Tag: M.W=250-300

Adams, H. Jack published the artcilePrimary local anesthetic testing and acute toxicity of N,N’-disubstituted 2,3-diamino-2′,6′-propionoxylidides, SDS of cas: 18791-02-1, the publication is Journal of Pharmaceutical Sciences (1973), 62(10), 1677-9, database is CAplus and MEDLINE.

The local anesthetic activity of the 8 N,N’-disubstituted-2,3-diamino-2′,6′-propionoxylidides (I) and 1-tert-butyl-2-aziridinecarboxy-2′,6′-xylidide (II) [50603-33-3] which were prepared fell between that of lidocaine-HCl [73-78-9] and tetracaine-HCl [136-47-0]. None of the compounds possessed the long duration of tetracaine in the guinea pig wheal. All the compds were more toxic than tetracaine i.p. in the mouse and except for II they were less irritating than tetracaine in the rabbit intradermal wheal.

Journal of Pharmaceutical Sciences published new progress about 18791-02-1. 18791-02-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 2,3-Dibromopropionylchloride, and the molecular formula is C3H3Br2ClO, SDS of cas: 18791-02-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Majewski, Piotr published the artcileSynthesis of Dichloromethylphosphonates, SDS of cas: 866-23-9, the publication is Phosphorus, Sulfur and Silicon and the Related Elements (2009), 184(4), 956-962, database is CAplus.

Efficient synthesis of O,O-dialkyl, O-alkyl-N,N-dialkylamido and N,N,N’,N’-tetraalkyldiamido dichloromethylphosphonates via treatment of O,O-dialkyl, O-alkyl-N,N-dialkylamido, and N,N,N’,N’-tetraalkyldiamido trichloromethylphosphonates with di-Et phosphite in the presence of triethylamine in ethanol has been described.

Phosphorus, Sulfur and Silicon and the Related Elements published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, SDS of cas: 866-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Gioti, Efthymia G. published the artcileA new scalable synthesis of entecavir, Application In Synthesis of 7080-50-4, the publication is Tetrahedron (2018), 74(4), 519-527, database is CAplus.

A new synthesis of entecavir from D-glucose in an average total yield of 3.5% was achieved via an intramol. nitrile oxide cycloaddition (INOC) reaction and a Peterson olefination as key-steps. The present process was designed for industrial application, using widely available raw materials, simple and cheap reagents and avoiding low reaction temperatures, which are very common in the synthetic approaches towards similarly complex structures.

Tetrahedron published new progress about 7080-50-4. 7080-50-4 belongs to chlorides-buliding-blocks, auxiliary class Halogenation Reagent,Inhibitor, name is Sodium chloro(tosyl)amide trihydrate, and the molecular formula is C7H13ClNNaO5S, Application In Synthesis of 7080-50-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Sasano, Yusuke published the artcile2-Azaadamantane N-oxyl (AZADO)/Cu Catalysis Enables Chemoselective Aerobic Oxidation of Alcohols Containing Electron-Rich Divalent Sulfur Functionalities, Category: chlorides-buliding-blocks, the publication is Organic Letters (2018), 20(19), 6104-6107, database is CAplus and MEDLINE.

The chemoselective oxidation of alcs. containing electron-rich sulfur functionalities (e.g., 1,3-dithianes and sulfides) into their corresponding carbonyl compounds with the sulfur groups can sometimes be a demanding task in modern organic chem. A reliable method for this transformation, which features azaadamantane-type nitroxyl radical/copper catalysis using ambient air as the terminal oxidant is reported. The superiority of the developed method was demonstrated by comparing it with various conventional alc. oxidation methods.

Organic Letters published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C10H15ClO3S, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Theodorou, Alexis published the artcileGreen Organocatalytic Synthesis of Indolines and Pyrrolidines from Alkenes, SDS of cas: 21286-54-4, the publication is Advanced Synthesis & Catalysis (2017), 359(9), 1577-1581, database is CAplus.

Employing a green and efficient 2,2,2-trifluoroacetophenone-catalyzed oxidation of alkenes, which utilized H₂O₂ as the green oxidant, a novel and sustainable synthesis of indolines and pyrrolidines was developed. This constituted a cheap, general and environmentally-friendly protocol for the synthesis of substituted nitrogen-containing heterocycles. A variety of substitution patterns, both aromatic and aliphatic moieties, were well tolerated led to the desired nitrogen heterocycles in good to excellent yields.

Advanced Synthesis & Catalysis published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C5H5ClO2, SDS of cas: 21286-54-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Swain, Asim kumar published the artcileC₂– and C₁-Symmetric Configurationally Stable Pyrene-Fused [5]Helicenes Connected via Hexagonal and Heptagonal Rings, Quality Control of 21286-54-4, the publication is Organic Letters (2021), 23(4), 1339-1343, database is CAplus and MEDLINE.

In this paper, we describe the stereospecific synthesis and functional properties of C₂– and C₁-sym. pyrene-fused [5]helicene mols. 1 and 2 connected via hexagonal and heptagonal rings, resp. Both mols. showed high configurational stability and distinct functional properties, which were attributed to the fusing mode of [5]helicene with the pyrene and mol. symmetry. The estimated Gibbs activation energy for enantiomerization of 2 is one of the highest reported values for any π-conjugated mols. incorporating [5]helicene moiety.

Organic Letters published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C12H14BNO2, Quality Control of 21286-54-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Kalcic, Filip published the artcilePolysubstituted Pyrimidines as mPGES-1 Inhibitors: Discovery of Potent Inhibitors of PGE₂ Production with Strong Anti-inflammatory Effects in Carrageenan-Induced Rat Paw Edema, Application of (4-((2-Chlorobenzyl)oxy)-3,5-dimethylphenyl)boronic acid, the publication is ChemMedChem (2020), 15(15), 1398-1407, database is CAplus and MEDLINE.

We report an extensive structure-activity relationship optimization of polysubstituted pyrimidines that led to the discovery of 5-butyl-4-(4-benzyloxyphenyl)-6-phenylpyrimidin-2-amine, and its difluorinated analog. These compounds are sub-micromolar inhibitors of PGE₂ production (IC₅₀ as low as 12 nM). In order to identify the mol. target of anti-inflammatory pyrimidines, we performed extensive studies including enzymic assays, homol. modeling and docking. The difluorinated analog simultaneously inhibits two key enzymes of the arachidonic acid cascade, namely mPGES-1 and COX-2, with mPGES-1 inhibition being the principal mechanism of action. Other pyrimidines studied are potent mPGES-1 inhibitors with no observed inhibition of COX-1/2 enzymes. Moreover, the two most potent compounds proved to be significantly effective in vivo in a model of acute inflammation, suppressing carrageenan-induced rat paw edema by 36 and 46%. The promising results of this study warrant further preclin. evaluation of selected anti-inflammatory candidates.

ChemMedChem published new progress about 849052-15-9. 849052-15-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Ether,Boronic Acids,Boronic Acids,Boronic acid and ester,, name is (4-((2-Chlorobenzyl)oxy)-3,5-dimethylphenyl)boronic acid, and the molecular formula is C15H16BClO3, Application of (4-((2-Chlorobenzyl)oxy)-3,5-dimethylphenyl)boronic acid.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Kalcic, Filip published the artcilePolysubstituted Pyrimidines as mPGES-1 Inhibitors: Discovery of Potent Inhibitors of PGE₂ Production with Strong Anti-inflammatory Effects in Carrageenan-Induced Rat Paw Edema, SDS of cas: 870778-91-9, the publication is ChemMedChem (2020), 15(15), 1398-1407, database is CAplus and MEDLINE.

We report an extensive structure-activity relationship optimization of polysubstituted pyrimidines that led to the discovery of 5-butyl-4-(4-benzyloxyphenyl)-6-phenylpyrimidin-2-amine, and its difluorinated analog. These compounds are sub-micromolar inhibitors of PGE₂ production (IC₅₀ as low as 12 nM). In order to identify the mol. target of anti-inflammatory pyrimidines, we performed extensive studies including enzymic assays, homol. modeling and docking. The difluorinated analog simultaneously inhibits two key enzymes of the arachidonic acid cascade, namely mPGES-1 and COX-2, with mPGES-1 inhibition being the principal mechanism of action. Other pyrimidines studied are potent mPGES-1 inhibitors with no observed inhibition of COX-1/2 enzymes. Moreover, the two most potent compounds proved to be significantly effective in vivo in a model of acute inflammation, suppressing carrageenan-induced rat paw edema by 36 and 46%. The promising results of this study warrant further preclin. evaluation of selected anti-inflammatory candidates.

ChemMedChem published new progress about 870778-91-9. 870778-91-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Ether,Boronic Acids,Boronic Acids,Boronic acid and ester,, name is (4-((4-Chlorobenzyl)oxy)phenyl)boronic acid, and the molecular formula is C13H12BClO3, SDS of cas: 870778-91-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Gabov, N. I. published the artcileThin-layer chromatography of chloromethylphosphonic acid esters, SDS of cas: 866-23-9, the publication is Zhurnal Analiticheskoi Khimii (1975), 30(5), 1024-7, database is CAplus.

The methyl hexyl ketone-Me2CO-heptane (4:1:5) system ensures effective thin-layer chromatog. separation (on silufol plates) of normal esters of methylphosphonic and chloromethylphosphoacids. There is a linear correlation between the Rf values and the number of Cl atoms in the chloromethyl radical. A procedure was developed for the identification of 32P-labeled chloromethylphosphonic acid esters in CCl4 and CHCl3 mixtures with PrOH produced by hot-atom reactions of 32P.

Zhurnal Analiticheskoi Khimii published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, SDS of cas: 866-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Li, Gao-Qiang published the artcileDirect conversion of pinacol arylboronic esters to aryl triolborates, SDS of cas: 408492-29-5, the publication is Chemistry Letters (2011), 40(7), 702-704, database is CAplus.

Conversion of pinacol arylboronic esters to aryl triolborates via transesterification with 1,1,1-tris(hydroxymethyl)ethane was established with the advantages of tolerance to various functional groups. Transesterification was carried out at 30-60° in dioxane in the presence of MOH (M = Na and K) and H₂O. High yields were achieved for stable aryl triolborates.

Chemistry Letters published new progress about 408492-29-5. 408492-29-5 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Ester,Boronate Esters,Boronate Esters,Boronic acid and ester,, name is Methyl 3-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate, and the molecular formula is C14H18BClO4, SDS of cas: 408492-29-5.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics