Tag: M.W=250-300

Alagiri, Kaliyamoorthy published the artcileCatalyst-Free Regio- and Stereospecific Synthesis of β-Sulfonamido Dithiocarbamates: Efficient Ring-Opening Reactions of N-Tosyl Aziridines by Dialkyldithiocarbamates, COA of Formula: C7H13ClNNaO5S, the publication is Chemistry – A European Journal (2011), 17(25), 6922-6925, S6922/1-S6922/62, database is CAplus and MEDLINE.

We have developed an efficient protocol for the synthesis of β-sulfonamido dithiocarbamates by using a ring-opening strategy of aziridines by thiocarbamates. These methods avoid toxic catalysts and, in most cases, give nearly quant. yields without any byproducts. This strategy provides an elegant method for synthesizing a wide range of β-sulfonamido dithiocarbamates by using inexpensive and readily available starting materials. In addition, a one-pot method has been developed for a facile ring-opening of aziridines by using in situ generated dialkyldithiocarbamate. This methodol. could potentially prove useful for the synthesis of medicinally active and other com. dithiocarbamate derivatives

Chemistry – A European Journal published new progress about 7080-50-4. 7080-50-4 belongs to chlorides-buliding-blocks, auxiliary class Halogenation Reagent,Inhibitor, name is Sodium chloro(tosyl)amide trihydrate, and the molecular formula is C7H13ClNNaO5S, COA of Formula: C7H13ClNNaO5S.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Wang, Fuxiang published the artcileSynthesis of clozapine, Related Products of chlorides-buliding-blocks, the publication is Zhongguo Yiyao Gongye Zazhi (2013), 44(10), 969-971, database is CAplus.

Compounds 2,5-dichloronitrobenzene and anthranilic acid were reacted in the presence of potassium carbonate with DMF as solvent to produce 2-(4-chloro-2-nitroanilino)benzoic acid, which was reduced to 2-(2-amino-4-chloroanilino)benzoic acid (5) by hydrazine hydrate and FeCl₃· 6H₂O. Catalyzed by polyphosphoric acid in xylene, compound 5 was cyclized into 8-chloro-5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one, which was coupled with N-methylpiperazine in the presence of titanium tetrachloride to give clozapine. The overall yield was 43%, based on 2,5-dichloronitrobenzene.

Zhongguo Yiyao Gongye Zazhi published new progress about 60091-87-4. 60091-87-4 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Nitro Compound,Carboxylic acid,Amine,Benzene, name is 2-((4-Chloro-2-nitrophenyl)amino)benzoic acid, and the molecular formula is C24H20Ge, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Villieras, J. published the artcileSimple route from aldehydes to alkynes and 1-chloro-1-alkynes, SDS of cas: 866-23-9, the publication is Synthesis (1975), 458-61, database is CAplus.

Reaction of RCHO (R = e.g., Et2CH, cyclohexyl, MeCH:CH, PhCH:CH, substituted phenyl) with LiCCl2P(O)(OEt)2 in THF-ether gave 85-90% RCH:CCl2 which 1) with LiNEt2 in THF-ether gave RCCCl and 2) with EtLi or BuLi in THF-ether at -10 to -70° gave RCCLi which was hydrolyzed with aqueous H2SO4 to RCCH or alkylated with chlorodimethyl ether to give methoxymethyl derivatives (e.g., 1-cyclohexyl-3-methoxy-1-propyne).

Synthesis published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C18H35NO, SDS of cas: 866-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Villieras, Jean published the artcileα-Haloenolates; VII. Diethyl 1-chloro-1-ethoxycarbonyl-1-lithiomethanephosphonate; a convenient one-step preparation of α-chloro-α,β-unsaturated esters from diethyl trichloromethanephosphonate, Quality Control of 866-23-9, the publication is Synthesis (1978), 31-3, database is CAplus.

α,β-Unsaturated esters (E)- and (Z)-RCH:CClCO₂Et (R = n-C₉H₁₉, BuCHEt, 3-cyclohexenyl, Cl₃C, Ph, 2-ClC₆H₄, 4-MeOC₆H₄) and I (n = 0, 1) were prepared by treating Cl₃CP(O)(OEt)₂ with BuLi at -90°, ClCO₂Et at -125°, and RCHO or the cycloalkanone at -60 to +20°. Hydrolysis of the intermediate Li enolate formed in the above reactions gave EtO₂CCHClP(O)(OEt)₂.

Synthesis published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C6H4ClNO2, Quality Control of 866-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Villieras, Jean published the artcileα-Chloroenolates; VI. Diethyl 1-chloro-1-lithio-2-oxoalkanephosphonates; synthesis of α-chloro-α,β-unsaturated ketones, Category: chlorides-buliding-blocks, the publication is Synthesis (1978), 29-31, database is CAplus.

1-Chloro-2-oxoalkanephosphonates RCOCHClP(O)(OEt)₂ (I; R = Pr, iso-Pr, tert-Bu) were prepared in 60-85% yield by treating LiCCl₂P(O)(OEt)₂ with BuLi at -90° followed by acylation with RCOCl at -125 and hydrolysis. In situ reaction of I α-Li derivatives with aldehydes R¹CHO (R¹ = Ph, 2- or 4-ClC₆H₄, Bu) gave α,β-unsaturated ketones (E)-R¹CH:CClCOR.

Synthesis published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C7H8BNO4, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Gottardi, Waldemar published the artcileThe Integral Method, a new approach to quantify bactericidal activity, Application In Synthesis of 7080-50-4, the publication is Journal of Microbiological Methods (2015), 71-78, database is CAplus and MEDLINE.

The bactericidal activity (BA) of antimicrobial agents is generally derived from the results of killing assays. A reliable quant. characterization and particularly a comparison of these substances, however, are impossible with this information. We here propose a new method that takes into account the course of the complete killing curve for assaying BA and that allows a clear-cut quant. comparison of antimicrobial agents with only one number The new Integral Method, based on the reciprocal area below the killing curve, reliably calculates an average BA [log₁₀ CFU/min] and, by implementation of the agent’s concentration C, the average specific bactericidal activity SBA = BA / C [log₁₀ CFU/min/mM]. Based on exptl. killing data, the pertaining BA and SBA values of exemplary active halogen compounds were established, allowing quant. assertions. N-chlorotaurine (NCT), chloramine T (CAT), monochloramine (NH₂Cl), and iodine (I₂) showed extremely diverging SBA values of 0.0020 ± 0.0005, 1.11 ± 0.15, 3.49 ± 0.22, and 291 ± 137 log₁₀ CFU/min/mM, resp., against Staphylococcus aureus. This immediately demonstrates an approx. 550-fold stronger activity of CAT, 1730-fold of NH₂Cl, and 150,000-fold of I₂ compared to NCT. The inferred quant. assertions and conclusions prove the new method suitable for characterizing bactericidal activity. Its application comprises the effect of defined agents on various bacteria, the consequence of temperature shifts, the influence of varying drug structure, dose-effect relationships, ranking of isosteric agents, comparison of competing com. antimicrobial formulations, and the effect of additives.

Journal of Microbiological Methods published new progress about 7080-50-4. 7080-50-4 belongs to chlorides-buliding-blocks, auxiliary class Halogenation Reagent,Inhibitor, name is Sodium chloro(tosyl)amide trihydrate, and the molecular formula is C7H13ClNNaO5S, Application In Synthesis of 7080-50-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Borah, Arun Jyoti published the artcileBromamine-T as an efficient amine source for Sharpless asymmetric aminohydroxylation of olefins, Quality Control of 7080-50-4, the publication is Tetrahedron Letters (2014), 55(3), 713-715, database is CAplus.

Asym. aminohydroxylation of various olefins was carried out using bromamine-T as nitrogen source in the presence of (DHQ)₂PHAL ligand. The new nitrogen source was effective in terms of yield and reaction time. The optical purities of the products could be obtained with ≤99% ee.

Tetrahedron Letters published new progress about 7080-50-4. 7080-50-4 belongs to chlorides-buliding-blocks, auxiliary class Halogenation Reagent,Inhibitor, name is Sodium chloro(tosyl)amide trihydrate, and the molecular formula is C7H13ClNNaO5S, Quality Control of 7080-50-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Corallo, Marcel published the artcileStudy of the reaction of α-chlorinated alkylphosphonyl dichlorides with alcohols and amines, Product Details of C5H10Cl3O3P, the publication is Phosphorus and Sulfur and the Related Elements (1978), 4(1), 19-25, database is CAplus.

Condensation reactions of alcs. and amines with Cl₃CP(O)Cl₂ and with α,α-dichlorinated alkylphosphonyl dichlorides were investigated. The best results were obtained in solution with Et₃N as HCl trapping agent. Thus, reaction of Cl₃CP(O)Cl₂ with MeOH at -20° gave Cl₃P(O)(OMe)Cl. Several side reactions occur, one leading to triethylammonium phosphonates. The exptl. conditions for the stepwise esterification of α-chlorinated phosphonyl dichlorides were also given.

Phosphorus and Sulfur and the Related Elements published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, Product Details of C5H10Cl3O3P.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Ye, Xiaohan published the artcileGold-Catalyzed Oxidative Coupling of Alkynes toward the Synthesis of Cyclic Conjugated Diynes, SDS of cas: 21286-54-4, the publication is Chem (2018), 4(8), 1983-1993, database is CAplus and MEDLINE.

Gold-catalyzed oxidative coupling of alkynes was developed as an efficient approach for the synthesis of challenging cyclic conjugated diynes (CCD), e.g., I. Compared with the classic copper-promoted oxidative coupling reaction of alkynes, this gold-catalyzed process exhibited a faster reaction rate due to rapid reductive elimination from the Au(III) intermediate. This unique reactivity thus allowed a challenging diyne macrocyclization to take place with high efficiency. Condition screening revealed an [(n-Bu)₄N]⁺[Cl-Au-Cl]^– salt as the optimal pre-catalyst. Macrocycles with ring size between 13 and 28 atoms were prepared in moderate to good yields, which highlighted the broad substrate scope of this new strategy. Furthermore, the synthetic utilities of the CCDs for copper-free click chem. have been demonstrated, showcasing the potential application of this strategy in biol. systems.

Chem published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C9H16BNO2, SDS of cas: 21286-54-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Carreras, Javier published the artcileExploiting the π-acceptor properties of carbene-stabilized phosphorus centered trications [L₃P] ³⁺: applications in Pt(II) catalysis, Computed Properties of 849052-15-9, the publication is Journal of the American Chemical Society (2012), 134(40), 16753-16758, database is CAplus and MEDLINE.

2-Ethynylbiaryls undergo 6-endo-dig cyclization into annulated phenanthrenes and helicenes, catalyzed by platinum complex with electron-accepting tricationic cyclopropenylium phosphine, [(Me₂N)₂C₃⁺]₃P (1), [[(Me₂N)₂C₃⁺]₃PPtCl₃][ClO₄]₂ (3). The complex 3 is a bench-stable compound, easily available from reaction of K₂PtCl₄ with 1; the complex 3 is an excellent catalyst for cyclization of 2-ethynylbiaryls, when activated by Ag[CB₁₁H₆Cl₆]. Complexation of platinum complex (3) with alkyne is approx. 6 kcal mol^-1 more favorable, than with triphenylphosphine analog [(PPh₃)PtCl₃]^–. This constitutes the first example ever reported of using a P₁-centered trication as ligand in catalysis. The strong π-acceptor character of 1 that derives from its three pos. charges substantially increases the intrinsic π-acidity of Pt in complex 1·PtCl₂ and dramatically enhances its ability to activate π-systems toward nucleophilic attack. As a consequence, a remarkable acceleration of the model transformation is observed when compared with other classical π-acceptor ligands such as P(OPh)₃ or P(C₆F₅)₃. Moreover, the employment of 1 as ligand also expands the scope of this reaction to previously inaccessible substitution patterns. Kinetic studies and deuterium labeling experiments as well as d. functional theory (DFT) calculations were performed in order to explain these findings.

Journal of the American Chemical Society published new progress about 849052-15-9. 849052-15-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Ether,Boronic Acids,Boronic Acids,Boronic acid and ester,, name is (4-((2-Chlorobenzyl)oxy)-3,5-dimethylphenyl)boronic acid, and the molecular formula is C15H16BClO3, Computed Properties of 849052-15-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics