Tag: M.W=200-250

Ye, Zenghui published the artcilePIDA-Mediated Rearrangement for the Synthesis of Enantiopure Triazolopyridinones, Name: Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate, the publication is Organic Letters (2020), 22(16), 6464-6467, database is CAplus and MEDLINE.

A tandem oxidative cyclization/1,2-carbon migration of hydrazides for the synthesis of otherwise inaccessible hindered or enantiopure triazolopyridinones has been developed. This protocol exhibits broad substrate scope and can be easily scaled up by continuous flow synthesis under mild conditions. Most importantly, this method demonstrates a rearrangement with retention of configuration and can be readily applied for the late-stage modification of carboxylic-acid-containing pharmaceuticals, amino acids, and natural products to access enantiopure triazolopyridinones.

Organic Letters published new progress about 637-07-0. 637-07-0 belongs to chlorides-buliding-blocks, auxiliary class Inhibitor,Cell Cycle,PPAR, name is Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate, and the molecular formula is C4H7BN2O2, Name: Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Cai, Yingying published the artcileDouble allylic defluorinative alkylation of 1,1-bisnucleophiles with (trifluoromethyl)alkenes: construction of all-carbon quaternary centers, Application In Synthesis of 864725-22-4, the publication is Organic Chemistry Frontiers (2020), 7(10), 1260-1265, database is CAplus.

A double allylic defluorinative alkylation reaction of 1,1-bisnucleophiles such as C₆H₅CH₂ R (R = H, Ph, C(O) C₆H₅, C(O)OEt, etc.), nitriles R¹CH₂CN (R¹ = Ph, thiophen-2-yl, n-decyl, etc.)and indolin-2-one with (trifluoromethyl)alkenes CH₂=C(R²)CF₃ (R² = Ph, naphthalen-2-yl, pyridin-3-yl, etc.) is reported that occurs via the exclusively regioselective SN2 reaction. Various aliphatic nitriles, esters, and indolin-2-one derivatives could serve as 1,1-bisnucleophiles, delivering diverse attractive sym. gem-difluoroalkene substituted products e.g., I in high yields via the construction of all-carbon quaternary centers. Interestingly, the chemoselective SNV reaction between gem-difluoroalkenes and nucleophiles is completely inhibited. The nitrile group might help to stabilize the α-carbanion intermediates.

Organic Chemistry Frontiers published new progress about 864725-22-4. 864725-22-4 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Alkenyl,Benzene, name is 1,3-Dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene, and the molecular formula is C9H5Cl2F3, Application In Synthesis of 864725-22-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Du, Mengyuan published the artcileN-Protecting group tuning of the enantioselectivity in Strecker reactions of trifluoromethyl ketimines to synthesize quaternary α-trifluoromethyl amino nitriles by ion pair catalysis, SDS of cas: 5860-95-7, the publication is Chemical Communications (Cambridge, United Kingdom) (2020), 56(10), 1581-1584, database is CAplus and MEDLINE.

An enantioselective Strecker reaction to construct trifluoromethylated quaternary stereocenters with N-PMP and unexplored N-Boc trifluoromethyl ketimines RC(CF₃)=NR¹ [R = Ph, 3,5-difluorophenyl, thiophen-2-yl, etc.; R¹ = 4-methoxyphenyl, C(O)OC(CH₃)₃] catalyzed using an organophosphine dual-reagent catalyst has been developed. The enantioselectivities of the corresponding products (R/S)-RC(CF₃)(CN)NH(R¹) with the same catalyst could be switched by using different N-protecting groups (N-PMP or N-Boc). The trifluoromethyl amino nitriles (R/S)-RC(CF₃)(CN)NH(R¹) were obtained in high yield and high enantioselectivity in a short time and could be easily converted to a variety of useful trifluoromethyl-containing compounds

Chemical Communications (Cambridge, United Kingdom) published new progress about 5860-95-7. 5860-95-7 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Benzene,Ketone, name is 1-(2-Chlorophenyl)-2,2,2-trifluoroethanone, and the molecular formula is C8H4ClF3O, SDS of cas: 5860-95-7.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Li, Congyu published the artcileDefluorinative C(sp³)-P Bond Construction for the Synthesis of Phosphorylation gem-Difluoroalkenes under Catalyst- and Oxidant-Free Conditions, Application In Synthesis of 864725-22-4, the publication is Chemistry – An Asian Journal (2019), 14(15), 2584-2587, database is CAplus and MEDLINE.

Defluorinative C(sp³)-P bond formation of α-trifluoromethyl alkenes with phosphine oxides or phosphonates were achieved under catalyst- and oxidant-free conditions, giving phosphorylation gem-difluoroalkenes as products. α-Trifluoromethyl alkenes bearing various of aryl substituents such as halogen, cyano, ester and heterocyclic groups are available in this transformation. The results of control experiments demonstrated that the mechanism of dehydrogenative/defluorinative cross-coupling reactions was not a radical route, but might be an S_N2′ process involving phosphine oxide anion.

Chemistry – An Asian Journal published new progress about 864725-22-4. 864725-22-4 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Alkenyl,Benzene, name is 1,3-Dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene, and the molecular formula is C9H5Cl2F3, Application In Synthesis of 864725-22-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Luo, Zonghua published the artcileDesign and synthesis of pyrazolopyridine derivatives as sphingosine 1-phosphate receptor 2 ligands, Application of 2-Chloro-6-methoxyisonicotinoyl chloride, the publication is Bioorganic & Medicinal Chemistry Letters (2018), 28(3), 488-496, database is CAplus and MEDLINE.

Eleven new sphingosine 1-phosphate receptor 2 (S1PR2) ligands were synthesized by modifying lead compound N-(2,6-dichloropyridin-4-yl)-2-(4-isopropyl-1,3-dimethyl-1H-pyrazolo[3,4-b]pyridin-6-yl)hydrazine-1-carboxamide (I, JTE-013) and their binding affinities toward S1PRs were determined in vitro using [³²P]S1P and cell membranes expressing recombinant human S1PRs. Among these ligands, 35a (II, IC₅₀ = 29.1 ± 2.6 nM) and 35b (III, IC₅₀ = 56.5 ± 4.0 nM) exhibit binding potency toward S1PR2 comparable to JTE-013 (IC₅₀ = 58.4 ±7.4 nM) with good selectivity for S1PR2 over the other S1PRs (IC₅₀ > 1000 nM). Further optimization of these analogs may identify addnl. and more potent and selective compounds targeting S1PR2.

Bioorganic & Medicinal Chemistry Letters published new progress about 116853-97-5. 116853-97-5 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,acyl chloride,Ether, name is 2-Chloro-6-methoxyisonicotinoyl chloride, and the molecular formula is C7H5Cl2NO2, Application of 2-Chloro-6-methoxyisonicotinoyl chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Baluta, Sylwia published the artcileEnzymatic platforms for sensitive neurotransmitter detection, Name: Dichloro(methyl)(octyl)silane, the publication is Sensors (2020), 20(2), 423, database is CAplus and MEDLINE.

A convenient electrochem. sensing pathway was investigated for neurotransmitter detection based on newly synthesized silole derivatives and laccase/horseradish-peroxidase-modified platinum (Pt)/gold (Au) electrodes. The miniature neurotransmitter’s biosensors were designed and constructed via the immobilization of laccase in an electroactive layer of the Pt electrode coated with poly(2,6-bis(3,4-ethylenedioxythiophene)-4-methyl-4-octyl-dithienosilole) and laccase for serotonin (5-HT) detection, and a Au electrode modified with the electroconducting polymer poly(2,6-bis(selenophen-2-yl)-4-methyl-4-octyl-dithienosilole), along with horseradish peroxidase (HRP), for dopamine (DA) monitoring. These sensing arrangements utilized the catalytic oxidation of neurotransmitters to reactive quinone derivatives (the oxidation process was provided in the enzymes’ presence). Under the optimized conditions, the anal. performance demonstrated a convenient degree of sensitivity: 0.0369 and 0.0256μA mM^-1 cm^-2, selectivity in a broad linear range (0.1-200) x 10-6 M with detection limits of ≈48 and ≈73 nM (for the serotonin and dopamine biosensors, resp.). Moreover, the method was successfully applied for neurotransmitter determination in the presence of interfering compounds (ascorbic acid, L-cysteine, and uric acid).

Sensors published new progress about 14799-93-0. 14799-93-0 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(methyl)(octyl)silane, and the molecular formula is C9H20Cl2Si, Name: Dichloro(methyl)(octyl)silane.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Sun, Caocao published the artcileIntegrating aryl chlorides into nickel-catalyzed 1,1-difunctionalization of alkenes, Product Details of C12H15ClO3, the publication is Chinese Chemical Letters (2022), 33(12), 5096-5100, database is CAplus.

Herein, a first achievement in 1,1-difunctionalization of alkenes RCH=CH₂ (R = hexyl, cyclohexyl, 3-(1H-pyrrol-1-yl)propyl, 9H-carbazol-9-ylmethyl, etc.) with aryl chlorides ArCl (Ar = Ph, 2,4-difluorophenyl, 1-[(tert-butoxy)(oxo)methane]-1H-indol-6-yl, 2H-1,3-benzodioxol-5-yl, etc.) as coupling partners was reported. The success is predominantly ascribed to the judicious selection of 1,2-diamine ligand. This study provides an efficient protocol for the synthesis of secondary benzyl boronates RCH₂CH(R¹)Ar (R¹ = tetramethyl-1,3,2-dioxaborolan-2-yl) from easily accessible feedstock chems. Furthermore, the distinguished features of this method include excellent 1,1-regio- and chemoselectivity, good functional group tolerance and easily-operational catalytic reaction conditions.

Chinese Chemical Letters published new progress about 637-07-0. 637-07-0 belongs to chlorides-buliding-blocks, auxiliary class Inhibitor,Cell Cycle,PPAR, name is Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate, and the molecular formula is C13H15NO6S, Product Details of C12H15ClO3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Kodama, Susumu published the artcileAssociation between in vitro nuclear receptor-activating profiles of chemical compounds and their in vivo hepatotoxicity in rats, Application In Synthesis of 637-07-0, the publication is Journal of Toxicological Sciences (2021), 46(12), 569-587, database is CAplus.

The liver plays critical roles to maintain homeostasis of living organisms and is also a major target organ of chem. toxicity. Meanwhile, nuclear receptors (NRs) are known to regulate major liver functions and also as a critical target for hepatotoxic compounds In this study, we established mammalian one-hybrid assay systems for five rat-derived NRs, namely PXR, PPARα, LXRα, FXR and RXRα, and evaluated a total of 326 compounds for their NR-activating profiles. Then, we assessed the association between their NR-activating profile and hepatotoxic endpoints in repeated-dose toxicity data of male rats from Hazard Evaluation Support System. In the in vitro cell-based assays, 68, 38, 20, 17 and 17 compounds were identified as positives for PXR, PPARα, LXRα, FXR and RXRα, resp. The association analyses demonstrated that the PXR-pos. compounds showed high frequency of endpoints related to liver hypertrophy, such as centrilobular hepatocellular hypertrophy, suggesting that PXR activation is involved in chem.-induced liver hypertrophy in rats. It is intriguing to note that the PXR-pos. compounds also showed statistically significant associations with both prolonged activated partial thromboplastin time and prolonged prothrombin time, suggesting a possible involvement of PXR in the regulation of blood clotting factors. Collectively, our approach may be useful for discovering new functions of NRs as well as understanding the complex mechanism for hepatotoxicity caused by chem. compounds

Journal of Toxicological Sciences published new progress about 637-07-0. 637-07-0 belongs to chlorides-buliding-blocks, auxiliary class Inhibitor,Cell Cycle,PPAR, name is Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate, and the molecular formula is C12H15ClO3, Application In Synthesis of 637-07-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Dong, Yanan published the artcileReductive cyanation of organic chlorides using CO₂ and NH₃ via Triphos-Ni(I) species, COA of Formula: C12H15ClO3, the publication is Nature Communications (2020), 11(1), 4096, database is CAplus and MEDLINE.

The reductive cyanation of organic chlorides RCl (R = C₆H₅, naphthalen-1-yl, cyclohexyl, etc.) using CO₂/NH₃ as the electrophilic CN source has been described. The use of tridentate phosphine ligand Triphos allows for the nickel-catalyzed cyanation of a broad array of aryl and aliphatic chlorides to produce the desired nitrile products RCN in good yields, and with excellent functional group tolerance. Cheap and bench-stable urea was also shown as suitable CN source, suggesting promising application potential. Mechanistic studies imply that Triphos-Ni(I) species are responsible for the reductive C-C coupling approach involving isocyanate intermediates. This method expands the application potential of reductive cyanation in the synthesis of functionalized nitrile compounds under cyanide-free conditions, which is valuable for safe synthesis of (isotope-labeled) drugs.

Nature Communications published new progress about 637-07-0. 637-07-0 belongs to chlorides-buliding-blocks, auxiliary class Inhibitor,Cell Cycle,PPAR, name is Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate, and the molecular formula is C12H15ClO3, COA of Formula: C12H15ClO3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Li, Longdi published the artcileRoom temperature phosphorescence properties of 6-coumarinsulfonyl chloride, HPLC of Formula: 10543-42-7, the publication is Fenxi Huaxue (1992), 20(11), 1257-60, database is CAplus.

6-Coumarinsulfonyl chloride (C₆SCl) was used as the fluorescence and low-temperature phosphorescence labeling reagent for amino acids. In this paper, the room-temperature phosphorescence (RPT) of C₆SCl on the several solid substrates, such as filter paper, polyamide films, microcrystalline cellulose, cellulose nitrate, and silica gel for chromatog. etc. was induced successfully by selection of the heavy atom perturbers and exptl. conditions. The RTP emission of C₆SCl has high selectivity, only divalent lead salts are efficient perturber among the examined fifteen compounds and the Pb(OAc)₂ induced the most strong RTP signal. Using 1.0 mol/L Pb(OAc)₂ as the perturber and filter paper as the solid substrate, more intensive RTP signal with high signal to blank ratio was obtained. The RTP signal intensity (λ_x/λ_m = 320/496 nm) as a function of the amount of C₆SCl has a good linear relationship in 0.2 μL sample solution containing 4 to 200 pmol. These results mean that C₆SCl, a new developing luminescence-labeling compound, can be expected to serve as not only a fluorescence labeling reagent, but also a RTP one.

Fenxi Huaxue published new progress about 10543-42-7. 10543-42-7 belongs to chlorides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Chloride,Sulfonyl chlorides,Ester, name is Coumarin-6-sulfonyl chloride, and the molecular formula is C9H5ClO4S, HPLC of Formula: 10543-42-7.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics