Tag: M.W=200-300

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 13918-92-8, name is 2,4-Difluorobenzene-1-sulfonyl chloride belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Product Details of 13918-92-8

To a cooled solution of 17 (4.0 g, 19.8 mmol) in pyridine (40 mL) was added 2,4-difluorobenzenesulfonyl chloride (18) (3.2 mL, 23.8 mmol) dropwise at 0 C. After the reaction mixture was allowed to warm to rt and stirred overnight, it was diluted with cold water. The precipitate was collected by filtration, washed with water, dried to afford 19 (3.42 g, 46%) as a pale pink solid, mp 154-156 C. 1H NMR (CDCl3) delta 7.91-7.88 (m+d, J = 2.0 Hz, 2H, Ar-H), 7.82 (d, J = 2.0 Hz, 1H, Ar-H), 7.22 (br s, 1H, NH), 7.00-6.92 (m, 2H, Ar-H), 3.90 (s, 3H, OCH3).

The synthetic route of 13918-92-8 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Wang, Min; Gao, Mingzhang; Miller, Kathy D.; Sledge, George W.; Zheng, Qi-Huang; Bioorganic and Medicinal Chemistry Letters; vol. 22; 4; (2012); p. 1569 – 1574;,
Chloride – Wikipedia,
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Some common heterocyclic compound, 1996-29-8, name is 1-Bromo-4-chloro-2-fluorobenzene, molecular formula is C6H3BrClF, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. SDS of cas: 1996-29-8

Under an argon atmosphere,9H-carbazole (9.3 g), 1-bromo-4-chloro-2-fluorobenzene (23.3 g), cesium carbonate (36.2 g) and DMF (222 mL) were stirred at 150 C. for 7 hours. Water was added at room temperature, and the resulting mixture was extracted with ethyl acetate. The organic layer was purified by silica gel chromatography, and the solvent was removed to obtain 9- (2-bromo-5-chlorophenyl) carbazole as a white solid (11.4 g, yield 58%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1996-29-8, its application will become more common.

Reference:
Patent; IDEMITSU KOSAN COMPANY LIMITED; HAKETA, TASUKU; ITO, HIROKATSU; KUDO, YU; (149 pag.)JP2018/108939; (2018); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 384-16-7, name is 2-Bromo-1-chloro-3-(trifluoromethyl)benzene, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 384-16-7, Formula: C7H3BrClF3

Under nitrogen substitution,2-Bromo-3-chlorobenzotrifluoride (212 mg)Of tetrahydrofuran (0.7 mL)Was added isopropyl magnesium chloride / lithium chloride complex / tetrahydrofuran solution (1.3 M, 0.63 mL) dropwise at room temperature and stirred for 1 hour.This solution was added to the ice-cooled compound (172 mg) obtained in Example 46c,In diethyl ether (3 mL) over 5 minutes.Thereafter, the mixture was stirred under ice-cooling for 2 hours and at room temperature for 2.5 hours.Since the reaction was not completed,Again 2-bromo-3-chlorobenzotrifluoride (212 mg),From isopropyl magnesium chloride / lithium chloride complex / tetrahydrofuran solution (1.3 M, 0.63 mL)Grignard reagent was prepared by the same operation as above,Was added dropwise to the ice-cooled reaction solution over 5 minutes.After stirring for 1 hour under ice cooling, 0.5N hydrochloric acid was added and the mixture was extracted with ethyl acetate.The extract layer was washed successively with water, saturated aqueous sodium hydrogen carbonate solution and saturated brine,After drying with anhydrous sodium sulfate and filtration, the solvent was distilled off under reduced pressure.The obtained residue was purified by silica gel column chromatography (ethyl acetate / hexane) to obtain the title compound (71.0 mg) as a colorless transparent gummy solid.

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Reference:
Patent; DAIICHI SANKYO COMPANY LIMITED; NAGAMOCHI, MASATOSHI; KOZAWA, YUJI; INAGAKI, HIROAKI; GOTANDA, KENTOKU; NOGUCHI, TETSUJI; TORIHATA, MUNEFUMI; YOSHINO, TOSHIHARU; ISOBE, TAKASHI; (113 pag.)JP2016/141632; (2016); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Related Products of 16793-91-2, These common heterocyclic compound, 16793-91-2, name is 2-Chlorophenethyl Bromide, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: General synthetic procedure for the final products.The appropriately substituted 4-phenethylpiperidine (6)(0.5 mmol) was dissolved in acetonitrile (5 mL) and K2CO3(0.75 mmol) and the appropriate phenethyl bromide (7) (0.5 mmol) added. The reaction mixture was refluxedfor 8 h.After completion of the reaction (monitored by TLC), the reaction mixture was cooled to ambient temperature and filtered through a Celite pad. The filtrate was concentrated under vacuum to obtain the desired crude product. The crude product was further purified by column chromatography (silica gel: 3-5% methanol in dichloromethane) to afford the corresponding 1,4-diphenethylpiperidine (8a-8y) in good yield (75-80 %), which was then converted to hydrochloride salt by treatment with 2M HCl in diethyl ether.Compounds12a-12dwere synthesized using the same procedure as above, except that an appropriately substituted 4-benzylpiperidine (11) was utilized in place of compound6.

Statistics shows that 2-Chlorophenethyl Bromide is playing an increasingly important role. we look forward to future research findings about 16793-91-2.

Reference:
Article; Nickell, Justin R.; Culver, John P.; Janganati, Venumadhav; Zheng, Guangrong; Dwoskin, Linda P.; Crooks, Peter A.; Bioorganic and Medicinal Chemistry Letters; vol. 26; 13; (2016); p. 2997 – 3000;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthetic Route of 933190-51-3, These common heterocyclic compound, 933190-51-3, name is 8-Bromo-6-chloroimidazo[1,2-b]pyridazine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To a solution of 6a-6c (1 mmol) in THF (5 mL) was addedmorpholine (or (S)-3-methylmorpholine, or 8-oxa-3-azabicyclo[3.2.1]octane) (1.2 mmol) and Et3N (2.2 mmol). The mixture washeated under reflux for 12 h. The crude product was extracted with CH2Cl2, dried over Na2SO4, purified over silica gel chromatographyeluting with PE and EtOAc to give 7a-7g [43].

Statistics shows that 8-Bromo-6-chloroimidazo[1,2-b]pyridazine is playing an increasingly important role. we look forward to future research findings about 933190-51-3.

Reference:
Article; Mao, Beibei; Gao, Shanyun; Weng, Yiran; Zhang, Liangren; Zhang, Lihe; European Journal of Medicinal Chemistry; vol. 129; (2017); p. 135 – 150;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 38762-41-3, name is 4-Bromo-2-chloroaniline, A new synthetic method of this compound is introduced below., HPLC of Formula: C6H5BrClN

2-Fluoro-4-bromoaniline (3.83 g, 18.55 mmol) was added to a reaction flask, then anhydrous tetrahydrofuran (20 ml) was added, and the mixture was cooled to -78 C with a dry ice ethanol bath, and LiHMDS (55.65 ml, 55.65 mmol), after reacting at -78 C for 30 minutes, methyl 2-chloro-1,5-dimethyl-6-oxo-1,6-dihydropyridine-3-carboxylate (4.00) was added. g, 18.55 mmol), after completion, the reaction was stirred at -78 C for 1 hour. After the completion of the reaction, the mixture was stirred at room temperature, and the reaction was quenched with saturated aqueous ammonium chloride.Column chromatography to obtain compounds(6.0 g, yield: 83.9%).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; BINJIANG PHARMA INC; Tianjin Binjiang Pharmaceutical Research And Development Co., Ltd.; TIAN HONGQI; Tian Hongqi; (39 pag.)CN109988105; (2019); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 14862-52-3, name is 3,5-Dibromochlorobenzene, A new synthetic method of this compound is introduced below., HPLC of Formula: C6H3Br2Cl

1-chloro-3,5-dibromobenzene (5.40 g, 20 mmol) and 3-pyridine boronic acid (5.17 g, 42 mmol) were added to a 100 mL three neck round bottom flask. To this flask, dioxane (80 mL) and aqueous K2CO3 (2 N, 40 mL) were added. The mixture was stirred and degassed with a steam of argon for 30 minutes. Then under argon atmosphere, 200 mg (0.16 mmol) Pd(PPh3)4 was added. The mixture was brought to 100 C. and stirred overnight. The next day, solvent was removed by roto-evaporation and residue was suspended into an equal amount of water (50 mL) and CH2Cl2 (50 mL). The organic layer was separated from aqueous layer and washed with brine (50 mL×3). After drying over Na2SO4, and removal of drying agent, 5.33 g transparent liquid 3,3′-(5-chloro-1,3-phenylene)dipyridine (100%, Compound L) was obtained. 1H NMR (400 MHz, CDCl3) 8.91 (s, 2H), 8.69 (d, 2H), 7.95 (d, 2H), 7.66 (s, 1H), 7.63 (s, 2H), 7.50-7.44 (m, 2H).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; General Electric Company; US2010/331547; (2010); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 61881-19-4, name is 2,2,2-Trifluoro-N-phenylacetimidoyl chloride, This compound has unique chemical properties. The synthetic route is as follows., SDS of cas: 61881-19-4

To 10 (3.0 g, 1.5 mmol) and N-phenyl trifluoroacetimidoyl chloride (0.95 g, 4.59 mmol, 3.0 eq) in acetone (57.5 ml) was added K2CO3 (0.6 g, 4.59 mmol, 3.0 eq), and the mixture was stirred at room temperature for 1 h. The mixture was filtered, concentrated, and purified by silica gel column chromatography (hexane : ethyl acetate = 2:1) to obtain the 11 (3.2 g, 97%) as a white solid. m.p. 149 – 151 oC. [a]25D = – 218.6 (c = 1.00 in CHCl3). 1H NMR (400 MHz, CDCl3) delta 8.57 – 6.52 (m, 65H), 6.25 (d, J = 10.5 Hz, 1H), 6.12 – 6.03 (m, 2H), 5.97 (d, J = 2.9 Hz, 1H), 5.89 – 5.68 (m, 4H), 5.59 (dd, J = 10.5, 3.2 Hz, 1H), 5.17 (d, J = 9.1 Hz, 1H), 4.61 (dd, J = 12.4, 6.2 Hz, 2H), 4.48 (d, J = 12.9 Hz, 1H), 4.35 (d, J = 12.3 Hz, 1H), 4.31 – 4.01 (m, 8H), 3.93 (d, J = 9.6 Hz, 1H), 3.88 – 3.65 (m, 5H), 1.64 (s, 3H).13C NMR (100 MHz, CDCl3) delta 171.1-164.7 (C, C=O), 143.1 (C, N-C), 141.0 133.9-128.0 (C, Ar), 124.9 (C, C-F), 119.2, 116.2q, CF3, 106.3, 100.7, 100.6, 98.8, 70.5, 70.2, 69.9, 69.8, 69.5, 69.1, 68.5, 67.4, 67.2, 66.9, 63.8, 63.3, 62.6, 61.5, 60.4, 60.1, 59.2, 58.8, 20.0.ESI-MS (m/z): [M+Na]+ : calcd for C118H96F3NO34Na+ 2150.5658, found 2150.5673.

According to the analysis of related databases, 61881-19-4, the application of this compound in the production field has become more and more popular.

Reference:
Article; Zhang, Hongliang; Wang, Hengtao; Xu, Qiulong; Lu, Rui; Cao, Yunhua; Wang, Zhefeng; Tang, Pingping; Lin, Feng; Li, Yingxia; Carbohydrate Research; vol. 448; (2017); p. 6 – 9;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1996-30-1, name is 3-Bromo-4-fluorochlorobenzene, A new synthetic method of this compound is introduced below., Computed Properties of C6H3BrClF

Example 9: 4- [3- (5-Chloro-2-fluoro-phenyl)-prop-2-ynyl]-piperazine-1- carboxylic acid ethyl ester; 4-Prop-2-ynyl-piperazine-1-carboxylic acid ethyl ester (0.22 g, 0.96 mmol), 2-bromo- 1-chloro-1-fluorobenzene (0.14 mL, 1.2 mmol) and diisopropylamine (0.17 mL, 1.2 mmol) were dissolved in dioxane (1 mL), and the solution degassed with argon for -10 minutes. Bis (methylcyanate) palladium (II) chloride (12 mg, 0.05 mmol), copper iodide (4 mg, 0.02 mmol) and tri-tert-butylphosphine (0.014 mL, 0.06 mmol) were added, and the reaction was sealed and allowed to stir for 16 h. Reaction mixture was diluted with EtOAc (5 mL) and filtered over celite using EtOAc. The organic layer was washed with NH4C1 solution (4 x 10 mL), then dried (Na2S04), filtered and concentrated onto silica gel. Chromatography (SPE) eluting with 30-50 % EtOAc/ hexanes afforded 113 mg (36 %) of the title compound as a yellow oil. 1H NMR (CDC13) 8 (ppm): 7.41 (dd, 1H), 7.26 (ddd, 1H), 7.02 (t, 1H), 4.16 (q, 2H), 3.60 (s, 2 H), 3.56 (t, 4H), 2.61 (t, 4H), 1.28 (t, 3H).

The synthetic route of 1996-30-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ASTRAZENECA AB?; NPS PHARMACEUTICALS, INC.; WO2005/80363; (2005); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Reference of 39226-96-5, These common heterocyclic compound, 39226-96-5, name is (2-Chloro-3-(trifluoromethyl)phenyl)methanamine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 102 : 4-Chloro-6-(2-chloro-3-trifluoromethyl-benzylamino)-2H-phthalazin- 1-one; A mixture 6-bromo-4-chloro-2H-phthalazin-l-one (150 mg, 0.58 mmol), 2- chloro-3-trifluoromethyl-benzylamine (124 mg, 0.64 mmol), Pd2(dba)3 (53 mg, 0.058 mmol), rac-BINAP (132 mg, 0.17 mmol) and NaOr-Bu (140 mg, 1.45 mmol) in DMA (6 mL) was heated at 8O0C for Ih. The mixture was allowed to cool, diluted with EtOAc (25 mL) and washed with water (25 mL). The organic layer was dried over anhydrous sodium sulfate and concentrated. Chromatography on silica (EtOAc/hexanes) yielded the title compound. 4-Chloro-6-(2-chloro-3-trifluoromethyl-benzylamino)-2H-phthalazin- 1 – one: 38 mg (17.6%): m/z (M+eta)=372. 1H-NMR (DMSO-^) delta: 12.38 (s,lH), 7.95 (d,lH), 7.71 (m, 3H), 7.39 (m,lH), 7.19 (dd,lH), 6.85 (s,lH), 4.57 (d,2H).

Statistics shows that (2-Chloro-3-(trifluoromethyl)phenyl)methanamine is playing an increasingly important role. we look forward to future research findings about 39226-96-5.

Reference:
Patent; FOREST LABORATORIES HOLDINGS LIMITED; WO2008/61108; (2008); A2;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics