Tag: M.W=250-300

Chen, Zhifei published the artcileSynthesis of 2,3-dihydro-3,5-dihydroxy-6-methyl-4H-pyran-4-one from maltol and its taste identification, Application In Synthesis of 21286-54-4, the publication is Food Chemistry (2021), 130052, database is CAplus and MEDLINE.

2,3-Dihydro-3,5-dihydroxy-6-methyl-4H-pyran-4-one (DDMP) exists in many foods, and its effect on taste is controversial. The aim of this study was to clarify whether DDMP has bitter taste or not. For this purpose, DDMP was synthesized from maltol instead of from glucose for the first time. In contrast, DDMP derived from glucose was also prepared and further purified. Their structures were identified by NMR and MS, and considered to be the same substance. The sensory anal. showed that DDMP derived from maltol was tasteless. Further studies indicated that some impurities in Maillard reaction made DDMP derived from glucose taste bitter.

Food Chemistry published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C10H15ClO3S, Application In Synthesis of 21286-54-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Shi, Lou published the artcileRegio- and Enantioselective Ni-Catalyzed Formal Hydroalkylation, Hydrobenzylation, and Hydropropargylation of Acrylamides to α-Tertiary Amides, Product Details of C3H3Br2ClO, the publication is Angewandte Chemie, International Edition (2021), 60(3), 1599-1604, database is CAplus and MEDLINE.

The development of enantioselective alkyl-alkyl cross-couplings with coinstantaneous formation of a stereogenic center without the use of sensitive organometallic species is attractive yet challenging. Herein, we report the intermol. regio- and enantioselective formal hydrofunctionalizations of acrylamides, forging a stereogenic center α-position to the newly formed C_sp3-C_sp3 bond for the first time. The use of a newly developed chiral ligand enables the electronically-reversed formal hydrofunctionalizations, including hydroalkylation, hydrobenzylation, and hydropropargylation, offering an efficient way to access diverse enantioenriched amides with a tertiary α-stereogenic carbon center which is facile to racemize. This operationally simple protocol allows for the anti-Markovnikov enantioselective hydroalkylation, and unprecedented hydrobenzylation, hydropropargylation under mild conditions with excellent functional group compatibility, delivering a wide range of amides with excellent levels of enantioselectivity.

Angewandte Chemie, International Edition published new progress about 18791-02-1. 18791-02-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 2,3-Dibromopropionylchloride, and the molecular formula is C15H14O3, Product Details of C3H3Br2ClO.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Wang, Zhen published the artcileChiral derivatives of covalent organic framework TpBD (NH₂)₂ used as stationary phases in gas chromatography, Product Details of C10H15ClO3S, the publication is Chirality (2022), 34(3), 462-472, database is CAplus and MEDLINE.

Chiral covalent organic framework materials have many excellent properties, which have received much attention in the field of separation Synthesized the covalent organic framework COF-TpBD (NH₂)₂ modified, resp., by L-valine trifluoroacetyl derivative, L-hydroxyproline, and (1S)-(+)-10-camphorsulfonyl chloride, three capillary columns of chiral covalent organic framework materials were obtained for gas chromatog. Those columns are able to sep. some chiral compounds, positional isomers, n-alkanes, n-alcs., aromatic hydrocarbon mixture, and Grob’s reagents. They are complementary to other chiral capillary columns and are possible for potential applications.

Chirality published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C4H4N2O2, Product Details of C10H15ClO3S.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Kong, Xianqiang published the artcileManganese-Catalyzed ortho-C-H Amidation of Weakly Coordinating Aromatic Ketones, Product Details of C10H15ClO3S, the publication is Organic Letters (2018), 20(15), 4495-4498, database is CAplus and MEDLINE.

An efficient manganese-catalyzed ortho-C-H amidation of weakly coordinating aromatic ketones using the readily available sulfonyl azide as the amination reagent is developed. The key step is the ketone directed aromatic metalation using the in situ generated reactive Mn intermediate, MnMe(CO)₅. This method offers excellent chem. yields, high regioselectivities, and good functional group tolerance.

Organic Letters published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C10H15ClO3S, Product Details of C10H15ClO3S.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Yu, Yongguo published the artcileDesign, synthesis and anticancer activity evaluation of diazepinomicin derivatives, Category: chlorides-buliding-blocks, the publication is Letters in Drug Design & Discovery (2013), 10(4), 369-373, 5 pp., database is CAplus.

A series of diazepinomicin derivatives [5,10-dihydro-4,6,8-trihydroxy-10-[(2E,6E)-3,7,11-trimethyl-2,6,10-dodecatrien-1-yl]-11H-dibenzo[b,e][1,4]diazepin-11-one derivatives] were synthesized and evaluated in vitro for their growth inhibitory activity against the human carcinoma cell lines. The results indicated the anticancer selectivity of this kind of compounds Based on the results, preliminary structure-activity relationships were discussed. The synthesis of the target compounds was achieved using 5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one derivatives and (2E,6E)-1-bromo-3,7,11-trimethyl-2,6,10-dodecatriene (trans,trans-farnesyl bromide) as key intermediates. The title compounds thus formed included a diazepinomicin analog (I) and related substances.

Letters in Drug Design & Discovery published new progress about 60091-87-4. 60091-87-4 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Nitro Compound,Carboxylic acid,Amine,Benzene, name is 2-((4-Chloro-2-nitrophenyl)amino)benzoic acid, and the molecular formula is C5H5ClIN, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Wu, Hsyueh-Liang published the artcileEnantioselective addition of organozinc reagents to carbonyl compounds catalyzed by a camphor derived chiral γ-amino thiol ligand, Category: chlorides-buliding-blocks, the publication is Tetrahedron (2016), 72(21), 2656-2665, database is CAplus.

The design and synthesis of the chiral camphor derived γ-amino thiol ligand I and its application in catalytic enantioselective carbon-carbon forming reactions through the addition of organozinc reagents (R)₂Zn (R = Me, Et) to carbonyl compounds R¹CHO (R¹ = 2-ClC₆H₄, 2-thienyl, cyclohexyl, etc.) have been described. The catalytic activity and enantioselectivity of ligand I were demonstrated in the enantioselective addition of various organozinc reagents to aldehydes and ketoesters ArC(O)CO₂CH₃ (Ar = 2-H₃CC₆H₄, 2-furyl, 2-naphthyl, etc.), offering the corresponding alcs. e.g., 4-BrC₆H₄CH(OH)CH₃ in high yields and enantioselectivities. The role of the mercapto group in the highly enantioselective 1,2-addition reaction of organozincs to aldehyde was also discussed.

Tetrahedron published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C7H11N, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Fu, Ying published the artcileDebenzylative Sulfonylation of Tertiary Benzylamines Promoted by Visible Light, Safety of 4-Chloro-3-(trifluoromethyl)benzenesulfonyl Chloride, the publication is European Journal of Organic Chemistry (2021), 2021(12), 1896-1900, database is CAplus.

An efficient, general, inexpensive, and environmentally friendly photosynthesis of sulfonamides via visible light promoted debenzylative sulfonylation of tertiary benzylamines is described. Compared to the traditional S-N coupling reactions, which are promoted by oxidative C-N bond cleavage of sym. tertiary alkylamines, this strategy provides a selective C-N bond cleavage protocol and avoids the use of transition-metal, explosive oxidants, and ligands.

European Journal of Organic Chemistry published new progress about 32333-53-2. 32333-53-2 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Sulfonyl chlorides,Benzene, name is 4-Chloro-3-(trifluoromethyl)benzenesulfonyl Chloride, and the molecular formula is C7H3Cl2F3O2S, Safety of 4-Chloro-3-(trifluoromethyl)benzenesulfonyl Chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Yang, Shan published the artcileRegioselective Sulfonylvinylation of the Unactivated C(sp³)-H Bond via a C-Centered Radical-Mediated Hydrogen Atom Transfer (HAT) Process, HPLC of Formula: 21286-54-4, the publication is Organic Letters (2019), 21(12), 4837-4841, database is CAplus and MEDLINE.

Given the similarity of multiple sp³ C-H bonds in electronic properties and bond dissociation energy (BDE), regioselective sp³ C-H bond functionalization remains a paramount challenge. Here, the authors report a C-centered radical-mediated approach for site-specific sulfonylvinylation of the C(sp³)-H bond via the hydrogen atom transfer (HAT) process. The reaction features mild conditions, broad substrate scope, and high regioselectivity and stereoselectivity, manifesting the nontrivial synthetic potential.

Organic Letters published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C9H9NO6S, HPLC of Formula: 21286-54-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Wang, Guan-Wu published the artcileMechanochemical aminochlorination of electron-deficient olefins with chloramine-T promoted by (diacetoxyiodo)benzene, Name: Sodium chloro(tosyl)amide trihydrate, the publication is Advanced Synthesis & Catalysis (2007), 349(11+12), 1977-1982, database is CAplus.

A direct and convenient procedure for the solvent-free mechanochem. aminochlorination of electron-deficient olefins promoted by (diacetoxyiodo)benzene [PhI(OAc)₂] was described using com. available and cheap chloramine-T as a nitrogen and chlorine source. The vicinal chloramine derivatives were obtained in high regio- and stereoselectivity with good yields. PhI(OAc)₂ was superior to metal salts for the aminochlorination of electron-deficient olefins.

Advanced Synthesis & Catalysis published new progress about 7080-50-4. 7080-50-4 belongs to chlorides-buliding-blocks, auxiliary class Halogenation Reagent,Inhibitor, name is Sodium chloro(tosyl)amide trihydrate, and the molecular formula is C10H10O2, Name: Sodium chloro(tosyl)amide trihydrate.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Gale, Douglas J. published the artcileFiber-reactive polymethine dyes containing the N-2,3-dibromopropionyl and N-chlorodifluoropyrimidyl groups, COA of Formula: C3H3Br2ClO, the publication is Textile Research Journal (1978), 48(9), 548-50, database is CAplus.

Treatment of 5-amino-1,3,3-trimethyl-2-methyleneindoline [6872-05-5] with 2,3-dibromopropionyl chloride [18791-02-1] or 5-chloro-2,4,6-trifluoropyrimidine [697-83-6] gives I (R = CH₂BrCHBrCO) [68699-06-9] and I (R = A) [68699-07-0], which are treated with 4-(dimethylamino)benzaldehyde [100-10-7], 4-[(2-chloroethyl)methylamino]benzaldehyde [94-31-5], or 1-methyl-2-phenylindole-3-carboxaldehyde [1757-72-8] to give 6 polymethine dyes. The lightfastness of the dyes on wool was significantly greater than that of the corresponding N-chloroacetyl and parent nonreactive dyes. Attempts to prepare the corresponding 2,4-dichloro-s-triazinyl derivative were unsuccessful.

Textile Research Journal published new progress about 18791-02-1. 18791-02-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 2,3-Dibromopropionylchloride, and the molecular formula is C3H3Br2ClO, COA of Formula: C3H3Br2ClO.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics