Tag: M.W=200-250

Whalley, David M.; Duong, Hung A.; Greaney, Michael F. published the artcile< A visible light-mediated, decarboxylative, desulfonylative Smiles rearrangement for general arylethylamines syntheses>, Quality Control of 22952-32-5, the main research area is arylethylamine preparation; alanine oxime ester decarboxylative desulfonylative Smiles rearrangement photocatalysis.

A decarboxylative, desulfonylative Smiles rearrangement is presented that employs activated-ester/energy transfer catalysis to decarboxylate β-amino acid derived starting materials at room-temperature under visible light irradiation The radical Smiles rearrangement gives a range of biol. active arylethylamine products highly relevant to the pharmaceutical industry, chem. biol. and materials science. The reaction is then applied to the synthesis of a chiral unnatural amino acid, 2-thienylalanine, used in the treatment of phenylketonuria. It was also shown how the reaction can proceed under metal-free and catalyst-free conditions.

Chemical Communications (Cambridge, United Kingdom) published new progress about Amino acids Role: RCT (Reactant), RACT (Reactant or Reagent). 22952-32-5 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2O3S, Quality Control of 22952-32-5.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Derand, Renaud; Bulteau-Pignoux, Laurence; Mettey, Yvette; Zegarra-Moran, Olga; Howell, L. Daniel; Randak, Christoph; Galietta, Luis J. V.; Cohn, Jonathan A.; Norez, Caroline; Romio, Leila; Vierfond, Jean-Michel; Joffre, Michel; Becq, Frederic published the artcile< Activation of G551D CFTR channel with MPB-91: regulation by ATPase activity and phosphorylation>, Synthetic Route of 2905-54-6, the main research area is cystic fibrosis transmembrane conductance regulator mutant activation MPB91 preparation; benzoquinolizinium derivative preparation activation CFTR chloride channel mutant.

We have designed and synthesized benzo[c]quinolizinium derivatives and evaluated their effects on the activity of G551D cystic fibrosis transmembrane conductance regulator (CFTR) expressed in Chinese hamster ovary and Fisher rat thyroid cells. We demonstrated, using iodide efflux, whole cell patch clamp, and short-circuit recordings, that 5-butyl-6-hydroxy-10-chlorobenzo[c]quinolizinium chloride (MPB-91) restored the activity of G551D CFTR (EC50 = 85 μM) and activated CFTR in Calu-3 cells (EC50 = 47 μM). MPB-91 has no effect on the ATPase activity of wild-type and G551D NBD1/R/GST fusion proteins or on the ATPase, GTPase, and adenylate kinase activities of purified NBD2. The activation of CFTR by MPB-91 is independent of phosphorylation because (1) kinase inhibitors have no effect and (2) the compound still activated CFTR having 10 mutated protein kinase A sites (10SA-CFTR). The new pharmacol. agent MPB-91 may be an important candidate drug to ameliorate the ion transport defect associated with CF and to point out a new pathway to modulate CFTR activity.

American Journal of Physiology published new progress about CFTR (cystic fibrosis transmembrane conductance regulator) Role: BSU (Biological Study, Unclassified), PRP (Properties), BIOL (Biological Study). 2905-54-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H6Cl2O2, Synthetic Route of 2905-54-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chen, Xiaohong; Liu, Xiaoguang; Martinez, Jenny S.; Mohr, Justin T. published the artcile< Practical regioselective halogenation of vinylogous esters: synthesis of differentiated mono-haloresorcinols and polyhalogenated resorcinols>, Electric Literature of 42413-03-6, the main research area is regioselective halogenation vinylogous ester; synthesis differentiated haloresorcinol polyhalogenated resorcinol.

A practical and efficient method for the direct, regioselective conversion of vinylogous esters to haloresorcinols is reported. Control of the reaction conditions enables synthesis of either the 4- or 6-haloresorcinol isomers from a common precursor with excellent regiocontrol and high yield. The generality and functional group tolerance of this novel protocol is demonstrated. The utility of this methodol. to access polyhaloresorcinols is also reported. These methods create useful functionalized building blocks for further synthetic applications.

Tetrahedron published new progress about Esters Role: RCT (Reactant), RACT (Reactant or Reagent) (vinylogous). 42413-03-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2O2S, Electric Literature of 42413-03-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Matsuno, Kenji; Takai, Kazushige; Isaka, Yoshinobu; Unno, Yuka; Sato, Masayuki; Takikawa, Osamu; Asai, Akira published the artcile< S-Benzylisothiourea derivatives as small-molecule inhibitors of indoleamine-2,3-dioxygenase>, Category: chlorides-buliding-blocks, the main research area is benzylisothiourea derivative preparation indoleamine dioxygenase inhibitor.

S-Benzylisothiourea was discovered by its ability to inhibit indoleamine-2,3-dioxygenase (IDO) in our screening program. Subsequent optimization of the initial hit leads to the identification of sub-μM inhibitors of which suppressed kynurenine production in A431 cells. Synthesis and structure-activity relationship of S-benzylisothiourea analogs as small-mol. inhibitors of IDO are described.

Bioorganic & Medicinal Chemistry Letters published new progress about Enzyme inhibitors (indoleamine dioxygenase). 16799-05-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H8BrCl, Category: chlorides-buliding-blocks.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Lee, Hiu-Fung; Lacbay, Cyrus M.; Boutin, Rebecca; Matralis, Alexios N.; Park, Jaeok; Waller, Daniel D.; Guan, Tian Lai; Sebag, Michael; Tsantrizos, Youla S. published the artcile< Synthesis and Evaluation of Structurally Diverse C-2-Substituted Thienopyrimidine-Based Inhibitors of the Human Geranylgeranyl Pyrophosphate Synthase>, Name: 3-Chloro-4-methylbenzene-1-sulfonyl chloride, the main research area is multiple myeloma antimyeloma liver toxicity thienopyrimidine hGGPPS inhibitor pharmacokinetics.

Novel analogs of C-2-substituted thienopyrimidine-based bisphosphonates (C2-ThP-BPs) are described that are potent inhibitors of the human geranylgeranyl pyrophosphate synthase (hGGPPS). Members of this class of compounds induce target-selective apoptosis of multiple myeloma (MM) cells and exhibit antimyeloma activity in vivo. A key structural element of these inhibitors is a linker moiety that connects their (((2-phenylthieno[2,3-d]pyrimidin-4-yl)amino)methylene)bisphosphonic acid core to various side chains. The structural diversity of this linker moiety, as well as the side chains attached to it, was investigated and found to significantly impact the toxicity of these compounds in MM cells. The most potent inhibitor CML-07-119(13c)(I) was evaluated in mouse and rat for liver toxicity and systemic exposure, resp., providing further optimism for the potential value of such compounds as human therapeutics.

Journal of Medicinal Chemistry published new progress about Antiproliferative agents. 42413-03-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2O2S, Name: 3-Chloro-4-methylbenzene-1-sulfonyl chloride.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Suzuki, Takayoshi; Ota, Yosuke; Ri, Masaki; Bando, Masashige; Gotoh, Aogu; Itoh, Yukihiro; Tsumoto, Hiroki; Tatum, Prima R.; Mizukami, Tamio; Nakagawa, Hidehiko; Iida, Shinsuke; Ueda, Ryuzo; Shirahige, Katsuhiko; Miyata, Naoki published the artcile< Rapid Discovery of Highly Potent and Selective Inhibitors of Histone Deacetylase 8 Using Click Chemistry to Generate Candidate Libraries>, Synthetic Route of 16799-05-6, the main research area is anticancer histone deacetylase 8 inhibitor preparation SAR.

To find HDAC8-selective inhibitors, we designed a library of HDAC inhibitor candidates, each containing a zinc-binding group that coordinates with the active-site zinc ion, linked via a triazole moiety to a capping structure that interacts with residues on the rim of the active site. These compounds were synthesized by using click chem. Screening identified HDAC8-selective inhibitors including (I) (IC50 = 0.070 μM), which was more potent than PCI-34058 (IC50 = 0.31 μM), a known HDAC8 inhibitor. Mol. modeling suggested that the phenylthiomethyl group of I binds to a unique hydrophobic pocket of HDAC8, and the orientation of the phenylthiomethyl and hydroxamate moieties (fixed by the triazole moiety) is important for the potency and selectivity. The inhibitors caused selective acetylation of cohesin in cells and exerted growth-inhibitory effects on T-cell lymphoma and neuroblastoma cells (GI50 = 3-80 μM). These findings suggest that HDAC8-selective inhibitors have potential as anticancer agents.

Journal of Medicinal Chemistry published new progress about Antitumor agents. 16799-05-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H8BrCl, Synthetic Route of 16799-05-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Qu, Tengfei; Qu, Lailiang; Wang, Xiaoguang; Xu, Ting; Xiao, Xiao; Ding, Min; Deng, Li; Guo, Yong published the artcile< Design, synthesis, and antibacterial activity of novel 8-methoxyquinoline-2-carboxamide compounds containing 1,3,4-thiadiazole moiety>, Related Products of 70057-67-9, the main research area is arylthiadiazolyl methoxyquinoline carboxamide preparation antibacterial activity SAR; 1,3,4-thiadiazole; 2-methyl-8-hydroxyquinoline; antibacterial activity; structure-activity relationships.

A series of novel 8-methoxyquinoline-2-carboxamide compounds containing 1,3,4-thiadiazole moiety was designed and synthesized by using an active substructure combination method. Then, the antibacterial activities of all the target compounds were evaluated in-vitro against three Gram-pos. bacteria and three Gram-neg. bacteria. The antibacterial assay showed that some target compounds displayed moderate to good antibacterial efficacy in comparison with the reference drug chloromycin. Some interesting results of structure-activity relationships were also discussed.

Zeitschrift fuer Naturforschung, C: Journal of Biosciences published new progress about Antibacterial agents. 70057-67-9 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H6ClN3S, Related Products of 70057-67-9.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Yang, Tianjiao; Wang, Jiayi; Song, Gonghua published the artcile< Synthesis and nematicidal activity of azabicyclo[3.3.1]nonane-thiadiazole derivatives>, SDS of cas: 70057-67-9, the main research area is nematicidal azabicyclo nonane thiadiazole preparation agrochem.

Nematodes are crop pests which can cause serious loss in crop production and food crisis. Traditional nematicides, such as Carbamate, isothiocyanate and organophosphates, have largely inhibited the damages of nematodes on agriculture, but they also generate neg. effects on both plants and human health, such as root harm and human poisoning. Hence developing novel nematicides with low toxicity and high nematicidal efficiency are extremely urgent. 5-HT(5-hydroxytryptamine) is an important monoamine neurotransmitter which plays important role in mammalian endocrine function as well as in the central and peripheral nervous system. 5-HT was also found to be an important substance which can control the physiol. activities of nematodes including feeding, movement and reproduction So far, some studies have been reported on the development of 5-HT receptor as potential target for nematicides. Based on the previous achievements performed in our group and the principles of drug development, MDL 72222, a typical 5-HT3 receptor antagonist which can significantly inhibit the swallowing function of the pharyngeal pump in caenorhabditis elegans, has a lethal effect on nematicides at certain doses. Upon changing the configuration or number of carbon atoms of the bridged ring and introducing the bioactive group thiadiazole into the structure of compound MDL 72222, 23 new 3-azabicyclo[3.3.1]nonane-thiadiazoles derivatives were designed and synthesized. All the involved compounds were characterized by 1H-NMR, 13C-NMR and HRMS. The in vivo bioactivity test was performed using the root-knot nematodes, and the com. nematocidal agent Avermectin was used as the control product. The nematicidal activity against root-knot nematode was determined Ten target compounds exhibited certain inhibitory activity against root-knot nematodes at a concentration of 40 mg/L.

Huadong Ligong Daxue Xuebao, Ziran Kexueban published new progress about 5-HT antagonists. 70057-67-9 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H6ClN3S, SDS of cas: 70057-67-9.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Katane, Masumi; Osaka, Naoko; Matsuda, Satsuki; Maeda, Kazuhiro; Kawata, Tomonori; Saitoh, Yasuaki; Sekine, Masae; Furuchi, Takemitsu; Doi, Issei; Hirono, Shuichi; Homma, Hiroshi published the artcile< Identification of Novel d-Amino Acid Oxidase Inhibitors by in Silico Screening and Their Functional Characterization in Vitro>, Recommanded Product: 5-(3-Chlorophenyl)-1,3,4-thiadiazol-2-amine, the main research area is Amino acid oxidase inhibitor screening.

D-Amino acid oxidase (DAO) is a degradative enzyme that is stereospecific for d-amino acids, including d-serine and d-alanine, which are potential coagonists of the N-methyl-d-aspartate (NMDA) receptor. Dysfunction of NMDA receptor-mediated neurotransmission has been implicated in the onset of various mental disorders such as schizophrenia. Hence, a DAO inhibitor that augments the brain levels of d-serine and/or d-alanine and thereby activates NMDA receptor function is expected to be an antipsychotic drug, for instance, in the treatment of schizophrenia. In the search for potent DAO inhibitor(s), a large number of compounds were screened in silico, and several compounds were estimated as candidates. These compounds were then characterized and evaluated as novel DAO inhibitors in vitro. The results reported in this study indicate that some of these compounds are possible lead compounds for the development of a clin. useful DAO inhibitor and have the potential to serve as active site probes to elucidate the structure-function relationships of DAO.

Journal of Medicinal Chemistry published new progress about Antipsychotics. 70057-67-9 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H6ClN3S, Recommanded Product: 5-(3-Chlorophenyl)-1,3,4-thiadiazol-2-amine.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Marivingt-Mounir, Cecile; Norez, Caroline; Derand, Renaud; Bulteau-Pignoux, Laurence; Nguyen-Huy, Dung; Viossat, Bernard; Morgant, Georges; Becq, Frederic; Vierfond, Jean-Michel; Mettey, Yvette published the artcile< Synthesis, SAR, Crystal Structure, and Biological Evaluation of Benzoquinoliziniums as Activators of Wild-Type and Mutant Cystic Fibrosis Transmembrane Conductance Regulator Channels>, Related Products of 2905-54-6, the main research area is benzoquinolizinium preparation cystic fibrosis transmembrane conductance regulator channel activation; benzoindoloquinolizinium preparation cystic fibrosis transmembrane conductance regulator channel activation.

Chloride channels play important roles in homeostasis and regulate cell volume, transepithelial transport, and elec. excitability. Despite recent progress made in the genetic and mol. aspect of chloride channels, their pharmacol. is still poorly understood. The cystic fibrosis transmembrane conductance regulator (CFTR) is a cAMP-regulated epithelial chloride channel for which mutations cause cystic fibrosis. Here we have synthesized benzo[c]quinolizinium, e.g., I, and benzo[f]indolo[2,3-a]quinolizinium salts (MPB), e.g., II, and performed a SAR to identify the structural basis for activation of the CFTR chloride channel. Synthesized compounds were evaluated on wild-type CFTR and on CFTR having the glycine-to-aspartic acid missense mutation at codon 551 (G551D-CFTR), using a robot and cell-based assay. The presence of an hydroxyl group at position 6 of the benzo[c]quinolizinium skeleton associated with a chlorine atom at position 10 or 7 and an alkyl chain at position 5 determined the highest activity. The most potent product is 5-butyl-7-chloro-6-hydroxybenzo[c]quinolizinium chloride (I, MPB-104). I is 100 times more potent than the parent compound III (MPB-07).

Journal of Medicinal Chemistry published new progress about CFTR (cystic fibrosis transmembrane conductance regulator) Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 2905-54-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H6Cl2O2, Related Products of 2905-54-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics