Tag: M.W=200-300

Application of 2770-11-8,Some common heterocyclic compound, 2770-11-8, name is 2-(4-Chlorophenoxy)aniline, molecular formula is C12H10ClNO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Preparation of 1- {4- [2-(4-chIorophenoxy)phenylamino] -piperidin-1 -yl}-2- methylpropan-1-one STX1701 C21H25ClN2O2, MW: 372.8939To a solution of 2-(4-chlorophenoxy)phenylamine (100 mg3 0.45 mmol), l-isobutyryl-4- piperidone (144 mg, 0.735 mmol) and acetic acid (147 mg, 2.45 mmol) in DCE (1.5 ml) was added sodium triacetoxyborohydride (260 mg, 1.23 mmol). This solution was then heated at 1000C for 15 minutes in a CEM discover microwave (fixed hold time set to on).The reaction mixture was then quenched with saturated aqueous sodium bicarbonate solution (5 ml) and extraction with ethyl acetate (3 x 5 ml) followed. The combined organics were concentrated in vacuo and purification by flash chromatography proceeded(eluant: 8:2 hexane: ethyl acetate) to provide the title compound as a transparent oil (44 mg, 26%). 1HNMR (270 MHz, CDCl3): delta 1.10 (6H, d, J= 6.7 Hz, CH(CH3)2), 1.25-1.35(2H, m, 2 x CH), 2.03-2.27 (2H, m, 2 x CH), 2.76-2.85 (2H, m, 2 x CH)3 3.18 (IH, t, J=11.4 Hz, CH), 3.48-3.60 (IH, m, CH), 3.83-3.88 (IH, bd, J = 13.9 Hz3 CH)3 3.97-4.12 (IH, m, NH), 4.41-4.46 (IH, bd, J= 13.9 Hz, CH), 6.61-6.67 (IH, td, J- 1.2, 0.7, 7.7 Hz3 EPO ArH)5 6.74-6.77 (IH, dd, J= 1.2, 8.2 Hz, ArH), 6.79-6.82 (IH3 dd, J= 1.5, 7.9 Hz, ArH), 6.85-6.90 (2H, m, ArH), 7.01-7.07 (IH, td, J= 1.2, 0.8, 7.2 Hz, ArH), 7.20-7.25 ppm (2H, m, ArH). LCMS: M+R: 373.49 HPLC: 93.75% (2.692 min, isocratic 90% acetonitrile, 10% water at 1 ml/min).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-(4-Chlorophenoxy)aniline, its application will become more common.

Reference:
Patent; STERIX LIMITED; WO2007/3934; (2007); A2;,
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Electric Literature of 13918-92-8, A common heterocyclic compound, 13918-92-8, name is 2,4-Difluorobenzene-1-sulfonyl chloride, molecular formula is C6H3ClF2O2S, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A mixture of 1.80 g (8.8 mmol) C-5, 2.29 mL (17 mmol) 2,4-difluorobenzenesulphonyl chloride, 1.07 mL (13.3 mmol) pyridine and 20 mL DCM is stirred at RT over night. 100 mL DCM is added and the reaction mixture is extracted three times with 50 mL aqueous 1M HCl. The organic layer is dried over MgSO4 and the solvent is removed under reduced pressure. The solid is dissolved in water/MeCN and further purified by RP-chromatograpy. Yield: 2.9 g (86%).

The synthetic route of 13918-92-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; WUNBERG, Tobias; KRAEMER, Oliver; van der VEEN, Lars; US2013/23533; (2013); A1;,
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Application of 344-65-0, These common heterocyclic compound, 344-65-0, name is 1-Bromo-4-chloro-2-(trifluoromethyl)benzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A 1,4-Dioxane solution (8 mL) of 10 (1.0 mmol), arylboronic acid 2 (1.0 equiv.), K3PO4, and Pd(PPh3)4 (5 molpercent) was heated at 75 C for 4 h. After cooling to room temperature, H2O was added and the reaction mixture was extracted with CH2Cl2. The organic layer was dried (Na2SO4), filtered and concentrated in vacuo. The residue was purified by column chromatography (pure n-heptane).

Statistics shows that 1-Bromo-4-chloro-2-(trifluoromethyl)benzene is playing an increasingly important role. we look forward to future research findings about 344-65-0.

Reference:
Article; Ali, Iftikhar; Siyo, Baraa; Hassan, Zahid; Malik, Imran; Ullah, Ihsan; Ali, Asad; Nawaz, Muhammad; Iqbal, Jamshed; Patonay, Tama?s; Villinger, Alexander; Langer, Peter; Journal of Fluorine Chemistry; vol. 145; (2013); p. 18 – 34;,
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Adding a certain compound to certain chemical reactions, such as: 210532-25-5, name is 3,5-Difluorobenzene-1-sulfonyl chloride, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 210532-25-5, name: 3,5-Difluorobenzene-1-sulfonyl chloride

At room temperature,2-methyl-4-carbonyl-6,7,8,9-tetrahydropyrido [1,2-a] thiophene [2,3-d] pyrimidin-3-amine hydrochlorideCompound 10 (0.31 g, 1 mmol) was dissolved in anhydrous dichloromethane (10 ml)Followed by the addition of 3,5-difluorobenzenesulfonyl chloride (0.23 g, 1.1 mmol)Triethylamine (0.12 g, 1.2 mmol) was slowly added with stirring, stirred at room temperature overnight,Reaction to the material completely disappeared,Dichloromethane, concentrated, using a 5: 1 by volume petroleum ether: ethyl acetate column chromatography gradient elution,To give compound 10f; yield: 82% as a white solid

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3,5-Difluorobenzene-1-sulfonyl chloride, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Chinese Academy Of Sciences Xinjiang Physics And Chemistry Technology Institute; A Jiaikebaier¡¤aisa; Nie Lifei; Huang Guozheng; (23 pag.)CN106749317; (2017); A;,
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14862-52-3, name is 3,5-Dibromochlorobenzene, belongs to chlorides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Formula: C6H3Br2Cl

Intermediate 1-2 (2.8 g, 0.010 mol) was added intermediate 1-3 (4.2 g, 0.011 mol),Pd (dba) 2 (0.5 g, 0.0005 mol), 100 mL of Toluene was added to sodium-tert-butoxide (1.9 g, 0.020 mol), and the mixture was reacted at 95 C. for 4 hours with stirring.After completion of the reaction, the mixture was separated into H 2 O: MC and purified by column (N-HEXANE: MC) to obtain 3.6 g (yield: 62%) of Intermediate 1-4. To 1,3-dibromo-5-chlorobenzene (2.7 g, 0.010 mol) was addedN-phenylbiphenyl-4-amine (5.4 g, 0.022 mol) was added to the reaction mixture to obtain 4.4 g (yield 73%) of Intermediate 7-1.

The synthetic route of 14862-52-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; P&H Tech Co.,Ltd; Hyun, Sao Yong; Jung, Sung Wook; Kim, Ha Yeon; (48 pag.)KR2016/79514; (2016); A;,
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These common heterocyclic compound, 67279-24-7, name is 1,4-Dichloro-5,6,7,8-tetrahydrophthalazine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. category: chlorides-buliding-blocks

A solution of l,4-dichloro-5,6,7,8-tetrahydro-phthalazine (CAS 67279-24-7; 348 mg, 1.7 mmol) in concentrated aqueous N (5 ml) and ethanol (5 ml) was stirred at 120C in an autoclave for 20 h. The mixture was cooled to r.t. and concentrated. The crude product was purified by silica gel chromatography using a chromatography using a CE^Ck/MeOH gradient as eluent, to provide the title compound (52 mg, 16%>) as off- white solid. MS: M = 184.2 (M+H)+

The synthetic route of 1,4-Dichloro-5,6,7,8-tetrahydrophthalazine has been constantly updated, and we look forward to future research findings.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; FLOHR, Alexander; GROEBKE ZBINDEN, Katrin; LERNER, Christian; WO2014/72261; (2014); A1;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 933190-51-3, name is 8-Bromo-6-chloroimidazo[1,2-b]pyridazine, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 8-Bromo-6-chloroimidazo[1,2-b]pyridazine

0O150] Step 1: To a solution of 8..bromo.-6chioroirnidazo[i,2bjpyridazine (1.0 equiv.) and diethyl 2-methylmalonate (1.0 equiv.) in DMF (0.15 M) was added sodium hydride (2.5 equiv.) at it The reaction was stined for 10 mm, then quenched with saturated ammoniurn chloride and extracted twice with ethyl acetate. The organic phase was dried with magnesium sulfate, filtered and concentrated. The residue was purified via reverse phase prep-1-IPLC to give cliethyl 2-(6-chloroimidazo[i ,2-bpyridazin-8.yI)-2-rnethylmalonate in 21% yield. LCMS (m/z) (M¡ÀH) 326.0, Rt 0.84 miii.

According to the analysis of related databases, 933190-51-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; NOVARTIS AG; AVERSA, Robert John; BURGER, Matthew T.; DILLON, Michael Patrick; DINEEN JR., Thomas A.; LOU, Yan; NISHIGUCHI, Gisele A; RAMURTHY, Savithri; RICO, Alice C.; RAUNIYAR, Vivek; SENDZIK, Martin; SUBRAMANIAN, Sharadha; SETTI, Lina Quattrocchio; TAFT, Benjamin R.; TANNER, Huw Rowland; WAN, Lifeng; (307 pag.)WO2016/38582; (2016); A1;,
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Synthetic Route of 51572-93-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 51572-93-1, name is O-(2,4-Dichlorobenzyl)hydroxylamine hydrochloride belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

General procedure: A mixture of substituted O-benzylhydroxylamine hydrochloride (1 equiv), TEA (1 equiv) and substituted salicylaldehyde (1 equiv) was dissolved in absolute ethanol and stirred for 0.5 h. The reaction was monitored by TLC. The precipitate was filtered and recrystallized from ethanol to gain salicylaldoxime (compounds 1g-20g).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, O-(2,4-Dichlorobenzyl)hydroxylamine hydrochloride, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Zhao, Ting-Ting; Lu, Xiang; Yang, Xian-Hui; Wang, Li-Ming; Li, Xi; Wang, Zhong-Chang; Gong, Hai-Bin; Zhu, Hai-Liang; Bioorganic and Medicinal Chemistry; vol. 20; 10; (2012); p. 3233 – 3241;,
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Related Products of 13918-92-8, A common heterocyclic compound, 13918-92-8, name is 2,4-Difluorobenzene-1-sulfonyl chloride, molecular formula is C6H3ClF2O2S, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

(1) 5-Bromo-3-amino-2-chloropyridine (0.10 g, 0.48 mmol), pyridine (0.057 g, 0.72 mmol), and dissolved in dichloromethane (0.77 mL) to prepare reaction solution 1. 2,4-difluorophenylsulfonyl chloride (0.12 g, 0.58 mmol) was used to prepare reaction solution 2. The flow rate (0.5 mL / min) set by the intelligent numerical control sampler was simultaneously introduced into the first via a 500 mum picker tube. Mix in a three-way mixer (ambient temperature 0 C), then flow out under its own pressure, enter a 500 mum inside diameter tube with a set temperature control (25 C), and set the residence time t1 (0.5min). the sulfonamide complete reaction, followed by after-pressure valve to obtain a first effluent;

The synthetic route of 13918-92-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Fudan University; Zhuhai Fudan Chuangxin Institute; Ling Yun; Zhou Yaming; Jia Yu; Deng Mingli; Liu Xiaofeng; Yang Yongtai; Chen Zhenxia; (30 pag.)CN110498798; (2019); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Reference of 14495-51-3, The chemical industry reduces the impact on the environment during synthesis 14495-51-3, name is 2-Bromo-5-chlorotoluene, I believe this compound will play a more active role in future production and life.

Compound 3 (20.7 mmol) was dissolved in CH2Cl2 (150 mL) and cooled to 0 C. with ice bath. To this solution under nitrogen were added in sequence N,N-di-isopropyl ethyl amine (5.4 mL, 31.02 mmol, 1.5 eq) and chloromethyl methyl ether (2 mL, 25.85 mmol, 1.25 eq). The reaction mixture was stirred overnight at room temperature and washed with NaHCO3-saturated water and then NaCl-saturated water. The residue after rotary evaporation was purified by flash column chromatography over silica gel to give 17.6 mmol of 4.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Bromo-5-chlorotoluene, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Baker, Stephen J.; Sanders, Virginia; Akama, Tsutomu; Bellinger-Kawahara, Carolyn; Freund, Yvonne; Maples, Kirk R.; Plattner, Jacob J.; Zhang, Yong-Kang; Zhou, Huchen; Hernandez, Vincent S.; US2007/293457; (2007); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics