Tag: M.W=200-250

Li, Huangong published the artcileTargeted Synthesis of Anthranilic Diamides Insecticides Containing Trifluoroethoxyl Phenylpyrazole, Name: 1-(2-Chloro-5-(trifluoromethyl)phenyl)hydrazine, the publication is Chemical Research in Chinese Universities (2021), 37(3), 655-661, database is CAplus.

A series of novel anthranilic diamides analogs I [R = 4-F, 5-F, 5-Cl, 5-Br, 4-F₃C; R¹ = Me, Et, i-Pr, etc.] containing trifluoroethoxyl pyrazole moiety was designed and synthesized and their insecticidal bioactivities against Mythimna separata (Walker, M. separata) and Plutellaxylostella (P. xylostella) were evaluated. The structures of the title compounds I were confirmed by ¹H NMR, ¹³C NMR and HRMS. Preliminary insecticidal activities showed that some of the title compounds possessed good to excellent bioactivities towards M. separata and P. xylostella. Compounds I [R = 5-F, R¹ = i-Pr; R = 4-F, R¹ = F₃CH₂C] exhibited 100% mortality rate against M.sep. at 0.2mg/L. For the P. xylostella, the synthesized compoundsI [R = 5-F, R¹ = i-Pr, cyclopropyl; R = 5-F₃C, 5-Br, R¹ = Me; R = 5-Cl, R¹ = HF₂CH₂C] showed 70%, 80%, 75%, 65% and 60% insecticidal activities at 1×10^-6 mg/L, resp., higher than that of chlorantraniliprole(0). Based on excellent insecticidal activities, the mode of the action was tested by the calcium-imaging technique, the results of which demonstrated that the novel compounds shared the same target with chlorantraniliprole. The binding pose of the most active compound I [R = 4-F, R¹ = F₃CH₂C] in RyRs of P. xylostella was predicted by mol. docking, which showed that compound I [R = 4-F, R¹ = F₃CH₂C] interacted with the residues Glu140(A) and His147(A) via hydrogen bond.

Chemical Research in Chinese Universities published new progress about 1869-22-3. 1869-22-3 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Hydrazine,Amine,Benzene, name is 1-(2-Chloro-5-(trifluoromethyl)phenyl)hydrazine, and the molecular formula is C7H6ClF3N2, Name: 1-(2-Chloro-5-(trifluoromethyl)phenyl)hydrazine.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Sun, Guo-Quan published the artcileNickel-catalyzed electrochemical carboxylation of unactivated aryl and alkyl halides with CO₂, Application In Synthesis of 637-07-0, the publication is Nature Communications (2021), 12(1), 7086, database is CAplus and MEDLINE.

A general and practical electro-reductive Ni-catalytic system, realizing the electrocatalytic carboxylation of unactivated aryl chlorides and alkyl bromides with CO₂ were reported. A variety of unactivated aryl bromides, iodides and sulfonates can also undergo such a reaction smoothly. Notably, realized the catalytic electrochem. carboxylation of aryl (pseudo)halides with CO₂ avoiding the use of sacrificial electrodes. Moreover, this sustainable and economic strategy with electron as the clean reductant features mild conditions, inexpensive catalyst, safe and cheap electrodes, good functional group tolerance and broad substrate scope. Mechanistic investigations indicated that the reaction might proceed via oxidative addition of aryl halides to Ni(0) complex, the reduction of aryl-Ni(II) adduct to the Ni(I) species and following carboxylation with CO₂.

Nature Communications published new progress about 637-07-0. 637-07-0 belongs to chlorides-buliding-blocks, auxiliary class Inhibitor,Cell Cycle,PPAR, name is Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate, and the molecular formula is C40H35N7O8, Application In Synthesis of 637-07-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Du, Qiuyao published the artcileSimultaneous determination and quantitation of hypolipidemic drugs in fingerprints by UPLC-Q-TRAP/MS, Formula: C12H15ClO3, the publication is Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences (2021), 122496, database is CAplus and MEDLINE.

An ultra-performance liquid chromatog. tandem triple quadrupole compound linear ion trap mass spectrometry (UPLC-Q-TRAP/MS) method was developed and validated for the detection of hypolipidemic drugs in fingerprints. 13 Hypolipidemic drugs were well separated by the gradient elution of 0.01% formic acid in water and methanol at a flow rate of 0.4 mL/min within 11 min. The analytes were detected in pos. (ESI⁺) and neg. (ESI^–) modes and scanned using scheduled multiple reaction monitoring-information dependent acquisition-enhanced product ion (SMRM-IDA-EPI) for best selectivity and sensitivity. The calibration curves showed good linearity in the range of 0.050-50.000 ng/patch with coefficients (r²) higher than 0.9904 for all analytes. Meantime, the LODs and LLOQs were in ranges of 0.001-0.034 and 0.003-0.050 ng/patch. The accuracies, intra-day and inter-day precision ranged from -13.3 to 0.3%, 1.1-10.4% and 3.7-14.5%, resp. The recoveries ranged from 79.9 to 114.8%, while the absolute and relative matrix effects were in the range of 83.0-107.2% and 2.2-9.7%. By comparing the non-spiked fingerprints from healthy volunteers with the fingerprints obtained from patients, demonstrated that the method was competent for determination and quantitation of hypolipidemic drugs in fingerprints.

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences published new progress about 637-07-0. 637-07-0 belongs to chlorides-buliding-blocks, auxiliary class Inhibitor,Cell Cycle,PPAR, name is Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate, and the molecular formula is C12H15ClO3, Formula: C12H15ClO3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Fu, Jun-Hao published the artcileEnantioselective vinylogous aldol/lactonization cascade reaction between β,γ-unsaturated amides and trifluoromethyl ketones: facile access to chiral trifluoromethyl dihydropyranones, Safety of 1-(2-Chlorophenyl)-2,2,2-trifluoroethanone, the publication is Organic & Biomolecular Chemistry (2020), 18(39), 7848-7851, database is CAplus and MEDLINE.

An efficient asym. vinylogous aldol/lactonization cascade reaction between β,γ-unsaturated amides I (R¹ = C₆H₅, 2-thienyl, 1-naphthyl, etc.) and trifluoromethyl ketones has R²C(O)CF₃ (R² = C₆H₅, 2-ClC₆H₄, CH=CHC₆H₅, etc.) been developed. Using a chiral cyclohexanediamine-based tertiary amine-thiourea catalyst II [Ar = 3,5-(CF₃)₂C₆H₃], optically active trifluoromethyl dihydropyranones (S)-III have been constructed in moderate-to-excellent yields (up to 99%) with excellent stereoselectivities (96-> 99.5% ee).

Organic & Biomolecular Chemistry published new progress about 5860-95-7. 5860-95-7 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Benzene,Ketone, name is 1-(2-Chlorophenyl)-2,2,2-trifluoroethanone, and the molecular formula is C8H4ClF3O, Safety of 1-(2-Chlorophenyl)-2,2,2-trifluoroethanone.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Calvo, Roxan published the artcileFacile access to nitroarenes and nitroheteroarenes using N-nitrosaccharin, Safety of Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate, the publication is Nature Communications (2019), 10(1), 1-8, database is CAplus and MEDLINE.

Nitroaroms. and nitroheteroaroms. serve as key building blocks and intermediates in synthesis, and form the core scaffold of a vast number of materials, dyes, explosives, agrochems. and pharmaceuticals. However, their synthesis relies on harsh methodologies involving excess mineral acids, which present a number of critical drawbacks in terms of functional group compatibility and environmental impact. Modern, alternative strategies still suffer from significant limitations in terms of practicality, and a general protocol amenable to the direct C-H functionalization of a broad range of aromatics has remained elusive. Herein, author introduces a bench-stable, inexpensive, easy to synthesize and recyclable nitrating reagent based on saccharin. This reagent acts as a controllable source of the nitronium ion, allowing mild and practical nitration of both arenes and heteroarenes displaying an exceptional functional group tolerance.

Nature Communications published new progress about 637-07-0. 637-07-0 belongs to chlorides-buliding-blocks, auxiliary class Inhibitor,Cell Cycle,PPAR, name is Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate, and the molecular formula is C12H15ClO3, Safety of Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Liu, Haitao published the artcileOptimization of clofibrate with O-desmethyl anetholtrithione lead to a novel hypolipidemia compound with hepatoprotective effect, Formula: C12H15ClO3, the publication is Bioorganic & Medicinal Chemistry Letters (2022), 128844, database is CAplus and MEDLINE.

Oxidative stress and inflammation were considered to be the major mechanisms in liver damage caused by clofibrate (CF). In order to obtain lipid-lowering drugs with less liver damage, the structure of clofibrate was optimized by O-desmethyl anetholtrithione and got the target compound clofibrate-O-desmethyl anetholtrithione (CF-ATT). CF-ATT significantly reduced the levels of plasma triglycerides (TG), total cholesterol (TC) in hyperlipidemia mice induced by Triton WR-1339. In addition, CF-ATT has a significantly protective effect on the liver compared with CF. The liver weight and liver coefficient were reduced. The hepatic function indexes were also decreased, such as aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alk. phosphatase (ALP). Histopathol. examination of the liver revealed that inflammatory cell infiltration, nuclear degeneration, cytoplasmic loosening and hepatocyte necrosis were ameliorated by administration with CF-ATT. The hepatoprotective mechanism showed that CF-ATT significantly up-regulated Nrf2 and HO-1 protein expression and down-regulated p-NF-κB P65 expression in the liver. CF-ATT has obviously antioxidant and anti-inflammatory activity. These findings suggested that CF-ATT has significant hypolipidemia activity and exact hepatoprotective effect possibly through the Nrf2/NF-κB-mediated signal pathway.

Bioorganic & Medicinal Chemistry Letters published new progress about 637-07-0. 637-07-0 belongs to chlorides-buliding-blocks, auxiliary class Inhibitor,Cell Cycle,PPAR, name is Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate, and the molecular formula is C12H15ClO3, Formula: C12H15ClO3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Bai, Ying published the artcileUse of functionalized PEG with 4-aminobenzoic acid stabilized platinum nanoparticles as an efficient catalyst for the hydrosilylation of alkenes, Synthetic Route of 14799-93-0, the publication is Journal of Colloid and Interface Science (2013), 428-433, database is CAplus and MEDLINE.

A catalyst containing functionalized polyethylene glycol with 4-aminobenzoic acid (PEG-AMB) stabilized Pt nanoparticles was synthesized and characterized, and its application in the hydrosilylation of alkenes studied. The functionalized PEG-stabilized Pt nanoparticles form a very efficient catalyst for the hydrosilylation of alkenes. The Pt nanoparticles can be fully immobilized in the PEG-AMB and recycled at least nine times without any obvious loss of catalytic activity.

Journal of Colloid and Interface Science published new progress about 14799-93-0. 14799-93-0 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(methyl)(octyl)silane, and the molecular formula is C9H20Cl2Si, Synthetic Route of 14799-93-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Yang, Hu published the artcileHydrosilylation of alkenes catalyzed by MCM-48 supported chitosan-platinum complex, Formula: C9H20Cl2Si, the publication is Hangzhou Shifan Daxue Xuebao, Ziran Kexueban (2012), 11(3), 217-221, database is CAplus.

A new Pt/CS-MCM-48 catalysts was prepared from chitosan supported on MCM-48. The catalyst was characterized by XRD, IR and TG. The results indicated that coordination bond between platinum and nitrogen atom of chitosan was formed. Pt/CS-MCM-48 catalyst has favorable catalytic performance for the hydrosilylation of alkenes, the regioselectivity of adduct is above 90%, and the catalyst can be reused for 14 times without noticeable loss of activity.

Hangzhou Shifan Daxue Xuebao, Ziran Kexueban published new progress about 14799-93-0. 14799-93-0 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(methyl)(octyl)silane, and the molecular formula is C11H24O3, Formula: C9H20Cl2Si.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Tian, Ze-Yu published the artcileVisible-light-initiated catalyst-free trifluoromethylselenolation of arylsulfonium salts with [Me₄N][SeCF₃], SDS of cas: 637-07-0, the publication is Organic Chemistry Frontiers (2022), 9(8), 2220-2227, database is CAplus.

The redox potential gap between arylsulfonium salts and [Me₄N][SeCF₃] has been clearly revealed by CV measurements. Construction of the carbon-selenium bond by overcoming this gap without using catalysts and additives is a challenging task. Here, the authors report an efficient visible-light-induced cross-coupling of arylsulfonium triflates, e.g., 5-[4-(4-cyanophenoxy)phenyl]-5H-thianthren-5-ium triflate, with [Me₄N][SeCF₃] by simply mixing these two species, which allowed the facile synthesis of various aryl trifluoromethyl selenoethers, e.g., ArSeCF₃ (Ar = 2-formyl-4-methoxyphenyl, N-methylcarbazol-6-yl, benzodioxol-5-yl, etc.) under catalyst- and additive-free conditions. The mechanistic study indicated that aryl and SeCF₃ radicals might be formed as key intermediates in the reactions. Merits of the reactions include operational simplicity, high efficiency, visible-light irradiation, good functional group tolerance, a wide range of substrates, excellent chemoselectivity, and good yields of (trifluoromethyl)selenolated products, which combined with a sulfenylation process enabled the selective and practical installation of SeCF₃ moieties onto complex arenes, including drug mols., via a formal C-H functionalization.

Organic Chemistry Frontiers published new progress about 637-07-0. 637-07-0 belongs to chlorides-buliding-blocks, auxiliary class Inhibitor,Cell Cycle,PPAR, name is Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate, and the molecular formula is C7H8O3, SDS of cas: 637-07-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Qi, Jing published the artcileNew Radical Borylation Pathways for Organoboron Synthesis Enabled by Photoredox Catalysis, Category: chlorides-buliding-blocks, the publication is Angewandte Chemie, International Edition (2020), 59(31), 12876-12884, database is CAplus and MEDLINE.

Radical borylation using N-heterocyclic carbene (NHC)-BH₃ complexes as boryl radical precursors has emerged as an important synthetic tool for organoboron assembly. However, the majority of reported methods are limited to reaction modes involving carbo- and/or hydroboration of specific alkenes and alkynes. Moreover, the generation of NHC-boryl radicals relies principally on hydrogen atom abstraction with the aid of radical initiators. A distinct radical generation method is reported, as well as the reaction pathways of NHC-boryl radicals enabled by photoredox catalysis. NHC-boryl radicals are generated via a single-electron oxidation and subsequently undergo cross-coupling with the in-situ-generated radical anions to yield gem-difluoroallylboronates. A photoredox-catalyzed radical arylboration reaction of alkenes was achieved using cyanoarenes as arylating components from which elaborated organoborons were accessed. Mechanistic studies verified the oxidative formation of NHC-boryl radicals through a single-electron-transfer pathway.

Angewandte Chemie, International Edition published new progress about 5860-95-7. 5860-95-7 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Benzene,Ketone, name is 1-(2-Chlorophenyl)-2,2,2-trifluoroethanone, and the molecular formula is C8H4ClF3O, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics