Tag: M.W=250-300

Dulski, Mateusz published the artcileDifferent route of hydroxide incorporation and thermal stability of new type of water clathrate: X-ray single crystal and Raman investigation, Safety of Sodium chloro(tosyl)amide trihydrate, the publication is Scientific Reports (2017), 7(1), 1-9, database is CAplus and MEDLINE.

Chlormayenite Ca₁₂Al₁₄O₃₂[₄Cl₂] (-vacancy) is partially hydrated micro porouss mineral with hydroxide groups situated at various crystallog. sites. There are few mechanisms describing its hydration. The first one assumes Cl^– substitution by OH^– at the center of the structural cages (W-site). The second one determines the converting a T1O₄ tetrahedron to a T1O₃(OH)₃ octahedron due to the replacement of oxygen at the O2 site by three OH-groups according to the scheme: (^O2O^2- + ^WCl^–) → 3 × ^O2aOH. The third mechanism, not considered so far in the case of zeolite-like minerals, includes the hydroxide incorporation in form of hydrogarnet defect due to the arrangement of tetrahedral (OH)₄ in vacant cages. This yields a strong hydrated phase containing even up to 35% of water more than in any currently known mineral applicable to Portland cement. Moreover, water mols. present in different structural cages are stable up to 355 K while dehydroxylation linked to the gradual loss of only 8% of OH^– groups according to 3^O2aOH^– → ^O2O^2- +^WOH^– + ^gH₂O occurs at temperature range from 355 K to 598 K.

Scientific Reports published new progress about 7080-50-4. 7080-50-4 belongs to chlorides-buliding-blocks, auxiliary class Halogenation Reagent,Inhibitor, name is Sodium chloro(tosyl)amide trihydrate, and the molecular formula is C7H13ClNNaO5S, Safety of Sodium chloro(tosyl)amide trihydrate.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Tan, Daniel A. published the artcileSynthesis of Distally-Bridged Chiral Resorcinarene Crowns, Category: chlorides-buliding-blocks, the publication is European Journal of Organic Chemistry (2020), 2020(35), 5695-5708, database is CAplus.

Our interest in the potential of chiral tetramethoxy-resorcinarene as agents for chiral recognition has led us to synthesize twelve distally-bridged chiral resorcinarene crowns. The fascinating architecture of these partially-enclosed chiral basket mols. is evident in the solid-state structures which have been determined by single-crystal X-ray crystallog. Moreover, the enantiomers of these chiral resorcinarene crowns have been resolved via diastereomeric resolution, with the absolute configuration of the diastereomers being determined by X-ray crystallog. This work enables further exploration of these enantio-pure chiral baskets as possible chiral resolving agents.

European Journal of Organic Chemistry published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C5H4N4, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Okawara, Tadashi published the artcileConvenient syntheses of cyclic carboxamides from α,β,γ,δ and ε-halocarboxamides under phase transfer conditions, COA of Formula: C3H3Br2ClO, the publication is Chemical & Pharmaceutical Bulletin (1982), 30(4), 1225-33, database is CAplus.

Piperazine-2,5-diones I (R = H, Me; R¹ = PhCH₂, Ph) were prepared by N-alkylation between two mols. of α-halocarboxamides RCHXCONHR¹ (same R, R¹; X = Cl, Br) in the presence of a phase transfer catalyst in yields of 64-88%. II (R=H, Me; R¹=H, Me, Br; R²=Ph, PhCH₂), III (Q= CH₂CH₂, o-, m-, and p-phenylene, p-C₆H₄SO₂C₆H₄–p), IV (R= H, Me; R¹= PhCH₂, Ph; n=1,2,3) were similarly synthesized by intramol. N-alkylation of the corresponding halocarboxamides under phase transfer conditions in 53-99 % yields.

Chemical & Pharmaceutical Bulletin published new progress about 18791-02-1. 18791-02-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 2,3-Dibromopropionylchloride, and the molecular formula is C3H3Br2ClO, COA of Formula: C3H3Br2ClO.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Roszkowski, Piotr published the artcileNovel (+)-3-carene derivatives and their application in asymmetric synthesis, COA of Formula: C7H13ClNNaO5S, the publication is Synthesis (2015), 47(4), 569-574, database is CAplus.

A simple synthetic procedure for the preparation of mono-N-tosylated 1,2-diamines derived from (+)-3-carene is described. (+)-3-Carene is transformed into the corresponding N-tosylaziridine using chloramine-T trihydrate. Subsequent ring-opening with NaN₃, followed by reduction of the azide function gives the optically pure mono-N-tosylated 1,2-diamine. This ligand is effective in asym. transfer hydrogenations of aromatic ketones. It can also be transformed into other chiral ligands by alkylation of the amino group for application in the addition of Et₂Zn to benzaldehydes.

Synthesis published new progress about 7080-50-4. 7080-50-4 belongs to chlorides-buliding-blocks, auxiliary class Halogenation Reagent,Inhibitor, name is Sodium chloro(tosyl)amide trihydrate, and the molecular formula is C7H13ClNNaO5S, COA of Formula: C7H13ClNNaO5S.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Raoufmoghaddam, Saeed published the artcileImportance of the Reducing Agent in Direct Reductive Heck Reactions, Synthetic Route of 21286-54-4, the publication is ChemCatChem (2018), 10(1), 266-272, database is CAplus.

The role of the reductant in the palladium N-heterocyclic carbene (NHC) catalyzed reductive Heck reaction and its effect on the mechanism of the reaction is reported. For the first time in this type of transformation, the palladium-NHC-catalyzed reductive Heck reaction was shown to proceed in the presence of LiOMe and iPrOH even at 10 °C to give the products very efficiently in excellent yields and with exceptional chemoselectivities. This study shows that the reaction proceeds through two distinct mechanisms that depend on the nature of the reducing agent. In the presence of a protic solvent or acidic medium the reaction undergoes protonation to yield the reduced product, whereas in the absence of proton source, it proceeds through the insertion of the reductant followed by reductive elimination. The kinetic data reveal that the oxidative addition is the rate-determining step in the reaction. The reaction profiles show first-order kinetics in aryl iodide and Pd and zero-order kinetics in LiOMe, benzylideneacetone, and the excess amount of NHC ligand. In addition, the reaction progress kinetic anal. shows that neither catalyst decomposition nor product inhibition occurs during the reaction. DFT calculations of the key steps confirm that the oxidative addition step is the rate-determining step in the reaction. Deuterium-labeling experiments indicate that the product is formed by the protonation of the Pd-C_alkyl bond of the intermediate formed after enone insertion into the Pd-C_Ar bond. Application of chiral NHC ligands in the asym. reductive Heck reaction only results in poor enantioselectivities (enantiomeric excess up to 20 %) and is also substrate specific. DFT calculations suggest that the migration of the aryl group to the alkene of the substrate is the enantioselectivity-determining step of the reaction. It is further shown that if the steric bulk at the enone is small (a Me group), the two transition state barriers from [Pd^II(L²)(ArI)(enone)] species C_re and C_si, which have the re and si face of the enone substrate coordinated to Pd, are very similar, in line with the exptl. results. With a slightly larger group (an iso-Pr substituent) a significant difference in energy barriers is calculated (2.6 kcal mol^-1), and in the experiment this product is formed with a modest enantiomeric excess (up to 20 %).

ChemCatChem published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C10H15ClO3S, Synthetic Route of 21286-54-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Saunders, K. G. published the artcilePoly(alkyl α-bromoacrylates). 2. Preparation and properties of the methyl, ethyl, n-propyl, isopropyl, n-butyl, and n-pentyl esters of varied tacticity, Computed Properties of 18791-02-1, the publication is Macromolecules (1982), 15(1), 1-10, database is CAplus.

Polymers of widely ranging tacticities, from highly isotactic to highly syndiotactic, were synthesized from Me [4519-46-4], Et [5459-35-8], Pr [13401-88-2], iso-Pr [79762-79-1], Bu [6420-76-4], and n-pentyl α-bromoacrylate  [13401-89-3]. The isotactic polymers were synthesized with a modified Grignard complex consisting a Grignard reagent and benzalacetophenone  [94-41-7]. A low-temperature, photolytically induced, free radical polymerization reaction was employed for the preparation of the syndiotactic polymers. Only atactic poly(tert-Bu α-bromoacrylate) [79794-49-3] could be synthesized because of the failure of the corresponding monomer to polymerize with the modified Grignard complex or at temperatures <20°. Polymer tacticity was determined by 19-Hz ¹³C NMR spectroscopy. Complete assignments for the ten pentad peaks of the carbonyl carbon resonance were achieved for all but the iso-Pr ester polymer while a complete anal. of the tetrad tacticity for the backbone methylene carbon resonance was possible for all but the Me ester polymer. The polymerization reaction mechanisms were discussed in terms of the propagation statistics which were calculated from the exptl. tetrads and pentads.

Macromolecules published new progress about 18791-02-1. 18791-02-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 2,3-Dibromopropionylchloride, and the molecular formula is C3H3Br2ClO, Computed Properties of 18791-02-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Ghosal, Nirnita Chakraborty published the artcileA Mild and Efficient Method for the Syntheses and Regioselective Ring-Opening of Aziridines, Formula: C7H13ClNNaO5S, the publication is SynOpen (2017), 1(1), 0015-0023, database is CAplus.

A new synthetic method for the synthesis of aziridines using Chloramine-T as an effective reagent in the presence of NH₂OH·HCl and NaIO₄. The same combination of NH₂OH·HCl and NaIO₄ was also very effective for nucleophilic ring opening of aziridines.

SynOpen published new progress about 7080-50-4. 7080-50-4 belongs to chlorides-buliding-blocks, auxiliary class Halogenation Reagent,Inhibitor, name is Sodium chloro(tosyl)amide trihydrate, and the molecular formula is C7H13ClNNaO5S, Formula: C7H13ClNNaO5S.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Bigolin, Alisson published the artcileA novel sulfonamide derivative as a strong and selective apototic agent against hematological malignancies, Safety of ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, the publication is Chemical Papers (2020), 74(9), 2965-2976, database is CAplus.

Abstract: Currently available chemotherapeutic drugs against hematol. malignancies have several adverse effects and are associated with high mortality rates. Thus, in this study we evaluated the cytotoxic effect of 26 new sulfonamide derivatives on acute leukemia and multiple myeloma cells in order to try to discover a new selective and safe compound that might be used as a prototype for new chemotherapeutic agents. The most cytotoxic compound, DFS16, reduced the cell viability of K562, Jurkat and MM.1S cells in a concentration- and time- dependent manner and it was significantly less cytotoxic to non-tumor cells. On acute leukemia cells, sulfonamide DFS16 activated intrinsic and extrinsic apoptosis with Bax/Bcl-2 inversion, increased FasR expression and m loss. In K562, DFS16 induced apoptosis by caspase-3 activation, while in Jurkat, it induced AIF release and caspase-3 independent apoptosis. In multiple myeloma, DFS16 induced cell cycle arrest at the G2/M phase and apoptosis with m loss. Altogether, the results suggest that the new sulfonamide derivative DFS16 induces apoptotic-like cell death in acute leukemia and multiple myeloma cells. DFS16 is a promising new mol. that could be used as a prototype for the development of chemotherapeutics against hematol. malignancies.

Chemical Papers published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C10H15ClO3S, Safety of ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Sureshkumar, Devarajulu published the artcileRegio- and Stereoselective Synthesis of Aziridino Epoxides from Cyclic Dienes, Synthetic Route of 7080-50-4, the publication is Journal of Organic Chemistry (2006), 71(4), 1653-1657, database is CAplus and MEDLINE.

Two different routes for the regio- and stereoselective synthesis of aziridino epoxides from cyclic dienes have been explored. The first strategy involves regiospecific aziridination of cyclic diene derivatives and subsequent epoxidation with m-CPBA to yield cis-aziridino epoxides as major products. The second strategy utilizes regiospecific epoxidation of cyclic diene derivatives followed by Sharpless aziridination to provide exclusively trans-aziridino epoxides. Synthesis of both enantiomers of cis-aziridino epoxides from (R)-(-)- and (S)-(+)-carvones are also reported.

Journal of Organic Chemistry published new progress about 7080-50-4. 7080-50-4 belongs to chlorides-buliding-blocks, auxiliary class Halogenation Reagent,Inhibitor, name is Sodium chloro(tosyl)amide trihydrate, and the molecular formula is C8H6ClNO, Synthetic Route of 7080-50-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Garvey, Edward P. published the artcileNucleotide and Nucleoside Analogs as Inhibitors of Cytosolic 5′-Nucleotidase I from Heart, Recommanded Product: Diethyltrichloromethylphosphonate, the publication is Biochemistry (1998), 37(25), 9043-9051, database is CAplus and MEDLINE.

Substrate and product specificity studies were used to develop inhibitors of the cytosolic 5′-nucleotidase I (c-N-I) from myocardium. As measured by V_max/K_m, c-N-I preferred pyrimidine 2′-deoxyribonucleotides as substrates with thymidine monophosphate (TMP) being the most efficient. In product inhibition studies, thymidine inhibited noncompetitively and inorganic phosphate inhibited competitively, consistent with an ordered release of nucleoside prior to phosphate. Mirroring nucleotide substrate specificities, pyrimidine nucleosides were more potent product inhibitors than purine nucleosides. Thus, pyrimidine nucleotide and nucleoside analogs were developed as inhibitors. Phosphonate analogs of TMP were synthesized by a novel method. The most potent was the 5′-phosphonate of 3′-deoxythymidine (ddT) (apparent K_i value of 63 nM). In addition, pyrimidine nucleoside analogs were inhibitors with 5-ethynyl-2′,3′-dideoxyuridine being the most potent (apparent K_i value of 3.7 μM). The most potent nucleotide and nucleoside inhibitor were both greater than 1000-fold more potent inhibiting c-N-I than the cytosolic 5′-nucleotidase II. The nucleoside analog was also greater than 1000-fold more potent against c-N-I than the membrane ecto-5′-nucleotidase (e-N). Because the phosphonate analogs measurably inhibited e-N (apparent K_i values of 6-12 μM), the selectivity of the phosphonates for c-N-I vs. e-N was less (40-200-fold). Because of the high selectivity for c-N-I vs. both of the other 5′-nucleotidases, the nucleoside inhibitors of c-N-I may be useful biochem. tools in discerning the role that c-N-I plays in generating adenosine within myocardium.

Biochemistry published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, Recommanded Product: Diethyltrichloromethylphosphonate.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics