Tag: M.W=200-250

Chen, Ping; Wang, Kai; Zhang, Boyu; Guo, Wengang; Liu, Yan; Li, Can published the artcile< Water enables an asymmetric cross reaction of α-keto acids with α-keto esters for the synthesis of quaternary isotetronic acids>, Application of C8H8BrCl, the main research area is quaternary isotetronic acid preparation chemoselective enantioselective; keto acid ester tandem cross coupling pyrrolidinyl imidazole catalyst.

A water promoted asym. aldol/lactonization/enolization cascade reaction of α-keto acids R1CH2C(O)C(O)OH (R1 = H, Me) and α-keto esters R2C(O)C(O)OC(CH3)3 [R2 = 4-FC6H4(CH2)2, CH2=CH(CH2)2, C6H5CH2O(CH2)3, etc.] was developed, affording the first general protocol for the construction of chiral quaternary isotetronic acids I with excellent enantioselectivity. Theor. results indicate that intramol. ionized enamine intermediates stabilized by water generate zwitterionic transition states in a lower activation energy and higher face selectivity, resulting in high activity and chemo- and enantioselectivity.

Chemical Communications (Cambridge, United Kingdom) published new progress about Cross-coupling reaction catalysts, stereoselective (regioselective). 16799-05-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H8BrCl, Application of C8H8BrCl.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chang, Suae-Chen; Gleicher, Gerald J. published the artcile< Attempt to observe neighboring group participation in hydrogen abstraction from β-(substituted phenyl)-ethyl bromides>, Synthetic Route of 16799-05-6, the main research area is hydrogen abstraction phenethyl bromide; mechanism hydrogen abstraction.

A series of β-(substituted phenyl)-ethyl bromides are reacted with bromotrichloromethane at 70°. Benzylic hydrogen abstraction comprises the only reaction. The exptl. ρ value for this process is -0.83 ± 0.02. A ρ value is calculated to have the range of -0.84 to -0.90. The negligible difference between these two ρ values is indicative of no anchimeric assistance in this reaction by the neighboring bromine atom under the conditions utilized.

Journal of Organic Chemistry published new progress about Abstraction reaction. 16799-05-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H8BrCl, Synthetic Route of 16799-05-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Yoshinaga, Hidefumi; Masumoto, Shuji; Koyama, Koji; Kinomura, Naoya; Matsumoto, Yuji; Kato, Taro; Baba, Satoko; Matsumoto, Kenji; Horisawa, Tomoko; Oki, Hitomi; Yabuuchi, Kazuki; Kodo, Toru published the artcile< Discovery of SMP-304, a novel benzylpiperidine derivative with serotonin transporter inhibitory activity and 5-HT1A weak partial agonistic activity showing the antidepressant-like effect>, Formula: C8H8BrCl, the main research area is benzylpiperidine derivative preparation serotonin transporter inhibitot antidepressant; 5-HT(1A) receptor; Antidepressant; Benzylpiperidine; Fast onset; Serotonin transporter.

We report the discovery of a novel benzylpiperidine derivative with serotonin transporter (SERT) inhibitory activity and 5-HT1A receptor weak partial agonistic activity showing the antidepressant-like effect. The 3-methoxyphenyl group and the phenethyl group of compound 1, which has weak SERT binding activity, but potent 5-HT1A binding activity, were optimized, leading to compound 35 with potent and balanced dual SERT and 5-HT1A binding activity, but also potent CYP2D6 inhibitory activity. Replacement of the methoxy group in the left part of compound 35 with a larger alkoxy group, such as ethoxy, isopropoxy or methoxy-ethoxy group ameliorated CYP2D6 inhibition, giving SMP-304 as a candidate. SMP-304 with serotonin uptake inhibitory activity and 5-HT1A weak partial agonistic activity, which could work as a 5-HT1A antagonist, displayed faster onset of antidepressant-like effect than a representative SSRI paroxetine in an animal model.

Bioorganic & Medicinal Chemistry published new progress about 5-HT reuptake inhibitors. 16799-05-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H8BrCl, Formula: C8H8BrCl.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Taylor, Steven J.; Soleymanzadeh, Fariba; Eldrup, Anne B.; Farrow, Neil A.; Muegge, Ingo; Kukulka, Alison; Kabcenell, Alisa K.; DeLombaert, Stephane published the artcile< Design and synthesis of substituted nicotinamides as inhibitors of soluble epoxide hydrolase>, COA of Formula: C7H6Cl2O2S, the main research area is nicotinamide derivative preparation soluble epoxide hydrolase inhibitory activity.

A series of potent nicotinamide inhibitors, e.g., I, of soluble epoxides hydrolase (sEH) is disclosed. This series was designed using structure-based deconstruction and a combination of two HTS hit series, resulting in hybrid analogs that retained the optimal potency from one series, and acceptable in vitro metabolic stability from the other. Structure-guided optimization of these analogs gave rise to nanomolar inhibitors of human sEH that had acceptable plasma exposure to qualify them as probes to determine the in vivo phenotypic consequences of sEH inhibition.

Bioorganic & Medicinal Chemistry Letters published new progress about Aralkyl amines Role: RCT (Reactant), RACT (Reactant or Reagent). 42413-03-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2O2S, COA of Formula: C7H6Cl2O2S.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Ovcharova, I. M.; Golovchinskaya, E. S. published the artcile< Syntheses of purines. VII. Some transformations of 2,6-dichloro-9-methylpurine>, Recommanded Product: 2,6-Dichloro-9-methyl-9H-purine, the main research area is .

2,6-Dichloro-9-methylpurine (I) in 4 hrs. with EtONa-EtOH at 20°, then heated briefly, gave 2-chloro-6-ethoxy-9-methylpurine, m. 121-2°; refluxing 2 hrs. with EtONa-EtOH gave 79.2% 2,6-diethoxy-9-methylpurine, m. 87-9°. I and 30% aqueous EtNH2 at 20° gave 92% 2-chloro-6-ethylamino-9-methylpurine, m. 182-5°. Similarly, I and aqueous Na2S at 20° gave 82.3% 2-chloro-9-methylpurine-6-thiol (II), decomposed >300°, which with red P and HI 1 hr. at reflux gave 81% 9-methylpurine-6-thiol, decomposed >300°. I refluxed 5 hrs. in N H2SO4, then quenched in aqueous NaOH, gave 82% 2-chloro-6-hydroxy-9-methylpurine (III), decomposed on heating; the same formed from I in 2 min. in N NaOH at 95°; the product, purified through the Na salt, decomposed 260-70°; it was also formed in 44-9% yield from I and N NaOH in 1 day at room temperature; the substance formed Na salt monohydrate. II heated to 95° with 25-30% aqueous NH3 or amines 12-24 hrs. gave the following 2-amino-9-methylpurine-6-thiols (amino group shown): Me2N (IV), decomposed 273-5°; Et2N, m. 225-8°; PhCH2NH, decomposed 292-4°; EtNH, decomposed >300°; H2N, decomposed >350°. As a by-product some bis-(2-dimethylamino-9-methyl-6-purinyl) disulfide, m. 207-9°, was isolated; this with Na2S solution was reduced to IV. III heated as above with aqueous amines 10-15 hrs. gave the following 2-amino-9-methyl-6-hydroxypurines (amino group shown): Me2N, decomposed 331-3° (HCl salt decomposed 289-90°); Et2N, m. 260-2° (HCl salt decomposed 267-70°); PhCH2NH, decomposed 334-5° (HCl salt decomposed 245-9°); EtNH, decomposed 356-8° (HCl salt decomposed 288-9°); H2N, decomposed 350° (HCl salt decomposed 300-2°). These refluxed in excess POCl3, concentrated in vacuo, and quenched in ice, then adjusted to pH 7, gave 2-amino-6-chloro-9-methylpurines: Me2N, m. 150.5-2.5°; Et2N, m. 86-8°; PhCH2NH, m. 142-3.5°; EtNH, m. 187-9°; H2N, decomposed 262-3°. These refluxed with 2 moles SC(NH2)2 in absolute EtOH gave the same thiols as shown above. These with MeI in N NaOH at 20° gave the following 6-methylthio-9-methylpurines (2-substituent shown): Cl, m. 161-2.5°; H, m. 169-70°; Me2N, m. 152-3.5°; Et2N, m. 105.5-6.5°; PhCH2NH, m. 131.5-3.5°; EtNH, m. 143.5-5.5°; H2N, m. 190°. The yields were 78-86%. Ethylenimine and the appropriate chloropurine gave in 18 hrs. at room temperature 33.8% 2-amino-6-(N-aziridinyl)-9-methylpurine, m. 181-3°; similarly was prepared at -15°, then at room temperature in Et2O, some 2-chloro-6-(N-aziridinyl)-9-methylpurine, m. 130-2 °.

Zhurnal Obshchei Khimii published new progress about 2382-10-7. 2382-10-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C6H4Cl2N4, Recommanded Product: 2,6-Dichloro-9-methyl-9H-purine.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Gillespie, Roger J.; Bamford, Samantha J.; Gaur, Suneel; Jordan, Allan M.; Lerpiniere, Joanne; Mansell, Howard L.; Stratton, Gemma C. published the artcile< Antagonists of the human A2A receptor. Part 5: Highly bio-available pyrimidine-4-carboxamides>, Formula: C8H4ClF3O2, the main research area is pyrimidine carboxamide preparation Parkinson disease antiparkinsonian; pyrimidinylamine arylcarboxylic chloride pyrimininylcarboxylic acid amine amidation; human A1 A2A A2B A3 receptor antagonist structure activity.

A novel series of antagonists of the human A2A receptor have been identified and have been shown to display good potency and high degrees of selectivity over other receptor sub-types. Displaying in vivo potency in commonly used disease models and high oral bio-availability, this class of compounds may serve as clin. useful treatments for the relief of the symptoms associated with Parkinson’s disease.

Bioorganic & Medicinal Chemistry Letters published new progress about Adenosine A1 receptors Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 162046-61-9 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H4ClF3O2, Formula: C8H4ClF3O2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Danner, Paulami; Bauer, Matthias; Phukan, Prodeep; Maier, Martin E. published the artcile< Total synthesis of cryptophycin 3>, COA of Formula: C8H8BrClO, the main research area is cyclodepsipeptide peptidomimetic cryptophycin analog total synthesis; glycine derivative stereoselective alkylation phenylalanine subunit preparation; oxidation Witting reaction hydroxy ester preparation seco acid esterification; peptide coupling Fmoc protection macrolactamization.

The depsipeptide cryptophycin 3 and the cryptophycin analog [I (R1 = Cl, R2 = OMe; R1 = R2 = H)] were prepared from the corresponding four subunits using Fmoc (Fmoc = 9-fluorenylmethyloxycarbonyl) protecting group for the amino functions. The phenylalanine derivative for cryptophycin 3 [subunit B (II)] was prepared by stereoselective alkylation of glycine derivative The tripeptide analogs, which contains fragments D and C was acquired from the starting amino ester III. After extension at the carboxyl function by esterification with the hydroxy ester III, the seco compounds IV (R1 = Cl, R2 = OMe; R1 = R2 = H) were deprotected and submitted to ring closure by macrolactamization in the presence of TBTU as condensing agent.

European Journal of Organic Chemistry published new progress about (Fluorenylmethoxy)carbonyl group. 320407-92-9 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H8BrClO, COA of Formula: C8H8BrClO.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Ullah, Safi; Saeed, Muhammad; Ullah, Irfan; Halimi, Syed Muhammad Ashhad; Khan, Khalid Mohammed; Jahan, Saqib; Mohani, Syed Nadeem; Khan, Saifullah; Khan, Ajmal published the artcile< Synthesis and characterization of novel piroxicam derivatives and their antiglycation activity>, Product Details of C7H6Cl2O3S, the main research area is piroxicam derivative preparation SAR antiglycation.

A series of sulfonated esters of piroxicam I (R = Me, Et, Ph, etc.) were synthesized by substitution of “”H”” from hydroxyl “”OH”” group of piroxicam with different alkyl/aryl sulfonyl chloride by continuous stirring at room temperature Compounds I were screened for antiglycation activity, in order to analyze the effect of substitution for the management of late diabetic complications. The preliminary results showed that compound I (R = Ph) exhibited potent antiglycation activity far better than the reference (rutin IC50 = 274.5 ± 0.05μM), while compounds I (R = 2,4-(MeO)2C6H3) and I (R = 4-ClC6H4) were similar with IC50 values of 178.9 ± 1.55μM, 237 ± 2.01μM, and 256.5 ± 2.56μM resp. Moreover a neg. effect of electron withdrawing groups was observed over the inhibition potential of different analogs depending upon the number and the positions of the substituents.

Journal of Molecular Structure published new progress about Advanced glycation end product inhibitors. 22952-32-5 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2O3S, Product Details of C7H6Cl2O3S.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Blades, Kevin; Demeritt, Julie; Fillery, Shaun; Foote, Kevin M.; Greenwood, Ryan; Gregson, Clare; Hassall, Lorraine A.; McGuire, Thomas M.; Pike, Kurt G.; Williams, Emma published the artcile< Expedient synthesis of biologically important sulfonylmethyl pyrimidines>, Computed Properties of 351003-34-4, the main research area is sulfonylmethyl pyrimidine preparation.

Two novel synthetic strategies that allow rapid diversification of the sulfone moiety in sulfonylmethyl pyrimidines, a class of compounds with a wide range of biol. activity, which are of interest in a wide variety of drug discovery programs, are described.

Tetrahedron Letters published new progress about Pyrimidines Role: SPN (Synthetic Preparation), PREP (Preparation). 351003-34-4 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H5ClF2O3S, Computed Properties of 351003-34-4.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Steinmetzer, Torsten; Baum, Bernhard; Biela, Adam; Klebe, Gerhard; Nowak, Goetz; Bucha, Elke published the artcile< Beyond Heparinization: Design of Highly Potent Thrombin Inhibitors Suitable for Surface Coupling>, Recommanded Product: 3-Chloro-4-methylbenzene-1-sulfonyl chloride, the main research area is dialysis equipment thrombin inhibitor SAR anticoagulant; X-ray crystallography; anticoagulants; inhibitors; serine proteases; thrombin.

During extracorporeal circulation, when blood comes in contact with artificial surfaces, patients receive a standard treatment with anticoagulants to avoid blood coagulation. Dialysis patients in particular are systemically treated with heparin up to four times a week, causing a high burden for the body. For potential anticoagulant modification of external materials, such as dialysis equipment, a series of highly potent thrombin inhibitors was developed. All inhibitors share the general formula arylsulfonyl-P3-Pro-4-amidinobenzylamide, where P3 is glycyl or a trifunctional amino acid residue in L-configuration. Among this series, several derivatives inhibit thrombin with Ki values of less than 1 nM. Specificity measurements revealed that this inhibitor type is highly specific for thrombin with negligible activity against related trypsin-like serine proteases. X-ray anal. of the most potent analog in complex with thrombin demonstrated that the N-terminal arylsulfonyl group occupies the aryl binding site, whereas the P3 side chain is directed into the solvent and therefore is well suited for further coupling. Based on their in vitro profile, these inhibitors are suitable candidates for the development of hemocompatible materials with anticoagulant properties.

ChemMedChem published new progress about Anticoagulants. 42413-03-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2O2S, Recommanded Product: 3-Chloro-4-methylbenzene-1-sulfonyl chloride.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics