Tag: M.W=200-300

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 63624-28-2, name is 2,4-Dimethoxybenzene-1-sulfonyl chloride, This compound has unique chemical properties. The synthetic route is as follows., SDS of cas: 63624-28-2

General procedure: To a solution of 0.5 mL of pyridine and 0.5 mmol of intermediate 5,20 mL of dried dichloromethane was added followed by 1 mmol of selectedsubstituted sulfonyl chlorides (a-k). The resulting reaction mixturewas refluxed for 12-17 h and reaction was monitored by TLC. Aftercompletion, the reaction mass was quenched using 20 mL of 10% NaOHfollowed by the extraction with chloroform with quantities 3×15 mL.The organic portion was then passed through anhydrous sodium sulfate,concentrated in vacuo and purified by column chromatography (DCM)to afford 7a-k.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 63624-28-2.

Reference:
Article; Patel, Rahul V.; Mistry, Bhupendra M.; Syed, Riyaz; Parekh, Nikhil M.; Shin, Han-Seung; Bioorganic Chemistry; vol. 87; (2019); p. 23 – 30;,
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Electric Literature of 174913-12-3, A common heterocyclic compound, 174913-12-3, name is 1-Bromo-3-chloro-5-methoxybenzene, molecular formula is C7H6BrClO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Preparation 3 [3-CHLORO-5-METHOXVBENZONITRILE] Tetrakis (triphenylphosphine) palladium (0) (174 mg, 0.15 [MMOL)] was added in one portion to a stirred solution of the bromide of Preparation 1 (500 mg, 2.26 [MMOL)] and zinc cyanide (146 mg, 1.24 [MMOL)] [IN N, N-DIMETHYLFORMAMIDE] (3 ml) at room temperature under a nitrogen atmosphere. The reaction was heated at [100C] for 14 hours and then cooled to room temperature. The solvent was evaporated under reduced pressure and the residue was purified by chromatography on silica gel using ethyl acetate in cyclohexane as eluant (5: 95) to provide the title compound as a yellow oil (380 mg).1H-NMR [(300MHZ,] [CDC13)] : [8 3.] 82 (s, 3H), 7.04 (s, [1H),] 7.12 (s, [1H),] 7.23 (s, 1H).

The synthetic route of 174913-12-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; PFIZER LIMITED; PFIZER INC.; WO2004/31178; (2004); A1;,
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Synthetic Route of 24279-39-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 24279-39-8, name is 2,6-Dichloro-4-(trifluoromethyl)aniline belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

EXAMPLE 6; Ethyl 2- {5-amino-3-cyano-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-1H-pyrazol-4- YL} CYCLOPROPANECARBOXYLATE; To a stirred solution OF 2, 6-DICHLORO-4- (TRIFLUOROMETHYL) PHENYLAMINE (3.0 g, 13 mmol) in ethanol (3 MT) at–5C was added TETRAFLUOROBORIC acid (48% in water, 27.3 MINOT). To the mixture was added isoamyl nitrite (1.8 ml, 13. 6 MMOL), dropwise over 10 min, and the reaction mixture was stirred for 30 min at room temperature. The solid was filtered and WASHED-WITB ETHANOL, followed by diethyl ether,. to give. the diazonium salt (3.2g, 9. 73 NIMOL, 75%) as a white solid. To a solution of Preparation 6 (50 mg, 0.20 mmol) in acetonitrile (2 ml) at 0C was added diazonium-salt (65 mg, 0.20 mmol). The reaction mixture was then allowed to warm to room temperature with stirring. The solution was concentrated under a stream of nitrogen and to the residue was added dichloromethane (2. 5 ml), ammonia (0.880, 2.5 ml) and water (2.5 ml), with vigorous stirring. The. mixture was partitioned between water (20 ml) and dichloromethane- (20 ml) and the two layers were separated. The aqueous layer was extracted with dichloromethane (2 X 10 ml) and the combined organic layers were dried (NA2SO4) and concentrated in vacuo. The residue was loaded on to an ABSOLUTE column (silica, 2 g) in a mixture of cyclohexane and dichloromethane mixture (4 :-1) and eluted with cyclohexane : ethyl acetate [1 : 0 to 3 : 7]. The appropriate fractions were combined and concentrated to give the product (15 mg, 0, 03 mmol, 17 %) as an orange oil. MS (ES) M/Z [MH+]. = 433. 42,. C17H13C12F3N402 +H REQUIRES 433. 04459. NMR (CDC13, selected data): 1.35 (t, 3H), 1.6-1. 7 (m, 2H), 1. 9- 2.0 (m, 1H), 2.0-2. 1 (m, 1H), 3.65 (S, 2H), 4. 2 (q, 2H), 8.8 (M, 2H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2,6-Dichloro-4-(trifluoromethyl)aniline, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; PFIZER LIMITED; PFIZER INC.; WO2005/23773; (2005); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 849367-49-3, name is 3-Bromo-4-chlorobenzylamine, This compound has unique chemical properties. The synthetic route is as follows., COA of Formula: C7H7BrClN

N-[(3-Bromo-4-chlorophenyl)methyl]-N’-{[1,6-diethyl-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridin-5-yl]methyl}butanediamide In a 100 mL round-bottomed flask was added 4-({[1,6-diethyl-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridin-5-yl]methyl}amino)-4-oxobutanoic acid (1.0 g, 2.478 mmol), 1-(3-bromo-4-chlorophenyl)methanamine (0.595 g, 2.7 mmol), HATU (1.065 g, 2.8 mmol) and triethylamine (0.641 ml, 4.6 mmol) in dichloromethane (35 mL) to give a yellow suspension. The mixture was stirred overnight at room temperature. The reaction was quenched with saturated NaHCO3 and diluted with DCM. The organic layer were separated, then washed with water followed by saturated NaCl. The organic layer was dried over Na2SO4 and evaporated to a small volume, about 15 mL, from which a crystalline solid appeared which was collected, washed very sparingly with DCM and dried to give N-[(3-bromo-4-chlorophenyl)methyl]-N’-{[1,6-diethyl-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridin-5-yl]methyl}butanediamide (1 g, 66.6%) as a solid. LC-MS m/z 605.5 (M+H)+, 0.75 min (ret time).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 849367-49-3.

Reference:
Patent; Glaxo Group Limited; US2009/203677; (2009); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 38762-41-3, name is 4-Bromo-2-chloroaniline, A new synthetic method of this compound is introduced below., HPLC of Formula: C6H5BrClN

To a solution of 4-bromo-2-chloroaniline 60 (2.50 g, 12.11 mmol) in acetic acid (25 ml) was added at room temperature potassium thiocyanate (4.71 g, 48.4 mmol). To the mixture was dropped for 15 minutes a solutions of bromine (1.25 ml, 24.22 mmol) in acetic acid (5 ml). After the end of dropping, it was stirred at room temperature for 15 minutes and further stirred at 30 C for 1 hour. After the end of the reaction, the mixture was neutralized with aqueous sodium hydroxide under ice-cooling and extracted with ethyl acetate. The organic layer was washed with saturated sodium bicarbonate solution and brine, respectively and dried over sodium sulfate. The solvent was evaporated under reduced pressure. To the residue was added ethyl acetate and di-isopropyl ether. The mixture was filtered to give Compound 61 (2.02 g, yield 43.3%) as a yellow solid. 1H-NMR (DMSO-d6) delta: 7.48 (dd, J= 2.1, 0.9 Hz, 1H), 7.89 (dd, J= 2.7, 1.8 Hz, 1H), 7.97 (brs, 2H).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Shionogi & Co., Ltd.; EP2351744; (2011); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthetic Route of 102170-53-6, A common heterocyclic compound, 102170-53-6, name is 4-Bromo-5-chloro-2-methoxyaniline, molecular formula is C7H7BrClNO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 20: Preparation of N-[4-(5-chloro-2-methylbenzoxazol-6-yl)phifluorophenyl)carboxamide (57):; Preparation of 2-amino-5-bromo-4-chlorophenol (53): To a suspension of 4- bromo-3-chloro-6-methoxyaniline (52) (5g, 21.1 mmol) in 50 ml DCM was added 1 M BBr3 in DCM (43 ml, 43 mmol) at 0C. The reaction mixture was stirred at r.t. for 3h, which turned to a light brown solution and back to a light brown suspension. After quenched with aq. sodium bicarbonate solution, the mixture was extracted with EA. The org. phase was washed with brine, dried over sodium sulfate, concentrated to dryness to give 4.746g 53 as light brown solid. Yield: 100%, purity > 95%.

The synthetic route of 102170-53-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; CALCIMEDICA, INC.; WHITTEN, Jeffrey P.; PEI, Yazhong; CAO, Jianguo; WANG, Zhijun; ROGERS, Evan; DYCK, Brian; GREY, Jonathan; WO2011/139765; (2011); A2;,
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Chlorides – an overview | ScienceDirect Topics

Application of 892845-59-9, These common heterocyclic compound, 892845-59-9, name is 1-Bromo-2-chloro-4-(trifluoromethoxy)benzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of 1 -Bromo-2-Chloro-4-(trifluoromethoxy)benzene (300 mg) in dry THF (1.3 mL) was added isopropylmagnesium chloride lithium chloride complex solution (1.3 M in THF, 1.0 mL) at 0 C and the resulting mixture was stirred at ambient temperature for 2 h. Trimethyl borate (244 pL) was added at 0 C and the reaction mixture was stirred at ambient temperature for 1 h. HCI (0.1 M, 1 mL) was added and the mixture was extracted with EtOAc. The combined organic layers were dried and the volatiles were removed under reduced pressure to yield the desired compound (77% yield).

The synthetic route of 892845-59-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; GRUeNENTHAL GMBH; NORDHOFF, Sonja; WACHTEN, Sebastian; KLESS, Achim; VOSS, Felix; RITTER, Stefanie; WO2014/108336; (2014); A1;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 454-78-4, name is 2-Bromo-1-chloro-4-(trifluoromethyl)benzene, This compound has unique chemical properties. The synthetic route is as follows., category: chlorides-buliding-blocks

Examples 1 :1 – 1 :8 (Procedure A).A mixture of VII (0.32 mmol), the appropriate aryl bromide (0.38 mmol), CS2CO3, (146 mg, 0.448 mmol), BINAP (15 mg, 0.024 mmol), Pd(OAc)2 (3.6 mg, 0.016 mmol) and toluene (3 mL) was stirred at 100 0C for 7 h and at rt for 14 h. The mixture was filtered through Celite and the solids washed with EtOAc. Concentration of the combined filtrates gave ester VIII in yields given in Tabe 1.

According to the analysis of related databases, 454-78-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BIOLIPOX AB; WO2009/127822; (2009); A2;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 102170-53-6, name is 4-Bromo-5-chloro-2-methoxyaniline, A new synthetic method of this compound is introduced below., Quality Control of 4-Bromo-5-chloro-2-methoxyaniline

This compound was prepared using a method analogous to that of 4-amino-2,5- dimethylbenzonitnle, 4-bromo-5-chloro-2-methoxyaniline replacing 4-bromo-2,5-dimethyl aniline except that the reaction mixture was stirred ON at 110C. LC-MS (A): tR = 0.76 min, [M+H]+: 183.19

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; ACTELION PHARMACEUTICALS LTD; HILPERT, Kurt; HUBLER, Francis; RENNEBERG, Dorte; STAMM, Simon; WO2014/97140; (2014); A1;,
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Chlorides – an overview | ScienceDirect Topics

Application of 1298031-94-3, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1298031-94-3 as follows.

Preparation of intermediate 31 : 6-Chloro-3-iodo-2-methyl-8-morpholin-l-yl- imidazo [ 1 ,2-&”|pyridazineN-Iodosuccinimide (0.95 g, 4.36 mmol) was added to a stirred solution of a mixture 70/30 of intermediate 3 (0.95 g, 3.36 mmol) in a mixture of dichloromethane (9 ml) and acetic acid (1 ml). The mixture was stirred at room temperature for 16 h. and then washed with a saturated solution of sodium carbonate. The organic layer was separated, dried (Na2S04), filtered and the solvents evaporated in vacuo to yield 1.33 g of crude product. A portion of this crude product (0.5 g) was dissolved in acetonitrile (8 ml) and morpholine (0.140 ml, 1.6 mmol) and N,N-diisopropylethylamine (0.393 ml, 2.29 mmol) were added. The mixture was stirred at 150 C for 10 min in a sealed tube, under microwave irradiation. The mixture was diluted with ethyl acetate and washed with a saturated solution of ammonium chloride. The organic layer was separated, dried (Na2S04), filtered and the solvents evaporated in vacuo to yield intermediate 31 (0.53 g, 69%).

According to the analysis of related databases, 1298031-94-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; JANSSEN PHARMACEUTICA NV; PASTOR-FERNANDEZ, Joaquin; BARTOLOME-NEBREDA, Jose, Manuel; MACDONALD, Gregor, James; CONDE-CEIDE, Susana; DELGADO-GONZALEZ, Oscar; VANHOOF, Greta, Constantia, Peter; VAN GOOL, Michiel, Luc, Maria; MARTIN-MARTIN, Maria, Luz; ALONSO-DE DIEGO, Sergio-Alvar; WO2011/51342; (2011); A1;,
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Chlorides – an overview | ScienceDirect Topics