Tag: M.W=250-300

Antczak, Monika I. published the artcileMild Synthesis of Organophosphorus Compounds: Reaction of Phosphorus-Containing Carbenoids with Organoboranes, Application of Diethyltrichloromethylphosphonate, the publication is Organic Letters (2008), 10(5), 977-980, database is CAplus and MEDLINE.

Organoboranes react with phosphorus-containing carbenoids to produce a variety of functionalized organophosphorus compounds under mild conditions. In some cases, selective migration of one group attached to boron can be observed Thus, reaction of (MeO)₂P(O)(CH₂N₂) with Bu₃B in THF/Et₂O at room temperature for 1h followed by hydrolysis (H₂O 2h reflux) gave 86% (MeO)₂P(O)CH₂Bu. Phosphonite-borane complexes are introduced as novel synthons for the synthesis of phosphinic esters.

Organic Letters published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, Application of Diethyltrichloromethylphosphonate.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Hayashi, Koichiro published the artcileChemoselective Synthesis of Folic Acid-Functionalized Magnetite Nanoparticles via Click Chemistry for Magnetic Hyperthermia, HPLC of Formula: 18791-02-1, the publication is Chemistry of Materials (2009), 21(7), 1318-1325, database is CAplus.

Folic acid-functionalized Fe₃O₄ nanoparticles (FA-Fe₃O₄ NPs) were synthesized from iron(III) 3-allylacetylacetonate (IAA) through in situ hydrolysis and ligand modification, by applying the principle of click chem. The γ-carboxylic acid of FA was successfully bound to the ligand of the Fe₃O₄ NPs without the loss of the α-carboxylic acid group of folic acid (FA), which has an affinity for folate receptors (FRs) expressed on tumor cells. The Fe₃O₄ NPs were monodisperse, and their size was controlled by varying the conditions of IAA hydrolysis. The FA-Fe₃O₄ NPs, which had diameters of 8 nm, exhibited superparamagnetic behavior and a relatively high magnetization at room temperature The blocking temperature is 220 K, and the magnetization curve exhibited a remanence of 19 emu/g and a coercivity of 550 Oe at 5 K. The specific absorption rate (SAR) was dependent on the size of the FA-Fe₃O₄ NPs and the strength of the applied magnetic field. The SAR of the 8-nm FA-Fe₃O₄ NPs was 670 W/g in a 230 kHz alternating magnetic field and 100 Oe. The chemoselective surface modification of magnetite particles with FA yielded a novel cancer-targeting system for use in hyperthermia treatment.

Chemistry of Materials published new progress about 18791-02-1. 18791-02-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 2,3-Dibromopropionylchloride, and the molecular formula is C3H3Br2ClO, HPLC of Formula: 18791-02-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Takano, Seiichi published the artcileChiral synthesis of both enantiomers of 1,4-dideoxy-1,4-iminolyxitol and 1,4-dideoxy-1,4-iminoribitol, Synthetic Route of 18791-02-1, the publication is Tetrahedron: Asymmetry (1992), 3(6), 681-4, database is CAplus.

Reaction of 2,3-dibromopropionyl chloride with 4-methoxyphenol and (S)-1-methylbenzylamine yielded a 4:5 mixture of readily separable diastereomeric aziridine esters I (R = C₆H₄OMe-4) in an excellent yield. Thermal intermol. 1,3-dipolar cycloaddition of both diastereomers with vinylene carbonate, furnished four readily separable diastereomeric pyrrolidine esters, resp., which were transformed into both enantiomers of title compounds

Tetrahedron: Asymmetry published new progress about 18791-02-1. 18791-02-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 2,3-Dibromopropionylchloride, and the molecular formula is C14H22O2, Synthetic Route of 18791-02-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Safonova, T. S. published the artcileRelation of the antitumor activity of spirobromine analogs to their structure, Application of 2,3-Dibromopropionylchloride, the publication is Khimiko-Farmatsevticheskii Zhurnal (1984), 18(12), 1437-40, database is CAplus.

The dispiropiperazines I [R = CHBrCH₂Br, CH:CH₂, CHMeCH₂Br, CH₂CH₂NHCH₂Ph, (CH₂)₃Ph, (CH₂)₃C₆H₄NO₂–p, and (CH₂)₃C₆H₄N(CH₂CH₂Cl)₂–p] were prepared and tested along with spirobromine (I, R = CH₂CH₂Br) [86641-76-1] and 8 dipiperazinylalkanes II (R = Me, H; X = Cl, Br; n = 2, 3, 6, 10) for antitumor activity in sarcoma-bearing rats. Although spirobromine itself showed high antitumor activity, its analogs were only ∼33% as active or completely inactive. Three dipiperazinylalkanes showed very high activity; the others were inactive. Structure-activity relations are discussed.

Khimiko-Farmatsevticheskii Zhurnal published new progress about 18791-02-1. 18791-02-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 2,3-Dibromopropionylchloride, and the molecular formula is C3H3Br2ClO, Application of 2,3-Dibromopropionylchloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Matsuyama, Naoki published the artcileNickel-Catalyzed Ring-Opening C-O Functionalization of peri-Xanthenoxanthenes for 8-Substituted Binaphthol Synthesis, Computed Properties of 21286-54-4, the publication is Organic Letters (2021), 23(10), 3908-3912, database is CAplus and MEDLINE.

Herein, authors disclose the Ni-catalyzed ring-opening C-O functionalization of peri-xanthenoxanthenes using Grignard reagents that forms 8-mono-functionalized binaphthols. 1,2-Bis(dicyclohexylphosphino)ethane was the best ligand for alkylations and ICy for arylation. After mechanistic investigations, authors assumed that the reaction proceeds via C-O reduction and subsequent C-O functionalization. To verify the mechanism, the intermediate after reduction was isolated. Moreover, the asym. addition, using 8-octylbinaphthol after optical resolution, was studied.

Organic Letters published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C10H15ClO3S, Computed Properties of 21286-54-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Perlikowska, Wieslawa published the artcileLithiation of diethyl trichloromethylphosphonate and the transformations of the α-lithiated derivative, Product Details of C5H10Cl3O3P, the publication is Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1996), 2611-2613, database is CAplus.

The lithiation of di-Et trichloromethylphosphonate below -100° leads to a stable α-lithiated derivative, but at temperatures of ∼-80° the lithiation is accompanied by spontaneous reactions leading to tetra-Et (chloromethylene)bisphosphonate as the exclusive product. Possible mechanisms of the reaction are discussed. Thus, treating Cl₃CPO₃Et₂ with BuLi and anhydrous LiCl in Et₂O at -105° gave 74% Cl₂CHPO₃Et₂, whereas reaction with BuLi in Et₂O at -80° gave 95% ClCH(PO₃Et₂)₂.

Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, Product Details of C5H10Cl3O3P.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Hell, Sandrine M. published the artcileHydrosulfonylation of Alkenes with Sulfonyl Chlorides under Visible Light Activation, Related Products of chlorides-buliding-blocks, the publication is Angewandte Chemie, International Edition (2020), 59(28), 11620-11626, database is CAplus and MEDLINE.

Sulfonyl chlorides are inexpensive reactants extensively explored for functionalization, but never considered for radical hydrosulfonylation of alkenes. Herein, the authors report that tris(trimethylsilyl)silane is an ideal hydrogen atom donor enabling highly effective photoredox-catalyzed hydrosulfonylation of electron-deficient alkenes with sulfonyl chlorides. To increase the generality of this transformation, polarity-reversal catalysis (PRC) was successfully implemented for alkenes bearing alkyl substituents. This late-stage functionalization method tolerates a remarkably wide range of functional groups, is operationally simple, scalable, and allows access to building blocks which are important for medicinal chem. and drug discovery.

Angewandte Chemie, International Edition published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C10H15ClO3S, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Bao, Zhi-Peng published the artcileA novel construction of acetamides from rhodium-catalyzed aminocarbonylation of DMC with nitro compounds, Synthetic Route of 21286-54-4, the publication is Chemical Communications (Cambridge, United Kingdom) (2021), 57(15), 1955-1958, database is CAplus and MEDLINE.

Di-Me carbonate (DMC), an environment-friendly compound prepared from CO₂, shows diverse reactivities. In this communication, construction of acetamides CH₃C(O)NHR (R = n-Pr, cyclohexyl, naphthalen-1-yl, 2H-1,3-benzodioxol-5-yl, quinolin-8-yl, etc.) by an efficient procedure using DMC as both a C1 building block and solvent in the aminocarbonylation reaction with nitro compounds RNO₂ has been developed. W(CO)₆ acts both a CO source and a reductant.

Chemical Communications (Cambridge, United Kingdom) published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C10H15ClO3S, Synthetic Route of 21286-54-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Ostacolo, Carmine published the artcileSynthesis and Pharmacological Characterization of Conformationally Restricted Retigabine Analogues as Novel Neuronal Kv7 Channel Activators, Application of ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, the publication is Journal of Medicinal Chemistry (2020), 63(1), 163-185, database is CAplus and MEDLINE.

Kv7 K⁺ channels represent attractive pharmacol. targets for the treatment of different neurol. disorders, including epilepsy. In this paper, 42 conformationally restricted analogs of the prototypical Kv7 activator retigabine have been synthesized and tested by electrophysiol. patch-clamp experiments as Kv7 agonists. When compared to retigabine (0.93 ± 0.43 μM), the EC₅₀s for Kv7.2 current enhancements by compound I (0.08 ± 0.04 μM) were lower, whereas no change in potency was observed for II (0.63 ± 0.07 μM). In addition, compared to retigabine, I and II showed also higher potency in activating heteromeric Kv7.2/Kv7.3 and homomeric Kv7.4 channels. Mol. modeling studies provided new insights into the chem. features required for optimal interaction at the binding site. Stability studies evidenced improved chem. stability of I and II in comparison with retigabine. Overall, the present results highlight that the N5-alkylamidoindole moiety provides a suitable pharmacophoric scaffold for the design of chem. stable, highly potent and selective Kv7 agonists.

Journal of Medicinal Chemistry published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C10H15ClO3S, Application of ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Romdhane, A. published the artcileSynthesis of alkyltrichloromethylphosphonates and their reactivity with some nucleophiles, Application of Diethyltrichloromethylphosphonate, the publication is Journal de la Societe Algerienne de Chimie (2008), 18(1), 55-60, database is CAplus.

The condensation of alkyltrichloromethylphosphonates (RO)₂P(:O)CCl₃ (1: R = Me (a), Et (b)) with primary amine H₂NC₆H₄Me-4, secondary amine HN(C₆H₁₁)₂ and 1,4-binucleophiles 1-HOC₆H₄NH₂-2 and C₆H₄(NH₂)₂-1,2 provides selectively ammonium trichloromethylphosphonate salts [(RO)(Cl₃C)P(:O)O]^–[H₂NR’R”]⁺ (2: R = Me, Et; R’ = C₆H₄Me-4, C₆H₁₁; R” = H, C₆H₁₁) and [(RO)(Cl₃C)P(:O)O]^–[H₃NC₆H₄X]⁺ (3: R = Me, Et; X = OH, NH₂), resp. The structures of all obtained organic compounds where determined by spectroscopic tech. such as IR, NMR (¹H, ¹³C, ³¹P) and in a few cases strengthened by mass spectrometry (FAB⁺).

Journal de la Societe Algerienne de Chimie published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, Application of Diethyltrichloromethylphosphonate.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics