Tag: M.W=200-300

HPLC of Formula: 1968-05-4. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 3,3′-Diindolylmethane, is researched, Molecular C17H14N2, CAS is 1968-05-4, about Anti-osteoclastogenic Effects of Indole Alkaloids Isolated from Barley (Hordeum vulgare Var. Hexastichon) Grass. Author is Ha, Manh Tuan; Tran, Phuong Thao; Tran, Huynh Nguyen Khanh; Kim, Okwha; Kim, Jeong Ah; Lee, Jeong-Hyung; Min, Byung Sun.

As part of our continuous program to identify new potential candidates for controlling osteolytic bone diseases from natural products, the alkaloid fraction of barley (Hordeum vulgare var. hexastichon) grass (HVA) significantly inhibited RANKL-induced osteoclast formation and protected mice from LPS-induced bone loss. A phytochem. investigation of HVA afforded nine indole alkaloids, including one new compound [hordeumin A (1)] and eight known analogs (2-9). Of them, four (1, 2, 4, and 5) were anti-osteoclastogenic compounds Of these four, compound 5 significantly suppressed RANKL-induced osteoclast formation, actin ring formation, and bone resorption in a concentration-dependent manner. It also suppressed the RANKL-induced NF-κB and MAPK signaling pathways and the activation of c-Fos and NFATc1. Compound 5 also reduced the expression levels of osteoclast-specific marker genes, including TRAP, CtsK, DC-STAMP, OSCAR, and MMP9. Our findings suggest that HVA and its alkaloid constituents could be valuable candidates for the prevention and treatment of osteolytic bone diseases.

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Mattiazzi, Juliane; Marcondes Sari, Marcel Henrique; Brum, Taine de Bastos; Araujo, Paulo Cesar Oliveira; Nadal, Jessica Mendes; Farago, Paulo Vitor; Nogueira, Cristina Wayne; Cruz, Leticia published an article about the compound: 3,3′-Diindolylmethane( cas:1968-05-4,SMILESS:C1(CC2=CNC3=C2C=CC=C3)=CNC4=C1C=CC=C4 ).SDS of cas: 1968-05-4. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:1968-05-4) through the article.

This study aimed to characterize the physicochem. properties of (DIM)-loaded (NCs) as well as the antinociceptive effect using distinct animal models (hot plate test, formalin-induced nociception and complete Freud’s adjuvant induced paw inflammation). The physicochem. characterization demonstrated that DIM could be molecularly dispersed into the NCs, whose size was nanometric with a spherical shape. An improvement in thermal stability was achieved by its encapsulation and there were no interactions among the formula components. For the nociceptive evaluation, male adult Swiss mice were pretreated with the NCs or free DIM by the intragastric route at the dose of (time-response curve), (dose-response curve). Both free and nanoencapsulated DIM reduced the mech. hypernociception induced by CFA, mitigated nociceptive behavior of formalin-induced neurogenic and inflammatory pain and increased paw withdrawal latency assessed by the hot-plate test. Importantly, the nanoencapsulation promoted a rapid initiation and prolonged the bioactive antinociceptive action as well as reduced the ED in comparison to its free form. In summary, this study reported that the NCs had adequate nanometric size, increased DIM stability and its antinociceptive action in different animal models, suggesting that the formulation may be a possible therapeutic alternative to the management of pain and inflammatory-related pathologies.

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Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 1968-05-4, is researched, Molecular C17H14N2, about Measuring the effects of bacteria and chemicals on the intestinal permeability of Caenorhabditis elegans, the main research direction is Caenorhabditis elegans diindolylmethane bacteria intestinal permeability.Category: chlorides-buliding-blocks.

In living organisms, intestinal hyperpermeability is a serious symptom that leads to many inflammatory bowel diseases (IBDs). Caenorhabditis elegans is a nonmammalian animal model that is widely used as an assay system due to its short lifespan, transparency, cost-effectiveness, and lack of animal ethics issues. In this study, a method was developed to investigate the effects of different bacteria and 3,3′-diindolylmethane (DIM) on the intestinal permeability of C. elegans with a high-throughput image anal. system. The worms were infected with different gut bacteria or cotreated with DIM for 48 h and fed with fluorescein isothiocyanate (FITC)-dextran overnight. Then, the intestinal permeability was examined by comparing the fluorescence images and the fluorescence intensity inside the worm bodies. This method may also have the potential to identify probiotic and pathogenic intestinal bacteria that affect intestinal permeability in the animal model and is effective for examining the effects of harmful or health-promoting chems. on intestinal permeability and intestinal health. However, this protocol also has some considerable limitations at the genetic level, especially for determining which genes are altered to control illness, because this method is mostly used for phenotypic determination In addition, this method is limited to determining exactly which pathogenic substrates cause inflammation or increase the permeability of the worms’ intestines during infection. Therefore, further in-depth studies, including investigation of the mol. genetic mechanism using mutant bacteria and nematodes as well as chem. component anal. of bacteria, are required to fully evaluate the function of bacteria and chems. in determining intestinal permeability.

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Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 1968-05-4, is researched, SMILESS is C1(CC2=CNC3=C2C=CC=C3)=CNC4=C1C=CC=C4, Molecular C17H14N2Journal, Advanced Synthesis & Catalysis called Ruthenium Pincer Complex Catalyzed Selective Synthesis of C-3 Alkylated Indoles and Bisindolylmethanes Directly from Indoles and Alcohols, Author is Biswas, Nandita; Sharma, Rahul; Srimani, Dipankar, the main research direction is alkyl indole selective preparation; bis indolyl methane preparation; indole alc alkylation ruthenium pincer complex catalyst.Computed Properties of C17H14N2.

Herein, we presented Ru-SNS complex that served as a useful catalyst for the synthesis of alkyl-indoles I [R1 = H, 2-Me, 5-OMe, etc.; R2 = H, Me; R3 = Me, Et, Bn, etc.] via C-3 alkylation of 1H-indoles with various aliphatic primary and secondary alcs. including cyclic alcs. as well as benzylic alcs. The selective synthesis of bisindolylmethane derivatives II [R4 = H, Me, Ph, etc.] was also achieved from the same set of indole and alc. just by altering the reaction parameters. Furthermore, the sustainable synthesis of C-3 alkylated indoles directly from 2-(2-nitrophenyl)ethan-1-ol and alcs. catalyzed by a Ru-complex via ‘borrowing hydrogen’ strategy was reported. This protocol provided an atom-economical sustainable route to access structurally important compounds like arundine, vibrindole A and tryptamine based derivatives

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Synthetic Route of C17H14N2. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 3,3′-Diindolylmethane, is researched, Molecular C17H14N2, CAS is 1968-05-4, about Acid condensation products of indole-3-carbinol and their in-vitro (anti)estrogenic, (anti)androgenic and aryl hydrocarbon receptor activities. Author is Amare, Dagnachew Eyachew; Bovee, Toine F. H.; Mulder, Patrick P. J.; Hamers, Astrid; Hoogenboom, Ron L. A. P..

The objective of the study was to investigate the (anti)estrogenic, (anti)androgenic and aryl hydrocarbon receptor (AhR) agonistic activities of a mixture of acid condensation products of indole-3-carbinol, termed RXM, and to identify the compounds most responsible for the observed effects, using in vitro receptor-reporter gene transcriptional activation bioassays. The fraction containing 3,3-diindolylmethane (DIM) displayed a weak estrogenic and relatively strong anti-androgenic activity. DIM was confirmed to be an androgen receptor (hAR) antagonist and a partial estrogen receptor (hERα) agonist. Also the fraction containing the trimer [2-(indol-3-ylmethyl)indol-3-yl]indol-3-ylmethane (LTr1) showed anti-androgenic activities. It was shown for the first time that DIM is not only estrogenic and anti-androgenic, but also possesses anti-estrogenic properties. Though indolo[3,2-b]carbazole (ICZ) is a potent AhR activator and was detected in the RXM, it did not contribute to AhR-agonist activity. Instead, fractions containing the trimers LTr1 and 5,6,11,12,17,18-hexahydrocyclonona[1,2-b:4,5-b:7,8-b]tri-indole (CTr), as well as some unidentified compounds showed the highest AhR activation. The fraction, containing the linear trimer LTr1, showed a weak anti-androgenic activity which has not been reported before. The study demonstrates the importance of a bioassay directed approach for identifying compounds that contribute most to the effects of mixtures

If you want to learn more about this compound(3,3′-Diindolylmethane)Synthetic Route of C17H14N2, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(1968-05-4).

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Category: chlorides-buliding-blocks. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 3,3′-Diindolylmethane, is researched, Molecular C17H14N2, CAS is 1968-05-4, about Humic acid: A Biodegradable Organocatalyst for Solvent-free Synthesis of Bis(indolyl)methanes, Bis(pyrazolyl)methanes, Bis-coumarins and Bis-lawsones. Author is Mitra, Bijeta; Ghosh, Pranab.

Humic acid, a biodegradable, non-toxic and easily accessible high mol. weight organocatalyst was explored for straightforward and environmentally benign approach toward preparation of diverse array of functionalized bis(indolyl)methanes I [R = H, 2-pyridyl, 4-MeOC6H4, 3,3-diylindolin-2-one, etc.], bis(pyrazolyl)methanes II [R1 = n-Pr, 4-FC6H4, 3,3-diylindolin-2-one, etc.], bis-coumarins III [R2 = Ph, 2-thienyl, 3-O2NC6H4, etc.] and bis-lawsones IV [R3 = n-hexyl, Ph, 3-pyridyl, etc.] by reaction of a vast range of aldehydes with indole, 3-methyl-1-Ph pyrazolone, 4-hydroxycoumarin and 2-hydroxynaphthalene-1,4-dione resp. under solvent-free condition. These protocols proceeded without any hazardous solvents, toxic metal catalysts and harsh reaction conditions. In addition, low catalyst loading, good yield and excellent functional group tolerance were key advantages of these protocols. The used catalyst and solvent-free approach made this strategy safe to our mother earth. For first time reusability of humic acid was investigated and found that it can be recycled up to fifth run without any significant loss of its activity at end of reaction. Some bioactive mols. such as arundine, trisindoline and vibribdole A were easily synthesized in lab by utilizing this designed strategy.

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HPLC of Formula: 1968-05-4. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 3,3′-Diindolylmethane, is researched, Molecular C17H14N2, CAS is 1968-05-4, about Efficient Sky-Blue Organic Light-Emitting Diodes Using a Highly Horizontally Oriented Thermally Activated Delayed Fluorescence Emitter. Author is Zhang, Zhen; Crovini, Ettore; dos Santos, Paloma L.; Naqvi, Bilal A.; Cordes, David B.; Slawin, Alexandra M. Z.; Sahay, Prakhar; Bruetting, Wolfgang; Samuel, Ifor D. W.; Braese, Stefan; Zysman-Colman, Eli.

Organic thermally activated delayed fluorescent (TADF) materials can harvest 100% of the elec. generated excitons as a result of their small singlet-triplet energy difference. However, maximizing the external quantum efficiency (EQE) of a device also requires enhancing the light out-coupling efficiency. This work presents a new acceptor-donor-acceptor (ADA) emitter employing an indolocarbazole donor and diphenyltriazine acceptors that show nearly-completely horizontal orientation regardless of the host matrix, leading to a sky-blue organic light-emitting diode (λEL = 483 nm, CIE coordinates of 0.17, 0.32) with EQEMAX of 22.1%, a maximum luminance of 7800 cd m-2, and blue emission.

Here is a brief introduction to this compound(1968-05-4)HPLC of Formula: 1968-05-4, if you want to know about other compounds related to this compound(1968-05-4), you can read my other articles.

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In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called 3,3′-Diindolylmethane Inhibits TNF-α- and TGF-β-Induced Epithelial-Mesenchymal Transition in Breast Cancer Cells, published in 2019, which mentions a compound: 1968-05-4, mainly applied to breast cancer DIM EMT ERK1 Smad2 vimentin fibronectin phosphorylation, Application of 1968-05-4.

Epithelial-mesenchymal transition (EMT) is the initial event required by cancer cells. Thus, inhibition of the EMT process could have potential benefits for preventing the spread of cancers. The phytochems. have been reported to have inhibitory activity against the EMT process in breast cancers, but the mechanism behind this effect has not been fully elucidated.3,3′-Diindolylmethane (DIM) is a major indole derived from bioactive compounds in cruciferous vegetables. In this study, we examined the effects of DIM cotreatment together with TNF-α/TGF-β on the EMT process as well as the mechanisms underlying its effects on human breast cancer cells. DIM significantly enhanced the mRNA and protein expression of E-cadherin and occludin in MCF-7 cells. The protein expression levels of E-cadherin and occludin in MCF-7 cells were significantly decreased after TNF-α/TGF-β treatment alone, but these effects were reversed by the DIM co-treatment. Furthermore, DIM with TNF-α/TGF-β co-treatment attenuated the phosphorylation of Smad2/3 and ERK1/2 proteins. DIM significantly inhibited the TNF-α/TGF-β-induced migration of breast cancer cells. Taken together, the results indicated that DIM effectively suppressed EMT processes through the inhibition of TNF-α/TGF-β-associated signaling pathways in breast cancer cells. Thus, DIM may be a novel preventive and/or therapeutic approach for the treatment of breast cancers.

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Application of 81927-55-1, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 81927-55-1, Name is Benzyl 2,2,2-trichloroacetimidate, SMILES is ClC(Cl)(Cl)C(=N)OCC1=CC=CC=C1, belongs to chlorides-buliding-blocks compound. In a article, author is Champaka, Gurudevaru, introduce new discover of the category.

Monomeric zinc ferrocene carboxylate [Zn(FcCOO)(3,5-dmp)(2)Cl] (1) has been synthesized from a reaction between the zinc chloride, sodium salt of ferrocene carboxylic acid (FcCOONa) and 3,5-dimethylpyrazole (3,5-dmp) at room temperature. Compound 1 was further characterized by elemental analysis, H-1 NMR, FT-IR, absorption, emission spectroscopic techniques, and molecular structure was confirmed by single-crystal X-ray diffraction studies. The molecular structure of compound 1 crystallized in triclinic system with P (1) over bar space group and the central Zn2+ ion is in a distorted tetrahedral geometry with -FeN2OCl coordination environment. Compound 1 was further stabilized with the aid of inter and intramolecular hydrogen bonding and pi-pi interaction between cyclopentadienyl ring of ferrocene and aromatic heterocyclic five membered 3,5-dimethylpyrazole. Compound 1 exhibits broad emission band, indicating ligandto-metal charger transfer (LMCT) or metal-to-ligand charger transfer (MLCT) nature. The electrochemical property of compound 1 revealed that one-electron anodic and cathodic peaks corresponding to the redox responsible of ferrocene/ferrocenium (FeII <-> Fe-III) moiety. Among the different strains of bacteria, the antibacterial activity of compound 1 showed comparatively a significant activity against gram negative bacterium Proteus vulgaris. (C) 2020 Elsevier B.V. All rights reserved.

Application of 81927-55-1, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 81927-55-1.

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Chloride – Wikipedia,
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Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds. 81927-55-1, Name is Benzyl 2,2,2-trichloroacetimidate, molecular formula is C9H8Cl3NO, belongs to chlorides-buliding-blocks compound, is a common compound. In a patnet, author is Meng, Xiaorong, once mentioned the new application about 81927-55-1, Category: chlorides-buliding-blocks.

A colour changeable optical sensing membrane was prepared for quantitative detection of Cd(II), Zn(II) and Cu (II) by using polyvinyl chloride membrane containing bis(2-ethylhexyl) phosphate for chemical absorption of chromogenic reagent 1-(2-pyridylazo)-2-naphthol. Under the optimum conditions, the three ions were measured by UV-visible spectrophotometer at lambda max = 547, 554 and 560 nm, respectively. The linear ranges of 8.90 x 10(-9)-8.90 x 10(-4) mol.L-1 [Cd(II)], 1.78 x 10(-9)-1.78 x 10(-4) mol.L-1 [Zn(II)] and 1.78 x 10(-7)-1.78 x 10(-3) mol.L-1 [Cu(II)] and detection limits of 3.89 x 10(-9), 3.42 x 10(-10) and 1.20 x 10(-7) mol.L-1 were obtained, respectively. The response time was between 7 and 15 min. For common anions and cations, the sensing membrane exhibited good selectivity. Selective determination of Cd(II), Zn(II) and Cu(II) was achieved by adding a suitable masking agent. The sensing membrane was regenerated by soaking in nitric acid for 1-3 min and maintained a stable response after three times of reuse. The sensing membrane was successfully used for the determination of Cd(II), Zn(II) and Cu(II) in real samples.

We’ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 81927-55-1. The above is the message from the blog manager. Category: chlorides-buliding-blocks.

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Chloride – Wikipedia,
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