Tag: M.W=250-300

Miklas, R. published the artcileSynthesis and antimicrobial properties of camphorsulfonic acid derived imidazolium salts, Synthetic Route of 21286-54-4, the publication is Acta Facultatis Pharmaceuticae Universitatis Comenianae (2014), 61(2), 42-48, database is CAplus.

A group of homochiral imidazolium salts bearing hydrophobic camphorsulfonyl alkyl esters I [R = decyl, dodecyl, tetradecyl] or amides II were synthesized and characterized. The novel imidazolium bromides were tested as antimicrobial and antifungal agents and their minimal inhibitory concentration (MIC) was evaluated and compared to clin. used benzalkonium bromide (BAB) and carbethopendecinium bromide. The MIC values of amide derivatives II [R = decyl, dodecyl] were slightly smaller than those for BAB, indicating their good activity. None of the prepared salts was more effective than carbethopendecinium bromide. The biocidal efficacy of amide derivatives was much higher when compared to the ester analogs.

Acta Facultatis Pharmaceuticae Universitatis Comenianae published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C10H15ClO3S, Synthetic Route of 21286-54-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Schaller, Rainer published the artcileSynthesis and fungicidal properties of ethyl phosphorodiamidates, Product Details of C11H14Cl3NO, the publication is Zeitschrift fuer Naturforschung, Teil B: Anorganische Chemie, Organische Chemie (1985), 40B(2), 298-304, database is CAplus.

Secondary amines, HNR₂, especially 2-(aryloxyethyl)propylamines and 4-arylpiperazines were treated with EtOP(O)Cl₂ yielding EtOP(O)(NR₂)Cl. Subsequent substitution of the chloro atom by morpholine derivatives, imidazole or triazole formed new ethylphosphorodiamidates with a broad-spectrum-fungicidal activity. Among the 25 compounds prepared were I and II (X = N, CH).

Zeitschrift fuer Naturforschung, Teil B: Anorganische Chemie, Organische Chemie published new progress about 67747-01-7. 67747-01-7 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Amine,Benzene,Ether,Benzene Compounds, name is N-(2-(2,4,6-Trichlorophenoxy)ethyl)propan-1-amine, and the molecular formula is C11H14Cl3NO, Product Details of C11H14Cl3NO.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Roszkowski, Piotr published the artcileNew N,N-diamine ligands derived from (-)-menthol and their application in the asymmetric transfer hydrogenation, Recommanded Product: Sodium chloro(tosyl)amide trihydrate, the publication is Tetrahedron: Asymmetry (2017), 28(4), 532-538, database is CAplus.

Natural (-)-menthol was applied to construction of mono-N-tosylated-1,2-diamine derivatives The O-tosylation and elimination of the tosylate of the menthol intermediate led to trans-p-menth-2-ene. The unsaturated menth-2-ene was next transformed into a mixture of N-tosylaziridines, which upon reaction with sodium azide gave four isomeric azides. The reduction of the formed tosylazides on Pd/C gave new chiral mono-N-tosylated-1,2-diamines, which were used as ligands in the asym. transfer hydrogenation protocol on aromatic ketones and endocyclic imine.

Tetrahedron: Asymmetry published new progress about 7080-50-4. 7080-50-4 belongs to chlorides-buliding-blocks, auxiliary class Halogenation Reagent,Inhibitor, name is Sodium chloro(tosyl)amide trihydrate, and the molecular formula is C7H13ClNNaO5S, Recommanded Product: Sodium chloro(tosyl)amide trihydrate.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Khalili, Gholamhossein published the artcileSynthesis and density functional theory studies of azirinyl and oxiranyl functionalized isoindigo and (3Z,3’Z)-3,3′-(ethane-1,2-diylidene)bis(indolin-2-one) derivatives, HPLC of Formula: 21286-54-4, the publication is Molecules (2019), 24(20), 3649pp., database is CAplus and MEDLINE.

A series of functionalized isoindigo compounds I (X = O, MeSO₂N, PhSO₂N, etc.) were synthesized in moderate yields by reaction of isoindigo with (S)-glycidyl tosylate, epibromohydrin or 2-(bromomethyl)-1-(aryl(or alkyl)sulfonyl)aziridines in the presence of MeONa under mild conditions. (3Z,3’Z)-3,3′-(Ethane-1,2-diylidene)bis(indolin-2-one), with an extended central olefin π-conjugated moiety, was also reacted with glycidyl tosylate and epibromohydrin to give the corresponding N,N’-disubstituted derivative II. Calculations with DFT and TD-DFT of hypothetical isoindigo-thiophene DA mols. with various electron withdrawing substituents, including aziridine, oxirane, nitrile, carbonyl, and sulfonate, indicated that the proximity and strength of the functional group have a significant effect on the HOMO, LUMO, vertical excitation energy and oscillator strength of the π-π* transitions.

Molecules published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C10H15ClO3S, HPLC of Formula: 21286-54-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Huynh, Uyen published the artcileFormation, Alkylation, and Hydrolysis of Chiral Nonracemic N-Amino Cyclic Carbamate Hydrazones: An Approach to the Enantioselective α-Alkylation of Ketones, Application of ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, the publication is Journal of Organic Chemistry (2018), 83(21), 12951-12964, database is CAplus and MEDLINE.

The α-alkylation of ketones is a fundamental synthetic transformation. The development of asym. variants of this reaction is important given that numerous natural products, drugs, and related compounds exist as α-functionalized ketones or derivatives thereof. Authors previously reported preliminary studies on the development of a new enantioselective ketone α-alkylation procedure using N-amino cyclic carbamate (ACC) auxiliaries. In comparison to other auxiliary-based methods, ACC alkylation offers a number of advantages and is both highly enantioselective and high yielding. Herein, authors provide a full account of their studies on the enantioselective ACC ketone α-alkylation method.

Journal of Organic Chemistry published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C10H15ClO3S, Application of ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Sanad, Sherif M. H. published the artcileTandem synthesis, cytotoxicity, and in silico study of new 1,3,4-oxadiazoles as potential thymidylate synthase inhibitors, Recommanded Product: Sodium chloro(tosyl)amide trihydrate, the publication is Archiv der Pharmazie (Weinheim, Germany), database is CAplus and MEDLINE.

A new series of pyrrole-linked mono- and bis(1,3,4-oxadiazole) hybrids I [R = H, Me, Cl, etc.] and II [R¹ = -PhO(CH₂)₂OPh-, -PhO(CH₂)₃OPh-, -PhO(CH₂)₄OPh-, etc.], attached to various arene units, was prepared using a two-step tandem protocol. Therefore, a benzohydrazide derivative was condensed with the appropriate aldehydes RCHO in ethanol at 80°C for 60-150 min to give the corresponding N-(benzoylhydrazones). Without isolation, the previous intermediates underwent intramol. oxidative cyclization in DMSO at 180°C for 90-200 min in the presence of chloramine trihydrate to afford the target hybrids I. The cytotoxicity of all hybrids was examined in vitro against the MCF-7, HEPG2 and Caco2 cell lines. Arene-linked hybrids I [R = NO2, 4-acetoxy], were the most potent ones, with IC₅₀ values ranging from 5.47 to 8.80 and 12.75 to 21.22 μM, resp., when tested on the above cell lines. At the tested concentrations of 5 and 7.5 μM, hybrid I [R = 4-nitro] inhibited thymidylate synthase (TS) with the best inhibition percentages of 72.3 and 91.3, whereas hybrid I [R = 4-acetoxy] displayed comparable inhibitory activity to the reference pemetrexed. Hybrid I [R = 4-acetoxy] had inhibition percentages of 62.7 and 82.6, whereas pemetrexed had inhibition percentages of 59.2 and 80.2, resp. The capability of hybrids I [R = 4-nitro, 4-acetoxy] as potential TS inhibitors was supported by mol. docking studies, while SwissADME predicts their efficacy as drug-like scaffolds.

Archiv der Pharmazie (Weinheim, Germany) published new progress about 7080-50-4. 7080-50-4 belongs to chlorides-buliding-blocks, auxiliary class Halogenation Reagent,Inhibitor, name is Sodium chloro(tosyl)amide trihydrate, and the molecular formula is C7H13ClNNaO5S, Recommanded Product: Sodium chloro(tosyl)amide trihydrate.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Lashkhi, V. L. published the artcileMicrocalorimetric study of the adsorption of additives for oils on metal, Computed Properties of 866-23-9, the publication is Neftekhimiya (1974), 14(3), 491-4, database is CAplus.

The adsorption heat, included in some formulas determining the wear, was determined by microcalorimetry, using cyclohexane as carrier liquid and solvent. The higher adsorption heat (≥2) prevailed for Sulfol [[CCl3(CH2)4]2S] [14146-66-8], CCl3(CH2)6P(O)(OEt)2 [53280-04-9], and DF-1 (Ba O,O-dialkyl dithiophosphate) [39360-55-9], while the lower one (≤1) for: MeP(O)(OEt)2 [683-08-9], PhP(O)(OEt2) [1754-49-0], and Zn O,O-diisobutyl O,O-diisooctyl dithiophosphate [54244-07-4]. The antiwear properties of the additives increased with increase of the heat of their adsorption on the metal, according to tests by the frictional machine at low contact loads.

Neftekhimiya published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, Computed Properties of 866-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Seyferth, Dietmar published the artcileHalomethyl-metal compounds. LXIII. Diethyl lithiodichloromethylphosphonate and tetraethyl lithiochloromethylenediphosphonate, Safety of Diethyltrichloromethylphosphonate, the publication is Journal of Organometallic Chemistry (1973), 237-45, database is CAplus.

The action of BuLi-THF at low temperature on (EtO)2P(O)CCl3 and (EtO)2P(O)CCl2P(O)(OEt)2 gave LiCCl2P(O)(OEt)2 and [(EtO)2(O)P]2CClLi, resp. Their hydrolysis, coupling reactions with di-Me sulfate, allyl bromide and ClMe3Si and their use in the synthesis of chloroolefins are described.

Journal of Organometallic Chemistry published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C8H13NO3, Safety of Diethyltrichloromethylphosphonate.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Rotroff, Daniel M. published the artcilePredictive Endocrine Testing in the 21st Century Using in Vitro Assays of Estrogen Receptor Signaling Responses, Recommanded Product: Sodium chloro(tosyl)amide trihydrate, the publication is Environmental Science & Technology (2014), 48(15), 8706-8716, database is CAplus and MEDLINE.

Thousands of environmental chems. are subject to regulatory review for their potential to be endocrine disruptors (ED). In vitro high-throughput screening (HTS) assays have emerged as a potential tool for prioritizing chems. for ED-related whole-animal tests. In this study, 1814 chems. including pesticide active and inert ingredients, industrial chems., food additives, and pharmaceuticals were evaluated in a panel of 13 in vitro HTS assays. The panel of in vitro assays interrogated multiple end points related to estrogen receptor (ER) signaling, namely binding, agonist, antagonist, and cell growth responses. The results from the in vitro assays were used to create an ER Interaction Score. For 36 reference chems., an ER Interaction Score >0 showed 100% sensitivity and 87.5% specificity for classifying potential ER activity. The magnitude of the ER Interaction Score was significantly related to the potency classification of the reference chems. ERα/ERβ selectivity was also evaluated, but relatively few chems. showed significant selectivity for a specific isoform. When applied to a broader set of chems. with in vivo uterotrophic data, the ER Interaction Scores showed 91% sensitivity and 65% specificity. Overall, this study provides a novel method for combining in vitro concentration response data from multiple assays and, when applied to a large set of ER data, accurately predicted estrogenic responses and demonstrated its utility for chem. prioritization.

Environmental Science & Technology published new progress about 7080-50-4. 7080-50-4 belongs to chlorides-buliding-blocks, auxiliary class Halogenation Reagent,Inhibitor, name is Sodium chloro(tosyl)amide trihydrate, and the molecular formula is C7H13ClNNaO5S, Recommanded Product: Sodium chloro(tosyl)amide trihydrate.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Esteruelas, Miguel A. published the artcileDirect C-H Borylation of Arenes Catalyzed by Saturated Hydride-Boryl-Iridium-POP Complexes: Kinetic Analysis of the Elemental Steps, Recommanded Product: 2-(4-Chloro-2-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, the publication is Chemistry – A European Journal (2020), 26(55), 12632-12644, database is CAplus and MEDLINE.

The saturated trihydride IrH₃{κ³-P,O,P-[xant(PiPr₂)₂]} (1; xant(PiPr₂)₂ = 9,9-dimethyl-4,5-bis(diisopropylphosphino)xanthene) activates the B-H bond of two mols. of pinacolborane (HBpin) to give H₂, the hydride-boryl derivatives IrH₂(Bpin){κ³-P,O,P-[xant(PiPr₂)₂]} (2) and IrH(Bpin)₂{κ³-P,O,P-[xant(PiPr₂)₂]} (3) in a sequential manner. Complex 3 activates a C-H bond of two mols. of benzene to form PhBpin and regenerates 2 and 1, also in a sequential manner. Thus, complexes 1, 2, and 3 define two cycles for the catalytic direct C-H borylation of arenes with HBpin, which have dihydride 2 as a common intermediate. C-H bond activation of the arenes is the rate-determining step of both cycles, as the C-H oxidative addition to 3 is faster than to 2. The results from a kinetic study of the reactions of 1 and 2 with HBpin support a cooperative function of the hydride ligands in the B-H bond activation. The addition of the B atom of the borane to a hydride facilitates the coordination of the B-H bond through the formation of κ¹– and κ²-dihydrideborate intermediates.

Chemistry – A European Journal published new progress about 765917-27-9. 765917-27-9 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Boronic acid and ester,Benzene,Boronate Esters, name is 2-(4-Chloro-2-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, and the molecular formula is C12H15BClFO2, Recommanded Product: 2-(4-Chloro-2-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics