Tag: M.W=250-300

Grabarczyk, Malgorzata published the artcileHydroxy lactones with the gem-dimethylcyclohexane system – Synthesis and antimicrobial activity, Recommanded Product: ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, the publication is Arabian Journal of Chemistry (2019), 12(8), 2280-2288, database is CAplus.

Two new lactones comprising the gem-dimethylcyclohexane ring: 2-chloro-5,5-dimethyl-9-oxabicyclo[4.3.0]nonan-8-one and 2-bromo-5,5-dimethyl-9-oxabicyclo[4.3.0]nonan-8-one as well as the already known 2-iodo-5,5-dimethyl-9-oxabicyclo[4.3.0]nonan-8-one, were obtained from (6,6-dimethylcyclohex-2-en-1-yl)acetic acid. These lactones were used as substrates for the screening of biotransformation by whole cells of nine fungal strains (Fusarium species, Syncephalastrum racemosum and Cunninghamella japonica). Some of these microorganisms (mainly Fusarium species) transformed all three lactones during the hydrolytic dehalogenation into 2-hydroxy-5,5-dimethyl-9-oxabicyclo[4.3.0]nonan-8-one. It is worth noting that two microorganisms (Fusarium culmorum and Fusarium scirpi) converted iodolactone with very high enantioselectivity (75.1% and 91.6%, resp.). The (+) isomer of hydroxy lactone was preferred. At the last step the hydroxy lactone obtained during biotransformation was examined for its biol. activity against bacteria, yeasts and fungi. It was found that this compound inhibits growth of some tested microorganisms.

Arabian Journal of Chemistry published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C10H15ClO3S, Recommanded Product: ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Blair, N. D. published the artcileNovel fire retardant intumescent coatings, Application In Synthesis of 866-23-9, the publication is Journal of Paint Technology (1972), 44(573), 75-82, database is CAplus.

The efficiency of 21 P compounds in epoxy coatings varied in series acids > phosphates .sim. phosphites >> phosphonates. The weight loss, char area, and char volume of epoxy coatings containing tri-Ph phosphite [101-02-0] and tri-Me phosphate [512-56-1] were generally minimized while the intumescence maximized as the concentration of amine catalyst, P compound, and film thickness were increased over a wide range. A combination of a high melting insoluble chlorocarbon and phosphoryltrianilide [5326-10-3] were used to prepare fire retardant pigmented alkyd and chlorinated alkyd paints with excellent water and scrub resistance. The fire retardant properties of epoxy coatings containing (PhO)3P were unchanged after immersion in water at 50.deg. for 24 hr.

Journal of Paint Technology published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, Application In Synthesis of 866-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Sellier, Guy published the artcileDetermination of energies of hydrogen bonds formed between phenol and various bases in carbon tetrachloride, Category: chlorides-buliding-blocks, the publication is Journal de Chimie Physique et de Physico-Chimie Biologique (1968), 65(5), 936-43, database is CAplus.

This method given uses the bonding formation enthalpy, the frequency shift of the proton donor group, and the free overtone value. The method is applied to associations of PhOH with 112 proton acceptors in CCl4 solution A linear relation exists between the formation enthalpy and the frequency shift and another between the H bonding energy and the frequency shift.

Journal de Chimie Physique et de Physico-Chimie Biologique published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C12H23N3S, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Kim, Yeong Bum published the artcileNi-Catalyzed Intermolecular C(sp³)-H Amidation Tuned by Bidentate Directing Groups, Safety of ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, the publication is ACS Catalysis (2021), 11(5), 3067-3072, database is CAplus.

Herein a directing group-assisted nickel-catalyzed intermol. C(sp³)-H amidation using organic azides as nitrene precursors is disclosed. With the installation of an electronically tailored directing group, enhanced amidation efficiency has been achieved. A series of exptl. and computational studies suggested that a putative nickel(III)-nitrenoid species is a key intermediate in the C-N bond-forming process.

ACS Catalysis published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C10H15ClO3S, Safety of ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Xu, Ren-Rui published the artcilePalladium-catalyzed cascade Heck-type cyclization and reductive aminocarbonylation for the synthesis of functionalized amides, Related Products of chlorides-buliding-blocks, the publication is Organic & Biomolecular Chemistry (2022), 20(13), 2605-2608, database is CAplus and MEDLINE.

A palladium-catalyzed Heck/carbonylative cyclization process was explored for the synthesis of functionalized amides. By using nitroarenes as readily accessible nitrogen sources, a variety of amide products, e.g., I (Ar = 4-MeC₆H₄, 2-ClC₆H₄, 1-naphthyl, 2-thienyl, 8-quinolinyl, etc.), was obtained from the corresponding o-iodoaryl alkenes, e.g., II, in moderate to excellent yields with good functional group compatibility. Furthermore, a late-stage modification of a natural mol. was also achieved by this protocol.

Organic & Biomolecular Chemistry published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C13H14N2O, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Ma, Hao published the artcileSynthesis of Bridging Chiral p-tert-Butylcalix[4]arenes with One and Two Carbamoyl Bridge-Substituents through Anionic Ortho-Fries Rearrangement, SDS of cas: 21286-54-4, the publication is ChemistrySelect (2020), 5(21), 6274-6277, database is CAplus.

Bridging chiral p-tert-butylcalix[4]arenes (p-t-Bu-BCC’s) with different N-substituted carbamoyl bridge-substituents (N,N-dimethylcarbamoyl, N,N-diethylcarbamoyl and morpholinocarbonyl) were successfully prepared through anionic ortho-Fries rearrangement from mono-O-carbamates of 1,3-dipropyl-p-tert-butylcalix[4]arene in 65-75% yield. In addition, p-t-Bu-BCC with two N,N-dimethylcarbamoyl bridge-substituents was produced by this method from mono-O-carbamate of p-t-Bu-BCC with one N,N-dimethylcarbamoyl bridge-substituent in 71% yield. However, the synthesis of p-t-Bu-BCC with addnl. carbamoyl bridge-substituents using this method could not be attempted, as the required rearrangement precursor failed to be synthesized. Finally, the racemic p-t-Bu-BCC with morpholinocarbonyl bridge-substituent was optically resolved into a pair of enantiomers, whose absolute configurations were determined through ROESY anal. and ECD comparison.

ChemistrySelect published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C10H15ClO3S, SDS of cas: 21286-54-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Giardina, Sarah F. published the artcileNovel, Self-Assembling Dimeric Inhibitors of Human β Tryptase, SDS of cas: 918331-73-4, the publication is Journal of Medicinal Chemistry (2020), 63(6), 3004-3027, database is CAplus and MEDLINE.

β-Tryptase, a homotetrameric serine protease, has four identical active sites facing a central pore, presenting an optimized setting for the rational design of bivalent inhibitors that bridge two adjacent sites. Using diol, hydroxymethyl phenols or benzoyl Me hydroxamates, and boronic acid chemistries to reversibly join two [3-(1-acylpiperidin-4-yl)phenyl]methanamine core ligands, we have successfully produced a series of self-assembling heterodimeric inhibitors. These heterodimeric tryptase inhibitors demonstrate superior activity compared to monomeric modes of inhibition. X-ray crystallog. validated the dimeric mechanism of inhibition, and compounds demonstrated high selectivity against related proteases, good target engagement, and tryptase inhibition in HMC1 xenograft models. Screening 3872 possible combinations from 44 boronic acid and 88 diol derivatives revealed several combinations that produced nanomolar inhibition, and seven unique pairs produced greater than 100-fold improvement in potency over monomeric inhibition. These heterodimeric tryptase inhibitors demonstrate the power of target-driven combinatorial chem. to deliver bivalent drugs in a small mol. form.

Journal of Medicinal Chemistry published new progress about 918331-73-4. 918331-73-4 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Carboxylic acid,Benzene,Boronate Esters,Boronic Acids,Boronic acid and ester,Boronate Esters, name is 4-Chloro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic acid, and the molecular formula is C13H16BClO4, SDS of cas: 918331-73-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Cordes, Jens published the artcilemeta-selective aromatic borylation as key step in the synthesis of poipuol, Recommanded Product: Diethyltrichloromethylphosphonate, the publication is Synthesis (2008), 2217-2220, database is CAplus.

A synthesis of the marine natural product poipuol is reported. The key reaction sequence consists of an iridium-catalyzed meta-selective CH-borylation followed by the conversion of the resulting arylboronic ester into an aryl chloride.

Synthesis published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, Recommanded Product: Diethyltrichloromethylphosphonate.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Wrobel, Zbigniew published the artcileThe reported formation of 5H-dibenzo [b,e][1,4]diazepin-11( 10H )-ones in the noncatalyzed, base-promoted double arylation of anthranilamide revisited. Correction of some product structures, Category: chlorides-buliding-blocks, the publication is Journal of Heterocyclic Chemistry (2021), 58(9), 1802-1808, database is CAplus.

The base-promoted reaction of 2-halonitro- or 1,2-dihalobenzenes with anthranilamide reported by Cao, Ma et al. (Synthesis2013, 45, 111) was reinvestigated. Some of the products reported, which was identified as dibenzodiazepinones, were actually benzoxazole derivatives In this paper, the correct structures of these products were established and confirmed by independent synthesis. For four other products, the supposed structures were found to be incompatible with the dibenzodiazepinones that were synthesized by the reliable method used.

Journal of Heterocyclic Chemistry published new progress about 60091-87-4. 60091-87-4 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Nitro Compound,Carboxylic acid,Amine,Benzene, name is 2-((4-Chloro-2-nitrophenyl)amino)benzoic acid, and the molecular formula is C6H17NO3Si, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Apgar, James M. published the artcileMK-5204: An orally active β-1,3-glucan synthesis inhibitor, Synthetic Route of 7080-50-4, the publication is Bioorganic & Medicinal Chemistry Letters (2020), 30(17), 127357, database is CAplus and MEDLINE.

Our previously reported efforts to produce an orally active β-1,3-glucan synthesis inhibitor through the semi-synthetic modification of enfumafungin focused on replacing the C2 acetoxy moiety with an aminotetrazole and the C3 glycoside with a N,N-dimethylaminoether moiety. This work details further optimization of the C2 heterocyclic substituent, which identified 3-carboxamide-1,2,4-triazole as a replacement for the aminotetrazole with comparable antifungal activity. Alkylation of either the carboxamidetriazole at C2 or the aminoether at C3 failed to significantly improve oral efficacy. However, replacement of the iso-Pr α-amino substituent with a t-Bu, improved oral exposure while maintaining antifungal activity. These two structural modifications produced MK-5204, which demonstrated broad spectrum activity against Candida species and robust oral efficacy in a murine model of disseminated Candidiasis without the N-dealkylation liability observed for the previous lead.

Bioorganic & Medicinal Chemistry Letters published new progress about 7080-50-4. 7080-50-4 belongs to chlorides-buliding-blocks, auxiliary class Halogenation Reagent,Inhibitor, name is Sodium chloro(tosyl)amide trihydrate, and the molecular formula is C7H13ClNNaO5S, Synthetic Route of 7080-50-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics