Tag: M.W=250-300

Sanin, P. I. published the artcileAntiwear additives of phosphonate type, Application of Diethyltrichloromethylphosphonate, the publication is Neftekhimiya (1974), 14(2), 317-22, database is CAplus.

The effectiveness of esters of phosphonic acids depended on their structure and on the friction regime. The esters containing no Cl had no effect at high and low loads. Those containing CCl3 groups were effective at both high and low loads or only at high and only at low ones. The difference was assumed to be due to different chem. and adsorption activity of the compounds and chem. modification of the friction surface. The effectiveness depended on the concentration of additive (1.5-6 mmole/100 g oil).

Neftekhimiya published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, Application of Diethyltrichloromethylphosphonate.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Hrdina, R. published the artcileIron complexes of reactive azo dyes, Related Products of chlorides-buliding-blocks, the publication is Advances in Colour Science and Technology (2004), 7(1), 6-17, database is CAplus.

A set of reactive mordant azo dyes was prepared by diazotization of aromatic amines and their subsequent coupling reaction with secondary components. The reactive dyes thus formed contained 2-sulfatoethylsulfonyl (-SO₂CH₂CH₂OSO₃Na), N-methyl-N-carboxymethyl-2-aminoethylsulfonyl (-SO₂CH₂CH₂NMeCH₂CO₂H) and 2,3-dibromopropionamidyl (-NHCOCHBrCH₂Br) reactive groups capable of liberating reactive vinyl groups in the application dyebath. Neg.-ion electrospray ionization mass spectrometry, UV/visible spectroscopy, and elemental anal. confirmed the structure of the prepared dyes. Dyed wool fabric samples (combination of acid and reactive dyeing conditions) were treated (mordanted) with iron salts (FeCl₂, FeCl₃) and a comparison chromium salt (CrF₃). The iron mordant dyeing showed acceptable wash fastness and light fastness comparable with chromium complexed dyes.

Advances in Colour Science and Technology published new progress about 18791-02-1. 18791-02-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 2,3-Dibromopropionylchloride, and the molecular formula is C3H3Br2ClO, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Mciteka, Lulama P. published the artcileSynthesis of camphor-derived chiral auxiliaries and their application in asymmetric Morita-Baylis-Hillman reactions, Product Details of C10H15ClO3S, the publication is ARKIVOC (Gainesville, FL, United States) (2016), 151-163, database is CAplus.

N-Substituted 2-exo-hydroxybornyl-10-sulfonamides, prepared as potential chiral auxiliaries for use in asym. Morita-Baylis-Hillman (MBH) reactions, were treated with acryloyl chloride to afford the corresponding 2-exo-acrylate esters as MBH substrates. Reaction of selected 2-exo-acrylate ester substrates with pyridine-4-carbaldehyde and 6-methylpyridine-2-carbaldehyde in the presence of DABCO gave the expected MBH adducts in >91% yield and with diastereoselectivities of 7-33% d.e.

ARKIVOC (Gainesville, FL, United States) published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C10H15ClO3S, Product Details of C10H15ClO3S.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Hanson, J. C. published the artcileDerivatives of 6-aminopenicillanic acid. VIII. Further analogs of 3-o-chlorophenyl-5-methyl-4-isoxazolylpenicillin, Recommanded Product: 3-(2-Chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylic acid, the publication is Journal of the Chemical Society (1965), 5976-83, database is CAplus.

cf. CA 60, 5475c. Various analogs of 3-o-chlorophenyl-5-methylisoxazole-4-carboxylic acid containing addnl. substituents in the benzene ring have been synthesized. Chlorides of these acids, together with certain other dihalogen derivatives of 5-methyl-3-phenyl- and 3-methyl-5-phenylisoxazole-4-carbonyl chlorides, were condensed with 6-aminopenicillanic acid to give new penicillins with useful anti-bacterial properties.

Journal of the Chemical Society published new progress about 3919-74-2. 3919-74-2 belongs to chlorides-buliding-blocks, auxiliary class Isoxazole,Fluoride,Chloride,Carboxylic acid,Benzene, name is 3-(2-Chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylic acid, and the molecular formula is C11H7ClFNO3, Recommanded Product: 3-(2-Chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylic acid.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Yang, De-Yong published the artcilePhotoredox Catalyzed Radical Cascade Aroylation (Sulfonylation)/Cyclization Enables Access to Fused Indolo-pyridones, Recommanded Product: ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, the publication is Journal of Organic Chemistry (2021), 86(24), 18042-18055, database is CAplus and MEDLINE.

A visible-light-initiated radical cascade reaction toward the synthesis of structurally diverse fused indolo-pyridones is described. The reaction involves the addition of aroyl or sulfonyl radicals to N-alkyl-acryloyl-1H-indole-3-carboxamides, cyclization, and oxidative aromatization. This telescoped method circumvents lengthy prefunctionalization steps of radical precursors, which is further underpinned by the superior compatibility with a series of C-centered radicals, allowing the rapid and facile construction of numerous valuable architectures.

Journal of Organic Chemistry published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C9H22OSi, Recommanded Product: ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Wang, Yan-Xiang published the artcileSynthesis and identification of novel berberine derivatives as potent inhibitors against TNF-α-induced NF-κB activation, Name: ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, the publication is Molecules (2017), 22(8), 1257/1-1257/14, database is CAplus and MEDLINE.

Twenty-three new berberine (BBR) analogs containing substituents on ring D, I [R¹ = OMe, NH₂, cyclopropanecarbonyloxy, (4-nitrophenyl)sulfonyloxy, etc., R² = OMe, (adamantan-1-yl)acetoxy, (adamantane-10-carbonyloxy)], were synthesized and evaluated for their activity for suppression of tumor necrosis factor (TNF)-α-induced nuclear factor (NF)-κB activation. Structure-activity relationship (SAR) anal. indicated that suitable tertiary/quaternary carbon substitutions at the 9-position or a rigid fragment at position 10 might be beneficial for enhancing their anti-inflammatory potency. Among them, compounds I [R¹ = (1-methylcyclohexane-1-carbonyl)oxy, 2-(bicyclo[2.2.1]heptan-2-yl)acetoxy, (2′-propylpentanoyl)oxy, (p-tert-butylbenzoyl)oxy, R² = OMe] exhibited satisfactory inhibitory potency against NF-κB activation, with an inhibitory rate of around 90% (5 μM), much better than BBR. A preliminary mechanism study revealed that all of them could inhibit TNF-α-induced NF-κB activation via impairing IκB kinase (IKK) phosphorylation as well as cytokines interleukin (IL)-6 and IL-8 induced by TNF-α. Therefore, the results provided powerful information on further structural modifications and development of BBR derivatives into a new class of anti-inflammatory candidates for the treatment of inflammatory diseases.

Molecules published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C8H6ClN, Name: ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Kang, Tao published the artcileMicrowave assistant synthesis and crystal structures of two substituted oxazole isoxazole carboxamides, HPLC of Formula: 3919-74-2, the publication is Chinese Journal of Structural Chemistry (2020), 39(10), No pp. given, database is CAplus.

Two novel substituted Ph oxazole isoxazole carboxamides I was synthesized by microwave assistant technol. The target compounds were characterized by IR, ¹H NMR, ¹³C NMR and HRMS, and their single-crystal structures were further determined by X-ray diffraction. Compound I [R¹=R² = H; R³ = Me; R⁴ = isopropyl] crystallizes in monoclinic system, space group P21/c with a = 6.2137(12), b = 19.923(4), c = 13.748(3) Å, β = 92.30(3)°, V = 1700.6(6) Å3, Dc = 1.228 Mg/m3, Z = 4, F(000) = 672, μ(MoKα) = 0.084 mm-1, R = 0.0526 and wR = 0.1259. Compound I [R¹ = F; R² = Cl; R³ = Me, R⁴ = Et] crystallizes in triclinic system, space group P1̅ with a = 7.8750(16), b = 10.596(2), c = 11.725(12) Å, β = 102.05(3)°, V = 859.5(3) Å3, Dc = 1.363 Mg/m3, Z = 2, F(000) = 368, μ(MoKα) = 0.250 mm-1, R = 0.0738 and wR = 0.1941. Both of the mols. prefer to form crystal packing through C-H···O hydrogen bonds. Compounds I [R¹=R² = H; R³ = Me; R⁴ = Et] and [R¹ = F; R² = Cl; R³ = Me; R⁴ = Et] show safener activity on maize against the injury of chlorsulfuron.

Chinese Journal of Structural Chemistry published new progress about 3919-74-2. 3919-74-2 belongs to chlorides-buliding-blocks, auxiliary class Isoxazole,Fluoride,Chloride,Carboxylic acid,Benzene, name is 3-(2-Chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylic acid, and the molecular formula is C11H7ClFNO3, HPLC of Formula: 3919-74-2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Wang, Xin published the artcileControlling cyclization pathways in palladium(II)-catalyzed intramolecular alkene hydro-functionalization via substrate directivity, Safety of ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, the publication is Chemical Science (2020), 11(41), 11307-11314, database is CAplus and MEDLINE.

The palladium(II)-catalyzed, intramol. alkene hydrofunctionalization reactions with carbon, nitrogen, and oxygen nucleophiles formed five- and six-membered carbo- and heterocycles. In these reactions, the presence of a proximal bidentate directing group controlled the cyclization pathway, dictating the ring size that was generated, even in cases that are disfavored based on Baldwin’s rules and in cases where there is an inherent preference for an alternative pathway. DFT studied shed light on the origins of pathway selectivity in these processes.

Chemical Science published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C8H5F3O2S, Safety of ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Li, Zeqing published the artcileMicrowave-assisted, Ir-catalyzed aromatic C-H borylation, Name: 2-(3-Chloro-5-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, the publication is Research on Chemical Intermediates (2013), 39(4), 1917-1926, database is CAplus.

One-step conversions of 1,3-disubstituted benzenes to aryl boronates and 2,6-disubstituted pyridines to heteroaryl boronates are described. Microwave heating was used for all reactions. [(COD)Ir(μ-OMe)]₂ and 4,4′-di-tert-butyl-2,2′-bipyridine were used as catalysts, in Me tert-Bu ether. Acceleration of the rate of reaction was remarkable compared with that of same reaction under conventional heating conditions.

Research on Chemical Intermediates published new progress about 929626-16-4. 929626-16-4 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Ether,Boronic Acids,Boronate Esters, name is 2-(3-Chloro-5-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, and the molecular formula is C13H18BClO3, Name: 2-(3-Chloro-5-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Huang, Hong-Gui published the artcileTrifluoromethanesulfonyl azide as a bifunctional reagent for metal-free azidotrifluoromethylation of unactivated alkenes, Safety of ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, the publication is Chemical Science (2021), 12(9), 3210-3215, database is CAplus and MEDLINE.

A simple and metal-free method that rapidly provides these building blocks, e.g., I from abundant alkenes RR¹C=CR²R³ (R = 3-[(pyridin-3-yl)carbonyloxy]propyl, C₈H₁₇, CH₂C₆H₅, etc.; R¹ = H, Me, n-Pr; R² = R³ = H, Me) and trifluoromethanesulfonyl azide (N₃SO₂CF₃). This unprecedented two-component reaction employs readily available N₃SO₂CF₃ as a bifunctional reagent to concurrently incorporate both CF₃ and N₃ groups, which avoids the use of their expensive and low atom economic precursors. A wide range of functional groups, including bio-relevant heterocycles and amino acids, was tolerated. Application of this method was further demonstrated by scale-up synthesis (5 mmol), product derivatization to CF₃-containing medicinal chem. motifs, as well as late-stage modification of natural products, e.g., 5-(2,2,2-trifluoroethyl)pyrrolidin-2-one and drug derivatives

Chemical Science published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C10H15ClO3S, Safety of ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics