Tag: M.W=250-300

Chen, Yiding published the artcileCopper(I)-catalyzed sulfonylative Suzuki-Miyaura cross-coupling, Name: (4-((4-Chlorobenzyl)oxy)phenyl)boronic acid, the publication is Chemical Science (2017), 8(4), 3249-3253, database is CAplus and MEDLINE.

By using a simple copper(I) catalyst a high yielding sulfonylative-Suzuki-Miyaura cross-coupling reaction was developed. The process provided a single step route to diaryl sulfones from the direct combination of arylboronic acids, sulfur dioxide and aryl iodides, and represents the first sulfonylative variant of a classic cross-coupling reaction. Sulfur dioxide was delivered from the surrogate reagent, DABSO. Variation of the reaction conditions allowed interruption of the sulfonylative-Suzuki coupling, resulted in the formation of a presumed Cu-sulfinate intermediate. These sulfinates was trapped as their sodium salts and treated with electrophiles to allow access to arylalkyl sulfones, β-hydroxyl sulfones, sulfonamides and sulfonyl fluorides.

Chemical Science published new progress about 870778-91-9. 870778-91-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Ether,Boronic Acids,Boronic Acids,Boronic acid and ester,, name is (4-((4-Chlorobenzyl)oxy)phenyl)boronic acid, and the molecular formula is C13H12BClO3, Name: (4-((4-Chlorobenzyl)oxy)phenyl)boronic acid.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zhou, Li published the artcileN-heterocyclic olefins catalyzed ring-opening polymerization of N-tosyl aziridines, Formula: C7H13ClNNaO5S, the publication is European Polymer Journal (2020), 110046, database is CAplus.

A N-heterocyclic olefins (NHOs) catalyzed ring-opening polymerization of N-tosyl aziridines has been developed under metal-free and mild conditions. The NHO serves as a highly efficient and versatile organocatalyst for the synthesis of linear poly(aziridine)s, delivering the corresponding polymers with high chain-end fidelity, controlled mol. weights (up to 83 kg/mol) and narrow mol. weight distributions (ETH = 1.10-1.16). Based on MALDI-TOF MS and ¹H NMR spectroscopies’ results, an anionic ring-opening polymerization (AROP) mechanism has been proposed.

European Polymer Journal published new progress about 7080-50-4. 7080-50-4 belongs to chlorides-buliding-blocks, auxiliary class Halogenation Reagent,Inhibitor, name is Sodium chloro(tosyl)amide trihydrate, and the molecular formula is C5H6BNO2, Formula: C7H13ClNNaO5S.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Chevis, Philip J. published the artcileHighly diastereoselective synthesis of enantioenriched anti-α-allyl-β-fluoroamines, Safety of ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, the publication is Chemical Communications (Cambridge, United Kingdom) (2019), 55(43), 6050-6053, database is CAplus and MEDLINE.

A highly diastereoselective synthesis of anti-α-allyl-β-fluoroamines was developed involving enantioselective α-fluorination of aldehydes followed by a diastereoselective Petasis allyl borono-Mannich reaction. The products are obtained generally in good overall yields for the two steps and with drs of 97 : 3-99 : 1 and ees of 86-92%. Selected products were converted to 3-, 5- and 6-membered ring heterocycles, the latter two types incorporating an exo-cyclic fluorine.

Chemical Communications (Cambridge, United Kingdom) published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C10H15ClO3S, Safety of ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Carran, John published the artcileAn improved synthesis of dichloroalkylphosphonates, chloro alkynes, and terminal alkynes via diethyl dichloromethylphosphonate, SDS of cas: 866-23-9, the publication is Synthesis (1996), 1494-1498, database is CAplus.

(EtO)₂P(O)CHCl₂ was synthesized in good yield by reduction of (EtO)₂P(O)CHCl₃ with Me₂CHMgCl and subsequent hydrolysis. The reactivity of (EtO)₂P(O)CHCl₂ towards α-alkylation and its utility in the synthesis of chloro alkynes and terminal alkynes was investigated.

Synthesis published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, SDS of cas: 866-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Ma, Zhi-Gang published the artcileAsymmetric Organocatalytic Synthesis of 2,3-Allenamides from Hydrogen-Bond-Stabilized Enynamides, Safety of 2,3-Dibromopropionylchloride, the publication is Organic Letters (2019), 21(7), 2468-2472, database is CAplus and MEDLINE.

Asym. catalytic synthesis of 2,3-allenamides from hydrogen-bond-stabilized enynamides in the presence of quinine-based bifunctional squaramide organocatalysts is described. This protocol forms a variety of 2,3-allenamides in high yields and excellent stereoselectivities, in which the elaborated introduction of intramol. H-bonds within the N,N-bidentate amide group constitutes one of the keys to this highly enantioselective transformation. The synthetic practicality of this reaction was demonstrated by the axis-to-center chirality transfer of allenamides to furnish enantiomerically enriched building blocks.

Organic Letters published new progress about 18791-02-1. 18791-02-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 2,3-Dibromopropionylchloride, and the molecular formula is C3H3Br2ClO, Safety of 2,3-Dibromopropionylchloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Li, Xuemin published the artcileQuantitative analysis of 2,3-dibromopropionyl chloride, Application of 2,3-Dibromopropionylchloride, the publication is Ranliao Yu Ranse (2011), 48(6), 56-59, database is CAplus.

An anal. method for a dye intermediate 2,3-dibromopropionyl chloride was established. The method was based on derivation of 2,3-dibromopropionyl chloride. 2,3-Dibromo-N-phenylpropanamide was almost quant. prepared from 2,3-dibromopropionyl chloride and aniline by amidation. The external standard calibration curve of 2,3-dibromo-N-phenylpropanamide was obtained by HPLC, thus the content of 2,3-dibromopropionyl chloride was determined The linear regression equation of the method was given, the liner correlation coefficient was 0.9997, the linear range was 0.1341-0.6707 mg/mL, the standard deviation was 0.005, the variation coefficient was 0.5%, and the recovery rate was 99.81%-100.05%.

Ranliao Yu Ranse published new progress about 18791-02-1. 18791-02-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 2,3-Dibromopropionylchloride, and the molecular formula is C3H3Br2ClO, Application of 2,3-Dibromopropionylchloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Yang, Shichao published the artcileVisible-Light Photoredox-Catalyzed Regioselective Sulfonylation of Alkenes Assisted by Oximes via [1,5]-H Migration, Computed Properties of 32333-53-2, the publication is Journal of Organic Chemistry (2020), 85(2), 564-573, database is CAplus and MEDLINE.

Herein, a visible-light photoredox-catalyzed regioselective sulfonylation of alkenes with sulfonyl hydrazides assisted by oximes at room temperature, which affords a variety of sulfones in good yields is reported. The initial mechanistic experiments demonstrate that the hydroxyl group within oximes plays a crucial role in this sulfonylation.

Journal of Organic Chemistry published new progress about 32333-53-2. 32333-53-2 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Sulfonyl chlorides,Benzene, name is 4-Chloro-3-(trifluoromethyl)benzenesulfonyl Chloride, and the molecular formula is C5H10O, Computed Properties of 32333-53-2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Ding, Siyi published the artcileNNB-type tridentate boryl ligands enabling a highly active iridium catalyst for C-H borylation, SDS of cas: 929626-16-4, the publication is Molecules (2019), 24(7), 1434, database is CAplus and MEDLINE.

Boryl ligands play a very important role in catalysis because of their very high electron-donating property. NNB-type boryl anions were designed as tridentate ligands to promote aryl C-H borylation. In combination with [IrCl(COD)]₂, they generate a highly active catalyst for a broad range of (hetero)arene substrates, including highly electron-rich and/or sterically hindered ones. This work provides a new NNB-type tridentate boryl ligand to support homogeneous organometallic catalysis.

Molecules published new progress about 929626-16-4. 929626-16-4 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Ether,Boronic Acids,Boronate Esters, name is 2-(3-Chloro-5-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, and the molecular formula is C13H18BClO3, SDS of cas: 929626-16-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Wang, Qiuzhu published the artcileSynthesis of β-Polychlorinated Alkynes Enabled by Copper-Catalyzed Multicomponent Reaction, Formula: C5H10Cl3O3P, the publication is Organic Letters (2022), 24(26), 4772-4777, database is CAplus and MEDLINE.

Functional mols. bearing polychlorinated moieties usually play versatile roles in organic synthesis and biochem. A copper-catalyzed multicomponent polychloro-carboalkynylation of alkenes presents an efficient and operationally simple approach for the synthesis of β-polychlorinated alkynes. Mechanistic experiments were conducted demonstrating that an in situ generated copper acetylide complex was the real catalyst and reactive intermediate during the copper-catalytic cycle. And enantioselective exploration demonstrated potential application for the synthesis of chiral β-polychlorinated alkynes.

Organic Letters published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C13H11NO, Formula: C5H10Cl3O3P.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Fronk, Stephanie L. published the artcileEffect of chiral 2-ethylhexyl side chains on chiroptical properties of the narrow bandgap conjugated polymers PCPDTBT and PCDTPT, COA of Formula: C10H15ClO3S, the publication is Chemical Science (2016), 7(8), 5313-5321, database is CAplus and MEDLINE.

Two narrow bandgap conjugated polymers containing chiral 2-ethylhexyl side chains were synthesized: poly[(4,4-bis(2-ethylhexyl)cyclopenta-[2,1-b:3,4-b‘]dithiophene)-2,6-diyl-alt-(2,1,3-benzothiadiazole)-4,7-diyl] (PCPDTBT*) and poly[(4,4-bis(2-ethylhexyl)cyclopenta[2,1-b:3,4-b‘]dithiophene)-2,6-diyl-alt-[1,2,5]-thiadiazolo[3,4-c]pyridine] (PCDTPT*). The presence of a chiral substituent provides a handle to study the geometry of interchain aggregates and/or the secondary structure of these conjugated polymers in solution and in thin films via CD spectroscopy, provided that the asymmetry in the side-chain was translated to the optically active conjugated backbone. CD signals were observed for PCPDTBT* and PCDTPT* in poor solvent systems, which indicated the presence of chiral ordering in the aggregates. PCPDTBT* showed greater chiral order than PCDTPT* based on their relative anisotropy factors. Addnl., GIWAXS anal. reveals that PCPDTBT* films were more ordered than what was observed for the same polymer containing racemic 2-ethylhexyl chains. Upon solution deposition, the chiral ordering was found to translate to the solid-state microstructure for PCPDTBT* but not PCDTPT*. The presence of a pyridyl nitrogen on the thiadiazolo[3,4-c]pyridine ring of PCDTPT* favored a planar conformation for the backbone such that it has a higher rotational barrier compared to PCPDTBT*. This larger rotational barrier appeared to limit the ability of PCDTPT* to adopt a helical structure or relevant chain distortions for achieving chiral aggregates.

Chemical Science published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C10H15ClO3S, COA of Formula: C10H15ClO3S.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics