of 866-23-9, the publication is Journal of the American Chemical Society (2000), 122(8), 1762-1775, database is CAplus.

As a method to generate all-carbon mols. having highly reactive polyyne units from stable precursors, the [2 + 2] cycloreversion of [4.3.2]propella-1,3,11-triene derivatives was developed. To test the efficiency of this method, the reaction was first applied to simple diethynyl- and dibutadiynyl-substituted propellatrienes, which produced upon UV-irradiation linear hexatriyne and decapentayne derivatives, resp. Next, dehydro[12]-, [16]-, [18]-, [20]-, and [24]annulene derivatives annelated by the [4.3.2]propellatriene units were prepared as precursors to the corresponding cyclo[n]carbons, a monocyclic form of carbon clusters. Laser-desorption mass spectra of the dehydroannulenes exhibited, in the neg. mode, peaks due to the corresponding cyclo[n]carbon anions (n = 12, 16, 18, 20, and 24) formed by successive losses of aromatic indane fragments. Solution photolysis of the dehydro[16]annulene and dehydro[18]annulene derivatives formed reactive polyyne intermediates by [2 + 2] cycloreversion which were intercepted by furan to give the corresponding Diels-Alder adducts. The structures and spectroscopic properties of the dehydroannulenes annelated by the [4.3.2]propellatriene units, the precursors to cyclo[n]carbons, and those annelated by the oxanorbornadiene units, the products of the photolysis in furan, are discussed. Safety: mild explosions were reported with the furan trapping products.

Journal of the American Chemical Society published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C6H5BFNO4, Application In Synthesis of 866-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Tobe, Yoshito published the artcilePhotochemical Method for Generation of Linear Polyynes: [2 + 2] Cycloreversion of [4.3.2]Propellatrienes Extruding Indan, Category: chlorides-buliding-blocks, the publication is Journal of Organic Chemistry (1994), 59(6), 1236-7, database is CAplus.

Photolysis of trienediynes I (R = Me₃Si, Me₃CSiMe₂) and trienetetrayne I [R = CCSi(CHMe₂)₃] having a [4.3.2]propellane framework yielded the resp. linear polyynes RCCCCCCR in good efficiency through [2 + 2] cycloreversion, extruding indan.

Journal of Organic Chemistry published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C6H5BFNO4, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Homma, Yuki published the artcileRuthenium-catalyzed regio- and site-selective ortho C-H borylation of phenol derivatives, Recommanded Product: 3-Chloro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol, the publication is Chemical Communications (Cambridge, United Kingdom) (2020), 56(73), 10710-10713, database is CAplus and MEDLINE.

Efficient synthesis of o-borylphenols, e.g. I, is achieved through the Ru-catalyzed regio- and site-selective sp² C-H borylation of aryl diphenylphosphinites followed by removal of the phosphorus directing group. A successful application to aryl phosphites enables practical one-pot borylation of phenols, demonstrating high synthetic utility of this protocol.

Chemical Communications (Cambridge, United Kingdom) published new progress about 1451391-17-5. 1451391-17-5 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Phenol,Boronate Esters,Boronic Acids,Boronic acid and ester,, name is 3-Chloro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol, and the molecular formula is C12H16BClO3, Recommanded Product: 3-Chloro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Otto, Sijbren published the artcileDynamic Combinatorial Libraries of Macrocyclic Disulfides in Water, Safety of 2,3-Dibromopropionylchloride, the publication is Journal of the American Chemical Society (2000), 122(48), 12063-12064, database is CAplus.

The disulfide exchange reaction was employed to generate dynamic combinatorial libraries (DCLs) of macrocyclic disulfides starting from five structurally diverse dithiol building blocks, e.g. I and II. The diverse library forms under mild conditions in a single step and surpasses existing DCLs in the fact that no external catalyst is required for the exchange process.

Journal of the American Chemical Society published new progress about 18791-02-1. 18791-02-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 2,3-Dibromopropionylchloride, and the molecular formula is C3H3Br2ClO, Safety of 2,3-Dibromopropionylchloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Taylor, Adam C. published the artcileUse of Chemcatcher passive sampler with high-resolution mass spectrometry and multi-variate analysis for targeted screening of emerging pesticides in water, HPLC of Formula: 67747-01-7, the publication is Analytical Methods (2020), 12(32), 4015-4027, database is CAplus and MEDLINE.

Pesticides present at trace concentrations are a common cause of poor water quality. Screening generates large qual. data sets, therefore, there is a need for improved monitoring methods and data interpretation strategies to reduce the need for repetition, and increase the quality of information for end-users. Passive sampling is an in situ time integrative technique, increasingly used for monitoring pesticides in water. Here, we describe a method using the Chemcatcher passive sampler, coupled to targeted screening using liquid chromatog.-quadrupole-time-of-flight mass spectrometry, and a com. available library. Statistical anal. was performed using Agilent Mass Profiler Professional software. Water sampling took place over one year, at three riverine sites in the south of England, UK. Statistical interpretation of time integrative data from passive sampling could distinguish regular and episodic pesticide inputs, and detected compounds neglected by routine monitoring methods. One hundred and eleven pesticides were identified including legacy and current use compounds with diverse origins and uses. Spatial and temporal trends were identified enabling prioritisation of seasonal monitoring at each site. This approach maximises the utility of qual. assessment and may help water quality managers to rationalise pesticide fate in future, providing significant addnl. insight without the need to increase the scope and cost of monitoring.

Analytical Methods published new progress about 67747-01-7. 67747-01-7 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Amine,Benzene,Ether,Benzene Compounds, name is N-(2-(2,4,6-Trichlorophenoxy)ethyl)propan-1-amine, and the molecular formula is C15H25BN2O4, HPLC of Formula: 67747-01-7.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Jennings, Lee D. published the artcileDesign and synthesis of indolo[2,3-a]quinolizin-7-one inhibitors of the ZipA-FtsZ interaction, HPLC of Formula: 18791-02-1, the publication is Bioorganic & Medicinal Chemistry Letters (2004), 14(6), 1427-1431, database is CAplus and MEDLINE.

The binding of FtsZ to ZipA is a potential target for antibacterial therapy. Based on a small mol. inhibitor of the ZipA-FtsZ interaction, a parallel synthesis of small mols. was initiated which targeted a key region of ZipA involved in FtsZ binding. The X-ray crystal structure of one of these mols. complexed with ZipA was solved. The structure revealed an unexpected binding mode, facilitated by desolvation of a loosely bound surface water.

Bioorganic & Medicinal Chemistry Letters published new progress about 18791-02-1. 18791-02-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 2,3-Dibromopropionylchloride, and the molecular formula is C3H3Br2ClO, HPLC of Formula: 18791-02-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Cadogan, J. I. G. published the artcileReactivity of organophosphorus compounds. V. Reaction of trichloromethyl radicals with trialkyl phosphites, COA of Formula: C5H10Cl3O3P, the publication is Journal of the Chemical Society (1961), 3071-6, database is CAplus.

–From a knowledge of the reactions of benzyl and β,β-dimethylphenethyl radicals evidence was produced in favor of the radical-induced reaction of CCl₄ with trialkyl phosphites to give dialkyl trichloromethylphosphonates proceeding by a radical chain reaction involving [(RO)₃PCCl₃]⁺ Cl^– rather than by decomposition of the phosphoranyl radical (RO)₃(Cl₃C)P. Evidence concerning the reactivity of phosphoranyl radicals was presented and discussed. Benzyl di-Et phosphite (I) b₀.1 70°, n²_D⁵ 1.4900. PhCMe₂CH₂Cl (Ia), b₁2 101°, n²_D¹ 1.5241, was converted into the alc. as follows: O passed during 3 h. through a solution in Et₂O of the Grignard reagent from 250 g. Ia at 0°, and the mixture poured into 2 l. dilute H₂SO₄, washed, and distilled gave PhCMe₂CH₂OH (II), b₁2 110-12°, n²4_D 1.5248. II (25 g.) and 56.5 g. Et₃PO₃ kept 4.5 h. at 140°, the alc. formed removed, and the residue distilled gave 27 g. β,β-dimethylphenethyl di-Et phosphite (III), b_0.1 98-102°. Attempts to prepare tris(β,β-dimethylphenethyl) phosphite gave oils which readily decomposed when heated. I (5.3 g.) and 0.3 g. Bz₂O₂ in 15 mL. CCl₄ refluxed 18 h. gave 4 fractions: (a) 1.5 g. PhCH₂Cl, b. 40-80°, n²_D^3.5 1.5240; (b) 0.8 g., b. 80-90°, n²_D^3.5 1.5070; (c) 0.95 g., b. 90-110°, n²3.5_D 1.4770; and (d) 4.2 g. di-Et trichloromethylphosphonate (IV), b. 120-30°; n²_D³⁰⁵ 1.4620. Fractions (b) and (c) were mixtures of PhCH₂Cl and IV. Bz₂O₂ (0.44 g.) and 10 g. III in 24 g. CCl₄ refluxed 18 h. and evaporated gave a residue, shown by gas chromatog. to contain no Ia. A portion (50%) of the residue distilled gave an unsaturated oil, b₁₂ 90-105°, n²_D⁰ 1.5208, a 53:47 mixture of 2-methyl-1-phenylpropene and 2-methyl-3-phenylpropene. Distillation of a further portion, attempted at 10^-4 mm., gave an oil, b. 110°, n²_D⁴ 1.5080. Some decomposition occurred and the product was formulated as impure β,β-dimethylphenethyl Et trichloromethylphosphonate. Et₃PO₃ (5 g.) and 0.05 mol Bz₂O₂ in 15 g. CCl₄ refluxed 18 h. gave 6.85 g. IV. In a similar experiment, in which CCl₄ that had been passed through Al₂O₃ was used and the reaction carried out in the dark without Bz₂O₂, 6.94 g. IV was obtained. Ph₃PO₃ did not react with CCl₄ or BrCCl₃ under either of the above sets of conditions. The rate of disappearance of Et₃PO₃ on reaction with CCl₄ at 80° was determined by following the reaction by gas-liquid chromatog. The first-order rate constant was 2.2 × 10^-4 sec.^-1. The experiment was repeated in the presence of Bz₂O₂ to give a rate constant of 3.5 × 10^-4 sec.^-1 Et₃PO₃ (5 g.) and 15 mL. CCl₄ degassed and irradiated 1 h. at room temperature in a quartz flask with ultraviolet light gave 70% IV. Et₃PO₃ and CCl₄ did not react in the dark at room temperature in 7 h. tert-Bu₂O₂ (3.7 g.) in 18.4 g. PhMe and 31.1 g. CCl₄ was heated 48 h. at 130° in a sealed tube and the product separated into 2 fractions. Fraction (a) by gas-liquid chromatog. was shown to be largely PhCH₂Cl and fraction (b) of 1.2 g., was PhCH₂CH₂Ph with an unidentified component, possibly PhCH₂CCl₃. Bis(9-benzyl-9-fluorenyl) peroxide (0.5 g.), m. 170.0-0.5°, was heated 48 h. at 130° in a sealed tube with 2.2 mL. CCl₄ and 2 mL. C₆H₆; gas chromatog. showed the presence of (PhCH₂)₂ and PhCH₂Cl. Et₃PO₃ (8.3 g.), 15.4 g. CCl₄, 9 g. butane-1-thiol, and 0.61 g. Bz₂O₂ refluxed overnight, evaporated, and the 10.8-g. residue gas-chromatographed indicated tri-Et phosphorothionate, 18%; IV, 22%; and S-Bu di-Et phosphorothioate, 60%. Irradiation of 3.18 g. I in 15 mL. CCl₄ under N at room temperature 4 h. followed by fractionation, gave 0.70 g. PhCH₂Cl and 1.27 g. IV and left 1.8 g. of residue. Their nature was confirmed by IR spectra.

Journal of the Chemical Society published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, COA of Formula: C5H10Cl3O3P.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Robertson, Jeremy published the artcileSynthesis and Claisen rearrangement of bridged bicyclic enol ethers of relevance to the course of ketene s-cis-diene cycloaddition, Name: Diethyltrichloromethylphosphonate, the publication is Organic & Biomolecular Chemistry (2006), 4(23), 4307-4318, database is CAplus and MEDLINE.

The synthesis is described of a range of 3-alkylidene-2-oxabicyclo[2.2.1]hept-5-ene and 3-alkylidene-2-oxabicyclo[2.2.2]oct-5-ene derivatives; Claisen rearrangement of these substrates either thermally or in the presence of an added Lewis acid results in the formation of bicyclic cyclobutanones with generally good conversions. These reactions may be performed in hydroxylic solvents, supporting a largely non-dissociative pathway for the rearrangement.

Organic & Biomolecular Chemistry published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, Name: Diethyltrichloromethylphosphonate.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Jubault, P. published the artcileElectrochemical activation of magnesium: a new, rapid and efficient method for the electrosynthesis of 1,1-dichloroalkylphosphonates from diisopropyl trichloromethylphosphonate, Recommanded Product: Diethyltrichloromethylphosphonate, the publication is Tetrahedron Letters (1995), 36(39), 7073-6, database is CAplus.

Various diisopropyl 1,1-dichloroalkylphosphonates, e.g., (Me₂CHO)₂P(O)CCl₂(CH₂)₅Me, were easily and rapidly prepared under mild conditions, by electrolyzing, in DMF medium, diisopropyl trichloromethylphosphonate in the presence of alkylating reagents. The use of an electrochem. activated Mg anode significantly improved the rate and the yield of the reaction.

Tetrahedron Letters published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, Recommanded Product: Diethyltrichloromethylphosphonate.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Wu, Fengshou published the artcileRecyclable Silica-Supported Iridium Bipyridine Catalyst for Aromatic C-H Borylation, Quality Control of 408492-29-5, the publication is ACS Catalysis (2014), 4(5), 1365-1375, database is CAplus.

A mesoporous SiO₂ (SBA-15)-supported bipyridine Ir complex was prepared by grafting of bipyridine onto the SiO₂ support, followed by complexation of [Ir(I)(COD)(OMe)]₂ precursor in the presence of HBpin and cyclooctene. Structural analyses by x-ray powder diffraction, N physisorption, FTIR, and solid-state NMR spectroscopy demonstrate that the 3-dimensional, hexagonal pore structure of SBA-15 is maintained after the immobilization. In particular, as a heterogeneous catalyst, this SiO₂-supported Ir complex shows moderate to good catalytic activity in the aromatic C-H borylation of a variety of substrates. More importantly, the heterogeneous catalyst is recovered easily and reused repeatedly by simple washing without chem. treatment and exhibits good recycling performance with a modest decrease in the catalytic rate, showing good potential for increasing the overall turnover number of this synthetically useful catalyst.

ACS Catalysis published new progress about 408492-29-5. 408492-29-5 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Ester,Boronate Esters,Boronate Esters,Boronic acid and ester,, name is Methyl 3-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate, and the molecular formula is C8H6ClF3, Quality Control of 408492-29-5.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics