Tag: M.W=200-300

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 60811-21-4, name is 4-Bromo-2-chloro-1-fluorobenzene, A new synthetic method of this compound is introduced below., Recommanded Product: 60811-21-4

Add 2-chloro-1-fluoro-4-bromobenzene (0.10 mol) to a 250 mL round bottom flask and dissolve in DMF (100 mL). Add potassium carbonate (0.20 mol) and di-n-hexylamine (0.10 mol) with stirring. The reaction system was heated to 90 C for 72 hours. After completion of the reaction, the mixture was cooled to room temperature, filtered, and the organic phase was concentrated to 50 mL, poured into dichloromethane (150 mL), washed with water (150 mL¡Á3) and brine (150 mL) The sodium was dried, and the solvent was evaporated under reduced pressure. and the crude material was purified by column chromatography to yield N, N-dihexyl-2-chloro-4-bromoaniline.

The synthetic route of 60811-21-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Ocean University of China; Shao Changlun; (69 pag.)CN108658937; (2018); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Reference of 1298031-93-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1298031-93-2, name is 6,8-Dichloro-2-methylimidazo[1,2-b]pyridazine belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

A mixture of intermediate 2 (250 g), morpholine ([CAS 110-91-8], 103 g, 1190 mmol)and N,N-diisopropylethylamine ([CAS 7087-68-5], 208.7 g, 1623 mmol) in CH3CN (2000 mL) was refluxed for 5 h. Then, the reaction mixture was concentrated underreduced pressure and the residue was purified by column chromatography over silicagel (eluent: petroleum ether/ethyl acetate, 3/1) to give 70 g (22.4%) of intermediate 3 as a yellow solid.

The synthetic route of 6,8-Dichloro-2-methylimidazo[1,2-b]pyridazine has been constantly updated, and we look forward to future research findings.

Reference:
Patent; JANSSEN PHARMACEUTICA NV; LECLERCQ, Laurent, Christian, L.; BARTOLOME-NEBREDA, Jose, Manuel; CONDE-CEIDE, Susana; VAN GOOL, Michiel, Luc, Maria; WO2014/9305; (2014); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 53531-69-4, name is (4-Bromophenyl)methanesulfonyl chloride, This compound has unique chemical properties. The synthetic route is as follows., Product Details of 53531-69-4

Step 3: C-(4-Bromo-phenyl)-N-(3-chloro-phenyl)-methanesulfonamide To a solution of (4-bromo-phenyl)-methanesulfonyl chloride (1.4 g, 5.2 mmol) in DCM (20 mL) at room temperature was added pyridine (1.26 mL, 15.6 mmol) followed by 3-chloroaniline (1.1 mL, 10.4 mmol) and the reaction was stirred at room temperature for 3 hours. 1 M aqueous HCl was added and then extracted with DCM, filtered through a separator, concentrated, dry loaded onto silica and purified by silica gel column chromatography (0-100% DCM in cyclohexane) to give C-(4-bromo-phenyl)-N-(3-chloro-phenyl)-methanesulfonamide (0.61 g, 1.68 mmol). 1H NMR (300 MHz, CDCl3): delta 7.49 (d, 2H), 7.26 (m, 1H), 7.13-7.15 (m, 4H), 6.96-6.98 (m, 1H), 6.31 (s, 1H), 4.31 (s, 2H).

According to the analysis of related databases, 53531-69-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; GENENTECH, INC.; Fauber, Benjamin; Rene, Olivier; Bodil van Niel, Monique; Ward, Stuart; US2014/163110; (2014); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

19752-55-7, name is 1-Bromo-3,5-dichlorobenzene, belongs to chlorides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. SDS of cas: 19752-55-7

3-(3,5-dichlorophenyl)pyridine Synthesised according to General Procedure 36. A mixture of 1-bromo-3,5-dichloro-benzene (424 mg, 1.88 mmol), 3-pyridineboronic acid pinacol ester (500 mg, 2.44 mmol), aqueous 2M Na2CO3 (1.96 mL, 3.93 mmol) and Pd(PPh3)4 (89 mg, 4 mol percent) in anhydrous toluene (18 mL) was stirred overnight at 80¡ã C. under nitrogen. The reaction was cooled down to room temperature, diluted with water (5 ml) and ethyl acetate (10 ml). The organic phase was separated, dried (Na2SO4), filtered and concentrated under reduced pressure to give a pale yellow oil, which was purified by silica-gel column chromatography to give 3-(3,5-dichlorophenyl)pyridine (481 mg, 74percent) as a white solid. 1H-NMR (400 MHz, CDCl3) delta 8.81 (d, J=2.1 Hz, 1H), 8.65 (dd, J=1.4, 4.8 Hz, 1H), 7.85-7.82 (m, 1H), 7.46 (d, J=1.8 Hz, 2H), 7.41-7.38 (m, 2H). LC/MS (10percent-99percent CH3CN (0.035percent TFA)/H2O (0.05percent TFA)), m/z: M+1 obs=224.3; tR=1.21 min.

The synthetic route of 19752-55-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Stamos, Dean; Martinborough, Esther; Zimmermann, Nicole; Neubert, Timothy; Numa, Mehdi Michel Djamel; Whitney, Tara; Kawatkar, Aarti Sameer; US2009/131440; (2009); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 51419-59-1, name is p-Tolylmethanesulfonyl chloride, A new synthetic method of this compound is introduced below., Recommanded Product: p-Tolylmethanesulfonyl chloride

6-Amino-1-allyl-3,4-dihydro-2 (1H)-quinolinone was prepared in the same manner as in Steps 1.1, 1.2 and 1.3 of Example 1, except that 3-bromopropene was used instead of 3-iodopropane. 1.01 g (5 mmol) of 6-amino-1-allyl-3,4-dihydro-2 (1H)-quinolinone and 1.23 g (6 mmol) of 4-methyl benzylsulfonyl chloride were added into 30 mL of DMF, and 2.01 g (15 mmol) of potassium carbonate was added as an acid-binding agent. The reaction was maintained at room temperature and stirred for 16 hours. After the reaction was completed, ice water was added, and extracted with ethyl acetate. The organic phase was dried over anhydrous sodium sulfate and concentrated. The crude product was subjected to silica gel column chromatography to give 1.36 g of the compound 130925 as a pale yellow solid, with a yield of 73%. 1H NMR (400 MHz, CDCl3): delta 7.22-6.93 (m, 7H), 5.91-5.83 (m, 1H), 5.25-5.13 (dd, 2H), 4.54 (s, 2H), 4.27 (d, 2H), 2.89 (t, 2H), 2.68 (t, 2H), 2.32 (s, 3H) ppm.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; SHANGHAI INSTITUTES FOR BIOLOGICAL SCIENCES, CHINESE ACADEMY OF SCIENCES; ZHU, Jiankang; CAO, Minjie; ZHANG, Yulu; LIU, Xue; (56 pag.)US2018/360039; (2018); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 157590-59-5, name is 4-Chloro-5-(trifluoromethyl)benzene-1,2-diamine, A new synthetic method of this compound is introduced below., Formula: C7H6ClF3N2

318 mg (3 MMOL) BRCN are dissolved in 0.6 ml acetonitrile and treated with 6 ML water. To this solution, 575 mg (2.73 MMOL) 5-CHLORO-6-TRIFLUOROMETHYL- benzene-1, 2-diamine, dissolved in 6 ML METHANOL, are added dropwise within 30 min. After 2 hrs of stirring at room temperature, the reaction mixture is concentrated and the water solution extracted 2X with ethyl acetate. The combined organic phases where RE-EXTRACTED 1x with water. The combined water phases where made alkaline (pH=8) with saturated NAHC03-SOLUTION and extracted 2x with ethyl acetate. The combined organic phases where dried, filtered and evaporated. Yield : 611 MG (95 %) 7, red solid

The synthetic route of 157590-59-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; MERCK PATENT GMBH; WO2005/4864; (2005); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 19230-27-4, name is 1,3-Dibromo-2-chlorobenzene, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 19230-27-4, Recommanded Product: 1,3-Dibromo-2-chlorobenzene

To a mixture of 1,3-dibromo-2-chlorobenzene (Combi-Blocks catQA-2717: 2.2 g, 8.14 mmol), Pd(OAc)2 (0.183 g, 0.814 mmol) and cesium carbonate (6.63 g, 20.34 mmol) in 1,4-dioxane (30 ml) was added 1,4-dioxa-8-azaspiro[4.5]decane (Aldrich cat178365: 1.165 g, 8.14 mmol) under N2. The reaction mixture was stirred at 90 C. overnight. After the reaction was cooled to room temperature it was quenched with saturated aqueous NaHCO3, and extracted with ethyl acetate (3¡Á50 mL). The combined organic layers were washed with brine, dried over MgSO4, filtered and concentrated under reduced pressure. The residue was purified by flash chromatography on a silica gel column with ethyl acetate in hexanes (0-20%) to afford the desired product. LC-MS calculated for C13H16BrClNO2 (M+H)+: m/z 332.0; found: 332.0/334.0.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,3-Dibromo-2-chlorobenzene, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Incyte Corporation; Wu, Liangxing; Qian, Ding-Quan; Lu, Liang; Lajkiewicz, Neil; Konkol, Leah C.; Li, Zhenwu; Zhang, Fenglei; Li, Jingwei; Wang, Haisheng; Xu, Meizhong; Xiao, Kaijiong; Yao, Wenqing; (101 pag.)US2018/177784; (2018); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 328-84-7, name is 3,4-Dichlorobenzotrifluoride, A new synthetic method of this compound is introduced below., Recommanded Product: 328-84-7

COMPARATIVE EXAMPLE 1 Synthesis of 2,3-dichloro-5-trifluoromethylbenzaldehyde STR13 57.3 g of 3,4-dichlorobenzotrifluoride was dissolved in 500 ml of dried tetrahydrofuran under nitrogen atmosphere and was cooled down to -78 C. To the resulting solution was dropped 200 ml of 1.6M hexane solution of n-butyl lithium. After the solution was further stirred for about 1.5 hours at the same temperature, 38.9 g of DMF was added dropwise into the reaction solution. After the completion of the addition, the temperature of the reaction system was gradually elevated to room temperature, while checking the progress of the reaction. Ice water was added to the reaction solution to extract with ether. The extract was dried over anhydrous magnesium sulfate. The solvent was distilled under reduced pressure. The obtained oily product was distilled under reduced pressure to give 45.3 g of oily residue (bp. 70~85 C./2 mmHg).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Nippon Soda Co., Ltd.; US5977414; (1999); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Reference of 32943-25-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 32943-25-2, name is 3-Chloro-10,11-dihydro-5H-dibenzo[b,f]azepine belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Example 17 1-(3-(3-Chloro-10,11-dihydro-5H-dibenz[b,f]azepin-5-yl)-1-propyl)4-piperidinecarboxylic acid hydrochloride 3-Chloro-10,11-dihydro-5H-dibenz[b,f]azepine (3.82 g, 16.6 mmol) was dissolved in toluene (20 ml). A solution of 3-chloropropionylchloride (2.53 g, 19.9 mmol) in toluene was added dropwise, and the resulting mixture was heated to 95 C. and stirred at that temperature for 30 minutes. The mixture was stirred overnight at room temperature. Further 3-chloropropionylchloride (2.53 g, 19.9 mmol) was added and the mixture was stirred at 95 C. for 1.5 h. After cooling, 0.2 M sodium hydroxide (10 ml) was added, and the phases were separated. The organic phase was diluted with more toluene (50 ml); and washed with first 0.2 M sodium hydroxide (6*10 ml) and then with more 0.2 M sodium hydroxide (3*20 ml) until the aqueous phase was alkaline. The organic phase was washed with water (3*15 ml), brine (25 ml), and dried (MgSO4). Evaporation in vacuo afforded 5.23 g (98%) of crude 3-chloro-1-(3-chloro-10,11-dihydro-5H-dibenz[b,f]azepin-5-yl)-1-propanone as an oil. This was further purified by addition of a mixture of heptane and ethyl acetate (1:1). This afforded 3.14 g (59%) of the product as a solid.

The synthetic route of 3-Chloro-10,11-dihydro-5H-dibenzo[b,f]azepine has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Novo Nordisk A/S; US6239148; (2001); B1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Related Products of 61881-19-4, The chemical industry reduces the impact on the environment during synthesis 61881-19-4, name is 2,2,2-Trifluoro-N-phenylacetimidoyl chloride, I believe this compound will play a more active role in future production and life.

General procedure: Add sodium acetate, trifluoroethylimidyl chloride (II), hydrazone (III), and 1 mL of organic solvent to the 35 mL Schlenk tube according to the raw material ratio in Table 1.Mix and stir well. After the reaction is completed according to the reaction conditions in Table 2, 2-4 hours,Add elemental iodine, continue the reaction for 1-2 hours, filter, and stir the sample in silica gel.After purification by column chromatography, the corresponding 5-trifluoromethyl-substituted 1,2,4-triazole compound (I) is obtained. The reaction process is shown by the following formula:

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2,2,2-Trifluoro-N-phenylacetimidoyl chloride, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Zhejiang Sci-Tech University; Chen Zhengkai; Hu Sipei; Yang Zuguang; (10 pag.)CN110467579; (2019); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics