Tag: M.W=250-300

Suzuki, Nobutaka published the artcilePhotochemical type I and II elimination reactions of dialkyl (trichloromethyl)phosphonates, Computed Properties of 866-23-9, the publication is Bulletin of the Chemical Society of Japan (1980), 53(5), 1421-4, database is CAplus.

Irradiation of CCl₃P(O)(OR)₂ (I; R = Et, Pr, CH₂CHMe₂) in MeCN gave the corresponding monoesters and olefins via photochem. type-II elimination. In addition, products via type-I elimination were obtained from I (R = Me, CH₂CHMe₂).

Bulletin of the Chemical Society of Japan published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H6BNO2, Computed Properties of 866-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

DeShong, Philip published the artcileIntermolecular and intramolecular azomethine ylide [3 + 2] dipolar cycloadditions for the synthesis of highly functionalized pyrroles and pyrrolidines, Safety of 2,3-Dibromopropionylchloride, the publication is Journal of Organic Chemistry (1985), 50(13), 2309-15, database is CAplus.

N-Alkyl and N-arylaziridines carrying a single carboxy ester function, e.g., I, undergo thermally induced electrocyclic ring opening to produce azomethine ylides, which subsequently react with acetylenes or olefins to yield substituted pyrroles, e.g., II, or pyrrolidines, e.g., III, resp. The [3 + 2] dipolar cycloaddition reaction can be performed in either an intermol. or intramol. mode and displays high regioselectivity and stereoselectivity with a variety of dipolarophiles. The yield of cycloadducts depends on the electronic characteristics and the substitution pattern of the dipolarophile, and on the mode of cycloaddition employed. In the intermol. reaction, the yield of adducts is poor unless the dipolarophile is activated. Intramol. cycloadditions with monosubstituted olefins or acetylenes give adducts in yields of 45-70%. Although the yields of adducts in these instances are moderate, the starting materials are readily prepared and the method is an effective means for the assembly of a structurally complex heterocyclic system with high regiochem. and stereochem. control of peripheral substituents. When the dipolarophilic component is disubstituted, the cycloaddition gives synthetically useful yields if the dipolarophile carries an electron-withdrawing functionality.

Journal of Organic Chemistry published new progress about 18791-02-1. 18791-02-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 2,3-Dibromopropionylchloride, and the molecular formula is C3H3Br2ClO, Safety of 2,3-Dibromopropionylchloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Goldberg, Frederick W. published the artcileGeneral synthetic strategies towards N-alkyl sulfoximine building blocks for medicinal chemistry and the use of dimethylsulfoximine as a versatile precursor, SDS of cas: 7080-50-4, the publication is Tetrahedron (2014), 70(37), 6613-6622, database is CAplus.

The sulfoximine group has great potential as a substituent in drug discovery, as evidenced by two new clin. candidates, and can be viewed as an isosteric alternative to the commonly used sulfone. Our aim was to improve the accessibility of this group by synthesizing a diverse range of S-alkyl and N-alkyl sulfoximine building blocks with procedures that are applicable on a practical scale (>10 g). In particular, synthesis of the less well exploited N-alkyl sulfoximines and the use of dimethylsulfoximine as a versatile, com. available precursor is discussed.

Tetrahedron published new progress about 7080-50-4. 7080-50-4 belongs to chlorides-buliding-blocks, auxiliary class Halogenation Reagent,Inhibitor, name is Sodium chloro(tosyl)amide trihydrate, and the molecular formula is C7H13ClNNaO5S, SDS of cas: 7080-50-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zaib, Sumera published the artcileEvaluation of indole-picolinamide hybrid molecules as carbonic anhydrase-II inhibitors: Biological and computational studies, HPLC of Formula: 32333-53-2, the publication is Journal of Molecular Structure (2022), 133048, database is CAplus.

The present study reported the successful synthesis and evaluation of a series of indole-picolinamide hybrids I, II [Ar = Ph, 3-CF₃C₆H₄, 3,4-di-ClC₆H₃], III, IV and V as potent inhibitors of bovine carbonic anhydrase II, a promising therapeutic target for the treatment of neurol. disorders, osteoporosis, glaucoma, cancer and obesity. Various multistep synthetic approaches were utilized to access the desired structures having exclusive sites for chem. modifications and diverse spots for biol. interactions between the ligand and enzyme. Compound I was observed as a potent inhibitor of the bovine CA-II with an IC₅₀ value of 0.0440 ± 0.009μM. The inhibition potency was about 22-fold higher than the standard drug acetazolamide (IC₅₀ = 0.9618 ± 0.180μM). Several relevant structure-activity relationships were deduced that enlighten the crucial role of substituents as well as the key pharmacophores involved in the inhibition process. Mol. docking tools reinforced the in vitro assay results. The most active compound I was also investigated for anticancer potential using sulforhodamine B assay and results showed two-fold efficacy against HeLa cells when compared to standard drug cisplatin (IC₅₀ = 8.045 ± 3.791μg/mL and 4.128 ± 1.473μg/mL, resp.). These findings were also confirmed by flow cytometry and comet tests. Moreover, fluorescence microscopy with DAPI staining revealed apoptosis as a mechanism of cancer cell death.

Journal of Molecular Structure published new progress about 32333-53-2. 32333-53-2 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Sulfonyl chlorides,Benzene, name is 4-Chloro-3-(trifluoromethyl)benzenesulfonyl Chloride, and the molecular formula is C7H3ClINS, HPLC of Formula: 32333-53-2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Okawara, Tadashi published the artcileA facile preparation of 4-thiazolone derivatives from thioamides and various haloacyl halides in a biphase system, Category: chlorides-buliding-blocks, the publication is Chemical & Pharmaceutical Bulletin (1985), 33(8), 3479-83, database is CAplus.

The reaction of thioamides with various haloacyl halides was carried out in saturate NaHCO₃-CH₂Cl₂ and 5% NaOH-CH₂Cl₂ to give several kinds of 4-thiazolones, e.q. I, thiazin-4-one II, and spiro compounds, e.g. III. Thus, PhCSNH₂ was treated with BrCH₂CO₂Br in satd NaHCO₃-CH₂Cl₂ to give 62% I.

Chemical & Pharmaceutical Bulletin published new progress about 18791-02-1. 18791-02-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 2,3-Dibromopropionylchloride, and the molecular formula is C3H3Br2ClO, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Guo, You-Yuan published the artcileSynthesis, crystal structure, and herbicidal activity of 3-(2-chloro-6-fluorophenyl)-4-(2-oxooxazolidine-3-carbonyl)-5-methylisoxazole, Computed Properties of 3919-74-2, the publication is Indian Journal of Heterocyclic Chemistry (2020), 30(4), 503-508, database is CAplus.

A novel N-aroyl diketone derivative, I (C₁₄H₁₀ClFN₂O₄, Mr = 324.69), was designed via fragment anal. and coupling strategy that led to highly potent and bio-selective herbicide. The title compound I was prepared by a multistep-reaction, including nucleophilic addition and N-acylation reaction using 2-chloro-6-fluorobenzaldehyde as the starting materials in 83.4% yield. The title compound I crystallized in the monoclinic system, space group P2₁/n with a = 10.7119(4) Å, b = 17.5875(7) Å, c = 11.5151(7) Å, β = 100.927(2)°, Z = 8, V = 2870.0(2) ų, F(000) = 1328, D_c = 1.503 Mg/m³, crystal size: 0.130 x 0.120 x 0.100 mm. The herbicidal activity was tested against the gramineous weed Echinochloa crus-galli and broadleaf Abutilon juncea.

Indian Journal of Heterocyclic Chemistry published new progress about 3919-74-2. 3919-74-2 belongs to chlorides-buliding-blocks, auxiliary class Isoxazole,Fluoride,Chloride,Carboxylic acid,Benzene, name is 3-(2-Chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylic acid, and the molecular formula is C11H7ClFNO3, Computed Properties of 3919-74-2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Ma, Jia published the artcileDiscovery of novel indole and indoline derivatives against Candida albicans as potent antifungal agents, Safety of 4-Chloro-3-(trifluoromethyl)benzenesulfonyl Chloride, the publication is Bioorganic & Medicinal Chemistry Letters (2022), 128826, database is CAplus and MEDLINE.

With the widespread use of azole antifungals in the clinic, the drug resistance has been emerging continuously. In this work, we have designed and prepared a series of novel indole and indoline derivatives, and in vitro antifungal activity against C. albicans were evaluated. The results showed that title compounds exhibited good antifungal effect on Azole-resistant C. albicans. Further mechanism study demonstrated that S18 could inhibit the biofilm formation and hyphae growth of C. albicans through the Ras-cAMP-PKA signaling pathway.

Bioorganic & Medicinal Chemistry Letters published new progress about 32333-53-2. 32333-53-2 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Sulfonyl chlorides,Benzene, name is 4-Chloro-3-(trifluoromethyl)benzenesulfonyl Chloride, and the molecular formula is C7H3Cl2F3O2S, Safety of 4-Chloro-3-(trifluoromethyl)benzenesulfonyl Chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Niswender, Colleen M. published the artcileContext-dependent pharmacology exhibited by negative allosteric modulators of metabotropic glutamate receptor, COA of Formula: C11H7ClFNO3, the publication is Molecular Pharmacology (2010), 77(3), 459-468, database is CAplus and MEDLINE.

Phenotypic studies of mice lacking metabotropic glutamate receptor subtype 7 (mGluR7) suggest that antagonists of this receptor may be promising for the treatment of central nervous system disorders such as anxiety and depression. Suzuki et al. recently reported the in vitro characterization of a novel mGluR7 antagonist called 6-(4-methoxyphenyl)-5-methyl-3-(4-pyridinyl)-isoxazolo[4,5-c]pyridin-4(5H)-one (MMPIP), which noncompetitively inhibited the activity of orthosteric and allosteric agonists at mGluR7. We describe that MMPIP acts as a noncompetitive antagonist in calcium mobilization assays in cells coexpressing mGluR7 and the promiscuous G protein Gα₁₅. Assessment of the activity of a small library of MMPIP-derived compounds using this assay reveals that, despite similar potencies, compounds exhibit differences in neg. cooperativity for agonist-mediated calcium mobilization. Examination of the inhibitory activity of MMPIP and analogs using endogenous G_i/o-coupled assay readouts indicates that the pharmacol. of these ligands seems to be context-dependent, and MMPIP exhibits differences in neg. cooperativity in certain cellular backgrounds. Electrophysiol. studies reveal that, in contrast to the orthosteric antagonist (2S)-2-amino-2-[(1S,2S)-2-carboxyclycloprop-1-yl]-3-(xanth-9-yl) propanoic acid (LY341495), MMPIP is unable to block agonist-mediated responses at the Schaffer collateral-CA1 synapse, a location at which neurotransmission has been shown to be modulated by mGluR7 activity. Thus, MMPIP and related compounds differentially inhibit coupling of mGluR7 in different cellular backgrounds and may not antagonize the coupling of this receptor to native G_i/o signaling pathways in all cellular contexts. The pharmacol. of this compound represents a striking example of the potential for context-dependent blockade of receptor responses by neg. allosteric modulators.

Molecular Pharmacology published new progress about 3919-74-2. 3919-74-2 belongs to chlorides-buliding-blocks, auxiliary class Isoxazole,Fluoride,Chloride,Carboxylic acid,Benzene, name is 3-(2-Chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylic acid, and the molecular formula is C11H7ClFNO3, COA of Formula: C11H7ClFNO3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Bakkas, Salem published the artcileReactivity of triethyl phosphite with tetrachloromethane: electron transfer versus ionic substitution on positive halogen, SDS of cas: 866-23-9, the publication is Tetrahedron (1987), 43(3), 501-12, database is CAplus.

The mechanism of the reaction of P(OEt)₃ (I) with CCl₄ (II) was studied. I reacts at 80° with II to form mostly (EtO)₂P(O)CCl₃ and EtCl. Trichloromethyl radical is trapped by BHT. The reaction is initiated by UV light (254 nm) and a charge-transfer complex is formed between I and II, and the reaction is inhibited by TCNQ. Tris(cyclopropylmethyl) phosphite and tri(1-hexene-6-yl) phosphite are used as potential radical clocks in these reactions. The first leads to CH₂:CHCHClMe and the second to CH₂:CHCH₂CH₂CHClMe. The first suggests a radical mechanism (but also may be rationalized by an ionic mechanism), but not the second. Electrochem. oxidation of I with added CCl₄ does not account for a radical chain process as the main pathway. Marcus anal. of the reaction viewed as an electron transfer gives a calculated rate constant in the range of 10^-20 M^-1s^-1. Thus, the thermal reaction is in fact an S_NCl⁺ substitution. The radical intermediates are derived from the electron-transfer reaction between CCl₃^– and CCl₄. The reaction of I with II is an example where the observed paramagnetic species during a donor (D)/acceptor (A) interaction suggests an electron-transfer between D and A where in fact they originate from an interaction between A and an electron donor formed after or during the first step of the reaction.

Tetrahedron published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, SDS of cas: 866-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Abhishek, Verma published the artcileMechanistic aspect of Iridium(III) catalyzed oxidation of ethylene glycol by Chloramine-T in aqueous acidic medium: a kinetic model, Formula: C7H13ClNNaO5S, the publication is G P Globalize Research Journal of Chemistry (2018), 1(2), 107-115, database is CAplus.

The kinetic investigation of homogeneously Ir(III) chloride catalyzed oxidation of Ethylene glycol by Chloramine- T [CAT] in perchloric acid medium has been carried out in the temperature range of 30 to 45°C. The reaction was carried out in the presence of mercuric acetate as a scavenger for chloride ion. The reaction exhibits first order kinetics with respect to the oxidant [CAT] and catalyst [Ir(III)] while zero order with respect to substrate, i.e., Ethylene glycol (EG) was observed The reaction shows negligible effect of [Hg(OAc)₂], [H⁺] and ionic strength of the medium. Chloride ion pos. influenced the rate of reaction. The various activation parameters have been calculated from the rate measurements at different temperatures (30 to 45°C). The product of the reaction has been identified as the corresponding monocarboxylic acid. The reaction between Chloramine-T and Ethylene glycol in acid medium shows 2:1 stoichiometry. On the basis of kinetic studies, reaction stoichiometry and product anal., a suitable mechanism has been proposed and rate law has been derived.

G P Globalize Research Journal of Chemistry published new progress about 7080-50-4. 7080-50-4 belongs to chlorides-buliding-blocks, auxiliary class Halogenation Reagent,Inhibitor, name is Sodium chloro(tosyl)amide trihydrate, and the molecular formula is C7H13ClNNaO5S, Formula: C7H13ClNNaO5S.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics