Tag: M.W=200-250

Li, Long-Di published the artcileRoom temperature phosphorescence properties of 27 coumarin derivatives on filter paper, Quality Control of 10543-42-7, the publication is Analytica Chimica Acta (1994), 296(1), 99-105, database is CAplus.

Some coumarin derivatives were used as fluorescence labeling agent. The room temperature phosphorescence (RTP) properties of 27 kinds of coumarin derivatives on filter paper were studied. Most of them can give more intensive RTP signals when using 1.0 mol L^-1 lead acetate as a heavy-atom perturber and there is an obvious relation between the RTP characteristics and the substituting group in some of the derivatives The fact that many of the coumarin derivatives can give RTP emission means that they can be expected to serve as RTP labeling agent.

Analytica Chimica Acta published new progress about 10543-42-7. 10543-42-7 belongs to chlorides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Chloride,Sulfonyl chlorides,Ester, name is Coumarin-6-sulfonyl chloride, and the molecular formula is C9H5ClO4S, Quality Control of 10543-42-7.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Sasaki, Shigeru published the artcileBisoxazoline-catalyzed asymmetric nucleophilic addition of diethyl zinc to fluorinated alkyl ketones: enantiofacial control by changing the bisoxazoline substituent, Application of 1-(2-Chlorophenyl)-2,2,2-trifluoroethanone, the publication is Bulletin of the Chemical Society of Japan (2015), 88(1), 200-208/1-200-208/9, 9 pp., database is CAplus.

Bisoxazoline (BOX)-catalyzed asym. nucleophilic addition of di-Et zinc to fluorinated alkyl ketones successfully afforded enantioenriched fluorinated alkyl tertiary alcs. The effect of the size of the substituent on the oxazoline ring on the stereoselectivity of the reaction was investigated. Furthermore, the enantioselectivity could be reversed by altering the BOX bridge structure while retaining the C-4 substituent on the oxazoline ring.

Bulletin of the Chemical Society of Japan published new progress about 5860-95-7. 5860-95-7 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Benzene,Ketone, name is 1-(2-Chlorophenyl)-2,2,2-trifluoroethanone, and the molecular formula is C8H4ClF3O, Application of 1-(2-Chlorophenyl)-2,2,2-trifluoroethanone.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Qi, Yan-yan published the artcileComparative efficacy of pharmacological agents on reducing the risk of major adverse cardiovascular events in the hypertriglyceridemia population: a network meta-analysis, Safety of Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate, the publication is Diabetology & Metabolic Syndrome (2021), 13(1), 15, database is CAplus and MEDLINE.

Hypertriglyceridemia (HTG) is considered an independent risk factor for major adverse cardiovascular events (MACE). This study analyzed the effects of various agents on MACE risk reduction in HTG (serum triglyceride �50 mg/dL) populations by performing a network meta-anal. We performed a frequentist network meta-anal. to conduct direct and indirect comparisons of interventions. PubMed, EMBASE, and the Cochrane library were searched for trials until Jul 6, 2020. Randomized controlled trials that reported MACE associated with agents in entire HTG populations or in subgroups were included. The primary outcome was MACE. Of the 2005 articles screened, 21 trials including 56,471 patients were included in the anal. The network meta-anal. results for MACE risk based on frequency data showed that eicosapentaenoic acid (EPA) (OR: 1.32; 95% CI 1.19-1.46), gemfibrozil (OR: 1.53; 95% CI 1.20-1.95), niacin plus clofibrate (OR: 2.00; 95% CI 1.23-3.25), pravastatin (OR: 1.32; 95% CI 1.15-1.52), simvastatin (OR: 2.38; 95% CI 1.55-3.66), and atorvastatin (OR: 0.55; 95% CI 0.37-0.82) significantly reduced the risk of MACE compared to the control conditions. In the subgroup anal. of HTG patients with triglycerides �200 mg/dL, bezafibrate (OR: 0.56; 95% CI 0.33-0.94), EPA (OR: 0.72; 95% CI 0.62-0.82), and pravastatin (OR: 1.33; 95% CI 1.01-1.75) significantly reduced the MACE risk. Simvastatin had a clear advantage in reducing the risk of MACE in the entire HTG population analyzed in this meta-anal. EPA, but not omega-3 fatty acid, was considered an effective HTG intervention. Among fibrates, gemfibrozil was most effective, though bezafibrate may significantly reduce the risk of MACE in populations with triglyceride levels of 200-300 mg/dL.

Diabetology & Metabolic Syndrome published new progress about 637-07-0. 637-07-0 belongs to chlorides-buliding-blocks, auxiliary class Inhibitor,Cell Cycle,PPAR, name is Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate, and the molecular formula is C12H15ClO3, Safety of Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Qiang, Wen published the artcileImpact of the gut microbiota on heat stroke rat mediated by Xuebijing metabolism, SDS of cas: 637-07-0, the publication is Microbial Pathogenesis (2021), 104861, database is CAplus and MEDLINE.

The goal of the present study was to evaluate the fecal microbiome and serum metabolites in Xuebijing (XBJ)-injected rats after heat stroke using 16S rRNA gene sequencing and gas chromatog.-mass spectrometry (GC-MS) metabolomics. Eighteen rats were divided into the control group (CON), heat stroke group (HS), and XBJ group. The 16S rRNA gene sequencing results revealed that the abundance of Bacteroidetes was overrepresented in the XBJ group compared to the HS group, while Actinobacteria was underrepresented. Metabolomic profiling showed that the pyrimidine metabolism pathway, pentose phosphate pathway, and glycerophospholipid metabolism pathway were upregulated in the XBJ group compared to the HS group. Taken together, these results demonstrated that heat stroke not only altered the gut microbiome community structure of rats but also greatly affected metabolic functions, leading to gut microbiome toxicity.

Microbial Pathogenesis published new progress about 637-07-0. 637-07-0 belongs to chlorides-buliding-blocks, auxiliary class Inhibitor,Cell Cycle,PPAR, name is Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate, and the molecular formula is C12H15ClO3, SDS of cas: 637-07-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Yu, Haihua published the artcileControllable access to multi-substituted imidazoles via palladium(II)-catalyzed C-C coupling and C-N condensation cascade reactions, Formula: C9H12BClO3, the publication is Chemical Communications (Cambridge, United Kingdom) (2017), 53(70), 9745-9748, database is CAplus and MEDLINE.

A novel and efficient protocol for the synthesis of various 2,4-disubstituted, 1,2,4-trisubstituted and 1,2,4,5-tetra-substituted imidazoles I [R¹ = Me, CF₃, Ph, etc.; R² = H, Ph, Bn; R³ = H, Me; R⁴ = Ph, 4-FC₆H₄, 2-MeC₆H₄, etc.] via cascade palladium catalyzed C-C coupling followed by intramol. C-N bond formation was developed. Readily accessible boronic acids and N-substituted-2-aminoacetonitriles were firstly reported as starting materials to construct di-, tri-, and tetra-substituted imidazoles in good to excellent yield. The protocol was the first report to prepare multi-substituted imidazoles from readily accessible aminoacetonitrile and boronic acid.

Chemical Communications (Cambridge, United Kingdom) published new progress about 480438-56-0. 480438-56-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Ether,Boronic Acids,Boronic acid and ester, name is 3-Chloro-4-isopropoxyphenylboronic acid, and the molecular formula is C19H21N3O3S, Formula: C9H12BClO3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Hu, Wenbin published the artcileSuper-microporous silica-supported platinum catalyst for highly regioselective hydrosilylation, Formula: C9H20Cl2Si, the publication is Catalysis Communications (2017), 51-55, database is CAplus.

Super-microporous micelle-templated platinum on silica catalysts were successfully prepared by an improved one-pot procedure, using a water/acetonitrile/n-dodecylamine mixture The catalyst showed high surface area and narrow pore size and was further characterized by powder X-ray diffraction and inductively coupled plasma mass spectrometry. The unique super-microporous materials were proven to be highly active for the microwave-assisted hydrosilylation reaction of terminal alkenes or alkynes using dichloromethylsilane as silicon source. The super-microporous structure was beneficial for the control of hydrosilylation regioselectivity, as the selectivity to the β-adduct reached 99%. Moreover, the catalyst could be easily recovered by simple filtration and re-used seven times without appreciable loss of activity and selectivity.

Catalysis Communications published new progress about 14799-93-0. 14799-93-0 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(methyl)(octyl)silane, and the molecular formula is C9H20Cl2Si, Formula: C9H20Cl2Si.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Li, Xiao-Juan published the artcileConvenient and efficient decarboxylative aldol reaction of malonic acid half esters with trifluoromethyl ketones, Formula: C8H4ClF3O, the publication is Tetrahedron Letters (2012), 53(16), 2117-2120, database is CAplus.

A convenient and efficient decarboxylative ketone aldol condensation of malonic acid half esters was reported. In the presence of catalytic amount of triethylamine, a series of aromatic and alkyl trifluoromethyl ketones were transformed into the desired adducts in 61-99% yields. In a preliminary experiment, a moderate stereoselectivity was obtained. Direct reduction of the aldol product with LiAlH₄ afforded trifluoromethylated 1,3-diol.

Tetrahedron Letters published new progress about 5860-95-7. 5860-95-7 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Benzene,Ketone, name is 1-(2-Chlorophenyl)-2,2,2-trifluoroethanone, and the molecular formula is C8H4ClF3O, Formula: C8H4ClF3O.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Song, W. published the artcileMicroscopic and Macroscopic Characterization of Organosilane-Functionalized Nanocrystalline NaZSM-5, Computed Properties of 14799-93-0, the publication is Langmuir (2005), 21(15), 7009-7014, database is CAplus and MEDLINE.

Nanocrystalline NaZSM-5 zeolites with systematically varied particle sizes (15, 60, and 200 nm) were functionalized with organosilanes. Through the systematic variation of particle size and therefore external surface area of NaZSM-5, the extent of functionalization and location of functional groups were spectroscopically verified. ²⁹Si magic-angle spinning (MAS) NMR and Fourier transform IR (FTIR) spectroscopy provided conclusive evidence that the silanol groups located on the external surface of NaZSM-5 were functionalized through reaction with the organosilanes. The ²⁹Si NMR results provided quant. information about the extent of functionalization on NaZSM-5. A nitroxide spin label was adsorbed on the external surface of NaZSM-5 to probe the surface properties by ESR (EPR) spectroscopy. The macroscopic and microscopic properties, such as the behavior of functionalized NaZSM-5 in different solvents, and the sp. surface areas were also investigated. The hydrophobicity of the functionalized NaZSM-5 was found to increase relative to the parent NaZSM-5 as expected for an organic surface coating.

Langmuir published new progress about 14799-93-0. 14799-93-0 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(methyl)(octyl)silane, and the molecular formula is C12H16N2O2, Computed Properties of 14799-93-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Grunwald, Marco Andre published the artcileColumnar Propeller-Like 1,3,5-Triphenylbenzenes: Probing the Effect of Chlorine on the Suzuki Cross-Coupling and Liquid Crystalline Properties, Category: chlorides-buliding-blocks, the publication is European Journal of Organic Chemistry (2020), 2020(15), 2190-2198, database is CAplus.

Suzuki cross-couplings either between chlorinated N-methyliminodiacetic acid (MIDA)-protected aryl boronates and 1,3,5-tribromobenzene or between chlorinated aryl bromides and phenyltrisboronic species to star-shaped 1,3,5-triphenylbenzenes with different substitution patterns and chloro substituents at the outer Ph rings were studied. The chlorinated precursors required for the resp. reaction were synthesized and characterized. Depending on the used coupling reaction target triphenylbenzenes were isolated in yields between 42% and 88%. Their mesomorphic properties were influenced by the substitution pattern and number of peripheral chlorine atoms. Triphenylbenzene with 3,5-alkoxy substitution and H in para-position self-assembled into either columnar hexagonal (Col_h) mesophases or a soft crystal. While threefold chloro substitution in meta-position of the outer Ph rings led to stable room temperature Col_ho phases, triphenylbenzenes with threefold para-chloro or 3,5-dichloro substitution were non-mesomorphic. Based on x-ray diffraction data a helical packing model for the observed phases similar to that of related alkoxy-substituted triphenylbenzenes is proposed.

European Journal of Organic Chemistry published new progress about 19652-33-6. 19652-33-6 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Bromide,Benzene,Phenol,Aldehyde, name is 5-Bromo-3-chloro-2-hydroxybenzaldehyde, and the molecular formula is C7H4BrClO2, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Yearick, Kimberly published the artcileCatalytic Enantioselective Addition of Diethylzinc to Trifluoromethyl Ketones, Synthetic Route of 5860-95-7, the publication is Organic Letters (2008), 10(17), 3915-3918, database is CAplus and MEDLINE.

A procedure for nucleophilic addition of diethylzinc to trifluoromethyl ketones was developed. The TMEDA-catalyzed method converts aromatic substrates to the corresponding 2-aryl-1,1,1-trifluorobutan-2-ols in up to 99% yield, and it is also applicable to less reactive aliphatic ketones if stoichiometric ligand amounts are employed. The first asym. variant producing tertiary alcs. with up to 61% ee when TBOX is used as catalyst is described.

Organic Letters published new progress about 5860-95-7. 5860-95-7 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Benzene,Ketone, name is 1-(2-Chlorophenyl)-2,2,2-trifluoroethanone, and the molecular formula is C9H12O, Synthetic Route of 5860-95-7.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics