Tag: M.W=250-300

Tanino, Keiji published the artcileTotal Synthesis of Ingenol, Quality Control of 866-23-9, the publication is Journal of the American Chemical Society (2003), 125(6), 1498-1500, database is CAplus and MEDLINE.

Total synthesis of ingenol (I), a diterpene isolated from the genus Euphorbia, was accomplished on the basis of the novel key reactions. The highly strained ingenane skeleton was constructed through an intramol. cyclization reaction of an acetylene dicobalt complex followed by a rearrangement reaction of an epoxy alc. II. The C(3),C(4),C(5)-triol moiety was introduced by a stereoselective double dihydroxylation reaction of a diene having C(2)-C(3) and C(4)-C(5) double bonds.

Journal of the American Chemical Society published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C7H7ClN2S, Quality Control of 866-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Lesniak, Robert K. published the artcileDiscovery of 1H-Pyrazole Biaryl Sulfonamides as Novel G2019S-LRRK2 Kinase Inhibitors, Category: chlorides-buliding-blocks, the publication is ACS Medicinal Chemistry Letters (2022), 13(6), 981-988, database is CAplus and MEDLINE.

G2019S (GS) is the most prevalent mutation in the leucine rich repeat protein kinase 2 gene (LRRK2), a genetic predisposition that is common for Parkinson’s disease, as well as for some forms of cancer, and is a shared risk allele for Crohn’s disease. GS-LRRK2 has a hyperactive kinase, and although numerous drug discovery programs have targeted LRRK2 kinase, few have reached clin. development. We report the discovery and preliminary development of an entirely novel structural class of potent and selective GS-LRRK2 kinase inhibitors: biaryl-1H-pyrazoles.

ACS Medicinal Chemistry Letters published new progress about 1030832-75-7. 1030832-75-7 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Boronate Esters,Boronic acid and ester, name is 2-(4-Chloro-2-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, and the molecular formula is C13H18BClO2, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Berte-Verrando, Sylvie published the artcileGeneral synthesis of α,α-dideuteriated phosphonic esters, Product Details of C5H10Cl3O3P, the publication is Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) (1994), 821-4, database is CAplus.

A range of α,α-dideuteriated phosphonic esters has been prepared by deuteriolysis of α-silylated α-phosphonylated carbanions with D₂O as deuterium source. In most cases, incorporation of deuterium is greater than 95% and the yields are good to excellent. The title products are potential trace compounds in many biol. and industrial applications.

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, Product Details of C5H10Cl3O3P.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Ishiyama, Tatsuo published the artcileRoom temperature borylation of arenes and heteroarenes using stoichiometric amounts of pinacolborane catalyzed by iridium complexes in an inert solvent, Recommanded Product: Methyl 3-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate, the publication is Chemical Communications (Cambridge, United Kingdom) (2003), 2924-2925, database is CAplus and MEDLINE.

Aromatic C-H borylation of arenes and heteroarenes using stoichiometric amounts of pinacolborane was catalyzed by an Ir complex generated from 1/2[Ir(OMe)(COD)]₂ and 4,4′-di-tert-butyl-2,2′-bipyridine at room temperature in hexane and afforded the corresponding aryl- and heteroarylboronates in high yields with excellent regioselectivities.

Chemical Communications (Cambridge, United Kingdom) published new progress about 408492-29-5. 408492-29-5 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Ester,Boronate Esters,Boronate Esters,Boronic acid and ester,, name is Methyl 3-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate, and the molecular formula is C14H18BClO4, Recommanded Product: Methyl 3-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Coote, Susannah C. published the artcileStereoselective aziridination of cyclic allylic alcohols using chloramine-T, Application In Synthesis of 7080-50-4, the publication is Organic & Biomolecular Chemistry (2008), 6(23), 4299-4314, database is CAplus and MEDLINE.

The stereoselective aziridination of a range of cyclic allylic alcs. using two different chloramine salts (4-MeC₆H₄SO₂NClNa, TsNClNa and Me₃CSO₂NClNa, BusNClNa) has been explored. The stereoselectivity of these reactions was highly dependent on the structure of the allylic alc. and the chloramine salt. Generally, mixtures of cis- and trans-hydroxy aziridines were obtained, in which the major diastereomer was the cis-hydroxy aziridine, while complete cis-diastereoselectivity was observed in the aziridination of 1,3-disubstituted allylic alcs. In each case studied, aziridination using BusNClNa gave higher cis-stereoselectivity than that observed for the same reaction using TsNClNa. Unexpectedly, application of the aziridination conditions to 1-substituted cyclopent-2-en-1-ols did not generate the aziridines. Instead, epoxy sulfonamides were obtained.

Organic & Biomolecular Chemistry published new progress about 7080-50-4. 7080-50-4 belongs to chlorides-buliding-blocks, auxiliary class Halogenation Reagent,Inhibitor, name is Sodium chloro(tosyl)amide trihydrate, and the molecular formula is C7H13ClNNaO5S, Application In Synthesis of 7080-50-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Sharath, N. published the artcileSynthesis, DNA Binding, and Photonuclease Activity of New Tetraaza Macrocyclic Constrained Isoxazole Rings as Subunit in Metal Complexes, Category: chlorides-buliding-blocks, the publication is Nucleosides, Nucleotides & Nucleic Acids (2012), 31(11), 813-829, database is CAplus and MEDLINE.

The DNA-binding and photonuclease activity of newly synthesized tetra-azamacrocyclic ligand L (C₃₂H₃₂N₈O₄) and its complexes of type [MLCl₂] and [ML]Cl₂ (where M = Co(II), Fe(II) and Cu(II)); L = N,N’-[3-(4-{5-[(2-amino-ethylamino)-methyl]-isoxazol-3yl}-phenyl)-isoxazol-5-yl methyl-ethane-1,2-diamine] are specified. An octahedral geometry has been proposed for Fe(II) and Co(II) complexes, while the Cu(II) complex has a square planar environment. The absorption spectral results indicate that the complexes bind with the base pairs of DNA, with an intrinsic binding constant K_b of, and complexes found to be 3.2 × 10⁴ M^-1, 5.3 × 10⁴ M^-1, and 4.2 × 10⁴ M^-1, resp., in 5 mM Tris-HCl/50 mM NaCl buffer at pH 7.2. The large enhancement in the relative viscosity of DNA on binding to the complexes supports the proposed DNA binding modes. The viscosity and thermal denaturation studies sustain the effective intercalation with DNA. The DNA photocleavage studies demonstrated that compounds exhibit significant photonuclease activity by a concentration dependent on singlet oxygen mediated mechanism.

Nucleosides, Nucleotides & Nucleic Acids published new progress about 7080-50-4. 7080-50-4 belongs to chlorides-buliding-blocks, auxiliary class Halogenation Reagent,Inhibitor, name is Sodium chloro(tosyl)amide trihydrate, and the molecular formula is C4H10BBrO2, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Iyoda, Masahiko published the artcileSynthesis and properties of a bisdehydro[14]annuleno[c]furan and an ortho-annelated tetrakisdehydro[14]annuleno[14]annulene, Recommanded Product: Diethyltrichloromethylphosphonate, the publication is Bulletin of the Chemical Society of Japan (1994), 67(3), 778-91, database is CAplus.

A bisdehydro[14]annuleno[c]furan I and a tetrakisdehydro[14]annuleno[14]annulene II have been synthesized; their properties and effects of annulation on annulene rings are discussed on the basis of ¹H NMR and electronic spectra. Attempts to synthesize the related [14]annuleno[16]annuleno[14]annulene are also described.

Bulletin of the Chemical Society of Japan published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, Recommanded Product: Diethyltrichloromethylphosphonate.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Okawara, Tadashi published the artcileA facile synthesis of thiazolidin-5-ones and their structural assignment, SDS of cas: 18791-02-1, the publication is Heterocycles (1982), 19(9), 1571-4, database is CAplus.

RNHCSNHR¹ (R = CH₂Ph, Me, Ph; R¹ = CH₂Ph, Ph) reacted with R²CHR³COR³ (R² = H, Me, R³ = halogen) in 5% NaOH-CH₂Cl₂ to give 34-89% iminothiazolidinones I. Reaction of RNHCSNHR¹ with BrCH₂CHBrCOCl gave 75 to 83% II.

Heterocycles published new progress about 18791-02-1. 18791-02-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 2,3-Dibromopropionylchloride, and the molecular formula is C3H3Br2ClO, SDS of cas: 18791-02-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Padwa, Albert published the artcileDichloroketene-Induced Cyclizations of Vinyl Sulfilimines: Application of the Method in the Synthesis of (±)-Desoxyeseroline, Application In Synthesis of 7080-50-4, the publication is Journal of Organic Chemistry (2005), 70(21), 8538-8549, database is CAplus and MEDLINE.

The reactions of several aryl-, furanyl-, and vinyl-substituted sulfilimines, e.g. I, with dichloroketene proceeded at 25 °C to yield thioalkyl-substituted γ-lactams, e.g. II. The overall process involves nucleophilic addition of the nitrogen atom of the sulfilimine onto the highly electrophilic dichloroketene to first generate a zwitterionic intermediate. A subsequent [3,3]-sigmatropic rearrangement is followed by intramol. trapping of the Pummerer cation by the amido anion to furnish the observed γ-lactam product. Incorporation of donor groups on the aromatic ring of the sulfonyl functionality had little effect when aryl-substituted sulfilimines were used but exhibited a major effect on the efficiency of the reaction with furanyl-substituted systems. The placement of an electron donor group (i.e., OMe) on the sulfonyl aryl group enhances the nucleophilicity of the amido anion contained within the sulfonium ion intermediate and facilitates the rate of the 3,3-sigmatropic rearrangement. Styryl-substituted sulfilimines cyclize in a stereospecific manner and produce a 3:2-mixture of γ-lactams and the isomeric imino-lactone system. The heavily functionalized γ-lactams are easily converted to a variety of nitrogen containing substrates. The vinyl sulfilimine cyclization method was applied to the total synthesis of the Calabar alkaloid (±)-desoxyeseroline (III).

Journal of Organic Chemistry published new progress about 7080-50-4. 7080-50-4 belongs to chlorides-buliding-blocks, auxiliary class Halogenation Reagent,Inhibitor, name is Sodium chloro(tosyl)amide trihydrate, and the molecular formula is C7H13ClNNaO5S, Application In Synthesis of 7080-50-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Wang, Qiu published the artcileA New Synthesis of γ-Lactams Based on the Reaction of Vinyl Sulfilimines with Dichloroketene, Synthetic Route of 7080-50-4, the publication is Organic Letters (2005), 7(5), 839-841, database is CAplus and MEDLINE.

The reactions of several aryl-, furanyl-, and vinyl substituted sulfilimines with dichloroketene proceeded at 25 °C to yield thioalkyl substituted γ-lactams which, in turn, were converted to a variety of nitrogen-containing substrates.

Organic Letters published new progress about 7080-50-4. 7080-50-4 belongs to chlorides-buliding-blocks, auxiliary class Halogenation Reagent,Inhibitor, name is Sodium chloro(tosyl)amide trihydrate, and the molecular formula is C8H6ClN, Synthetic Route of 7080-50-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics