Tag: M.W=250-300

Kodolov, V. I. published the artcileMechanism of the reaction of diethyl alkylphosphonates with hydroxyl-containing polyethers, Safety of Diethyltrichloromethylphosphonate, the publication is Vysokomolekulyarnye Soedineniya, Seriya A (1968), 10(11), 2541-9, database is CAplus.

Di-Et alkylor arylphosphonates are treated with OH-containing oligoethers to obtain products which are useful as additives possessing fire resistance in foamed plastics, glass reinforced plastics, and other materials. Di-Et phosphonate and methyl-, allyl-, trichloromethyl-, and phenylphosphonates are used, and the oligoethers are HO[CH2CH2O2CRCO]mOCH2CH2OH, where R = -CH2-CH2-, -CH:CH-, or -o-C6H4-, where m is 1-2. The compounds are heated at 160-80° under N. The quantity of condensate increases after 4-6 hrs. with the acid number increasing and the OH-group content decreasing. Chromatograms, kinetic data, and ir spectra are given for the products and discussed, and a mechanism for the reaction, based on the destruction of the oligoether by alcoholysis, followed by a proton-radical exchange between the oligoether and the Et Cellosolve formed is proposed.

Vysokomolekulyarnye Soedineniya, Seriya A published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, Safety of Diethyltrichloromethylphosphonate.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Le Menn, J. C. published the artcileThe methoxy-iminium cation issued from DMF in organic electrosynthesis: an electrophile and a supporting-electrolyte cation, Related Products of chlorides-buliding-blocks, the publication is Electrochimica Acta (1991), 36(5-6), 819-23, database is CAplus.

Electrophilic reactivity of the methoxy-iminium cation (I), resulting from the reaction between dimethyl sulfate and DMF, has been investigated towards electrogenerated carbanions produced by electroreduction of activated polyhalo compounds Controlled potential reduction of di-Et trichloromethylphosphonate (II) in the presence of three equivalent of I in DMF leads to the expected adduct (EtO)₂P(O)CCl₂-CH(NMe₂)OMe (60% yield). Galvanostatic reduction of II in the presence of two equivalent of I leads to mixtures of the enamine (EtO)₂P(O)CCl=CH(NM₂) and the ynamine (EtO)₂P(O)CCNMe₂; when acetic acid is added, a mixture of the enamine and the enol-ether (EtO)₂P(O)CCl=CH(OMe) is obtained. Lastly, the enamine can be synthesized with a 80% yield by electroreducing II in the presence of four equivalent of I in the same way, enamines (MeO₂C)₂C=CH(NMe₂) (40% yield) and (EtO₂C)CCl=CH(NMe₂) (50% yield) are obtained from the electroreduction of di-Me dibromomalonate or Et trichloroacetate, resp.

Electrochimica Acta published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Kukhar, V. P. published the artcileReactions of trialkyl phosphites with polyhalomethanes, Quality Control of 866-23-9, the publication is Zhurnal Obshchei Khimii (1979), 49(7), 1470-4, database is CAplus.

In the reaction of CCl₄, CBr₄, and CHCl₃ with (RO)₃P (R = Et, Pr), one, two or three halo atoms are replaceable depending on the corresponding reagents used. Thus, reaction of CCl₄ with 2 mols. (EtO)₃P gave [(EtO)₂P(O)]₂CCl₂ whereas with 4 mols (EtO)₃P it gave [(EtO)₂P(O)]₂CH₂, (EtO)₂P(O)Cl, CH₂:CH₂ and EtCl.

Zhurnal Obshchei Khimii published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, Quality Control of 866-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Neyt, N. C. published the artcileBatch-flow hybrid synthesis of the antipsychotic clozapine, Name: 2-((4-Chloro-2-nitrophenyl)amino)benzoic acid, the publication is Reaction Chemistry & Engineering (2018), 3(1), 17-24, database is CAplus.

The implementation of an on-the-fly purification by trituration which was also utilized to perform solvent swaps. This above concept demonstrated through the synthesis of the antipsychotic clozapine. In addition, reported a novel means of performing a reduction of an aryl nitro group under flow conditions and an overall improved process route for the total synthesis of clozapine.

Reaction Chemistry & Engineering published new progress about 60091-87-4. 60091-87-4 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Nitro Compound,Carboxylic acid,Amine,Benzene, name is 2-((4-Chloro-2-nitrophenyl)amino)benzoic acid, and the molecular formula is C13H9ClN2O4, Name: 2-((4-Chloro-2-nitrophenyl)amino)benzoic acid.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Rueger, Carla published the artcileNew derivatives of 5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-ones with anticholinergic activity, Safety of 2-((4-Chloro-2-nitrophenyl)amino)benzoic acid, the publication is Pharmazie (1990), 45(8), 555-9, database is CAplus.

Condensation of 4,2-R(O₂N)C₆H₃Cl (R = H, Cl) with 2-H₂NC₆H₄CO₂H gave 2-[4,2-R(O₂N)C₆H₃NH]C₆H₄CO₂H (same R). The reduction of the latter gave 2-[4,2-R(H₂N)C₆H₃NH]C₆H₄CO₂H which upon cyclocondensation gave 5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one and its 8-chloro derivative The latter products were acylated or methylated and acylated to give 5-acyl-5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-ones I (R = H, Cl; R¹ = H, Me; R² = Cl, CH₂Cl, etc.); the I thus obtained were aminated to give I [R = H, Cl; R¹ = H, Me; R² = N(CH₂CH₂OH)₂, NMe(CH₂CH₂OH), etc.] (II). The ulcer-inhibiting activity of II was postulated; II (R = Cl; R¹ = H; R² = N(CH₂CH₂)H)].HCl, i.e. AWD 26-06, is selected for clin. evaluation (no data). II thus prepared differ from other tricyclic psychopharmaceuticals in their lipid solubility and hence have no effect as central nervous system agents.

Pharmazie published new progress about 60091-87-4. 60091-87-4 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Nitro Compound,Carboxylic acid,Amine,Benzene, name is 2-((4-Chloro-2-nitrophenyl)amino)benzoic acid, and the molecular formula is C13H9ClN2O4, Safety of 2-((4-Chloro-2-nitrophenyl)amino)benzoic acid.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Fu, Qiuguo published the artcileBioaccumulation, Biotransformation, and Synergistic Effects of Binary Fungicide Mixtures in Hyalella azteca and Gammarus pulex: How Different/Similar are the Two Species?, SDS of cas: 67747-01-7, the publication is Environmental Science & Technology (2018), 52(22), 13491-13500, database is CAplus and MEDLINE.

Aquatic organisms are consistently exposed to a mixture of micropollutants that can bioaccumulate, undergo biotransformation, and may exert mixture effects. However, little is known on the underlying mechanisms and species-specificity. Herein the authors investigated bioaccumulation, biotransformation and synergistic effects of azole (i.e., prochloraz) and strobilurin (i.e., azoxystrobin) fungicides in the two aquatic invertebrate species, Hyalella azteca and Gammarus pulex. Bioaccumulation of azoxystrobin was similar, whereas bioaccumulation of prochloraz was slightly different in the two species but was still significantly below the REACH criteria for bioaccumulative substances. Similar biotransformation patterns were observed in both species, and only a few unique biotransformation reactions were detected in H. azteca such as malonyl-glucose and taurine conjugation. Toxicokinetic modeling addnl. indicated that biotransformation is a more important elimination pathway in H. azteca. In mixtures, no-observed-adverse-effect levels of prochloraz decreased the LC50s of azoxystrobin in both species which correlated well with increased internal azoxystrobin concentrations This synergistic effect is partly due to the inhibition of cytochrome P 450 monooxygenases by prochloraz which subsequently triggered the reduced biotransformation of azoxystrobin (lower by 5 folds in H. azteca). The largely similar responses in both species suggest that the easier-to-cultivate H. azteca is a promising representative of invertebrates for toxicity testing.

Environmental Science & Technology published new progress about 67747-01-7. 67747-01-7 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Amine,Benzene,Ether,Benzene Compounds, name is N-(2-(2,4,6-Trichlorophenoxy)ethyl)propan-1-amine, and the molecular formula is C11H14Cl3NO, SDS of cas: 67747-01-7.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Ramana, P. Venkata published the artcileSynthesis of 1,2,3-triazole substituted isoxazoles via copper(I) catalyzed cycloaddition, Application In Synthesis of 3919-74-2, the publication is Journal of Heterocyclic Chemistry (2012), 49(3), 621-627, database is CAplus.

The synthesis of a series of 3,5-disubstituted isoxazole-4-carboxylic esters containing N-substituted 1,2,3-triazoles starting from various benzaldehydes was reported. Initially, the benzaldehydes underwent oximation with NH₂OH.HSO₄. Later, chlorination followed by condensation with AcCH₂CO₂Me and hydrolysis of the resulting ester afforded the resp. carboxylic acids, which on chlorination with PCl₅ gave the corresponding acid chlorides. Subsequent propargylation gave propargylic esters, which led to the title compounds on click reaction.

Journal of Heterocyclic Chemistry published new progress about 3919-74-2. 3919-74-2 belongs to chlorides-buliding-blocks, auxiliary class Isoxazole,Fluoride,Chloride,Carboxylic acid,Benzene, name is 3-(2-Chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylic acid, and the molecular formula is C11H7ClFNO3, Application In Synthesis of 3919-74-2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Ramana, Parikibanda Venkata published the artcileSynthesis of dihydrooxazoylarylisoxazoles by conventional and under microwave conditions, Recommanded Product: 3-(2-Chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylic acid, the publication is European Journal of Chemistry (2011), 2(3), 300-307, database is CAplus.

The synthesis of series of 3-aryl-4-dihydrooxazolyl-5-Me trisubstituted isoxazoles I(R¹ = R² = H, Cl, R¹ = H, R² = Cl, R¹ = Cl, R² = F; R³ = R⁴ = H, Me, R³ = Me, iPr, R⁴ = H ) is reported, both under thermal and microwave conditions starting from various benzaldehydes. Benzaldehydes undergo oximation with hydroxylamine hydrosulfate to provide oximes that upon chlorination, followed by condensation with methylacetoacetate, resulted in the formation of esters. Hydrolysis of the esters to acids followed by treatment with PCl₅, resulted in the formation of acid chlorides that upon reaction with hydroxyamines, gave N-β-hydoxyalkyl amides. These on further reaction with SOCl₂, followed by cyclization with 2 N NaOH provided oxazoline substituted isoxazoles in good yields. The conversion acidchlorides to isoxazoles was also achieved by microwave irradiation in moderate to excellent yields, with shorter reaction times compared to the conventional thermal method.

European Journal of Chemistry published new progress about 3919-74-2. 3919-74-2 belongs to chlorides-buliding-blocks, auxiliary class Isoxazole,Fluoride,Chloride,Carboxylic acid,Benzene, name is 3-(2-Chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylic acid, and the molecular formula is C11H7ClFNO3, Recommanded Product: 3-(2-Chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylic acid.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Amata, Emanuele published the artcile(+)-Methyl (1R,2S)-2-{[4-(4-Chlorophenyl)-4-hydroxypiperidin-1-yl]methyl}-1-phenylcyclopropanecarboxylate [(+)-MR200] Derivatives as Potent and Selective Sigma Receptor Ligands: Stereochemistry and Pharmacological Properties, Recommanded Product: ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, the publication is Journal of Medicinal Chemistry (2018), 61(1), 372-384, database is CAplus and MEDLINE.

Methoxycarbonyl-1-phenyl-2-cyclopropylmethyl based derivatives [cis-(+)-MR200], [cis-(-)-MR201], and [trans-(±)-MR204], have been identified as new potent sigma (σ) receptor ligands. In the present paper, novel enantiomerically pure analogs were synthesized and optimized for their σ receptor affinity and selectivity. Docking studies rationalized the results obtained in the radioligand binding assay. Absolute stereochem. was unequivocally established by X-ray anal. of a precursor as camphorsulfonyl derivative The most promising compound, I, showed remarkable selectivity over a panel of more than 15 receptors as well as good chem. and enzymic stability in human plasma. An in vivo evaluation evidenced that I, in contrast to its isomers, which behave as σ₁ antagonists, exhibited a σ₁ agonist profile. These data clearly demonstrated that compound I, due to its σ₁ agonist activity and favorable receptor selectivity and stability, provided an useful tool for the study of σ₁ receptors.

Journal of Medicinal Chemistry published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C10H15ClO3S, Recommanded Product: ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zhang, Xiulian published the artcileAryldiazonium ion initiated C-N bond cleavage for the versatile, efficient and regioselective ring opening of aziridines, Name: Sodium chloro(tosyl)amide trihydrate, the publication is Organic Chemistry Frontiers (2019), 6(11), 1832-1836, database is CAplus.

Aryldiazonium salts were proved to initiate the regioselective cleavage of aziridines for the installation of varied functional groups to gave β-substituted aryl sulfonamides I [R¹ = Ph, 4-MeC₆H₄, 4-ClC₆H₄, etc.; R² = H, Me; R³ = OMe, OBn, SPh, etc.]. The ring-opening process was effective and general for a variety of nucleophiles, including [O], [S] and [N] at room temperature This highly regioselective process, which could be performed at the gram scale, enjoys operational simplicity, as well as mild and metal-free conditions. The postulated reaction mechanism involved a single electron transfer from aziridines to aryldiazonium salts, which generates a highly reactive amino radical cation.

Organic Chemistry Frontiers published new progress about 7080-50-4. 7080-50-4 belongs to chlorides-buliding-blocks, auxiliary class Halogenation Reagent,Inhibitor, name is Sodium chloro(tosyl)amide trihydrate, and the molecular formula is C8H10S, Name: Sodium chloro(tosyl)amide trihydrate.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics