Tag: M.W=200-300

Adding a certain compound to certain chemical reactions, such as: 309721-44-6, name is 2-Bromo-1-chloro-3-fluorobenzene, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 309721-44-6, Recommanded Product: 309721-44-6

40.0 g (1.0 eq) of Compound 1 (5,12-dihydroindolo [3,2-a] carbazole) and 26.27 g (1.5 eq) of Potassium tert-butoxide (KOtBu) were dissolved in dimethylformamide (DMF)And the mixture was heated and stirred.At the start of the reflux, 40.0 g (1.1 eq) of compound 1a (2-bromo-1-chloro-3-fluorobenzene) was added.After the reaction was completed after 3 hours, the reaction was poured into water and the crystals were dropped and filtered.The filtered solid was completely dissolved in chloroform (CHCl3), washed with water, and again reduced in pressure to remove the solvent. The residue was purified by column chromatography to obtain 49.5 g of Compound A-1 (yield: 71%).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; LG Chem, Ltd.; Lee Jeong-ha; Park Tae-yun; (125 pag.)KR2017/126814; (2017); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Some common heterocyclic compound, 56961-77-4, name is 1-Bromo-2,3-dichlorobenzene, molecular formula is C6H3BrCl2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. SDS of cas: 56961-77-4

EXAMPLE 10 6-(2,3-Dichlorophenyl)-1,2-dihydro-2,2,4-trimethylquinoline (Compound 109, structure 4 of Scheme II, where R1 =2,3-dichlorophenyl) This compound was prepared according to General Method 2 (EXAMPLE 9). From Compound 9 (68.0 mg, 0.21 mmol) and commercially available 2,3-dichlorobromobenzene (40.1 mg, 0.18 mmol, Lancaster) was obtained a crude product which was isolated and purified by reverse phase HPLC (ODS column, 97% methanol/water, 3.0 mL/min) to afford 20 mg (29%) of Compound 109. Data for Compound 109: 1 H-NMR (400 MHz, CDCl3)7.39(dd, J=8, 1.6, 1H), 7.19 (dd, J=16, 8, 1H), 7.23 (dd, J=4, 1.6, 1H), 7.11 (d, J=1.6, 1H), 7.05 (dd, J=8, 1.6, 1H), 6.46 (d, J=8, 1H), 5.34 (s, 1H), 3.82 (br s, 1H), 1.99 (s, 3H), 1.32 (s, 6H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 56961-77-4, its application will become more common.

Reference:
Patent; Ligand Pharmaceuticals Incorporated; US5693647; (1997); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Some common heterocyclic compound, 61881-19-4, name is 2,2,2-Trifluoro-N-phenylacetimidoyl chloride, molecular formula is C8H5ClF3N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Quality Control of 2,2,2-Trifluoro-N-phenylacetimidoyl chloride

Compound 16 (97 mg, 42.9 mol) was reacted with (N-phenyl)-2,2,2-trifluoroacetoimidoyl chloride (17.8 mg, 85.8 mol) andK2CO3 (29.7 mg, 215 mol) in acetone (1.7 mL) as described for 13. The crude product was purified bysilica gel column chromatography with hexane-EtOAc (83:17) and gel permeation chromatography[S-X1, toluene-EtOAc (75:25)] to give the title product 17 (94.7 mg, 91%). [alpha]D -35.2 (c 1.3, CHCl3);1H-NMR (500 MHz, CDCl3) delta7.38-7.07 (m, 43H, Ar), 6.82 (d, 1H, J2,NH = 9.4 Hz, NH), 6.71-6.69 (m,2H, Ar), 6.26 (br, 1H, H-1GlcN), 6.00 (d, 1H, J2,NH = 4.7 Hz, NH), 5.88-5.81 (m, 1H, H2C=CHCH2),5.30-5.14 (m, 10H, H2C=CHCH2 2, H-1Fuc 2, H-2Fuc 2, H-3Fuc 2, H-4Fuc 2), 5.07 (d, 1H,J1,2 = 8.1 Hz, H-1GlcN), 5.03-5.00 (m, 2H, H-5Fuc, PhCH2), 4.94 (dd, 1H, J4,5 = 12.7 Hz, J5,6 = 6.4 Hz,H-5Fuc), 4.78 (d, 1H, Jgem = 11.6 Hz, PhCH2), 4.71 (d, 1H, Jgem = 11.2 Hz, PhCH2), 4.63 (d, 1H,Jgem = 11.9 Hz, PhCH2), 4.60-4.37 (m, 13H, PhCH2 11, H-1Gal, H-2GlcN), 4.32 (d, 1H, J1,2 = 7.8 Hz,H-1Gal), 4.20 (t, 1H, J2,3 = J3,4 = 9.2 Hz, H-3GlcN), 4.07-4.01 (m, 3H, H2C=CHCH2 2, H-4GlcN),3.93-3.77 (m, 8H, H-4GlcN, H-2GlcN, H-6aGal, H-6aGal, H-4Gal, H-5GlcN, H-4Gal, H-6bGal), 3.76-3.65(m, 3H, H-3Gal, H-3GlcN, H-2Gal), 3.62-3.52 (m, 5H, H-6aGlcN, H-6bGlcN, H-6aGlcN, H-6bGal, H-2Gal),3.49-3.44 (m, 2H, H-5Gal, H-6bGlcN), 3.38 (dd, 1H, J5,6a = 5.5 Hz, J5,6b = 7.5 Hz, H-5Gal), 3.21-3.18 (m,2H, H-3Gal, H-5GlcN), 2.16 (s, 3H, Ac), 2.15 (s, 3H, Ac), 2.14 (s, 3H, Ac), 2.05 (s, 3H, Ac), 2.01 (s, 6H,Ac 2), 0.85 (d, 3H, H-6Fuc), 0.69 (d, 3H, J5,6 = 6.4 Hz, H-6Fuc); 13C-NMR (125 MHz, CDCl3) delta170.4,170.3, 170.2, 170.1, 169.4, 160.9, 160.7, 142.7, 139.0, 138.8, 138.4, 138.3, 138.2, 138.1, 137.8, 137.6, 137.3,134.9, 129.3, 129.0, 129.0, 128.8, 128.5, 128.4, 128.4, 128.3, 128.2, 128.2, 128.2, 128.1, 128.1, 127.9, 127.8,127.7, 127.7, 127.6, 127.5, 127.3, 127.3, 125.2, 124.6, 119.2, 117.0, 116.6, 114.8, 103.4, 103.2, 99.4, 96.0, 95.6,93.3, 92.6, 92.4, 81.8, 80.8, 78.5, 78.1, 77.6, 76.5, 75.1, 74.9, 74.7, 74.6, 74.4, 74.3, 74.1, 73.4, 73.3, 73.2, 72.9,72.8, 72.4, 72.0, 71.6, 71.5, 71.4, 68.8, 68.5, 68.2, 68.1, 68.0, 67.9, 67.1, 66.7, 64.8, 64.5, 58.7, 54.6, 30.9,29.6, 21.4, 20.9, 20.8, 20.8, 20.7, 20.7, 15.7, 15.2, 14.1. HRMS (ESI) m/z: found [M + Na]+ 2450.6466,C119H130Cl6F3N3O35 calcd. for [M + Na]+ 2450.6466.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 61881-19-4, its application will become more common.

Reference:
Article; Kobayashi, Daisuke; Ueki, Akiharu; Yamaji, Tomoya; Nagao, Kazuya; Imamura, Akihiro; Ando, Hiromune; Kiso, Makoto; Ishida, Hideharu; Molecules; vol. 21; 5; (2016);,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthetic Route of 6579-54-0, The chemical industry reduces the impact on the environment during synthesis 6579-54-0, name is 2,6-Dichlorobenzenesulfonyl chloride, I believe this compound will play a more active role in future production and life.

General procedure: Benzenesulfonyl chloride (1 mmol) in butanone (5 mL) was heated with stirring to 40C, and cyanamide solution (50%)was added dropwise, then the temperature was raised to 60C and stirring continued for 3 h. The compound 7 (0. 8 mmol)was added and heated to 80C for 3 h. After cooling to 40C, the reaction mixture was poured into cold water while stirring, white crystals or powders were precipitated, filtered,washed with water, and dried. Analytically pure samples were obtained by recrystallization from aqueous ethanol.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2,6-Dichlorobenzenesulfonyl chloride, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Li, Jie; Zheng, Tu-Cai; Jin, Yi; Xu, Jian-Guo; Yu, Jian-Gang; Lv, Yan-Wen; Chemical and Pharmaceutical Bulletin; vol. 66; 1; (2018); p. 55 – 60;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Reference of 38762-41-3,Some common heterocyclic compound, 38762-41-3, name is 4-Bromo-2-chloroaniline, molecular formula is C6H5BrClN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

[A] N-(4-Bromo-2-chloro-phenyl)-3-chloro-propionamideTo a solution of 4-bromo-2-chloro-phenylamine (32 g, 0.15 mol) and pyridine (13.45 g, 0.17 mol) in DCM (200 mL) was added 3-chloropropionyl chloride (21.65 g, 0.17 mol) dropwise at 15 C. After stirring at room temperature for 1 fir, the mixture was washed with water and then 2 N aq. hydrochloric acid. The organic layer was dried over anhy. Na2S04, filtered, and concentrated in vacuo to afford the title compound (10.9 g, 90% yield) as a white solid.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-Bromo-2-chloroaniline, its application will become more common.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; AEBI, Johannes; AMREIN, Kurt; FANTASIA, Serena Maria; HORNSPERGER, Benoit; KUHN, Bernd; LIU, Yongfu; MAERKI, Hans P.; MAYWEG, Alexander, V.; MOHR, Peter; SCALONE, Michelangelo; TAN, Xuefei; ZHOU, Mingwei; WO2013/41591; (2013); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Reference of 60633-25-2, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 60633-25-2, name is 2-Bromo-4-chloro-1-methoxybenzene, This compound has unique chemical properties. The synthetic route is as follows.

To a solution of the product from preparation 7 (45 mg, 0.075 mmol) in ethanol (0.2 ml_) was added 2-bromo-4-chloro-1-methoxybenzene(11 mg, 0.05 mmol) in 1 ,4-dioxane (0.2 ml_) followed by Pd(PPh3)4 (10 mg) and 2M aq Na2CO3 (0.2 mL, 0.4 mmol). The mixture was stirred at 95C for 2 hours, after which the solvent was removed. The residue was partitioned between water (2ml) and ethyl acetate (twice at 2ml). The combined organic layers were washed with saturated NaCI (2ml), dried (magnesium sulfate) and concentrated. The residue was purified by HPLC to yield the title compound (9.7 mg). MS (ES+) CaIc: 623.11 , Found: 623.9 (M+1 ).

The chemical industry reduces the impact on the environment during synthesis 2-Bromo-4-chloro-1-methoxybenzene. I believe this compound will play a more active role in future production and life.

Reference:
Patent; PFIZER PRODUCTS INC.; WO2006/56854; (2006); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 27139-97-5, name is 2-Bromo-4-chloro-1-methylbenzene, This compound has unique chemical properties. The synthetic route is as follows., category: chlorides-buliding-blocks

An agitator provided, 200 ml of a Schlenk tube substd. argon, as shown in the above-mentioned chemical eq. (116) 2-bromo-4-chlorotoluene (5. 02g, 20. A 0mmol) and diethyl ether (50 ml), stirring, -15 ¡ã C are cooled. There, 1. ¡¤ Phenylbicyclohexane soln. 6M-n-butyl lithium (13. 0 ml, 20. 5mmol) is dropped. 1 period, trimethyl borate (2. 13g, 20. 5mmol) is added, while warming up to a room temperature, a cooling bath is removed from 15¡ã C-, 18 hours. By adding distilled water (20 ml) little by little, the reaction is stopped, and diethyl ether Phenylbicyclohexane under reduced pressure is removed.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 27139-97-5.

Reference:
Patent; NIPPON HOSO KYOKAI <NHK>; KANTO CHEM CO INC; FUKAGAWA HIROHIKO; SHIMIZU TAKAHISA; TAKAHASHI JUNPEI; SHINNAI SATONOBU; TSUCHIYA KAZUHIKO; (53 pag.)JP2015/160849; (2015); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Reference of 27139-97-5,Some common heterocyclic compound, 27139-97-5, name is 2-Bromo-4-chloro-1-methylbenzene, molecular formula is C7H6BrCl, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

1) Preparation of 4-[3-(2-bromo-4-chlorobenzyl)-4,4-dimethyl-2,5-dioxoimidazolidin-1-yl]-2-trifluoromethylbenzonitrile 109.2Compound 109.2 was prepared as described for example 1.2, by reacting compound 1.1, instead of 2-bromobenzyl bromide, with 2-bromo-1-bromomethyl-4-chlorobenzene (prepared by N-bromosuccinimide bromination from 2-bromo-4-chloro-1-methylbenzene; 1H NMR: 7.82, d, 1H; 7.65, s, 1H, 7.5, d, 1H, 4.72, s, 2H). 4-[3-(2-Bromo-4-chlorobenzyl)-4,4-dimethyl-2,5-dioxoimidazolidin-1-yl]-2-trifluoromethylbenzonitrile was obtained. (Molecular weight 498.99 (C20H14BrClF3N3O2); retention time Rt=2.30 min. [B]; MS (ESI): 541.04 (MH++CH3CN).

The synthetic route of 27139-97-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SANOFI-AVENTIS; US2009/215728; (2009); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Reference of 33863-76-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 33863-76-2 name is 1-Bromo-3-chloro-5-fluorobenzene, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Sodium methoxide (4.5M solution in methanol, 2.20 [ML,] 10.0 [MMOL)] was added dropwise to a stirred solution of 1-fluoro-3-chloro-5-bromobenzene (1.00 g, 4.77 [MMOL)] in methanol (28 [ML)] at room temperature under a nitrogen atmosphere. The mixture was heated at reflux for 3 days and then cooled to room temperature. The mixture was evaporated under reduced pressure and the resulting yellow oil was dissolved in [DICHLOROMETHANE] (30 [ML).] The [DICHLOROMETHANE] solution was washed with water [(2X20] [ML)] dried over magnesium sulphate, filtered and evaporated under reduced pressure. The residue was purified by chromatography on silica gel eluting with cyclohexane to provide the title compound as a colourless oil (302 mg). [1 H-NMR (400MHZ, CDC13)] : [8] 3.77 (s, 3H), 6.82 (s, 1 H), 6.94 (s, 1 H), 7.09 (s, [1 H).] Microanalysis : Found: C, 37.94 ; H, 2.75. [C7H6BRCIO] requires ; C, 37.96 ; H, 2.73%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Bromo-3-chloro-5-fluorobenzene, and friends who are interested can also refer to it.

Reference:
Patent; PFIZER LIMITED; PFIZER INC.; WO2004/29051; (2004); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Related Products of 41965-95-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 41965-95-1, name is 3-Chloro-4-methoxybenzylamine Hydrochloride belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Compound 13 (5 g, 21.86 mmole) and compound 18 (5.34 g, 25.4 mmol) were added to 75 ml of dry DMF 1 and dissolved with stirring. After stirring for 10 minutes, the reaction system was placed in an ice-water mixture. Triethylamine (21.4 g, 0.217 mole) was slowly added dropwise to the reaction flask and slowly warmed to room temperature. After 4 hours, TLC showed the reaction was completed. Dichloromethane was added, washed with water five times, dried and filtered, concentrated by rotary evaporation and passed through a column (PE: EA = 25: 1). Compound 19 (7.3 g, yield 78%) was obtained as a white powder.

The synthetic route of 3-Chloro-4-methoxybenzylamine Hydrochloride has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Anrun Pharmaceutical (Suzhou) Co., Ltd.; Hong Jian; Xu Xin; Liu Guobin; Liu Huahui; (14 pag.)CN104710411; (2017); B;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics