Tag: M.W=250-300

Matheny, Jonathon P. published the artcileFacile assembly of 1,5-diazocan-2-ones via cyclization of tethered sulfonamides to cyclopropenes, SDS of cas: 21286-54-4, the publication is RSC Advances (2020), 10(72), 44183-44190, database is CAplus and MEDLINE.

The sulfonamide moiety was evaluated as an activating and stabilizing functional group in the metal-templated strain release-driven intramol. nucleophilic addition of amines to cyclopropenes to generate 1,5-diazocan-2-ones I [R = Me, 4-BrC₆H₄, 2-naphthyl, etc.].

RSC Advances published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C10H15ClO3S, SDS of cas: 21286-54-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Chen, Zhi-wei published the artcileSynthesis of 3-(2-chloro-6-fluorophenyl)-5-methyl-4-isoxazolecarbonyl chloride, Application of 3-(2-Chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylic acid, the publication is Zhongguo Xiandai Yingyong Yaoxue (2008), 25(4), 308-309, database is CAplus.

A method for the synthesis of the title compound [i.e., 3-(2-chloro-6-fluorophenyl)-5-methyl-4-isoxazolecarbonyl chloride] is reported here. The synthesis of the target compound was achieved by a synthetic sequence involving an oximation reaction, chlorination, cyclization, hydrolysis, acyl chlorination using 2-chloro-6-fluorobenzaldehyde as starting material. The structure was determined by IR, NMR, ¹³C-NMR, MS (overall yield 60.2%). This is a practical and low-cost synthetic route. The above-mentioned target compound is an intermediate for flucloxacillin [i.e., (2S,5R,6R)-6-[[[3-(2-Chloro-6-fluorophenyl)-5-methyl-4-isoxazolyl]carbonyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid].

Zhongguo Xiandai Yingyong Yaoxue published new progress about 3919-74-2. 3919-74-2 belongs to chlorides-buliding-blocks, auxiliary class Isoxazole,Fluoride,Chloride,Carboxylic acid,Benzene, name is 3-(2-Chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylic acid, and the molecular formula is C11H7ClFNO3, Application of 3-(2-Chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylic acid.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Wang, Guanghui published the artcileDouble N,B-Type Bidentate Boryl Ligands Enabling a Highly Active Iridium Catalyst for C-H Borylation, Computed Properties of 929626-16-4, the publication is Journal of the American Chemical Society (2015), 137(25), 8058-8061, database is CAplus and MEDLINE.

Boryl ligands hold promise in catalysis due to their very high electron-donating property. In this communication double N,B-type boryl anions were designed as bidentate ligands to promote an sp² C-H borylation reaction. A sym. pyridine-containing tetraaminodiborane(4) compound was readily prepared as the ligand precursor that could be used, in combination with [Ir(OMe)(COD)]₂, to in situ generate a highly active catalyst for a broad range of (hetero)arene substrates including highly electron-rich and/or sterically hindered ones. This work provides the 1st example of a bidentate boryl ligand in supporting homogeneous organometallic catalysis.

Journal of the American Chemical Society published new progress about 929626-16-4. 929626-16-4 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Ether,Boronic Acids,Boronate Esters, name is 2-(3-Chloro-5-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, and the molecular formula is C14H21BO2, Computed Properties of 929626-16-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

He, Weixuan published the artcileα-Elimination of diethyl dichlorolithiomethanephosphonate, Recommanded Product: Diethyltrichloromethylphosphonate, the publication is Huaxue Xuebao (1987), 45(3), 291-4, database is CAplus.

The α-elimination of (EtO)₂P(O)C^–Cl₂ Li⁺ generates dichlorocarbene, in which the leaving group is diethyl phosphite anion not Cl^–. A discussion on the reaction is given.

Huaxue Xuebao published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, Recommanded Product: Diethyltrichloromethylphosphonate.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Liang, Yong-min published the artcileFe₂(SO₄)₃·4H₂O/concentrated H₂SO₄. An efficient catalyst for esterification, Application In Synthesis of 866-23-9, the publication is Journal of Chemical Research (2004), 226-227, database is CAplus.

The mixed catalyst system, Fe₂(SO₄)₃·4H₂O/concentrated H₂SO₄ was applied to catalyze effectively the esterification of α,β-unsaturated acids, aliphatic acids and heterocyclic aromatic acids with ethanol and methanol.

Journal of Chemical Research published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, Application In Synthesis of 866-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Fu, Ying published the artcileSulfonylation of 1,4-Diazabicyclo[2.2.2]octane by Charge-Transfer Complex Triggered C-N Bond Cleavage, Quality Control of 21286-54-4, the publication is ChemistryOpen (2019), 8(1), 127-131, database is CAplus and MEDLINE.

A novel charge-transfer complex triggered sulfonylation of 1,4-diazabicyclo[2.2.2]octane (DABCO) with mild reaction conditions has been developed. The formation of a charge-transfer complex between electron-withdrawing (hetero)aryl sulfonyl chloride and DABCO allows the synthesis of N-ethylated piperazine sulfonamide in good yields. The reaction has a high functional group tolerance. Spectroscopic studies confirmed the charge-transfer complex formation between sulfonyl chlorides and DABCO, which facilitates the C-N bond cleavage of DABCO.

ChemistryOpen published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C10H15ClO3S, Quality Control of 21286-54-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Fu, Ying published the artcileCharge-Transfer Complex Promoted Regiospecific C-N Bond Cleavage of Vicinal Tertiary Diamines, Recommanded Product: 4-Chloro-3-(trifluoromethyl)benzenesulfonyl Chloride, the publication is Advanced Synthesis & Catalysis (2018), 360(18), 3502-3506, database is CAplus.

A catalyst-free, charge-transfer complex promoted coupling of sulfonyl chlorides RSO₂Cl (R = cyclopropyl, Ph, 3,5-F₂C₆H₃, 2-naphthyl, 2-thienyl, 8-quinolinyl, etc.) with vicinal tertiary diamines R¹R²NCH₂CH₂NR¹R² (R¹ = R² = Me, Et, n-Pr, i-Pr, i-Bu; R¹ = Me, R² = Ph, 3-MeC₆H₄, etc.; R¹R²N = 1-pyrrolidinyl, 4-morpholinyl) to generate sulfonamides RSO₂NR¹R² is presented. Mechanistic studies showed that these reactions proceed via charge transfer of vicinal tertiary diamines to sulfonyl chlorides, forming the unstable sulfonyl quaternary ammonium-like complexes which induce the regiospecific intramol. C-N bond cleavage of vicinal tertiary diamines.

Advanced Synthesis & Catalysis published new progress about 32333-53-2. 32333-53-2 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Sulfonyl chlorides,Benzene, name is 4-Chloro-3-(trifluoromethyl)benzenesulfonyl Chloride, and the molecular formula is C7H3Cl2F3O2S, Recommanded Product: 4-Chloro-3-(trifluoromethyl)benzenesulfonyl Chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Guo, Zhenbo published the artcileDesign, synthesis and evaluation of novel (S)-tryptamine derivatives containing an allyl group and an aryl sulfonamide unit as anticancer agents, Safety of 4-Chloro-3-(trifluoromethyl)benzenesulfonyl Chloride, the publication is Bioorganic & Medicinal Chemistry Letters (2019), 29(9), 1133-1137, database is CAplus and MEDLINE.

A series of (S)-tryptamine derivatives containing an allyl group and an aryl sulfonamide unit, I (R = Ph, 3-Cl-4-FC₆H₃, 4-Br-2-ClC₆H₄, etc.) and II [R = Ph, 2,4,6-(Me₂CH)₃C₆H₂], were designed, synthesized and evaluated for their potential application as anticancer agents. The structures of the synthesized compounds were characterized by ¹H NMR, ¹³C NMR and ESI-MS spectral analyses. The target compounds were evaluated for their in vitro cytotoxicity against HepG2, HeLa, CNE1 and A549 human cancer cell lines. Some of the synthesized compounds showed moderate to good anticancer activities against four selected cancer cell lines, among of which I [R = 2,4,6-(Me₂CH)C₆H₂] (III) was found to be the most active analog possessing IC₅₀ values 16.5-18.7 μM. Further mechanism studies revealed that compound III could significantly induce HepG2 cell cycle arrest at G1 phase, promote cell apoptosis, and inhibit the colony formation as well.

Bioorganic & Medicinal Chemistry Letters published new progress about 32333-53-2. 32333-53-2 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Sulfonyl chlorides,Benzene, name is 4-Chloro-3-(trifluoromethyl)benzenesulfonyl Chloride, and the molecular formula is C7H3Cl2F3O2S, Safety of 4-Chloro-3-(trifluoromethyl)benzenesulfonyl Chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Tian, Yazhen published the artcileStudies on the NMR and configuration of derivatives of aziridine, COA of Formula: C3H3Br2ClO, the publication is Bopuxue Zazhi (1990), 7(3), 269-80, database is CAplus.

Cyclocondensation of 4-NaO₃SC₆H₄NHCOCBr:CH₂ with amino acids under basic conditions gave aziridine derivatives I [R = CH₂CO₂Na, CH₂CH₂CO₂Na, L-CHMeCO₂Na, DL-CH(CH₂Ph)CO₂Na]. The configurations of I were determined by ¹H and ¹³C NMR; the latter two I were 1:1 mixtures of diastereomers.

Bopuxue Zazhi published new progress about 18791-02-1. 18791-02-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 2,3-Dibromopropionylchloride, and the molecular formula is C9H10N2O, COA of Formula: C3H3Br2ClO.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Downie, Ian M. published the artcileA high yield route to ethyl esters of carboxylic acids, Safety of Diethyltrichloromethylphosphonate, the publication is Tetrahedron (1982), 38(10), 1457, database is CAplus.

On treatment with (EtO)₂POCCl₃ (I), aromatic and aliphatic carboxylic acids gave the corresponding Et esters in good-to-high yield through transesterification. E.g., treatment of PhCO₂H with I, prepared in 92% yield from (EtO)₃P and CCl₄, at 120° for 1 day gave 96% PhCO₂Et. 2,4,6-Me₃C₆H₂CO₂H was esterified in 93% yield.

Tetrahedron published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, Safety of Diethyltrichloromethylphosphonate.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics